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  • 1.
    Almosawi, M.
    et al.
    Karolinska Inst, Med K2, Stockholm, Sweden..
    Ferrannini, G.
    Karolinska Inst, Med K2, Stockholm, Sweden..
    Buhlin, K.
    Karolinska Inst, Dent Med, Stockholm, Sweden..
    Gustafsson, A.
    Karolinska Inst, Dent Med, Stockholm, Sweden..
    Kjellstrom, B.
    Karolinska Inst, Med K2, Stockholm, Sweden..
    Klinge, B.
    Karolinska Inst, Dent Med, Stockholm, Sweden..
    Nygren, A.
    Karolinska Inst, Clin Sci, Stockholm, Sweden..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. Royal Inst Technol, Ctr Safety Res, Stockholm, Sweden..
    Svenungsson, E.
    Karolinska Inst, Med K2, Stockholm, Sweden..
    Ryden, L.
    Karolinska Inst, Med K2, Stockholm, Sweden..
    Norhammar, A.
    Karolinska Inst, Med K2, Stockholm, Sweden..
    Long term outcome after a first myocardial infarction2021In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 42, p. 1106-1106Article in journal (Other academic)
  • 2.
    Andersson, Linda
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Cinato, Mathieu
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Mardani, Ismena
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Miljanovic, Azra
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Arif, Muhammad
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Koh, Ara
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sungkyunkwan Univ SKKU, Sch Med, Dept Precis Med, Suwon 16419, South Korea..
    Lindbom, Malin
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Laudette, Marion
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Bollano, Entela
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Omerovic, Elmir
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Klevstig, Martina
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Henricsson, Marcus
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Fogelstrand, Per
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Sward, Karl
    Lund Univ, Dept Expt Med Sci, SE-22184 Lund, Sweden..
    Ekstrand, Matias
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Levin, Max
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Wikstrom, Johannes
    AstraZeneca Gothenburg, BioPharmaceut R&D, Biosci Res & Early Dev Cardiovasc Renal & Metab, Pepparedsleden 1, SE-43183 Mölndal, Sweden..
    Doran, Stephen
    Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..
    Hyotylainen, Tuulia
    Örebro Univ, Sch Nat Sci & Technol, Fakultetsgatan 1, SE-70182 Örebro, Sweden..
    Sinisalu, Lisanna
    Örebro Univ, Sch Nat Sci & Technol, Fakultetsgatan 1, SE-70182 Örebro, Sweden..
    Oresic, Matej
    Örebro Univ, Sch Med Sci, SE-70182 Örebro, Sweden.;Univ Turku, Turku Biosci Ctr, FIN-20521 Turku, Finland..
    Tivesten, Asa
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Adiels, Martin
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Bergo, Martin O.
    Karolinska Inst, Dept Biosci & Nutr, SE-14183 Huddinge, Sweden..
    Proia, Richard
    NIDDK, NIH, Bethesda, MD 20892 USA..
    Mardinoglu, Adil
    KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology. Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..
    Jeppsson, Anders
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Boren, Jan
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Levin, Malin C.
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Bruna Straket 16, SE-41345 Gothenburg, Sweden..
    Glucosylceramide synthase deficiency in the heart compromises beta 1-adrenergic receptor trafficking2021In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 42, no 43, p. 4481-+Article in journal (Refereed)
    Abstract [en]

    Aims Cardiac injury and remodelling are associated with the rearrangement of cardiac lipids. Glycosphingolipids are membrane lipids that are important for cellular structure and function, and cardiac dysfunction is a characteristic of rare monogenic diseases with defects in glycosphingolipid synthesis and turnover. However, it is not known how cardiac glycosphingolipids regulate cellular processes in the heart. The aim of this study is to determine the role of cardiac glycosphingolipids in heart function. Methods and results Using human myocardial biopsies, we showed that the glycosphingolipids glucosylceramide and lactosylceramide are present at very low levels in non-ischaemic human heart with normal function and are elevated during remodelling. Similar results were observed in mouse models of cardiac remodelling. We also generated mice with cardiomyocyte-specific deficiency in Ugcg, the gene encoding glucosylceramide synthase (hUgcg(-/-) mice). In 9- to 10-week-old hUgcg(-/-) mice, contractile capacity in response to dobutamine stress was reduced. Older hUgcg(-/-) mice developed severe heart failure and left ventricular dilatation even under baseline conditions and died prematurely. Using RNA-seq and cell culture models, we showed defective endolysosomal retrograde trafficking and autophagy in Ugcg-deficient cardiomyocytes. We also showed that responsiveness to beta-adrenergic stimulation was reduced in cardiomyocytes from hUgcg(-/-) mice and that Ugcg knockdown suppressed the internalization and trafficking of beta 1-adrenergic receptors. Conclusions Our findings suggest that cardiac glycosphingolipids are required to maintain beta-adrenergic signalling and contractile capacity in cardiomyocytes and to preserve normal heart function.

