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  • 1. Gustafsson, A. C.
    et al.
    Guo, Z. M.
    Hu, X. R.
    Ahmadian, Afshin
    KTH, Superseded Departments, Biotechnology.
    Brodin, B.
    Nilsson, A.
    Ponten, J.
    Ponten, F.
    Lundeberg, Joakim
    KTH, Superseded Departments, Biotechnology.
    HPV-related cancer susceptibility and p53 codon 72 polymorphism2001In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 81, no 2, p. 125-129Article in journal (Refereed)
    Abstract [en]

    Conflicting results regarding the association of a polymorphism at codon 72 of the p53 tumour suppressor gene and susceptibility to develop human papilloma virus (HPV)-associated cervical cancer have been published over the last year, implicating differences in ethnic background, sample origin, sample size and/or detection assay, The material for this study was collected in the identical geographical region as for 2 previous reports with contradictory results regarding the association of codon 72 genotype with squamous cell cancer (SCC), We have used an alternative detection assay, based on pyrosequencing technology, that interrogates the variable position by the accuracy of DNA polymerase. In addition to cervical clinical specimens from SCC, HPV16- and HPV18-infected adenocarcinoma cases as well as cervical intraepithelial neoplasia (CM) were investigated. No significant association was found between p53 codon 72 genotype and the risk to develop adenocarcinoma, SCC or CIN in the Swedish population.

  • 2.
    Gustafsson, Anna C.
    et al.
    KTH, Superseded Departments, Biotechnology.
    Ren, Z. P.
    Asplund, A.
    Ponten, F.
    Lundeberg, Joakim
    KTH, Superseded Departments, Biotechnology.
    The role of p53 codon 72 and human papilloma virus status of cutaneous squamous cell carcinoma in the Swedish population2004In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 84, no 6, p. 439-444Article in journal (Refereed)
    Abstract [en]

    The arginine variant of the p53 codon 72 polymorphism as well as anogenital and epidermodysplasia verruciformis (EV) types of human papilloma virus (HPV) are suggested to confer increased risk for developing cutaneous squamous cell carcinoma (SCC). In this pilot study, we analysed the p53 codon 72 genotype distribution in 106 microdissected samples from normal and tumour tissues of 53 cases of cutaneous SCC and 96 controls from Sweden. Both normal and tumour samples from cases of SCC were screened for anogenital and EV HPV. The p53(Arg) allele was not associated with the development of cutaneous SCC. Anogenital HPV (44%) was more prevalent than EV HPV (12%). Data also indicate that anogenital HPV is more common in tumour samples, but HPV infection was not identified as a significant risk factor for developing SCC. The presence of anogenital HPV, but not EV HPV might be a risk factor for development of cutaneous SCC.

  • 3. He, Zehui
    et al.
    Lo Martire, Riccardo
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering. Guangzhou University of Chinese Medicine Second Affiliated Hospital, China.
    Lu, Chuanjian
    Liu, Hongxia
    Ma, Lin
    Huang, Ying
    Li, Yongmei
    Sun, Liyun
    Bai, Yanping
    Liu, Wali
    Zha, Xushan
    Rasch Analysis of the Dermatology Life Quality Index Reveals Limited Application to Chinese Patients with Skin Disease2018In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 98, no 1, p. 59-64Article in journal (Refereed)
    Abstract [en]

    The objective of this study was to examine the psychometric properties of the Chinese version of the Dermatology Life Quality Index (DLQI) and to assess the invariance of its items with respect to several patient parameters via Rasch analysis. Data were aggregated from 9,845 patients with various skin diseases across 9 hospitals in different regions of China. The response structure, local independence, and reliability of the DLQI scale were analysed in a partial credit model, and differential item functioning (DIF) across region, disease, sex, and age were assessed with a Mantel-Haenszel procedure. Although acceptable scale reliability (Person Separation Index=2.3) was obtained, several problems were revealed, including disordered response thresholds, misfitting items, DIF by geographical region and disease, and mis-targeting patients with mild impairment regarding health-related quality of life (HRQL). In conclusion, the DLQI provides inadequate information on patients' impairments in HRQL, and the application of the DLQI in Chinese patients with skin disease is limited.

  • 4.
    Hedberg, Yolanda S.
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science. Karolinska Institutet, Sweden.
    Liden, Carola
    Lindberg, Magnus
    Chromium Dermatitis in a Metal Worker Due to Leather Gloves and Alkaline Coolant2016In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 96, no 1, p. 104-105Article in journal (Refereed)
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