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  • 1. A. Hosseini, V.
    et al.
    Karlsson, L.
    Örnek, Cem
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Swerea KIMAB AB.
    Reccagni, P.
    Wessman, S.
    Engelberg, D.
    Microstructure and functionality of a uniquely graded super duplex stainless steel designed by a novel arc heat treatment method2018Inngår i: Materials Characterization, ISSN 1044-5803, E-ISSN 1873-4189, Vol. 139, s. 390-400Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A novel arc heat treatment technique was applied to design a uniquely graded super duplex stainless steel (SDSS), by subjecting a single sample to a steady state temperature gradient for 10 h. A new experimental approach was used to map precipitation in microstructure, covering aging temperatures of up to 1430 °C. The microstructure was characterized and functionality was evaluated via hardness mapping. Nitrogen depletion adjacent to the fusion boundary depressed the upper temperature limit for austenite formation and influenced the phase balance above 980 °C. Austenite/ferrite boundaries deviating from Kurdjumov–Sachs orientation relationship (OR) were preferred locations for precipitation of σ at 630–1000 °C, χ at 560–1000 °C, Cr2N at 600–900 °C and R between 550 °C and 700 °C. Precipitate morphology changed with decreasing temperature; from blocky to coral-shaped for σ, from discrete blocky to elongated particles for χ, and from polygonal to disc-shaped for R. Thermodynamic calculations of phase equilibria largely agreed with observations above 750 °C when considering nitrogen loss. Formation of intermetallic phases and 475 °C-embrittlement resulted in increased hardness. A schematic diagram, correlating information about phase contents, morphologies and hardness, as a function of exposure temperature, is introduced for evaluation of functionality of microstructures.

  • 2. Aartsma-Rus, A.
    et al.
    Ferlini, A.
    McNally, E. M.
    Spitali, P.
    Sweeney, H. L.
    Al-Khalili Szigyarto, Cristina
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi.
    Bello, L.
    Bronson, A.
    Brown, K.
    Buccella, F.
    Chadwick, J.
    Frank, D.
    Hoffman, E.
    Larkindale, J.
    McClorey, G.
    Munschauer, R.
    Muntoni, F.
    Owens, J.
    Schara, U.
    Straub, V.
    Tinsley, J.
    Versnel, J.
    Vroom, E.
    Welch, E.
    226th ENMC International Workshop:: Towards validated and qualified biomarkers for therapy development for Duchenne muscular dystrophy 20–22 January 2017, Heemskerk, The Netherlands2018Inngår i: Neuromuscular Disorders, ISSN 0960-8966, E-ISSN 1873-2364, Vol. 28, nr 1, s. 77-86Artikkel i tidsskrift (Fagfellevurdert)
  • 3.
    Abad, Nadeem
    et al.
    aTrustlife Labs, Drug Research & Development Center, 34774 Istanbul, Turkiye.
    Buhlak, Shafeek
    aTrustlife Labs, Drug Research & Development Center, 34774 Istanbul, Turkiye.
    Hajji, Melek
    bResearch Unit: Electrochemistry, Materials and Environment, University of Kairouan, 3100 Kairouan, Tunisia.
    Saffour, Sana
    aTrustlife Labs, Drug Research & Development Center, 34774 Istanbul, Turkiye.
    Akachar, Jihane
    aTrustlife Labs, Drug Research & Development Center, 34774 Istanbul, Turkiye.
    Kesgun, Yunus
    aTrustlife Labs, Drug Research & Development Center, 34774 Istanbul, Turkiye.
    Al-Ghulikah, Hanan
    cDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia, P.O. Box 84428.
    Hanashalshahaby, Essam
    aTrustlife Labs, Drug Research & Development Center, 34774 Istanbul, Turkiye.
    Turkez, Hasan
    dDepartment of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkiye.
    Mardinoglu, Adil
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. KTH, Centra, Science for Life Laboratory, SciLifeLab. fCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, United Kingdom.
    Unveiling structural features, chemical reactivity, and bioactivity of a newly synthesized purine derivative through crystallography and computational approaches2024Inngår i: Journal of Molecular Structure, ISSN 0022-2860, E-ISSN 1872-8014, Vol. 1311, artikkel-id 138400Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We introduce the synthesis and characterization of a novel purine derivative, 2-amino-6‑chloro-N,N-diphenyl-7H-purine-7-carboxamide. X-ray crystallography was utilized to elucidate its molecular and crystal structure. A comprehensive crystal packing analysis uncovered a network of diverse intermolecular interactions, including classical and unconventional hydrogen bonding. Remarkably, a unique halogen···π (C—Cl···π(ring)) interaction was identified and theoretically analyzed within a multi-approach quantum mechanics (QM) framework, revealing its lone-pair⋯π (n→π*) nature. Furthermore, insights into the electronic and chemical reactivity properties are provided by means of Conceptual Density Functional Theory (CDFT) at wB97X-D/aug-cc-pVTZ level. The compound's drug-likeness, pharmacokinetics, and toxicology profiles are assessed using ADMETlab 2.0. Finally, molecular docking simulations were conducted to evaluate its bioactivity as a potential cyclooxygenase-2 (COX-2) inhibitor. This study significantly advances our understanding of purine structure and reactivity, offering valuable insights for the development of targeted purine-based COX-2 inhibitors and anticancer therapeutics.

  • 4.
    Abada, Maria
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi.
    Spent Nuclear Fuel under Repository Conditions: Update and Expansion of Database and Development of Machine Learning Models2022Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [sv]

    Förbrukat kärnbränsle är mycket radioaktivt och behöver därför lagras i djupa geologiska förvar i tusentals år innan det säkert kan återföras till naturen. På grund av de långa lagringsperioderna görs säkerhetsanalyser av de djupa geologiska förvaren. Under säkerthetsanalyserna görs upplösningsexperiment på förbrukat kärnsbränsle för att utvärdera konsekvenserna av att grundvatten läcker in i bränslet vid barriärbrott. Dessa experiment är både dyra och tidskrävande, varför beräkningsmodeller som kan förutsäga förburkat kärnbränsles upplösningsbeteende är önskvärda.

    Denna avhandling fokuserar på att samla in tillgängliga experimentella data från upplösningsexperiment för att uppdatera och utöka en databas. Med hjälp av databasen har upplösningsbeteendet för varje radionuklid utvärderats och jämförts med tidigare kunskap från befintlig litteratur. Även om det var svårt att vara avgörande om beteendet hos element där en begränsad mängd data fanns tillgänglig, motsvarar de upplösningsbeteenden som hittats för olika radionuklider i denna avhandling inte bara tidigare studier utan ger också ett verktyg för att hantera och jämföra förbrukat kärnbränsles upplösningsdata från olika utgångsmaterial, bestrålningshistorik och betingeleser under upplösning. Dessutom gjorde sammanställningen av en så stor mängd experimentella data det möjligt att förstå var framtida experimentella ansträngningar bör fokuseras, exempelvis finns det en brist på data under reducerande förhållanden.

    Dessutom utvecklades och kördes maskininlärningsmodeller med hjälp av Artificial Neural Network (ANN), Random Forest (RF) och XGBoost-algoritmer med hjälp av databasen, varefter prestandan utvärderades. Prestanda för varje algoritm jämfördes för att få en förståelse för vilken modell som presterade bäst, men också för att förstå om dessa typer av modeller är lämpliga verktyg för att förutspå förbrukat kärnbränsles upplösningsbeteende. Den bäst presterande modellen, med träning och test R2 resultat nära 1, var XGBoost-modellen. Även om XGBoost hade en hög prestanda, drogs slutsatsen att mer experimentell data behövs innan maskininlärningsmodeller kan användas i verkliga situationer.

    Fulltekst (pdf)
    fulltext
  • 5.
    Abada, Maria
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    Fossum, Elin
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    Brandt, Louise
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    Åkesson, Anton
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    Property prediction of super-strong nanocellulose fibers2020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    The innovative technology behind production of strong biofilaments involves the process of spinning filaments from nanoparticles extracted from wood. These nanoparticles are called cellulose nanofibrils (CNFs). The spun filaments can have high mechanical properties, rivaling many other plant based materials, and could be an environmentally friendly replacement for many materials in the future such as fabrics and composites. Before mass production might be possible, the optimal dispersion properties must be determined for the intended use, with regard to concentration, method of oxidation (TEMPO-oxidation or carboxymethylation) and pretreatment through sonication and centrifugation.

    In this bachelor’s thesis attributes of spun filaments were investigated in order to find a correlation between mechanical properties and the effects of concentration, method of oxidation as well as sonication and centrifugation of the dispersions. The mechanical properties were also compared to the fibrils’ ability to entangle and align during flow-focusing. A variety of analytical methods: flow-stop, tensile testing, scanning electron microscopy (SEM) and wide angle X-ray scattering (WAXS) were implemented for the dispersions and filaments.

    The results from this study show that flow-stop analysis could be used to determine which CNF dispersions are spinnable and which are non-spinnable, along with which spinnable dispersion would yield the strongest filament. It was also concluded that crystallinity of fibrils affects the mechanical properties of filaments and that TCNFs are generally more crystalline than CMCs. Pretreatment through sonication and centrifugation seems to have a negative impact on spinnability and sonication in combination with low concentration seems to lead to non-spinnable conditions. On the other hand, sonicated dispersions seem to yield a greater number of samples without aggregates than non-sonicated ones. Aggregates, however, seem to only affect ultimate stress out of the measured mechanical properties. Furthermore, concentration and viscosity affect spinnability and CMC dispersions seem to yield thicker filaments than TCNF dispersions. However, due to lack of statistically validated data any definitive conclusions could not be drawn.

    Fulltekst (pdf)
    fulltext
  • 6.
    Abaid, Mohammed Abderhman
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Ergonomi.
    Validation of a new iPhone application for measurements of wrist velocity during actual work tasks2023Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    The breakthrough in mobile technology and the development of smartphones, supplied with sensing devices such as Inertial Measurement Units (IMUs), has made it possible to obtain accurate and reliable data on the angular velocity for different objects. The available technical sensors for wrist movements, such as electrogoniometers, are costly, time-consuming, and need a particular computer program to be analyzed. Therefore, there is a need to develop user-friendly risk assessment methods for wrist angular velocity measurements. This master thesis aimed to validate the accuracy of a newly developed iPhone application (App), "ErgoHandMeter," for wrist velocity in actual work tasks, by comparing the “ErgoHandMeter” to standard electrogoniometers. The project study was performed with four participants, two females and two males, from three jobs performing actual work tasks. The total angular velocity obtained by the mobile application was compared with the angular velocity data from the standard electrogoniometer. The total angular velocities obtained from the smartphone and the goniometer were computed at the 10th, 50th and 90th percentile for the four subjects. The 50th percentile of goniometer-flexion velocity (G-flex) was 7.4 ± 5.4°/s, for the goniometer-total (G-tot) 8.7 ± 6.5)°/s and for App 7.2 ± 4.9°/s. The correlation coefficient for the 50th percentile of goniometer-flexion (G-flex) parameter and smartphone application was 0.994. For the goniometer-total (G-tot) and the application, it was 0.993. In a Bland-Altman plot the mean difference between G-flex and App for the 50th percentile was -0.18 °/s and for G-tot and App was -1.54 °/s, i.e. the App was lower in average. The limit of the agreement between G-Flex and App, and G-tot and App stayed within two standard deviations. For G-Flex and App (mean+1.96SD) was 1.34 °/s, (mean-1.96SD) was -1.71 °/s, while for G-tot and App (mean+1.96SD) was 1.89 °/s, (mean-1.96SD) was -4.96 °/s, indicating an adequate agreement between the two methods. A limitation was that the included occupations were all relatively low velocity. However, in conclusion, the results indicate that the two methods agree adequately and can be used interchangeably.