  • 3.
    Chireh, A.
    et al.
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Grankvist, R.
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Sandell, Mikael
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Micro and Nanosystems.
    Mukarram, A. K.
    Jaff, N.
    Berggren, I.
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Persson, H.
    Danderyd Hosp, Dept Cardiol, Stockholm, Sweden..
    Linde, C.
    Karolinska Univ Hosp, Heart & Vasc Theme, Stockholm, Sweden..
    Arnberg, F.
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Lundberg, J.
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Ugander, M.
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    La Manno, G.
    Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden..
    Jonsson, Stefan
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering.
    Daub, C. O.
    Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden..
    Holmin, S.
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Novel endomyocardial micro-biopsy device for higher precision and reduced complication risks2019In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 40, p. 1739-1739Article in journal (Refereed)
  • 4.
    Ferrannini, G.
    et al.
    Karolinska Inst, Med, Stockholm, Sweden..
    Norhammar, A.
    Karolinska Inst, Med, Stockholm, Sweden..
    Almosawi, M.
    Karolinska Inst, Med, Stockholm, Sweden..
    Kjellstrom, B.
    Karolinska Inst, Med, Stockholm, Sweden..
    Buhlin, K.
    Karolinska Inst, Dent Med, Stockholm, Sweden..
    De Faire, U.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Gustafsson, A.
    Karolinska Inst, Dent Med, Stockholm, Sweden..
    Nygren, L. A.
    Clin Sci Danderyds Hosp, Karolinska Inst, Stockholm, Sweden..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Lindahl, B.
    Uppsala Univ, Med Sci, Uppsala, Sweden..
    Naslund, U.
    Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden..
    Svenungsson, E.
    Karolinska Inst, Med, Stockholm, Sweden..
    Klinge, B.
    Karolinska Inst, Dent Med, Stockholm, Sweden..
    Ryden, L.
    Karolinska Inst, Med, Stockholm, Sweden..
    Periodontitis and cardiovascular outcome - a prospective follow-up of the PAROKRANK cohort2021In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 42, p. 1120-1120Article in journal (Other academic)
  • 5.
    Fortin, E.
    et al.
    Karolinska Inst, Dept Med K2, Stockholm, Sweden..
    Campi, B.
    CNR, Inst Clin Physiol, Pisa, Italy..
    Ferrannini, E.
    CNR, Inst Clin Physiol, Pisa, Italy..
    Mari, A.
    CNR, Inst Neurosci, Padua, Italy..
    Mellbin, L.
    Karolinska Inst, Dept Med K2, Stockholm, Sweden..
    Norhammar, A.
    Karolinska Inst, Dept Med K2, Stockholm, Sweden..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Traffic Research, CTR. KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Real Estate Economics and Finance.
    Ryden, L.
    Karolinska Inst, Dept Med K2, Stockholm, Sweden..
    Saba, A.
    Univ Pisa, Dept Pathol, Mass Spectrometry Lab, Pisa, Italy..
    Ferrannini, G.
    Karolinska Inst, Dept Med K2, Stockholm, Sweden..
    High mannose correlates with surrogate indexes of insulin resistance and predicts cardiovascular events independently of glycaemic status and traditional risk factors2023In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 44Article in journal (Other academic)
  • 6.
    Fuchs, G.
    et al.
    Sundsvall Reg Hosp, Dept Cardiol, Sundsvall, Sweden..
    Berg, Niclas
    KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW.
    Broman, L. M.
    Prahl Wittberg, Lisa
    KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW.
    Method for detection of blood clots in ventricular assist devices2019In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 40, p. 1740-1740Article in journal (Refereed)
  • 7.
    Gustafsson, U.
    et al.
    Umea Univ Hosp, Ctr Heart, S-90185 Umea, Sweden..
    Larsson, M.
    KTH, School of Technology and Health (STH).
    Bjällmark, Anna
    KTH, School of Technology and Health (STH).
    Lindqvist, P.
    Umea Univ Hosp, Ctr Heart, S-90185 Umea, Sweden..
    Aroch, R.
    Umea Univ Hosp, Ctr Heart, S-90185 Umea, Sweden..
    Haney, M.
    Umea Univ Hosp, Ctr Heart, S-90185 Umea, Sweden..
    Waldenstrom, A.
    Umea Univ Hosp, Ctr Heart, S-90185 Umea, Sweden..
