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  • 1. Almquist, T.
    et al.
    Jacobson, S. H.
    Mobarrez, F.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis. KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Hjemdahl, P.
    Lipid-lowering treatment and inflammatory mediators in diabetes and chronic kidney disease2014In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 44, no 3, p. 276-284Article in journal (Refereed)
    Abstract [en]

    Background: Inflammation may contribute to the high cardiovascular risk in diabetes mellitus (DM) and chronic kidney disease (CKD). Monocyte chemoattractant protein-1 (MCP-1) facilitates the recruitment of monocytes into atherosclerotic lesions and is involved in diabetic nephropathy. Interferon gamma (IFNγ) is important in atherosclerosis and increases the synthesis of chemokines including MCP-1. Lipid-lowering treatment (LLT) with statins may have anti-inflammatory effects, and ezetimibe cotreatment provides additional cholesterol lowering. Methods: After a placebo run-in period, the effects of simvastatin alone (S) or simvastatin + ezetimibe (S+E) were compared in a randomized, double-blind, cross-over study on inflammatory parameters. Eighteen DM patients with estimated glomerular filtration rate (eGFR) 15-59 mL/min × 1·73 m2 (CKD stages 3-4) (DM-CKD) and 21 DM patients with eGFR > 75 mL/min (DM only) were included. Results: At baseline, monocyte chemoattractant protein 1 (MCP-1) (P = 0·03), IFNγ (P = 0·02), tumour necrosis factor-α (TNFα) (P < 0·01) and soluble vascular adhesion molecule (sVCAM) (P = 0·001) levels were elevated in DM-CKD compared with DM-only patients. LLT with S and S+E reduced MCP-1 levels (P < 0·01 by anova) and IFNγ levels (P < 0·01) in DM-CKD patients but not in DM-only patients. Reductions were most pronounced with the combination treatment. Conclusions: DM patients with CKD stages 3-4 had increased inflammatory activity compared with DM patients with normal GFR. Lipid-lowering treatment decreased the levels of MCP-1 and IFNγ in DM patients with concomitant CKD, which may be beneficial with regard to the progression of both atherosclerosis and diabetic nephropathy.

  • 2.
    Gomez-Cid, L.
    et al.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Fuentes, L.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Fernandez-Santos, M. E.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Suarez-Sancho, S.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Plasencia, V.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Climent, A. M.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Sanz-Ruiz, R.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Hedhammar, My
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Protein Technology.
    Atienza, F.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Aviles, F. F.
    Hosp GU Gregorio Maranon, Serv Cardiol, CIBERCV, Madrid, Spain..
    Effect of spider silk matrix on cardiac tissue regeneration of mesenchymal stem cells2018In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 48, p. 150-150Article in journal (Other academic)
  • 3. Kahan, T.
    et al.
    Forslund, L.
    Held, C.
    Björkander, I.
    Billing, E.
    Eriksson, S. V.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Rehnqvist, N.
    Hjemdahl, P.
    Risk prediction in stable angina pectoris2013In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 43, no 2, p. 141-151Article in journal (Refereed)
    Abstract [en]

    Background: Although stable angina pectoris often carries a favourable prognosis, it remains important to identify patients with an increased risk of cardiovascular (CV) complications. Many new markers of disease activity and prognosis have been described. We evaluated whether common and easily accessible markers in everyday care provide sufficient prognostic information. Materials and methods: The Angina Pectoris Prognosis Study in Stockholm treated 809 patients (248 women) with stable angina pectoris with metoprolol or verapamil double blind during a median follow-up of 3·4 years, with a registry-based extended follow-up after 9·1 years. Clinical and mechanistic variables, including lipids and glucose, renal function, ambulatory and exercise-induced ischaemia, heart rate variability, cardiac and vascular ultrasonography, and psychosocial variables were included in an integrated analysis. Main outcome measures were nonfatal myocardial infarction (MI) and CV death combined. Results: In all, 139 patients (18 women) suffered a main outcome. Independent predictive variables were (odds ratio [95% confidence intervals]), age (1·04 per year [1·00;1·08], P = 0·041), female sex (0·33 [0·16;0·69], P = 0·001), fasting blood glucose (1.29 per mM [1.14; 1.46], P < 0·001), serum creatinine (1·02 per μM [1·00;1·03], P < 0·001) and leucocyte counts (1·21 per 106 cells/L [1·06;1·40], P = 0·008). Smoking habits, lipids and hypertension or a previous MI provided limited additional information. Impaired fasting glucose was as predictive as manifest diabetes and interacted adversely with serum creatinine. Sexual problems were predictive among men. Conclusions: Easily accessible clinical and demographic variables provide a good risk prediction in stable angina pectoris. Impaired glucose tolerance and an elevated serum creatinine are particularly important.

  • 4. Keramidas, Michail E.
    et al.
    Norman, Barbara
    Gustafsson, Thomas
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Mekjavic, Igor B.
    Long-term intermittent hyperoxic exposures do not enhance erythropoiesis2012In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 42, no 3, p. 260-265Article in journal (Refereed)
    Abstract [en]

    Eur J Clin Invest 2011 ABSTRACT: Background  Based on a report of a marked increase in the erythropoietin concentration ([EPO]) a few hours after the cessation of a single 2-h session of O(2) breathing, short periods of O(2) administration have been advocated as a therapy for anaemia. Accordingly, the purpose of the present study was to evaluate this theory by investigating the effect of 10 daily short-term exposures to normobaric O(2) over a 2-week period on the plasma [EPO] in healthy individuals. Material and methods  Twenty men were assigned to either an experimental (NBO(2) ) or to a control (AIR) group. The NBO(2) group breathed 100% normobaric O(2) for 2 h every weekday over a 2-week period. The AIR group breathed air within the same time protocol. Blood samples were collected at the pre-, mid- and post-intervention periods to determine [EPO]. Results  [EPO] of the NBO(2) group was significantly lower than that of the AIR group during the mid- and post-periods (P < 0·001). [EPO] of the NBO(2) group showed a slight, albeit statistically nonsignificant, decrease during the mid (∼ 11%)- and post (∼ 16%)-periods. Conclusions  Daily short-term exposures to normobaric hyperoxia do not increase the [EPO] in healthy individuals. The increased O(2) tension suppresses [EPO]. Hence, administration of pure O(2) to enhance erythropoiesis is not warranted.

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