    Fulltekst (pdf)
    fulltext
  • 7.
    Abbadessa, Anna
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi. Univ Santiago de Compostela, IDIS Res Inst, Ctr Res Mol Med & Chron Dis CIMUS, Campus Vida,Ave Barcelona S-N, Santiago De Compostela 15706, Spain.;Univ Santiago de Compostela, Sch Pharm, Dept Pharmacol Pharm & Pharmaceut Technol, Campus Vida,Ave Barcelona S-N, Santiago De Compostela 15706, Spain..
    Dogaris, Ioannis
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Träkemi och massateknologi.
    Farahani, Saina Kishani
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Reid, Michael S.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Fiberteknologi. RISE Res Inst Sweden, Dept Mat & Surface Design, Drottning Kristinas Vag 61, SE-11428 Stockholm, Sweden..
    Rautkoski, Hille
    VTT Tech Res Ctr Finland Ltd, POB 1000, FI-02044 Espoo, Finland..
    Holopainen-Mantila, Ulla
    VTT Tech Res Ctr Finland Ltd, POB 1000, FI-02044 Espoo, Finland..
    Oinonen, Petri
    Ecohelix AB, Teknikringen 38, S-10044 Stockholm, Sweden..
    Henriksson, Gunnar
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Träkemi och massateknologi.
    Layer-by-layer assembly of sustainable lignin-based coatings for food packaging applications2023Inngår i: Progress in organic coatings, ISSN 0300-9440, E-ISSN 1873-331X, Vol. 182, artikkel-id 107676Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Packaging plays a critical role in ensuring food safety and shelf life by protecting against e.g., moisture, gases, and light. Polyethylene (PE) is widely used in food packaging, but it is mainly produced from non-renewable resources and it is an inefficient oxygen and light barrier. In this study, the layer-by-layer (LbL) assembly of a sustainably produced lignin-based polymer (EH) with polyethylenimine (PEI) or chitosan (CH) was used to fabricate (partially or fully) bio-based coatings with the aim of improving barrier properties of PE films. The charge density of EH was calculated using a polyelectrolyte titration method and the hydrodynamic diameters of EH, PEI and CH were determined by Dynamic Light Scattering (DLS). LbL assembly was monitored in situ via Quartz Crystal Microbalance with Dissipation (QCM-D) and Stagnation Point Adsorption Reflectometry (SPAR). PE films were coated with a variable number of PEI/EH or CH/EH bilayers (BL) using an immersive LbL assembly method. Coated films were studied in terms of light-blocking ability, wettability, thermal behaviour, surface structure, as well as oxygen and water vapor barrier properties. QCM-D and SPAR data showed a stepwise multilayer formation and strong interactions between the oppositely charged polymers, with PEI/EH coating having a greater amount of deposited polymer compared to CH/EH coating at the same number of BL. Overall, light barrier properties and wettability of the coated films increased with the number of deposited bilayers. Coated PE films maintained the overall thermal behaviour of PE. A number of BL of 20 was found to be the most promising based on the studied properties. Selected samples showed improved oxygen and water vapor barrier properties, with PEI/EH coating performing better than CH/EH coating. Taken altogether, we demonstrated that a novel and sustainable lignin-based polymer can be combined with PEI or CH to fabricate (partially or fully) bio-based coatings for food packaging.

  • 8.
    Abbadessa, Anna
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Oinonen, Petri
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi. Ecohelix AB, Teknikringen 38, SE-10044 Stockholm, Sweden..
    Henriksson, Gunnar
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Characterization of Two Novel Bio-based Materials from Pulping Process Side Streams: Ecohelix and CleanFlow Black Lignin2018Inngår i: BioResources, E-ISSN 1930-2126, Vol. 13, nr 4, s. 7606-7627Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The characteristics of two novel types of technical lignin, namely Ecohelix (EH) and CleanFlow black lignin (CFBL), isolated from two different pulping process side streams, were analyzed. EH and CFBL were analyzed in terms of general composition, chemical functionalities, molar mass distribution, and thermal stability. For comparison, two relevant types of commercially available lignosulfonate and kraft lignin were used. The results showed that EH contains a large amount of sulfonated lignin, together with carbohydrates and ash. As such, it can be considered a lignin-carbohydrate hybrid molecule. CFBL was found to contain 91.5% Klason lignin and the lowest amount of carbohydrates (0.3%). EH showed the highest content of aliphatic OH groups (5.44 mmol/g) and CFBL a high content of phenols (4.73 mmol/g). EH had a molecular weight of 31.4 kDa and a sufficient thermal stability. CFBL had the lowest molecular weight (M-w = 2.0 kDa) and thermal stability of all kraft lignins analyzed in this study. These properties highlighted that EH is a suitable building block for material development and that CFBL is a promising material for the production of biofuel and biochemicals.

  • 9.
    Abbasi Aval, Negar
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Fiberteknologi.
    Utilizing Biopolymers in 3D Tumor Modeling and Tumor Diagnosis2023Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Cancer represents a significant global public health challenge and ranks as the second mostcommon cause of death in the United States. The onset of cancer entails an initial phasewhere cells lose their polarity and disconnect from the normal basement membrane, allowingthem to form distinct three-dimensional (3D) configurations that interact with adjacent cellsand the surrounding microenvironment. Cells grown in 2D monolayers demonstrate differentgene expression patterns and different activation of signaling pathways compared to cellscultivated within the natural structure of tumor tissue of the same cell type. Multicellulartumor spheroids (MCTS) are extensively investigated as a well-studied model of organotypiccancer. These spheroids are formed by tumor cells, either alone or in combination with othercell types, and they can be created with or without the application of supportive scaffolds.The MCTSs are also considered promising models for preclinical assessments of chemosensitivity.However, the creation of these tumor spheroids presents challenges, as not alltumor cell lines can consistently form regular spheroids.Cellulose nanofibrils (CNF) have become essential as a sustainable and environmentallyfriendly material. For example, thin films, with inherent mechanical properties, and flexibility,offer versatility across various applications. Also known for its biocompatibility and non-toxicnature, native CNF is a natural option to use. Its fibrous structure closely mimics the collagenmatrix in human tissue, showing potential as an effective scaffold for 3D cell culture. In thisregard, an innovative Layer-by-Layer (LbL) coating technique using CNF-polyelectrolytebilayers was investigated to generate spheroids. This method constructs bilayers of CNFand polyelectrolytes and can coat various surfaces. In this thesis, the first focus was ondemonstrating the spheroid formation capability using low molecular weight polyelectrolytesin LbL assembly. Secondly, an investigation was conducted involving embedding of LbLgrownspheroids in a decellularized extracellular matrix (ECM) aiming to determine howECM, possessing suitable mechanical characteristics, could influence the cancer stem celltraits in spheroids. Thirdly, the thesis demonstrated the utilization of LbL for capturing andreleasing of circulating tumor cells. Lastly, the shift from using low molecular weightpolyelectrolytes in the LbL assembly to high molecular weight counterparts and analyzingthe differences in spheroid formation abilities to assess the underlying differences inmolecular weights of the polyelectrolytes was explored. All-in-all, employing the CNF-basedLbL surface coating strategy explored in the thesis has proven to be promising for thedevelopment of spheroid models closely resembling in vivo conditions and holds significantpotential for applications in drug development.

  • 10.
    Abbasi Aval, Negar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Fiberteknologi. Isfahan Univ Technol, Dept Mat Engn, Biomat Res Grp, Esfahan 8475683777, Iran.;Isfahan Univ Med Sci, Sch Med, Dept Anat Sci, Esfahan, Iran..
    Emadi, Rahmatollah
    Isfahan Univ Technol, Dept Mat Engn, Biomat Res Grp, Esfahan 8475683777, Iran..
    Valiani, Ali
    Isfahan Univ Med Sci, Sch Med, Dept Anat Sci, Esfahan, Iran..
    Kharaziha, Mahshid
    Isfahan Univ Technol, Dept Mat Engn, Biomat Res Grp, Esfahan 8475683777, Iran..
    Finne Wistrand, Anna
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Polymerteknologi.
    An aligned fibrous and thermosensitive hyaluronic acid-puramatrix interpenetrating polymer network hydrogel with mechanical properties adjusted for neural tissue2022Inngår i: Journal of Materials Science, ISSN 0022-2461, E-ISSN 1573-4803, Vol. 57, nr 4, s. 2883-2896Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Central nervous system (CNS) injuries such as stroke or trauma can lead to long-lasting disability, and there is no currently accepted treatment to regenerate functional CNS tissue after injury. Hydrogels can mimic the neural extracellular matrix by providing a suitable 3D structure and mechanical properties and have shown great promise in CNS tissue regeneration. Here we present successful synthesis of a thermosensitive hyaluronic acid-RADA 16 (Puramatrix (TM)) peptide interpenetrating network (IPN) that can be applied in situ by injection. Thermosensitive hyaluronic acid (HA) was first synthesized by combining HA with poly(N-isopropylacrylamide). Then, the Puramatrix (TM) self-assembled peptide was combined with the thermosensitive HA to produce a series of injectable thermoresponsive IPNs. The HA-Puramatrix (TM) IPNs formed hydrogels successfully at physiological temperature. Characterization by SEM, rheological measurements, enzymatic degradation and swelling tests was performed to select the IPN optimized for neurologic use. SEM images of the optimized dry IPNs demonstrated an aligned porous structure, and the rheological measurements showed that the hydrogels were elastic, with an elastic modulus of approximately 500 Pa, similar to that of brain tissue. An evaluation of the cell-material interactions also showed that the IPN had biological characteristics required for tissue engineering, strongly suggesting that the IPN hydrogel possessed properties beneficial for regeneration of brain tissue.