    The rotation axis of the left ventricle in acute myocardial ischemia2010In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 31, p. 862-863Article in journal (Other academic)
  • 8. Hayashi, S. Y.
    et al.
    Seeberger, A.
    Lind, B.
    Gunnes, S.
    Lindholm, B.
    Brodin, Lars-Åke
    Acute effects of low intravenous doses of furosemide on left ventricular function in end stage renal disease patients evaluated by color tissue Doppler velocity imaging2005In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 26, p. 107-107Article in journal (Other academic)
  • 9. Janszky, I
    et al.
    Ericson, Mats
    KTH, School of Technology and Health (STH), Ergonomics.
    Blom, M
    Georgiades, A
    Magnusson, J O
    Alinagizadeh, H
    Ahnve, S
    Wine drinking is associated with increased heart rate variability in women with coronary heart disease2004In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 25, p. 435-435Article in journal (Refereed)
  • 10.
    Johansson, I.
    et al.
    Karolinska Inst, Cardiol Unit, Dept Med K2, Stockholm, Sweden..
    Dahlstrom, U.
    Linköping Univ, Dept Cardiol, Linköping, Sweden.;Linköping Univ, Dept Med & Hlth Sci, Linköping, Sweden..
    Edner, M.
    Karolinska Inst, Cardiol Unit, Dept Med K2, Stockholm, Sweden..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Real Estate Economics and Finance.
    Ryden, L.
    Karolinska Inst, Cardiol Unit, Dept Med K2, Stockholm, Sweden..
    Norhammar, A.
    Karolinska Inst, Cardiol Unit, Dept Med K2, Stockholm, Sweden..
    Random plasma glucose predicts long-term mortality in patients with heart failure without previously known diabetes - insights from the Swedish heart failure registry (SwedeHF)2018In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 39, p. 224-225Article in journal (Other academic)
  • 11. Johansson, I
    et al.
    Dahlström, U
    Edner, M
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Ryden, L
    Heart failure with mid range ejection fraction, characteristics and prognosis in patients with and without type 2 diabetes.2017In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 38Article in journal (Other academic)
  • 12. Johansson, I.
    et al.
    Edner, M.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Dahlstrom, U.
    Ryden, L.
    Norhammar, A.
    Diabetes mellitus, a serious co-morbidity especially in younger heart failure patients: A report from the Swedish Heart Failure Registry (RiksSvikt)2012In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, p. 640-640Article in journal (Other academic)
  • 13. Johansson, I.
    et al.
    Edner, M.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport Planning, Economics and Engineering.
    Dahlstrom, U.
    Ryden, L.
    Norhammar, A.
    Impact of diabetes mellitus on heart failure with reduced ejection fraction: a Swedish registry based analysis2015In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 36, p. 877-877Article in journal (Other academic)
  • 14. Johansson, I.
    et al.
    Edner, M.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Dahlstrom, U.
    Ryden, L.
    Norhammar, A.
    Women with heart failure and diabetes are at increased risk for mortality compared to men with and women without diabetes2012In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, p. 178-178Article in journal (Other academic)
  • 15. Johansson, I.
    et al.
    Edner, M.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Dahlström, U.
    Rydén, L.
    Norhammar, A.
    Impact of diabetes mellitus on long-term prognosis in patients with preserved heart failure - a report from the Swedish Heart Failure Registry (S-HFR)2014In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 35, p. 334-335Article in journal (Other academic)
  • 16. Madler, C. F.
    et al.
    Payne, N.
    Wilkenshoff, U.
    Cohen, A.
    Derumeaux, G. A.
    Pierard, L. A.
    Engvall, J.
    Brodin, Lars-Åke
    Sutherland, G. R.
    Fraser, A. G.
    Non-invasive diagnosis of coronary artery disease by quantitative stress echocardiography: optimal diagnostic models using off-line tissue Doppler in the MYDISE study2003In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 24, no 17, p. 1584-1594Article in journal (Refereed)
    Abstract [en]

