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  • 1.
    Ivanisevic, Nikola
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Electronics, Integrated devices and circuits.
    Rodriguez, Saul
    KTH, School of Electrical Engineering and Computer Science (EECS), Electronics, Integrated devices and circuits.
    Rusu, Ana
    KTH, School of Electrical Engineering and Computer Science (EECS), Electronics, Integrated devices and circuits.
    Impedance Spectroscopy Based on Linear System Identification2019In: IEEE Transactions on Biomedical Circuits and Systems, ISSN 1932-4545, E-ISSN 1940-9990, Vol. 13, no 2, p. 396-402Article in journal (Refereed)
    Abstract [en]

    Impedance spectroscopy is a commonly used mea-surement technique for electrical characterization of a sample-under-test over a wide frequency range. Most measurementmethods employ a sine wave excitation generator, which implies apoint-by-point frequency sweep and a complex readout architec-ture. This paper presents a fast, wide-band, measurement methodfor impedance spectroscopy based on linear system identification.The main advantage of the proposed method is the low hardwarecomplexity, which consists of a 3-level pulse waveform, aninverting voltage amplifier and a general purpose ADC. A proof-of-concept prototype, which is implemented with off-the-shelfcomponents, achieves an estimation fit of approximately 96%.The prototype operation is validated electrically using knownRC component values and tested in real application conditions.

  • 2.
    Rodriguez, S.
    et al.
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Ollmar, S.
    Waqar, M.
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Rusu, A.
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    A Batteryless Sensor ASIC for Implantable Bio-Impedance Applications2015In: IEEE Transactions on Biomedical Circuits and Systems, ISSN 1932-4545, E-ISSN 1940-9990Article in journal (Refereed)
    Abstract [en]

    The measurement of the biological tissue’s electrical impedance is an active research field that has attracted a lot of attention during the last decades. Bio-impedances are closely related to a large variety of physiological conditions; therefore, they are useful for diagnosis and monitoring in many medical applications. Measuring living tissues, however, is a challenging task that poses countless technical and practical problems, in particular if the tissues need to be measured under the skin. This paper presents a bio-impedance sensor ASIC targeting a battery-free, miniature size, implantable device, which performs accurate 4-point complex impedance extraction in the frequency range from 2 kHz to 2 MHz. The ASIC is fabricated in 150 nm CMOS, has a size of 1.22 mm × 1.22 mm and consumes 165 μA from a 1.8 V power supply. The ASIC is embedded in a prototype which communicates with, and is powered by an external reader device through inductive coupling. The prototype is validated by measuring the impedances of different combinations of discrete components, measuring the electrochemical impedance of physiological solution, and performing ex vivo measurements on animal organs. The proposed ASIC is able to extract complex impedances with around 1 Ω resolution; therefore enabling accurate wireless tissue measurements.

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