  • 11.
    Abbasi Aval, Negar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Khati, Vamakshi
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.
    Pettersson, Torbjörn
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Russom, Aman
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.
    Layer-by-Layer cellulose nanofibril coating for spheroid formation combined with decellularized extracellular matrix for 3D tumor modelingManuskript (preprint) (Annet vitenskapelig)
  • 12.
    Abbasi Aval, Negar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Khati, Vamakshi
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.
    Russom, Aman
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.
    Pettersson, Torbjörn
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Influence of Decellularized Extra Cellular Matrix on 3D spheroids formed on Layer-by-Layer cellulose nanofibril/Polyelectrolytes coating as an in-vitro model for Hepatocellular CarcinomaManuskript (preprint) (Annet vitenskapelig)
  • 13.
    Abbasi Aval, Negar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Fiberteknologi.
    Lahchaichi, Ekeram
    Fayazbakhsh, Farzaneh
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.
    Tudoran, Oana
    Russom, Aman
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.
    Pettersson, Torbjörn
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Evaluating the Impact of Positively Charged Polyelectrolyte Molecular Weightand Bilayer Number on Tumor Spheroid Formation in the Interaction with Negatively Charged Cellulose Nanofibrils in layer by layer assembly2023Manuskript (preprint) (Annet vitenskapelig)
  • 14.
    Abbasi Aval, Negar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Fiberteknologi.
    Lahchaichi, Ekeram
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.
    Tudoran, Oana
    Department of Genetics, Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. I. Chiricuta”, 400015 Cluj-Napoca, Romania.
    Fayazbakhsh, Farzaneh
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Heuchel, Rainer
    Pancreas Cancer Research Lab, Department of Clinical Science, Intervention and Technology, (CLINTEC), Karolinska Institutet, 17177 Stockholm, Sweden.
    Löhr, Matthias
    Pancreas Cancer Research Lab, Department of Clinical Science, Intervention and Technology, (CLINTEC), Karolinska Institutet, 17177 Stockholm, Sweden.
    Pettersson, Torbjörn
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Russom, Aman
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Assessing the Layer-by-Layer Assembly of Cellulose Nanofibrils and Polyelectrolytes in Pancreatic Tumor Spheroid Formation2023Inngår i: Biomedicines, E-ISSN 2227-9059, Vol. 11, nr 11Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Three-dimensional (3D) tumor spheroids are regarded as promising models for utilization as preclinical assessments of chemo-sensitivity. However, the creation of these tumor spheroids presents challenges, given that not all tumor cell lines are able to form consistent and regular spheroids. In this context, we have developed a novel layer-by-layer coating of cellulose nanofibril–polyelectrolyte bilayers for the generation of spheroids. This technique builds bilayers of cellulose nanofibrils and polyelectrolytes and is used here to coat two distinct 96-well plate types: nontreated/non-sterilized and Nunclon Delta. In this work, we optimized the protocol aimed at generating and characterizing spheroids on difficult-to-grow pancreatic tumor cell lines. Here, diverse parameters were explored, encompassing the bilayer count (five and ten) and multiple cell-seeding concentrations (10, 100, 200, 500, and 1000 cells per well), using four pancreatic tumor cell lines—KPCT, PANC-1, MiaPaCa-2, and CFPAC-I. The evaluation includes the quantification (number of spheroids, size, and morphology) and proliferation of the produced spheroids, as well as an assessment of their viability. Notably, our findings reveal a significant influence from both the number of bilayers and the plate type used on the successful formation of spheroids. The novel and simple layer-by-layer-based coating method has the potential to offer the large-scale production of spheroids across a spectrum of tumor cell lines.

    Fulltekst (pdf)
    fulltext
  • 15.
    Abbasi, M.
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Tillämpad elektrokemi.
    Backstrom, J.
    Mid Sweden Univ, FSCN Mat Phys, Dept Nat Sci, SE-85170 Sundsvall, Sweden..
    Cornell, Ann M.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Tillämpad elektrokemi.
    Fabrication of Spin-Coated Ti/TiHx/Ni-Sb-SnO2 Electrode: Stability and Electrocatalytic Activity2018Inngår i: Journal of the Electrochemical Society, ISSN 0013-4651, E-ISSN 1945-7111, Vol. 165, nr 9, s. H568-H574Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A novel three-layer anode having the composition Ti/TiHx/Ni-Sb-SnO2 (Ti/TiHx/NATO) was successfully prepared by a spin-coating and pyrolysis process aiming at a long service lifetime and good electrocatalytic properties for ozone formation. The TiHx as an interlayer was produced by electrochemical cathodic reduction of a coated layer of the TiOx on the titanium substrate. Spin coating and thermal decomposition were used to deposit the Sn-Sb-Ni precursor on the surface of the prepared Ti/TiHx electrode. Cyclic and linear scanning voltammetry, Raman spectroscopy, scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used to reveal the electrode performance and morphology. Results show that the onset potential for the oxygen evolution reaction (OER) of Ti/TiHx /NATO is higher than for Ti/NATO. They also indicate that the service lifetime of the Ti/TiHx/NATO is twice as long as the Ti/NATO at a current density of 50 mA.cm(-2) at room temperature. Electrochemical ozone generation and degradation of the methylene blue were investigated to confirm selectivity and activity of the electrodes. After 5 min electrolysis, a current efficiency for ozone generation of 56% was obtained the electrode with TiHx while 38% was obtained on Ti/NATO under same conditions. The results also confirm that the Ti/TiH x /NATO has a higher kinetic rate constant and decolorization efficiency for removal of the methylene blue compare to the Ti/NATO. The rate constant for the pseudo-first ordered reaction of methylene blue degradation showed high values of 350 x 10(-3) min(-1) for Ti/NATO and 440 x 10(-3) min(-1) for Ti/TiHx/NATO. 

  • 16.
    Abbasiasl, Taher
    et al.
    Sabanci University.
    Niazi, Soroush
    Sabanci University.
    Sheibani Aghdam, Araz
    Sabanci University.
    Chen, Hongjian
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Medicinsk avbildning.
    Cebeci, Fevzi Cakmak
    Sabanci University.
    Ghorbani, Morteza
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Medicinsk avbildning. 1 Sabanci University Nanote.
    Grishenkov, Dmitry
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Medicinsk avbildning.
    Kosar, Ali
    Sabanci University.
    Effect of intensified cavitation using poly (vinyl alcohol) microbubbles on spray atomization characteristics in microscale2020Inngår i: AIP Advances, E-ISSN 2158-3226, Vol. 10, nr 2Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study, cavitating flows inside a transparent cylindrical nozzle with an inner diameter of 0.9 mm were visualized, and the effect of cavitation on atomization characteristics of emerging sprays was investigated. Different patterns of cavitating flows inside the nozzle were visualized using a high-speed camera. In-house codes were developed to process the captured images to study the droplet size distribution and droplet velocity in different flow regimes. The results show that cavitating flows at the microscale have significant effects on atomization characteristics of the spray. Two working fluids, namely, water and poly(vinyl alcohol) microbubble (PVA MB) suspension, were employed. Accordingly, the injection pressures were detected as 690 kPa, 1035 kPa, and 1725 kPa for cavitation inception, supercavitation, and hydraulic flip flow regimes in the case of water, respectively. The corresponding pressures for the aforementioned patterns for PVA MB suspension were 590 kPa, 760 kPa, and 1070 kPa, respectively. At the microscale, as a result of a higher volume fraction of cavitation bubbles inside the nozzle, there is no large difference between the cavitation numbers corresponding to cavitating and hydraulic flip flows. Although the percentage of droplets with diameters smaller than 200 μm was roughly the same for both cases of water and PVA MB suspension, the Sauter mean diameter was considerably lower in the case of PVA MBs. Moreover, higher droplet velocities were achieved in the case of PVA MBs at lower injection pressures.

    Fulltekst (pdf)
    fulltext
  • 17.
    Abbasiasl, Taher
    et al.
    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey.;Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey..
    Sutova, Hande
    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey.;Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey..
    Niazi, Soroush
    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey.;Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey..
    Celebi, Gizem
    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey.;Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey..
    Karavelioglu, Zeynep
    Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey..
    Kirabali, Ufuk
    Yildiz Tech Univ, Dept Mechatron Engn, Istanbul, Turkey..
    Yilmaz, Abdurrahim
    Yildiz Tech Univ, Dept Mechatron Engn, Istanbul, Turkey..
    Uvet, Huseyin
    Yildiz Tech Univ, Dept Mechatron Engn, Istanbul, Turkey..
    Kutlu, Ozlem
    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey.;Sabanci Univ, Ctr Excellence Funct Surfaces & Interfaces Nanodi, TR-34956 Istanbul, Turkey..
    Ekici, Sinan
    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey..
    Ghorbani, Morteza
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Medicinsk avbildning. Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey.;Sabanci Univ, Ctr Excellence Funct Surfaces & Interfaces Nanodi, TR-34956 Istanbul, Turkey..
    Kosar, Ali
    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey.;Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey.;Sabanci Univ, Ctr Excellence Funct Surfaces & Interfaces Nanodi, TR-34956 Istanbul, Turkey..
    A Flexible Cystoscope Based on Hydrodynamic Cavitation for Tumor Tissue Ablation2022Inngår i: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 69, nr 1, s. 513-524Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Hydrodynamic cavitation is characterized by the formation of bubbles inside a flow due to local reduction of pressure below the saturation vapor pressure. The resulting growth and violent collapse of bubbles lead to a huge amount of released energy. This energy can be implemented in different fields such as heat transfer enhancement, wastewater treatment and chemical reactions. In this study, a cystoscope based on small scale hydrodynamic cavitation was designed and fabricated to exploit the destructive energy of cavitation bubbles for treatment of tumor tissues. The developed device is equipped with a control system, which regulates the movement of the cystoscope in different directions. According to our experiments, the fabricated cystoscope was able to locate the target and expose cavitating flow to the target continuously and accurately. The designed cavitation probe embedded into the cystoscope caused a significant damage to prostate cancer and bladder cancer tissues within less than 15 minutes. The results of our experiments showed that the cavitation probe could be easily coupled with endoscopic devices because of its small diameter. We successfully integrated a biomedical camera, a suction tube, tendon cables, and the cavitation probe into a 6.7 mm diameter cystoscope, which could be controlled smoothly and accurately via a control system. The developed device is considered as a mechanical ablation therapy, can be a solid alternative for minimally invasive tissue ablation methods such as radiofrequency (RF) and laser ablation, and could have lower side effects compared to ultrasound therapy and cryoablation.