    Aims To develop optimal methods for the objective non-invasive diagnosis of coronary artery disease, using myocardial Doppler velocities during dobutamine stress echocardiography. Methods and results We acquired tissue Doppler digital data during dobutamine stress in 289 subjects, and measured myocardial responses by off-line analysis of 11 left ventricular segments. Diagnostic criteria developed by comparing 92 normal subjects with 48 patients with coronary disease were refined in a prospective series of 149 patients referred with chest pain. Optimal diagnostic accuracy was achieved by logistic regression models, using systolic velocities at maximal stress in 7 myocardial segments, adjusting for independent correlations directly with heart rate and inversely with age and female gender (all p<0.001). Best cut-points from receiver-operator curves diagnosed left anterior descending, circumflex and right coronary disease with sensitivities and specificities of 80% and 80%, 91% and 80%, and 93% and 82%, respectively. All models performed better than velocity cut-offs alone (p<0.001). Conclusion Non-invasive diagnosis of coronary artery disease by quantitative stress echocardiography is best performed using diagnostic models based on segmental velocities at peak stress and adjusting for heart rate, and gender or age.

  • 17. Manouras, A.
    et al.
    Nyktari, E.
    Sahlen, A.
    Winter, R.
    Vardas, P.
    Brodin, Lärs-Åke
    KTH, School of Technology and Health (STH), Medical Engineering.
    Evaluation of E/Em predictive capacity: Impact of acute load reduction2010In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 31, p. 733-733Article in journal (Refereed)
  • 18. Mattsson, C. M.
    et al.
    Lind, Britta
    KTH, School of Technology and Health (STH), Medical Engineering.
    Enqvist, J. K.
    Mårtensson, Mattias
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Ekblom, B.
    Brodin, Lars-Åke
    KTH, School of Technology and Health (STH), Medical Engineering.
    No evidence of cardiac fatigue in tissue velocity curves at rest after 6 days of ultra-endurance exercise2010In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 31, p. 304-305Article in journal (Refereed)
  • 19. Nagy, A. I.
    et al.
    Venkatesharan, Ashwin I.
    KTH, School of Technology and Health (STH). Sri Sathya Sai Institute of Higher Medical Sciences, India.
    Merkely, B.
    Winter, Reidar
    KTH, School of Technology and Health (STH), Medical Engineering. Karolinska University Hospital, Sweden.
    Barooah, B.
    Dash, P. K.
    Manouras, Aristomenis I.
    KTH, School of Technology and Health (STH), Medical Engineering. Karolinska University Hospital, Sweden.
    The pulmonary capillary wedge pressure accurately reflects both normal and elevated left atrial pressure2014In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 35, p. 1184-1184Article in journal (Other academic)
  • 20. Norhammar, A.
    et al.
    Johansson, I.
    Edner, M.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Dahlström, U.
    Rydén, L.
    Impact of diabetes mellitus on long-term prognosis in patients with ischemic heart failure - a report from the Swedish Heart Failure Registry (S-HFR)2014In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 35, p. 141-142Article in journal (Other academic)
  • 21. Norhammar, A.
    et al.
    Kjellstrom, B.
    Habib, N.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport Planning, Economics and Engineering.
    Gustafsson, A.
    Ryden, L.
    Previously unknown glucose disturbances are common among individuals with periodontitis, especially in those with a previous myocardial infarction2015In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 36, p. 115-116Article in journal (Other academic)
  • 22.
    Olsson, A.
    et al.
    Karolinska Inst, Stockholm, Sweden..
    Samuelsson, Mathias
    KTH.
    Performance evaluation of dual vs. single lead automatic, real-world arrhythmic ECG recordings2019In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 40, p. 192-192Article in journal (Refereed)
  • 23.
    Petras, A.
    et al.
    BCAM, Bilbao, Spain..
    Echeverria Ferrero, M.
    Univ Pompeu Fabra, Barcelona, Spain..
    Leoni, Massimiliano
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Computational Science and Technology (CST).
    Guerra, J. M.
    Hosp Santa Creu & Sant Pau, Barcelona, Spain..
    Jansson, Johan
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Computational Science and Technology (CST).
    Gerardo-Giorda, L.
    BCAM, Bilbao, Spain..
    Stay on the safe side: in-silico assessment of ablation protocols to prevent steam pops during radiofrequency ablation2019In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 40, p. 1398-1398Article in journal (Refereed)
  • 24. Quintana, M.
    et al.
    Saha, S.
    Govind, S.
    Brodin, Lars-Åke
    Patients with both diabetes and hypertension have diminished systolic and diastolic functional reserve: results of the myocardial Doppler in diabetes study (MYDID) II2005In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 26, p. 232-232Article in journal (Other academic)
  • 25. Quintana, M
    et al.
    Sollevi, A
    Rehnqvist, N
    Kahan, T
    Edner, M
    Swahn, E
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Kjerr, A-C
    Hjemdahl, P
    The effects of adenosine as adjuvant therapy in acute myocardial infarction on cardiovascular events: Results of the ATTenuation by Adenosine of Cardiac Complications (ATTAC) study2001In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 22, no Supplement S, p. 287-287Article in journal (Refereed)
  • 26. Quintana, M
    et al.
    Storck, N
    Lindblad, L E
    Lindvall, K
    Ericson, Mats
    KTH, School of Technology and Health (STH), Ergonomics.
    Heart rate variability as a means of assessing prognosis after acute myocardial infarction. A 3-year follow-up study.1997In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 18, no 5, p. 789-97Article in journal (Refereed)
    Abstract [en]

