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  • 1.
    Carlberg, Konstantin
    et al.
    KTH, School of Biotechnology (BIO), Gene Technology.
    Vickovic, Sanja
    KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Ståhl, Patrik
    KTH, School of Biotechnology (BIO), Gene Technology.
    Salmén, Fredrik
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Korotkova, Marina
    Malmstrom, Vivianne
    Lundeberg, Joakim
    KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    TRANSCRIPTOME VISUALISATION OF THE INFLAMED RHEUMATOID ARTHRITIS JOINT2017In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 76, A58-A59 p.Article in journal (Refereed)
  • 2. Idborg, Helena
    et al.
    Zandian, Arash
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Hellstrom, Cecilia
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Mattsson, Cecilia
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Fredolini, Claudia
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Uhlén, Mathias
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
    Schwenk, Jochen M.
    KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
    Ayoglu, Burcu
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Neiman, Maja
    Gunnarsson, Iva
    Svenungsson, Elisabet
    Jakobsson, Per-Johan
    Nilsson, Peter
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
    PROTEIN PROFILING IN PLASMA REVEALS MOLECULAR SUBGROUPS IN SYSTEMIC LUPUS ERYTHEMATOSUS2017In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 76, A52-A52 p.Article in journal (Refereed)
  • 3. Notarnicola, A.
    et al.
    Hellstrom, C.
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Mattsson, C.
    KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
    Andersson, E.
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Idborg, H.
    Jemseby, E.
    Neiman, Maja
    KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
    Jakobsson, P-J
    Nilsson, Peter
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Lundberg, I. E.
    NEW AUTOIMMUNE TARGETS IN IDIOPATHIC INFLAMMATORY MYOPATHIES - AN ANTIGEN BEAD ARRAY APPROACH2017In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 76, 626-626 p.Article in journal (Other academic)
  • 4. Sekiguchi, M.
    et al.
    Iwasaki, T.
    Shibasaki, S.
    Nygren, Per-Åke
    KTH, School of Biotechnology (BIO), Protein Technology.
    Gräslund, Torbjörn
    KTH, School of Biotechnology (BIO), Protein Technology.
    Sano, H.
    Affibody Molecules Inhibiting The Interaction Between Ras And Raf Suppress The Proliferation And The Production Of Inflammatory Mediators By Synovial Cells2014In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 73, 848-848 p.Article in journal (Other academic)
  • 5. Snir, O.
    et al.
    Widhe, M.
    von Spee, C.
    Lindberg, Johan
    KTH, School of Biotechnology (BIO), Gene Technology.
    Padyukov, L.
    Lundberg, K.
    Engstrom, A.
    Venables, P. J.
    Lundeberg, Joakim
    KTH, School of Biotechnology (BIO), Gene Technology.
    Holmdahl, R.
    Klareskog, L.
    Malmstrom, V.
    Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles2009In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 68, no 5, 736-743 p.Article in journal (Refereed)
    Abstract [en]

    Background: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis ( RA), and associate with HLA-DRB1 shared epitope (SE) alleles. Objective: To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their association with genetic variants within HLA-DRB1 SE alleles. Methods: Serum samples from 291 patients with established RA and 100 sex- and age-matched healthy subjects were included in this study. Sera were first analysed for presence of anti-CCP antibodies and further for IgG and IgA antibodies towards candidate autoantigens in both their native and citrullinated form including: fibrinogen, alpha-enolase peptide-1 and the C1-epitope of type II collagen (C1(III)). Antibody specificity was confirmed by cross-reactivity tests. HLA-DR genotyping was performed. Results: 72% of patients with RA were anti-CCP positive. Among the candidate autoantigens examined, IgG antibodies to citrullinated fibrinogen were found in 66% of patients' sera and in 41% for both citrullinated alpha-enolase peptide-1 and citrullinated C1(III). These antibodies were mainly seen in the anti-CCP-positive patient group; they were specific for their respective antigen and displayed limited cross reactivity. IgA responses were also detected, but less frequently than IgG. Anti-CCP and anti-citrullinated protein antibodies were associated with HLA-DRB1*04 rather than with HLA-DRB1*01 alleles. Conclusions: Antibodies directed against several citrullinated antigens are present in CCP-positive RA, with many patients displaying multireactivity. All specific reactivities were primarily associated with the HLA-DRB1*04 alleles, suggesting common pathways of anti-citrulline immunity.

  • 6. Steen, Johanna
    et al.
    Forsstrom, Bjorn
    Israelsson, Lena
    Krishnamurthy, Akilan
    Hansson, Monika
    Sahlstrom, Peter
    Stalesen, Ragnhild
    Odowd, Victoria
    Rapecki, Stephen
    Klareskog, Lars
    Catrina, Anca
    Nilsson, Peter
    Lightwood, Daniel
    Malmstrom, Vivianne
    MONOCLONAL ACPA ANTIBODIES RECOGNISING A COMMON CITRULLINE MOTIF ARE MAINLY DEPENDENT ON LIGHT CHAIN HYPERMUTATIONS FOR ANTIGEN RECOGNITION2017In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 76, A85-A85 p.Article in journal (Refereed)
  • 7. Venalis, P.
    et al.
    Pandya, J.
    Al-Khalili, Lubna
    KTH, School of Biotechnology (BIO), Industrial Biotechnology.
    Hossein, M. S.
    Stache, V.
    Lundberg, I. E.
    Malmström, V.
    Fasth, A. E. R.
    CD28NULL T CELLS KILL AUTOLOGOUS MUSCLE CELLS FROM POLYMYOSITIS PATIENTS IN VITRO BY PERFORIN-DEPENDENT MECHANISMS2014In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 73, 576-576 p.Article in journal (Other academic)
1 - 7 of 7
CiteExportLink to result list
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
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  • de-DE
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  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
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Output format
  • html
  • text
  • asciidoc
  • rtf