  • 18.
    Abbasi-Ravasjani, Sonia
    et al.
    Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Cell Biol, Amsterdam Movement Sci, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam, Netherlands..
    Seddiqi, Hadi
    Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Cell Biol, Amsterdam Movement Sci, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam, Netherlands..
    Moghaddaszadeh, Ali
    Islamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran..
    Ghiasvand, Mohammad-Ehsan
    Amirkabir Univ Technol, Dept Mech Engn, Tehran, Iran..
    Jin, Jianfeng
    Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Cell Biol, Amsterdam Movement Sci, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam, Netherlands..
    Oliaei, Erfan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Biokompositer.
    Bacabac, Rommel Gaud
    Univ San Carlos, Dept Phys, Med Biophys Grp, Cebu, Philippines..
    Klein-Nulend, Jenneke
    Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Cell Biol, Amsterdam Movement Sci, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam, Netherlands..
    Sulfated carboxymethyl cellulose and carboxymethyl kappa-carrageenan immobilization on 3D-printed poly-epsilon-caprolactone scaffolds differentially promote pre-osteoblast proliferation and osteogenic activity2022Inngår i: Frontiers in Bioengineering and Biotechnology, E-ISSN 2296-4185, Vol. 10, artikkel-id 957263Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The lack of bioactivity in three-dimensional (3D)-printing of poly-epsilon-caprolactone (PCL) scaffolds limits cell-material interactions in bone tissue engineering. This constraint can be overcome by surface-functionalization using glycosaminoglycan-like anionic polysaccharides, e.g., carboxymethyl cellulose (CMC), a plant-based carboxymethylated, unsulfated polysaccharide, and kappa-carrageenan, a seaweed-derived sulfated, non-carboxymethylated polysaccharide. The sulfation of CMC and carboxymethylation of kappa-carrageenan critically improve their bioactivity. However, whether sulfated carboxymethyl cellulose (SCMC) and carboxymethyl kappa-carrageenan (CM-kappa-Car) affect the osteogenic differentiation potential of pre-osteoblasts on 3D-scaffolds is still unknown. Here, we aimed to assess the effects of surface-functionalization by SCMC or CM-kappa-Car on the physicochemical and mechanical properties of 3D-printed PCL scaffolds, as well as the osteogenic response of pre-osteoblasts. MC3T3-E1 pre-osteoblasts were seeded on 3D-printed PCL scaffolds that were functionalized by CM-kappa-Car (PCL/CM-kappa-Car) or SCMC (PCL/SCMC), cultured up to 28 days. The scaffolds' physicochemical and mechanical properties and pre-osteoblast function were assessed experimentally and by finite element (FE) modeling. We found that the surface-functionalization by SCMC and CM-kappa-Car did not change the scaffold geometry and structure but decreased the elastic modulus. Furthermore, the scaffold surface roughness and hardness increased and the scaffold became more hydrophilic. The FE modeling results implied resilience up to 2% compression strain, which was below the yield stress for all scaffolds. Surface-functionalization by SCMC decreased Runx2 and Dmp1 expression, while surface-functionalization by CM-kappa-Car increased Cox2 expression at day 1. Surface-functionalization by SCMC most strongly enhanced pre-osteoblast proliferation and collagen production, while CM-kappa-Car most significantly increased alkaline phosphatase activity and mineralization after 28 days. In conclusion, surface-functionalization by SCMC or CM-kappa-Car of 3D-printed PCL-scaffolds enhanced pre-osteoblast proliferation and osteogenic activity, likely due to increased surface roughness and hydrophilicity. Surface-functionalization by SCMC most strongly enhanced cell proliferation, while CM-kappa-Car most significantly promoted osteogenic activity, suggesting that surface-functionalization by CM-kappa-Car may be more promising, especially in the short-term, for in vivo bone formation.

  • 19.
    Abbott, Andrew
    et al.
    Univ Leicester, Leicester, Leics, England..
    Liu, Sichao
    KTH, Skolan för industriell teknik och management (ITM), Industriell produktion. KTH Royal Inst Technol, Stockholm, Sweden..
    Rutland, Mark W.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. KTH Royal Inst Technol, Stockholm, Sweden..
    Watanabe, Seiya
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. KTH Royal Inst Technol, Stockholm, Sweden..
    Wishart, James
    Brookhaven Natl Lab, Upton, NY 11973 USA..
    Ionic liquids at interfaces: general discussion2018Inngår i: Faraday discussions, ISSN 1359-6640, E-ISSN 1364-5498, Vol. 206, s. 549-586Artikkel i tidsskrift (Annet vitenskapelig)
  • 20.
    Abd Alwaheb, Sofia
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Implementering DevSecOps metodik vid systemutveckling för hälso och sjukvård2023Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Inom hälso- och sjukvården är IT-säkerhet avgörande för att skydda både personlig information och patientsäkerheten. För närvarande genomförs implementering av säkerhetsåtgärder och tester efter mjukvaruutvecklingen, vilket kan minska effektiviteten och utgöra en potentiell risk för patienternas integritet. Detta arbete undersökte implementeringen av DevSecOps-metodiken inom hälso- och sjukvården med fokus på utvecklingsfasen. Genom att intervjua anställda och använda säkerhetsverktyg som SAST, kodgranskning, penetrationstestning och DAST identifierades fördelar och utmaningar. Utmaningarna inkluderade brist på säkerhetskunskap och svårighet att integrera verktyg kostnadsfritt. Trots detta visade resultatet på möjligheten att förbättra säkerheten, effektivisera arbetet och spara pengar genom att använda gratis verktyg och implementera säkerhet redan i utvecklingsfasen. Utbildning och anställning av säkerhetskompetent personal betonades också som viktigt för att upprätthålla höga säkerhetsstandarder

    Fulltekst (pdf)
    fulltext
  • 21.
    Abdalla, Abdulbasit
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik.
    Odgren, Emilia
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik.
    Biodiesel production from rape seed oil catalyzed by calcium oxide doped with lithium2023Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Biodiesel ses som ett av de främsta substituten för fossila bränslen, då den relativt enkelt kan appliceras i redan existerande dieselmotorer. Dagens produktion av biodiesel använder sig av homogena katalysatorer som inte återanvänds i processen, men för en mer cirkulär och i längden en billigare process ses heterogena katalysatorer som ett alternativ. Syftet med denna studie var att undersöka litium dopad kalciumoxid katalytiska egenskaper, de optimala förhållandena för reaktionen och även kinetiken för reaktionen. Den valda katalysatorn syntetiserades med kalcinering och sedan testades den katalytiska förmågan i reaktionen vid olika reaktionsförhållanden, för att finna de optimala förhållandena. Även katalysatorns fysiska egenskaper analyserades och kinetiken för reaktionen. De optimala förhållanden för transesterifieringen bestämdes till 3 h, 1:6 olja- metanolförhållande, 60°C och 5 vikts% katalysator, där 96% utbyte av biodiesel uppnåddes. Övriga utbyten från de andra försöken var betydligt lägre, vilket kan bero på icke optimala förhållanden, men även relativ dålig katalytisk förmåga. Ytarea och porstorlek konstateras vara små, vilket påverkar den katalytiska förmågan negativt. Anledningen till katalysatorns egenskaper beror huvudsakligen på tillverkningsprocessen, men även mängden litium i dopningen. Kinetiken visar en oväntad reaktionsutveckling med initialt hög koncentration FAME (Fatty acid Methylester), vilket troligen beror på felkällor.

    Fulltekst (pdf)
    fulltext
  • 22.
    Abdalla, Osman
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Design and implementation of a signaling system for a novel light-baseed bioprinter: Design och implementering av ett signalsystem för en ny ljusbaserad bioprinter2023Independent thesis Basic level (university diploma), 10 poäng / 15 hpOppgave
    Abstract [en]

    A 3D bioprinter employing light-based technology has been designed and constructed in an EU-funded research initiative known as BRIGHTER (Bioprinting by Light-Sheet Lithography). This initiative is a collaborative effort between institutions and companies and aims to develop a technique for efficient and accurate production of engineered tissue.

    Presently, the bioprinter’s function is limited to 2D printing, with the lack of 3D printing capabilities. 

    The problem addressed is the integration of two separate electronic systems within the bioprinter to control the laser beam’s trajectory for 3D printing. The goal of the project is to create functional software and simulation tools to control the hardware modules in a precise and synchronized manner, thereby enabling 3D printing.

    The outcome manifests as a software prototype, which successfully facilitates intercommunication between the two electronic subsystems within the bioprinter, thereby enabling further progress on the bioprinter with 3D printing available. Nevertheless, the prototype requires thorough testing to determine its optimal operational efficiency in terms of timing the movements for the various hardware modules.

    Fulltekst (pdf)
    Bioprinter
  • 23.
    Abdel Alim, Richard
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    Formation of Soft Particles in Drop-in Fuels2018Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    AAs the mission to the decrease global warming and phase out highly polluting environmental practices globally, regulations including Euro 6 and policies generated by the United Nations Framework Convention on Climate Change (UNFCCC) are pushing companies to be more innovative when it comes to their energy sources. These regulations involve many factors related to the cleanliness of the fuel and produced emissions, for example, properties of the fuels such as sulfur content, ash content, water content, and resulting emission values of Carbon dioxide (CO2)and Nitrogen Oxides (NOx). Furthermore, Sweden has set a challenging target of a fossil-fuel-independent vehicle fleet by 2030 and no net greenhouse-gas emissions by 2050. One way to cut down on the polluting properties in the fuel, as well as weakening the dependence on fossil fuel based fuel includes utilizing higher blending ratios of biofuels in the transport sector. This transition to biofuels comes with many challenges to the transport industry due to higher concentrations of these new fuels leads to clogging of the filters in the engine, as well as, internal diesel injector deposits (IDIDs) that produce injector fouling. This clogging of the filters leads to lower performance by the engines which leads to higher repair times (uptime) and less time on the road to transport goods. The formation of these soft particles at the root of the clogging issue is a pivotal issue because the precise mechanisms behind their formation are highly unknown. Scania, a leader in the Swedish automotive industry, is very interested in figuring out what mechanisms are the most influential in the formation of these particles in the engine. Understanding the key mechanisms would allow Scania to make appropriate adjustments to the fuel or the engines to ensure more time on the road and less maintenance. There are many conditions known to be possible causes of the formation of soft particles in engines such as water content, ash content, and temperature. After generating soft particles using a modified accelerated method, particles were analyzed using infrared technology (RTX-FTIR) and a Scanning Electric Microscope (SEM-EDX). Many different experiments were performed to be able to make a conclusion as to which mechanisms were most influential including temperature, time, water, air, and oil. The combination of aging biofuels (B100, B10, HVO) with metals, and water produced the largest amount of particles followed by aging the biofuels with aged oil, metals, and water. Aging the fuels with aged oil increased particles, meanwhile the addition of water prevented particle production possibly due to additives. B100 produced the highest amount of particles when aged with Copper, B10 with Brass, and HVO with Iron.

    Fulltekst (pdf)
    fulltext
  • 24.
    Abdelaziz, Omar Y.
    et al.
    Department of Chemical Engineering, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia; Interdisciplinary Research Center for Refining & Advanced Chemicals, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.
    Vives, Mariona Battestini
    Division of Chemical Engineering, Department of Process and Life Science Engineering, Lund University, SE-221 00 Lund, Sweden.
    Mankar, Smita V.
    Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden.
    Warlin, Niklas
    Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden; Department of Chemistry, Stanford University, Stanford, California 94306, United States.
    Nguyen, Tran Tam
    Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden.
    Zhang, Baozhong
    Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden.
    Hulteberg, Christian P.
    Division of Chemical Engineering, Department of Process and Life Science Engineering, Lund University, SE-221 00 Lund, Sweden.
    khataee, Amirreza
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Tillämpad elektrokemi.
    Recent strides toward transforming lignin into plastics and aqueous electrolytes for flow batteries2024Inngår i: iScience, E-ISSN 2589-0042, Vol. 27, nr 4, artikkel-id 109418Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Lignin is an abundant polyaromatic polymer with a wide range of potential future uses. However, the conversion of lignin into valuable products comes at a cost, and medium- to high-value applications are thus appropriate. Two examples of these are polymers (e.g., as fibers, plasticizers, or additives) and flow batteries (e.g., as redox species). Both of these areas would benefit from lignin-derived molecules with potentially low molecular weight and high (electro)chemical functionality. A promising route to obtain these molecules is oxidative lignin depolymerization, as it enables the formation of targeted compounds with multiple functionalities. An application with high potential in the production of plastics is the synthesis of new sustainable polymers. Employing organic molecules, such as quinones and heterocycles, would constitute an important step toward the sustainability of aqueous flow batteries, and lignin and its derivatives are emerging as redox species, mainly due to their low cost and renewability.