    AIMS: The present study evaluated the prognostic value of heart rate variability after acute myocardial infarction in comparison with other known risk factors. The cut-off points that maximized the hazards ratio were also explored.

    PATIENTS AND METHODS: Heart rate variability was assessed with 24 h ambulatory electrocardiography in 74 patients with acute myocardial infarction, 4 +/- 2 days after hospital admission and in 24 healthy controls. Patients were followed for 36 +/- 15 months.

    RESULTS: During follow-up, 18 patients died, nine suffered a non-fatal infarction and 20 underwent revascularization procedures. Heart rate variability was higher in survivors than in non-survivors (P = 0.005). This difference was found at higher statistical levels when comparing non-survivors vs controls (P = 0.0002). A similar statistically significant difference was also found between survivors vs controls (P = 0.04). Patients suffering non-fatal infarction and cardiac events (defined as death, non-fatal infarction or revascularization) had a lower heart rate variability than those without (P = 0.03 and P = 0.03, respectively). With multivariate regression analysis, decreased heart rate variability independently predicted mortality and death or non-fatal infarction. The presence of a left ventricular ejection fraction < 40% and a history of systemic hypertension were, however, stronger predictors. The cut-off points that maximized the hazards ratio using the Cox model differed from those reported by others.

    CONCLUSION: Decreased heart rate variability independently predicted poor prognosis after myocardial infarction. However, the cut-off points that should be used in clinical practice are still a matter for further investigation.

  • 27. Rehnqvist, N.
    et al.
    Hjemdahl, P.
    Billing, E.
    Bjorkander, I.
    Eriksson, V.
    Forslund, L.
    Held, C.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport and Economics, Safety Research.
    Wallen, H.
    Effects of metoprolol vs verapamil in patients with stable angina pectoris: The Angina Prognosis Study in Stockholm (APSIS)1996In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 17, no 1, p. 76-81Article in journal (Refereed)
    Abstract [en]

    Objective To study long-term treatment effects of metoprolol or verapamil on combined cardiovascular end points and psychological variables in patients with stable angina pectoris. Design Randomized, double-blind, double-dummy trial. Patients The study included 809 patients under 70 years of age with stable angina pectoris. The mean age of the patients was 59 +/- 7 years and 31% were women. Exclusion criteria were myocardial infarction within the previous 3 years and contraindications to beta-blockers and calcium antagonists. The patients were followed between 6 and 75 months (median 3.4 years and a total of 2887 patient years). Intervention The patients were treated with either metoprolol (Seloken ZOC 200 mg o.d.) or verapamil (Isoptin Retard 240 b.i.d.). Acetylsalicylic acid, ACE inhibitors, lipid lowering drugs and long acting nitrates were allowed in the study. End points Death, non-fatal cardiovascular events including acute myocardial infarction, incapacitating or unstable angina, cerebrovascular or peripheral vascular events. Psychological variables reflecting quality of life i.e. psychosomatic symptoms, sleep disturbances and an evaluation of overall life satisfaction. Results Combined cardiovascular events did not differ and occurred in 30.8% and 29.3% of metoprolol and verapamil treated patients respectively. Total mortality in metoprolol and verapamil treated patients was 5.4 and 6.2%, respectively. Cardiovascular mortality was 4.7% in both groups. Non-fatal cardiovascular events occurred in 26.1 and 24.3% of metoprolol and verapamil-treated patients, respectively. Psychosomatic symptoms and sleep disturbances were significantly improved in both treatment groups. The magnitudes of change were small and did not differ between treatments. Life satisfaction did not change on either drug. Withdrawals due to side effects occurred in 11.1 and 14.6%, respectively. Conclusion This long term study indicates that both drugs are well tolerated and that no difference was shown on the effect on mortality, cardiovascular end points and measures of quality of life.

  • 28. Rehnqvist, N
    et al.
    Hjemdahl, P
    Billing, E
    Björkander, I
    Eriksson, SV
    Forslund, L
    Held, C
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Wallen, NH
    Effects of metoprolol vs verapamil in patients with stable angina pectoris: The Angina Prognosis Study in Stockholm (APSIS)1996In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 17, no 1, p. 76-81Article in journal (Refereed)
  • 29. Ritsinger, V
    et al.
    Brismar, K
    Mellbin, L
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis. KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Ryden, L
    Elevated levels of IGFBP-1 predict outcome after acute myocardial infarction. Long-term follow-up of the GAMI cohort.2017In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 38, article id P6470Article in journal (Other academic)
  • 30. Sahlen, A.
    et al.
    Abdula, G.
    Norman, M.
    Manouras, Aristomenis
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Lund, L. H.
    Shahgaldi, Kambiz
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Brodin, Lars-Åke
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Winter, Reidar
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Altered arterial haemodynamics during exercise in elderly female hypertensives with poor stroke volume reserve2011In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 32, p. 10-11Article in journal (Other academic)
  • 31. Sahlen, A.
    et al.
    Shahgaldi, Kambiz
    KTH, School of Technology and Health (STH), Medical Engineering.
    Manouras, Aristomenis
    KTH, School of Technology and Health (STH), Medical Engineering.
    Johnson, Jonas
    KTH, School of Technology and Health (STH), Medical Engineering.
    Analysis of aortic characteristic impedance in the time domain: validation using computer simulation2012In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, p. 138-138Article in journal (Other academic)
  • 32. Sahlen, A.
    et al.
    Shahgaldi, Kambiz
    KTH, School of Technology and Health (STH), Medical Engineering.
    Manouras, Aristomenis
    KTH, School of Technology and Health (STH), Medical Engineering.
    Winter, Reidar
    KTH, School of Technology and Health (STH), Medical Engineering.
    Johnson, Jonas
    KTH, School of Technology and Health (STH), Medical Engineering.
    Altered visco-elasticity of common carotid artery of elderly female hypertensives2012In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, p. 618-618Article in journal (Other academic)
  • 33.
    Smaradottir, M. I.
    et al.
    Karolinska Inst, Dept Med, Stockholm, Sweden..
    Andersen, K.
    Univ Iceland, Dept Hlth Sci, Reykjavik, Iceland..
    Eiriksdottir, G.
    Icelandic Heart Assoc, Kopavogur, Iceland..
    Gudnason, V.
    Icelandic Heart Assoc, Kopavogur, Iceland..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Real Estate Economics and Finance.
    Ryden, L.
    Karolinska Inst, Dept Med, Stockholm, Sweden..
    Mellbin, L. G.
    Karolinska Inst, Dept Med, Stockholm, Sweden..
    Copeptin and coronary artery calcium score in elderly adults without a cardiovascular history. A report from the ICELAND MI cohort2019In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 40, p. 2717-2717Article in journal (Refereed)
  • 34. Smaradottir, M I
    et al.
    Andersen, K
    Gudnason, V
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Building and Real Estate Economics. KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Ryden, L
    Mellbin, L G
    Vasopressin, measured as copeptin, in elderly individuals with or without unrecognized myocardial infarction. A report from the ICELAND MI Cohort.2017In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 38, no suppl_1, p. 863-864Article in journal (Other academic)
    Abstract [en]