  • 25.
    Abdelhamid, Hani Nasser
    et al.
    Stockholm Univ, Dept Mat & Environm Chem, S-10691 Stockholm, Sweden.;Assiut Univ, Dept Chem, Adv Multifunct Mat Lab, Assiut 71515, Egypt..
    El-Zohry, Ahmed M.
    Uppsala Univ, Dept Chem, Angstrom Labs, POB 523, S-75120 Uppsala, Sweden..
    Cong, Jiayan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi.
    Thersleff, Thomas
    Stockholm Univ, Dept Mat & Environm Chem, S-10691 Stockholm, Sweden..
    Karlsson, Karl Martin
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi.
    Kloo, Lars
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi.
    Zou, Xiaodong
    Stockholm Univ, Dept Mat & Environm Chem, S-10691 Stockholm, Sweden..
    Towards implementing hierarchical porous zeolitic imidazolate frameworks in dye-sensitized solar cells2019Inngår i: Royal Society Open Science, E-ISSN 2054-5703, Vol. 6, nr 7, artikkel-id 190723Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A one-pot method for encapsulation of dye, which can be applied for dye-sensitized solar cells (DSSCs), and synthesis of hierarchical porous zeolitic imidazolate frameworks (ZIF-8), is reported. The size of the encapsulated dye tunes the mesoporosity and surface area of ZIF-8. The mesopore size, Langmuir surface area and pore volume are 15 nm, 960-1500 m(2). g(-1) and 0.36-0.61 cm(3). g(-1), respectively. After encapsulation into ZIF-8, the dyes show longer emission lifetimes (greater than 4-8-fold) as compared to the corresponding non-encapsulated dyes, due to suppression of aggregation, and torsional motions.

  • 26.
    Abdelhamid, Hani Nasser
    et al.
    Stockholm Univ, Div Mat & Environm Chem, Svante Arrhenius Väg 16 C, SE-10691 Stockholm, Sweden.;Assiut Univ, Fac Sci, Dept Chem, Adv Multifunct Mat Lab, Assiut 71515, Egypt..
    Georgouvelas, Dimitrios
    Stockholm Univ, Div Mat & Environm Chem, Svante Arrhenius Väg 16 C, SE-10691 Stockholm, Sweden..
    Edlund, Ulrica
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Polymerteknologi.
    Mathew, Aji P.
    Stockholm Univ, Div Mat & Environm Chem, Svante Arrhenius Väg 16 C, SE-10691 Stockholm, Sweden..
    CelloZIFPaper: Cellulose-ZIF hybrid paper for heavy metal removal and electrochemical sensing2022Inngår i: Chemical Engineering Journal, ISSN 1385-8947, E-ISSN 1873-3212, Vol. 446, artikkel-id 136614Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The processing of hierarchical porous zeolitic imidazolate frameworks (ZIF-8) into a cellulose paper using sheet former Rapid-Kothen (R.K.) is reported. The procedure is a promising route to overcome a significant bottleneck towards applying metal-organic frameworks (MOFs) in commercial products. ZIF-8 crystals were integrated into cellulose pulp (CP) or TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl radical)-oxidized cellulose nanofibrils (TOCNF) following an in-situ or ex-situ process; the materials were denoted as CelloZIFPaper_In Situ and CelloZIFPaper_Ex Situ, respectively. The materials were applied as adsorbents to remove heavy metals from water, with adsorption capacities of 66.2-354.0 mg/g. CelloZIFPaper can also be used as a stand-alone working electrode for the selective sensing of toxic heavy metals, for instance, lead ions (Pb2+), using electrochemical-based methods with a limit of detection (LOD) of 8 mu M. The electrochemical measurements may advance 'Lab-onCelloZIFPaper' technologies for label-free detection of heavy metal ions.

  • 27.
    Abdellah, Tebani
    et al.
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi.
    Gummesson, Anders
    Zhong, Wen
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Koistinen, Ina Schuppe
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Lakshmikanth, Tadepally
    Olsson, Lisa M.
    Boulund, Fredrik
    Neiman, Maja
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Stenlund, Hans
    Hellström, Cecilia
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Karlsson, Max
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Arif, Muhammad
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Dodig-Crnkovic, Tea
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Affinitets-proteomik. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Mardinoglu, Adil
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England.
    Lee, Sunjae
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Zhang, Cheng
    Chen, Yang
    Olin, Axel
    Mikes, Jaromir
    Danielsson, Hanna
    von Feilitzen, Kalle
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Jansson, Per-Anders
    Angerås, Oskar
    Huss, Mikael
    Kjellqvist, Sanela
    Odeberg, Jacob
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Edfors, Fredrik
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi.
    Tremaroli, Valentina
    Forsström, Björn
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi.
    Schwenk, Jochen M.
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Affinitets-proteomik.
    Nilsson, Peter
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Affinitets-proteomik.
    Moritz, Thomas
    Bäckhed, Fredrik
    Engstrand, Lars
    Brodin, Petter
    Bergström, Göran
    Uhlén, Mathias
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. Danish Tech Univ, Ctr Biosustainabil, Copenhagen, Denmark.
    Fagerberg, Linn
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi.
    Integration of molecular profiles in a longitudinal wellness profiling cohort2020Inngår i: Nature Communications, E-ISSN 2041-1723, Vol. 11, nr 1, artikkel-id 4487Artikkel i tidsskrift (Fagfellevurdert)
  • 28.
    Abdellah, Tebani
    et al.
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. Normandie Univ, Dept Metab Biochem, UNIROUEN, INSERM,U1245,CHU Rouen, F-76000 Rouen, France..
    Jotanovic, Jelena
    Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, Uppsala, Sweden..
    Hekmati, Neda
    Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden..
    Sivertsson, Åsa
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Gudjonsson, Olafur
    Uppsala Univ, Dept Neurosci, Uppsala, Sweden..
    Engstrom, Britt Eden
    Uppsala Univ, Dept Med Sci Endocrinol & Mineral Metab, Uppsala, Sweden..
    Wikstrom, Johan
    Uppsala Univ, Dept Surg Sci, Neuroradiol, Uppsala, Sweden..
    Uhlén, Mathias
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi.
    Casar-Borota, Olivera
    Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, Uppsala, Sweden..
    Ponten, Fredrik
    Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden..
    Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis2021Inngår i: Acta neuropathologica communications, E-ISSN 2051-5960, Vol. 9, nr 1, artikkel-id 181Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Pituitary neuroendocrine tumors (PitNETs) are common, generally benign tumors with complex clinical characteristics related to hormone hypersecretion and/or growing sellar tumor mass. PitNETs can be classified based on the expression pattern of anterior pituitary hormones and three main transcriptions factors (TF), SF1, PIT1 and TPIT that regulate differentiation of adenohypophysial cells. Here, we have extended this classification based on the global transcriptomics landscape using tumor tissue from a well-defined cohort comprising 51 PitNETs of different clinical and histological types. The molecular profiles were compared with current classification schemes based on immunohistochemistry. Our results identified three main clusters of PitNETs that were aligned with the main pituitary TFs expression patterns. Our analyses enabled further identification of specific genes and expression patterns, including both known and unknown genes, that could distinguish the three different classes of PitNETs. We conclude that the current classification of PitNETs based on the expression of SF1, PIT1 and TPIT reflects three distinct subtypes of PitNETs with different underlying biology and partly independent from the expression of corresponding hormones. The transcriptomic analysis reveals several potentially targetable tumor-driving genes with previously unknown role in pituitary tumorigenesis.

  • 29.
    Abdel-Magied, Ahmed Fawzy
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Resursåtervinning. Nuclear Materials Authority. P. O. Box 530, El Maadi, Cairo, Egypt.
    Abdelhamid, Hani Nasser
    Assiut University.
    Ashour, Radwa M.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Resursåtervinning. Nuclear Materials Authority. P. O. Box 530, El Maadi, Cairo, Egypt.
    Fu, Le
    Central South University.
    Dowaidar, Moataz
    King Fahd University of Petroleum and Minerals (KFUPM).
    Xia, Wei
    Uppsala University.
    Forsberg, Kerstin
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Resursåtervinning.
    Magnetic Metal-Organic Frameworks for Efficient Removal of Cadmium(II), and Lead(II) from Aqueous Solution2022Inngår i: Journal of Environmental Chemical Engineering, ISSN 2213-3437, s. 107467-107467, artikkel-id 107467Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Efficient and convenient methods for the removal of toxic heavy metal ions especially Cd(II) and Pb(II) from aqueous solutions is of great importance due to their serious threat to public health and the ecological system. In this study, two magnetic metal-organic frameworks (namily: Fe3O4@ZIF-8, and Fe3O4@UiO-66–NH2) were synthesized, fully characterized, and applied for the adsorption of Cd(II) and Pb(II) from aqueous solutions. The adsorption efficiencies for the prepared nanocomposites are strongly dependent on the pH of the aqueous solution. The maximum adsorption capacities of Fe3O4@UiO-66–NH2, and Fe3O4@ZIF-8 at pH 6.0 were calculated to be 714.3 mg·g 1, and 370 mg·g 1 for Cd(II), respectively, and 833.3 mg·g 1, and 666.7 mg·g 1 for Pb(II), respectively. The adsorption process follows a pseudo-second-order model and fit the Langmuir isotherm model. Moreover, the thermodynamic studies revealed that the adsorption process is endothermic, and spontaneous in nature. A plausible adsorption mechanism was discussed in detail. The magnetic adsorbents: Fe3O4@ZIF-8, and Fe3O4@UiO-66–NH2 showed excellent reusability, maintaining the same efficiency for at least four consecutive cycles. These results reveal the potential use of magnetic Fe3O4@ZIF-8, and Fe3O4@UiO-66–NH2 as efficient adsorbents in removing Cd(II) and Pb(II) from aqueous solutions.

  • 30.
    Abdel-Magied, Ahmed Fawzy
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Resursåtervinning.
    Nasser Abdelhamid, Hani
    Ashour, Radwa M.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik.
    Zou, Xiaodong
    Stockholms Universitet.
    Forsberg, Kerstin
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemiteknik, Resursåtervinning.
    Hierarchical porous zeolitic imidazolate framework nanoparticles for efficient adsorption of rare-earth elements2019Inngår i: Microporous and Mesoporous Materials, ISSN 1387-1811, E-ISSN 1873-3093, Vol. 278, s. 175-184Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Hierarchical porous zeolitic imidazolate frameworks nanoparticles (ZIF-8 NPs) were synthesized at room temperature via a template-free approach under dynamic conditions (stirring) using water as a solvent. The ZIF-8 NPs were evaluated as adsorbents for rare earth elements (La3+, Sm3+ and Dy3+). Adsorption equilibrium was reached after 7h and high adsorption capacities were obtained for dysprosium and samarium (430.4 and 281.1 mg g(-1), respectively) and moderate adsorption capacity for lanthanum (28.8 mg g(-1)) at a pH of 7.0. The high adsorption capacitiese, as well as the high stability of ZIF-8 NPs, make the hierarchical ZIF-8 materials as an efficient adsorbent for the recovery of La3+, Sm3+ and Dy3+ from aqueous solution.

  • 31.
    Abdi Dahir, Najiib
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Dahir Ali, Ikran
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Privacy preserving data access mechanism for health data2023Independent thesis Basic level (university diploma), 10 poäng / 15 hpOppgave
    Abstract [en]

    Due to the rise of digitalization and the growing amount of data, ensuring the integrity and security of patient data has become increasingly vital within the healthcare industry, which has traditionally managed substantial quantities of sensitive patient and personal information. This bachelor's thesis focused on designing and implementing a secure data sharing infrastructure to protect the integrity and confidentiality of patient data. Synthetic data was used to enable access for researchers and students in regulated environments without compromising patient privacy. The project successfully achieved its goals by evaluating different privacy-preserving mechanisms and developing a machine learning-based application to demonstrate the functionality of the secure data sharing infrastructure. Despite some challenges, the chosen algorithms showed promising results in terms of privacy preservation and statistical similarity. Ultimately, the use of synthetic data can promote fair decision-making processes and contribute to secure data sharing practices in the healthcare industry.

    Fulltekst (pdf)
    Examensarbete
  • 32.
    Abdi Yusuf Isse, Muna
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    Identifying Patient Safety and The Healthcare Environment in Puntland, Somalia2018Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    Independent on where in the world one is, patient safety is regarded as one of the most important aspects in the healthcare industry. On the contrary, depending on where you are, the patient safety will differ and is therefore location dependent. The patient safety in a developing country will therefore be evaluated in a different way compared to a developed country. This study, therefore aimed to identify the patient safety in Puntland, Somalia and with it, its healthcare environment in the hospitals. The goal was to identify the main factors that affected the patient safety.

    To investigate this, a field study to the region of interest was made and subsequently interviews with staff at the site were conducted as well as observations in the concerned hospitals. The obtained results were analysed using the method of Qualitative Content Analysis. At a later stage, the results could be thematized into four categories; “​Need​”, “​Device​”, “​Training​” and “​Knowledge​”, which pinpointed the main issues.

    The study show that there was a common transversal issue of a inherent lack of devices, training and knowledge which in turn could severely affect the patients and their safety in ways such as misdiagnosis, delayed treatment and in worst cases death. Furthermore, it was evident that rather than the lack of actual devices, the absence of knowledge was more prevalent. 

    Fulltekst (pdf)
    fulltext
  • 33.
    Abdirahman Ahmed, Fatima
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    Reologistudie av vattenbaserade industrifärger2018Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [sv]

    I detta examensarbete har reologiska egenskaper av färg studerats varav viskoelasticitet, rinning och utflytning har varit av huvudsakligt intresse. I denna studie presenteras metoder som förutser hur färg rinner vid industriell applicering med hjälp av data från reologisk mätningsutrustning. Studiens övergripande syfte är att förstå hur vattenbaserad färg beter sig vid sprutning på vertikala ytor. Målet med studien har uppfyllts då det har kunnat visas att det går att förutse hur färg rinner med en påläggningsmängd på 300 μm i vått tillstånd.

    Med hjälp av en reometer kunde mätdata insamlas för att bestämma ett värde på en graderad skala. Fördelen med att använda en graderad skala istället är att det då går att undvika en kostsam och tidskrävande fysisk applicering av färgerna. Ett så kallat ”Shear rate loop test” användes för detta ändamål med hjälp av en grafisk tolkning. Den utvecklade metoden gav information som söktes om färgen rann eller ej.

    Varianter av oscillationstester som 3ITT, amplitudsvep och frekvenssvep används för att bestämma elastiska (G’) och viskösa (G’’) egenskaper, vilket kunde åskådliggöra vilket beteende som var dominerade hos färgerna. Studien har utgått från mätdata av 28 stycken olika färger. Studien har resulterat i två metoder som går att använda för att förutse rinning efter färgapplicering: Shear rate loop och 3ITT är metoderna.

    Fulltekst (pdf)
    fulltext
  • 34.
    Abdirahman, Khalid
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Förnberg, Sebastian
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Styrsystem för solcellsladdade batterier2018Independent thesis Basic level (university diploma), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Användandet av solceller ökar kontinuerligt i Sverige och effekten som genererasav solcellerna förvaras oftast i bly-syra batterier. Dessa batterier har en dåligpåverkan på miljön eftersom det krävs mycket energi och miljöfarliga material såsom bly och svavelsyra för att tillverka dessa batterier. Östersjökompaniet AB ochmånga av dess kunder inser vikten av ett hållbart tänkande och var intresseradeav att veta om det var möjligt att maximera livslängden av dessa batterier. Underarbetets gång analyserades olika metoder för upp- och urladdning av batterier somkan påverka ett batteris livslängd och hur man kan bära sig åt för att optimera det.En laddningskontroller användes för att optimera laddningen av batteriet. För attberäkna laddningsnivån i batteriet användes metoden ”Extended voltmeter”. Enprototyp som kunde ladda batterierna på ett optimalt sätt, varna då batterietsladdningsnivå blev för låg samt en användarvänlig applikation för övervakning avbatteriet konstruerades. Ett batteris beräknade livslängd är ingen exakt vetenskap.Enligt studier kan livslängden av ett batteri fördubblas om det laddas upp ochladdas ur på ett optimalt sätt i jämförelse med då det laddas ur helt.

    Fulltekst (pdf)
    Styrsystem för solcellsladdade batterier
  • 35.
    Abduljabar, Haya
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem.
    Hadi, Hanan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem.
    Sterilization of Medical Equipment in a Third World Country: A Minor Field Study in Linga Linga, Mozambique2020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    The non-profit organization Project Vita has recently built a maternity clinic in Linga Linga, where the medical instruments to be sterilized are boiled in water for an hour. The fuel needed to boil the water is wood, which is a scarce resource. This is why, according to the healthcare worker that was interviewed in Mozambique, it is desirable to have an electric-powered solution to sterilise the medical instruments.

    After research on the different sterilization techniques that exist, the conclusion was drawn that the safest way to sterilise is by the use of an autoclave. However, it would be difficult to implement and maintain an autoclave in Linga Linga. Therefore, it was proposed to build an autoclave using a pressure cooker. Through experimentation, different programs, times and pressures were tested to find out if a pressure cooker could sterilise a common object. It could be concluded that theoretically, it seems that the pressure cooker reached a temperature of over 121 degrees Celsius. However, the pressure could not be measured nor was a biological indicator, that could indicate if an autoclave or pressure cooker does sterile, used. 

    This project was to be done in Mozambique, but because of COVID-19, a travel ban was set in motion and universities and laboratories had limited access, thus limiting the project. As a result, it is still unclear if a pressure cooker can be used to sterilize medical instruments.

    Fulltekst (pdf)
    fulltext
  • 36.
    Abdulnoor, John
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Gawriyeh, Ramy
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    A study of methods to synchronize different sensors between two smartphones2021Independent thesis Basic level (university diploma), 10 poäng / 15 hpOppgave
    Abstract [en]

    Obtaining data simultaneously from different sensors located on different mobile devices can be useful for applications such as sports and medicine. In order for the data from the different sensors to be combined for analysis, the mobile devices need to be time synchronized first. This paper presents an application that can be used to calculate the difference between the internal clocks of two android devices using a combination of the Cristian and Marzullo algorithms. Different methods to connect the devices over Wi-Fi as well as the internet are tested to determine the optimal method for clock synchronization. The paper also validates the synchronization by testing different sensors on two identical android smartphones. The results show that clock synchronization between two mobile devices can be achieved with a round-trip time of 2 milliseconds or less using Wi-Fi Direct. Validation of the synchronization shows that a delay of 7 milliseconds or less can be achieved between two sensors of the same type on two identical android smartphones. It also shows that the least achievable delay between sensors of different types is 16 milliseconds. The conclusion is that once two android smartphones’ clocks are synchronized, only data from sensors of the same type can be combined, with the exception of the camera sensor. Further testing with more robust equipment is needed in order to eliminate human error which could possibly yield more desirable results.

    Fulltekst (pdf)
    fulltext
  • 37.
    Abed, Ala
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    eValuate - A Sports Analytics mHealth App: Featuring the Perceived Load and Fitness Scale for Overtraining Prevention and Intervention2020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    Health and fitness apps have become ubiquitous as smart devices become a major necessity in day-to-day life. However, an obvious issue with mobile health (mHealth) apps is that a substantial portion of them lack a scientific foundation and instead utilize  experiential  stratagems.  Hence,  the  acquired  data  becomes  unreliable.  In sports, where data collection is extensive, this becomes a vital factor for success due to  the  increasing  usage  of  mHealth.  Therefore,  the  Swedish  School  of  Sport  and Health Sciences has, in collaboration with other organizations, created the Perceived Load  and  Fitness  Scale  Questionnaire.  The  purpose  of  this  questionnaire  is  to function as a marker for overtraining, and thus injury prevention and intervention will become a simpler and more efficient task. A computer software was developed for the questionnaire; however, a mobile version was required, and thus requested. Consequently, the mHealth prototype app eValuate was developed. Research, in the form of literature studies, and dissection of other apps, for additional information, contributed  to  the  development  of  it.  The  prototype  was  developed  using  the programming language Java with Android Studio as the Integrated Development Environment  and  Cloud  Firebase  Firestore  as  a  database  solution.  The  finished prototype, eValuate, had to be trialled to ensure that it satisfies the criteria. Thus, the Mobile Application Rating Scale was employed as the most appropriate means of evaluation. A small-scale study was planned to trial the prototype by utilizing this scale.  However,  due  to  unforeseen  events,  only  four  respondents  could  provide feedback. The prototype performed admirably and scored 3.8 stars out of 5 stars. Nonetheless, the testing sample is too small to draw any real conclusions. 