    Background: A subset of patients with myocardial infarction (MI) has minimal or no symptoms, i.e. clinically unrecognized MI (UMI). Copeptin, a marker of vasopressin, predicts cardiovascular events (CVE).

    Purpose: To investigate the prognostic implication of copeptin in people with or without MI and to study whether it differs between UMI and recognized MI (RMI).

    Methods: Copeptin was measured in 926 participants (age 76.0; male 48.5%) in the observational ICELAND MI study. At baseline 246 patients had hospital/surveillance records supporting a RMI (n=91) or myocardial scars detected by magnetic resonance imaging (UMI, n=155). Cox proportional hazard regression was used to assess the prognostic capability of (log) copeptin, in the multiple model adjusted for prior heart failure, fasting blood glucose, age groups and creatinine. The primary endpoint was CVE (cardiovascular death/MI/stroke/PCI/CABG) and the secondary endpoint was total mortality during 9.1 years of follow-up.

    Results: Copeptin levels were significantly higher in participants with compared to those without a MI (8.9 pmol/L vs. 6.4 pmol/L; p<0.01), but did not differ between the subsets with RMI vs. UMI.

    In the unadjusted analysis CVE:s were predicted by copeptin in the total cohort (HR 1.60; 95% CI 1.17–2.19; p<0.01) but not after adjustments (HR 1.18; 95% CI 0.84–1.65; p=0.33).

    Total mortality in the total cohort was predicted by copeptin in the unadjusted analysis. The same was found in patients with and without MI as well as in the subset with RMI, however, not in those with UMI. In the adjusted model copeptin remained as a predictor in the total cohort (HR 1.77; 95% CI 1.24–2.51; p<0.01), in all patients with MI (HR 2.20; 95% CI 1.25–3.87; p<0.01), and in those with RMI (HR 5.73; 95% CI 2.13–15.36; p<0.01).

    Conclusion: Copeptin levels were higher for participants with MI, however no difference was seen for those with RMI or UMI. Copeptin did not remain as a significant predictor for CVE after adjustments while it was an independent predictor for total mortality in patients with MI including the subset with RMI. This implies that copeptin is a general marker of disease rather than a specific marker for cardiovascular disease.

  • 35. Westholm, C.
    et al.
    Johnson, Jonas
    KTH, School of Technology and Health (STH), Medical Engineering.
    Jernberg, T.
    Winter, Reider
    KTH, School of Technology and Health (STH), Medical Engineering.
    Peak Systolic Velocity (PSV) using colour-coded Tissue Doppler Imaging (TDI) is a strong and independent predictor of outcome in acute coronary syndrome patients2012In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, p. 924-924Article in journal (Other academic)
  • 36. Zahid, W.
    et al.
    Johnson, Jonas
    KTH, School of Technology and Health (STH), Medical Engineering.
    Westholm, C.
    Eek, C.
    Skulstad, R.
    Fosse, E.
    Winter, Reider
    Edvardsen, T.
    Mitral annular excursion in patients with suspected non-ST-elevation acute coronary syndrome can identify coronary occlusion and predict mortality2012In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, p. 912-912Article in journal (Other academic)
1 - 36 of 36
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