    Fulltekst (pdf)
    fulltext
  • 38.
    Abellan-Flos, Marta
    et al.
    Univ Namur, Dept Chim, Lab Chim Bioorgan, Rue Bruxelles 61, B-5000 Namur, Belgium.;PSL Univ, CNRS, ESPCI Paris, Mol Macromol Chem & Mat, 10 Rue Vauquelin, F-75005 Paris, France..
    Timmer, Brian J. J.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi.
    Altun, Samuel
    Attana AB, Bjornnasvagen 21, S-11419 Stockholm, Sweden..
    Aastrup, Teodor
    Attana AB, Bjornnasvagen 21, S-11419 Stockholm, Sweden..
    Vincent, Stephane P.
    Univ Namur, Dept Chim, Lab Chim Bioorgan, Rue Bruxelles 61, B-5000 Namur, Belgium..
    Ramström, Olof
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi. Univ Massachusetts, Dept Chem, One Univ Ave, Lowell, MA 01854 USA.;Linnaeus Univ, Dept Chem & Biomed Sci, SE-39182 Kalmar, Sweden..
    QCM sensing of multivalent interactions between lectins and well-defined glycosylated nanoplatforms2019Inngår i: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 139, artikkel-id 111328Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Quartz crystal microbalance (QCM) methodology has been adopted to unravel important factors contributing to the "cluster glycoside effect" observed in carbohydrate-lectin interactions. Well-defined, glycosylated nanostructures of precise sizes, geometries and functionalization patterns were designed and synthesized, and applied to analysis of the interaction kinetics and thermodynamics with immobilized lectins. The nanostructures were based on Borromean rings, dodecaamine cages, and fullerenes, each of which carrying a defined number of carbohydrate ligands at precise locations. The synthesis of the Borromeates and dodecaamine cages was easily adjustable due to the modular assembly of the structures, resulting in variations in presentation mode. The binding properties of the glycosylated nanoplatforms were evaluated using flow-through QCM technology, as well as hemagglutination inhibition assays, and compared with dodecaglycosylated fullerenes and a monovalent reference. With the QCM setup, the association and dissociation rate constants and the associated equilibrium constants of the interactions could be estimated, and the results used to delineate the multivalency effects of the lectin-nanostructure interactions.

  • 39. Abitbol, T.
    et al.
    Ahniyaz, A.
    Álvarez-Asencio, R.
    Fall, A.
    Swerin, Agne
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Nanocellulose-Based Hybrid Materials for UV Blocking and Mechanically Robust Barriers2020Inngår i: ACS Applied Bio Materials, E-ISSN 2576-6422, Vol. 3, nr 4, s. 2245-2254Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nanocellulose (NC)-based hybrid coatings and films containing CeO2 and SiO2 nanoparticles (NPs) to impart UV screening and hardness properties, respectively, were prepared by solvent casting. The NC film-forming component (75 wt % of the overall solids) was composed entirely of cellulose nanocrystals (CNCs) or of CNCs combined with cellulose nanofibrils (CNFs). Zeta potential measurements indicated that the four NP types (CNC, CNF, CeO2, and SiO2) were stably dispersed in water and negatively charged at pH values between 6 and 9. The combination of NPs within this pH range ensured uniform formulations and homogeneous coatings and films, which blocked UV light, the extent of which depended on film thickness and CeO2 NP content, while maintaining good transparency in the visible spectrum (∼80%). The addition of a low amount of CNFs (1%) reduced the film hardness, but this effect was compensated by the addition of SiO2 NPs. Chiral nematic self-assembly was observed in the mixed NC film; however, this ordering was disrupted by the addition of the oxide NPs. The roughness of the hybrid coatings was reduced by the inclusion of oxide NPs into the NC matrix perhaps because the spherical oxide NPs were able to pack into the spaces between cellulose fibrils. We envision these hybrid coatings and films in barrier applications, photovoltaics, cosmetic formulations, such as sunscreens, and for the care and maintenance of wood and glass surfaces, or other surfaces that require a smooth, hard, and transparent finish and protection from UV damage.

  • 40.
    Abitbol, Tiffany
    et al.
    Institute of Materials, School of Engineering, EPFL, 1015 Lausanne, Switzerland;Bioeconomy and Health, RISE Research Institutes of Sweden, SE-114 28 Stockholm, Sweden.
    Kubat, Mikaela
    Bioeconomy and Health, RISE Research Institutes of Sweden, SE-114 28 Stockholm, Sweden.
    Brännvall, Elisabet
    Bioeconomy and Health, RISE Research Institutes of Sweden, SE-114 28 Stockholm, Sweden.
    Kotov, Nikolay
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Johnson, C. Magnus
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Nizamov, Rustem
    Department of Mechanical and Materials Engineering, Faculty of Technology, University of Turku, FI-20014 Turku, Finland.
    Nyberg, Mikael
    Department of Mechanical and Materials Engineering, Faculty of Technology, University of Turku, FI-20014 Turku, Finland.
    Miettunen, Kati
    Department of Mechanical and Materials Engineering, Faculty of Technology, University of Turku, FI-20014 Turku, Finland.
    Nordgren, Niklas
    Bioeconomy and Health, RISE Research Institutes of Sweden, SE-114 28 Stockholm, Sweden.
    Stevanic, Jasna S.
    Bioeconomy and Health, RISE Research Institutes of Sweden, SE-114 28 Stockholm, Sweden.
    Guerreiro, Maria Pita
    Bioeconomy and Health, RISE Research Institutes of Sweden, SE-114 28 Stockholm, Sweden.
    Isolation of Mixed Compositions of Cellulose Nanocrystals, Microcrystalline Cellulose, and Lignin Nanoparticles from Wood Pulps2023Inngår i: ACS Omega, E-ISSN 2470-1343, Vol. 8, nr 24, s. 21474-21484Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    From a circular economyperspective, one-pot strategies for theisolation of cellulose nanomaterials at a high yield and with multifunctionalproperties are attractive. Here, the effects of lignin content (bleachedvs unbleached softwood kraft pulp) and sulfuric acid concentrationon the properties of crystalline lignocellulose isolates and theirfilms are explored. Hydrolysis at 58 wt % sulfuric acid resulted inboth cellulose nanocrystals (CNCs) and microcrystalline celluloseat a relatively high yield (>55%), whereas hydrolysis at 64 wt% gaveCNCs at a lower yield (<20%). CNCs from 58 wt % hydrolysis weremore polydisperse and had a higher average aspect ratio (1.5-2x),a lower surface charge (2x), and a higher shear viscosity (100-1000x).Hydrolysis of unbleached pulp additionally yielded spherical nanoparticles(NPs) that were <50 nm in diameter and identified as lignin bynanoscale Fourier transform infrared spectroscopy and IR imaging.Chiral nematic self-organization was observed in films from CNCs isolatedat 64 wt % but not from the more heterogeneous CNC qualities producedat 58 wt %. All films degraded to some extent under simulated sunlighttrials, but these effects were less pronounced in lignin-NP-containingfilms, suggesting a protective feature, but the hemicellulose contentand CNC crystallinity may be implicated as well. Finally, heterogeneousCNC compositions obtained at a high yield and with improved resourceefficiency are suggested for specific nanocellulose uses, for instance,as thickeners or reinforcing fillers, representing a step toward thedevelopment of application-tailored CNC grades.

  • 41.
    Abourraja, Mohamed Nezar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Kringos, Nicole
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Byggvetenskap, Bro- och stålbyggnad.
    Meijer, Sebastiaan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Exploiting simulation model potential in investigating handling capacity of Ro-Ro terminals: The case study of Norvik seaport2022Inngår i: Simulation Modelling Practice and Theory, ISSN 1569-190X, Vol. 117, s. 102513-102513, artikkel-id 102513Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this paper, the spotlight is directed towards studying the handling capacity of pure Ro-Ro terminals, especially the new terminal of Norvik port. To this end, a simulation model based on a distributed architecture is built to assess the handling capacity under different flow scenarios with a particular focus on the trailer flow and export-lorry flow the terminal can handle in terms of resource availability, trailer-dwell times and management rules. This helped to determine the number of resources required to evacuate smoothly the incoming flows and to identify where potential bottlenecks happen the most inside the terminal. The established model is verified then validated by experts to conduct properly the experiment study where the model is fed with empirical data provided by terminal authorities. This experiment showed that the terminal can handle flows of which trailers do not exceed 17% and the export fraction of lorries is at most 42%.

  • 42.
    Abourraja, Mohamed Nezar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Kringos, Nicole
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Byggvetenskap, Bro- och stålbyggnad.
    Meijer, Sebastiaan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Proposal of a module-driven architecture for building simulation models devoted to container terminals: dilemmas in applying generic, flexible, and modular principles2023Inngår i: Simulation (San Diego, Calif.), ISSN 0037-5497, E-ISSN 1741-3133, Vol. 99, nr 7, s. 703-727Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Container terminals are complex systems where containerized cargo undergoes a set of processing and handling operations to be delivered to their outgoing modes. A pool of decision support methods and simulation models has been developed to assist planners and managers in making decisions about daily operations. Nevertheless, most are designed for a particular terminal and not generic types. Indeed, a generic model serves as a conceptual factory to create specific models which greatly reduces the time and efforts of development; however, building such a model is no mean feat. To this aim, the paper on hand discusses the complexity of applying genericity, flexibility, and modularity in system modeling and proposes a generic architecture to build modular and flexible simulation models for container terminals. This architecture is split into a set of smaller, manageable, well-connected, and generic modules that facilitate the creation of highly parametrized specific models. An illustrative example of the architecture usage is presented in a case study, the new container terminal of Stockholm, and the resulting models were validated by subject matter experts. Finally, to prove its efficiency, a numerical study fed with real data is conducted to investigate the handling capacity of the studied system under different handling and flow scenarios. The obtained results show that the terminal handling capacity can be increased by around 50% if three to four more straddle carriers are added to the existing fleet.

  • 43.
    Abourraja, Mohamed Nezar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Marzano, Luca
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Raghothama, Jayanth
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Boodaghian Asl, Arsineh
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Darwich, Adam S.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Meijer, Sebastiaan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Lethvall, Sven
    Uppsala University Hospital,Uppsala,Sweden.
    Falk, Nina
    Uppsala University Hospital,Uppsala,Sweden.
    A Data-Driven Discrete Event Simulation Model to Improve Emergency Department Logistics2022Inngår i: Proceedings of the 2022 Winter Simulation Conference, Institute of Electrical and Electronics Engineers (IEEE) , 2022Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Demands for health care are becoming overwhelming for healthcare systems around the world regarding theavailability of resources, particularly, in emergency departments (EDs) that are continuously open and mustserve immediately any patient who comes in. Efficient management of EDs and their resources is requiredmore than ever. This could be achieved either by optimizing resource utilization or by the improvement ofhospital layout. This paper investigates, through data-driven simulation alternative designs of workflowsand layouts to operate the ED of the Uppsala University Hospital in Sweden. Results are analyzed tounderstand the requirements across the hospital for reduced waiting times in the ED. The main observationrevealed that introducing a new ward dedicated to patients having complex diagnoses with a capacity ofless than 20 beds leads to lower waiting times. Furthermore, the use of data-mining was of great help inreducing the efforts of building the simulation model.

  • 44.
    Abourraja, Mohamed Nezar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Meijer, Sebastiaan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Boukachour, Jaouad
    Normandie University, UNIHAVRE, 76600 Le Havre, France.
    A model-driven design approach for Ro-Ro and container terminals: from requirements analysis down to simulation model implementation2021Inngår i: 20th International Conference on Modeling and Applied Simulation, MAS 2021, Cal-Tek Srl , 2021, s. 9-20Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Modeling, one of the main pillars of good scientific research, is a long-standing multidisciplinary activity to understand and analyze complex systems. In this paper, the focus is directed toward conceptual modeling of multi-terminal seaports specialized in handling and treatment of intermodal transport units (ITU). These systems are complex with highly dynamic and stochastic behaviors and actors, therefore, studying them as a coherent whole or just analyzing one part by taking into account the high degree of integration among the different aspects and actors linked by a flow of activities, information, and interactions is a bet lost in advance without a well-defined design process. Several design approaches and methodologies have been proposed over the years, but nonetheless, there is still no agreement on how to conduct modeling of complex systems because they are of different kinds. In this line, this paper proposes a top-down approach for container and Ro-Ro terminals largely inspired by the Unified Process Methodology and refined through several research projects that we have been involved in. It gives some recommendations and guidelines as well as a helpful way to successfully build modular and consistent simulation models. To prove its efficiency, it was applied to a case study and the resulting models were validated by the subject matter's experts.

  • 45.
    Abourraja, Mohamed Nezar
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik. Ecole Cent Casablanca, Casablanca, Morocco..
    Rouky, Naoufal
    Euro-Mediterranean University, Fez, Morocco.
    Kornevs, Maksims
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Meijer, Sebastiaan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Kringos, Nicole
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Byggvetenskap, Bro- och stålbyggnad. Euro Mediterranean Univ, Fes, Morocco..
    A simulation-based decision support framework devoted to Ro-Ro terminals: Design, implementation and evaluation2023Inngår i: Computers & industrial engineering, ISSN 0360-8352, E-ISSN 1879-0550, Vol. 180, s. 109248-, artikkel-id 109248Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    As a type of intermodal terminal, pure Ro-Ro terminals are one of the most important logistic hubs in the supply chain for rolling freight stored in containerized and wheeled steel boxes. These large-scale systems are highly complex, with nonlinear and hard-to-predict behavior evolving in a stochastic environment. Consequently, making decisions about any problem thereof is no mean feat, particularly for terminal planners. To assist them in decision-making, a pool of relevant models and tools have been developed over the years in the literature. Nevertheless, models that are oriented toward specific objectives dominate, and generic ones are rare. This paper tries to fill this gap and proposes a generic framework to be used as a factory to create specific decision support models based on simulation for pure Ro-Ro terminals. This framework is formulated following two artifacts: (1) the known classification of key performance indicators combined with the typical functional and physical organization of pure Ro-Ro terminals; (2) the three main arteries of harbor systems, namely flows, decisions and operations. Then a scalable way of making decisions based on a flexible form of the cost function weighted according to a set of coefficients is integrated. These designed coefficients allow decision-makers a wide flexibly in choosing how the best solutions are determined. An application of this framework is illustrated through a real case study, where the weights are estimated using an expert-profiling based approach then pushed into the OptQuest optimizer to be calibrated before analyzing the results. These results are aggregated, then expressed as scores on a scale of 0 to 1. This is to help terminal planners to easily identify the worst and best planning scenarios as well as the relationships and compatibilities between the involved handling rules to suggest different alternatives for managing operations.

  • 46.
    Abouzayed, A.
    et al.
    Uppsala Univ, Uppsala, Sweden..
    Rinne, S. S.
    Uppsala Univ, Uppsala, Sweden..
    Wadeea, F.
    Uppsala Univ, Uppsala, Sweden..
    Tano, Hanna
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Proteinvetenskap.
    Nagy, Abel
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Eriksson Karlström, Amelie
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Proteinvetenskap.
    Tolmachev, V.
    Uppsala Univ, Uppsala, Sweden..
    Orlova, A.
    Uppsala Univ, Uppsala, Sweden..
    Conjugation of GRPR-targeting antagonist RM26 to albumin-binding domain extends antagonist's blood circulation and residence in tumours2020Inngår i: European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, E-ISSN 1619-7089, Vol. 47, nr SUPPL 1, s. S652-S652Artikkel i tidsskrift (Annet vitenskapelig)
  • 47.
    Abouzayed, Ayman
    et al.
    Uppsala Univ, Dept Med Chem, S-75183 Uppsala, Sweden..
    Borin, Jesper
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Proteinteknologi.
    Lundmark, Fanny
    Uppsala Univ, Dept Med Chem, S-75183 Uppsala, Sweden..
    Rybina, Anastasiya
    Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, Dept Nucl Med, Tomsk 634009, Russia.;Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Res Ctr Oncotheranost, Tomsk 634050, Russia..
    Hober, Sophia
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Zelchan, Roman
    Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, Dept Nucl Med, Tomsk 634009, Russia.;Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Res Ctr Oncotheranost, Tomsk 634050, Russia..
    Tolmachev, Vladimir
    Uppsala Univ, Dept Immunol Genet & Pathol, S-75237 Uppsala, Sweden..
    Chernov, Vladimir
    Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, Dept Nucl Med, Tomsk 634009, Russia..
    Orlova, Anna
    Uppsala Univ, Dept Med Chem, S-75183 Uppsala, Sweden.;Uppsala Univ, Sci Life Lab, S-75237 Uppsala, Sweden..
    The GRPR Antagonist [Tc-99m]Tc-maSSS-PEG(2)-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity2023Inngår i: Diagnostics, ISSN 2075-4418, Vol. 13, nr 9, s. 1611-, artikkel-id 1611Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Gastrin-releasing peptide receptors (GRPRs) are overexpressed in the majority of primary prostate tumors and in prostatic lymph node and bone metastases. Several GRPR antagonists were developed for SPECT and PET imaging of prostate cancer. We previously reported a preclinical evaluation of the GRPR antagonist [Tc-99m]Tc-maSSS-PEG2-RM26 (based on [D-Phe(6), Sta(13), Leu(14)-NH2]BBN(6-14)) which bound to GRPR with high affinity and had a favorable biodistribution profile in tumor-bearing animal models. In this study, we aimed to prepare and test kits for prospective use in an early-phase clinical study. The kits were prepared to allow for a one-pot single-step radiolabeling with technetium-99m pertechnetate. The kit vials were tested for sterility and labeling efficacy. The radiolabeled by using the kit GRPR antagonist was evaluated in vitro for binding specificity to GRPR on PC-3 cells (GRPR-positive). In vivo, the toxicity of the kit constituents was evaluated in rats. The labeling efficacy of the kits stored at 4 degrees C was monitored for 18 months. The biological properties of [Tc-99m]Tc-maSSS-PEG2-RM26, which were obtained after this period, were examined both in vitro and in vivo. The one-pot (gluconic acid, ethylenediaminetetraacetic acid, stannous chloride, and maSSS-PEG(2)-RM26) single-step radiolabeling with technetium-99m was successful with high radiochemical yields (>97%) and high molar activities (16-24 MBq/nmol). The radiolabeled peptide maintained its binding properties to GRPR. The kit constituents were sterile and non-toxic when tested in living subjects. In conclusion, the prepared kit is considered safe in animal models and can be further evaluated for use in clinics.

  • 48.
    Abouzayed, Ayman
    et al.
    Uppsala Univ, Dept Med Chem, S-75183 Uppsala, Sweden..
    Tano, Hanna
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Proteinvetenskap.
    Nagy, Abel
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Rinne, Sara S.
    Uppsala Univ, Dept Med Chem, S-75183 Uppsala, Sweden..
    Wadeea, Fadya
    Uppsala Univ, Dept Med Chem, S-75183 Uppsala, Sweden..
    Kumar, Sharmishtaa
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap.
    Westerlund, Kristina
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Proteinvetenskap.
    Tolmachev, Vladimir
    Uppsala Univ, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden..
    Eriksson Karlström, Amelie
    KTH, Skolan för bioteknologi (BIO), Centra, Albanova VinnExcellence Center for Protein Technology, ProNova. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap. KTH Royal Inst Technol, AlbaNova Univ Ctr, Dept Prot Sci, Sch Engn Sci Chem Biotechnol & Hlth, S-10691 Stockholm, Sweden..
    Orlova, Anna
    Uppsala Univ, Dept Med Chem, S-75183 Uppsala, Sweden.;Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Res Centrum Oncotheranost, Tomsk 634050, Russia.;Uppsala Univ, Sci Life Lab, S-75105 Uppsala, Sweden..
    Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer2020Inngår i: Pharmaceutics, E-ISSN 1999-4923, Vol. 12, nr 10, artikkel-id 977Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The targeting of gastrin-releasing peptide receptors (GRPR) was recently proposed for targeted therapy, e.g., radiotherapy. Multiple and frequent injections of peptide-based therapeutic agents would be required due to rapid blood clearance. By conjugation of the GRPR antagonist RM26 (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2) to an ABD (albumin-binding domain), we aimed to extend the blood circulation of peptides. The synthesized conjugate DOTA-ABD-RM26 was labelled with indium-111 and evaluated in vitro and in vivo. The labelled conjugate was stable in PBS and retained specificity and its antagonistic function against GRPR. The half-maximal inhibitory concentration (IC50) of In-nat-DOTA-ABD-RM26 in the presence of human serum albumin was 49 +/- 5 nM. [In-111]In-DOTA-ABD-RM26 had a significantly longer residence time in blood and in tumors (without a significant decrease of up to 144 h pi) than the parental RM26 peptide. We conclude that the ABD-RM26 conjugate can be used for GRPR-targeted therapy and delivery of cytotoxic drugs. However, the undesirable elevated activity uptake in kidneys abolishes its use for radionuclide therapy. This proof-of-principle study justified further optimization of the molecular design of the ABD-RM26 conjugate.

  • 49.
    Abraham, Johannes
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Romano, Robin
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Automatisk kvalitetssäkring av information för järnvägsanläggningar: Automatic quality assurance of information for railway infrastructure2019Independent thesis Basic level (university diploma), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Järnvägsbranschen står i dagsläget inför stora utmaningar med planerade infrastrukturprojekt och underhåll av befintlig järnväg. Med ökade förväntningar på  utbyggnaden av den framtida järnvägen, medför det en ökad risk för belastning på det nuvarande nätet. Baksidan av utbyggnaden kan bli fler inställda resor och  förseningar. Genom att dra nytta av tekniska innovationer såsom digitalisering och  automatisering kan det befintliga system och arbetsprocesser utvecklas för en  effektivare hantering.  Trafikverket ställer krav på Byggnadsinformationsmodeller (BIM) i upphandlingar. Projektering för signalanläggningar sker hos Sweco med CAD-programmet  Promis.e. Från programmet kan Baninformationslistor (BIS-listor) innehållande  information om objekts attribut hämtas. Trafikverket ställer krav på att attributen ska bestå av ett visst format eller ha specifika värden. I detta examensarbete  undersöks metoder för att automatisk verifiera ifall objekt har tillåtna värden från projekteringsverktyget samt implementering av en metod. Undersökta metoder  innefattar kalkyleringsprogrammet Excel, frågespråket Structured Query Language (SQL) och processen Extract, Transform and Load (ETL).  Efter analys av metoder valdes processen ETL. Resultatet blev att ett program  skapades för att automatiskt välja vilken typ av BIS-lista som skulle granskas och för att verifiera om attributen innehöll tillåtna värden. För att undersöka om kostnaden för programmen skulle gynna företaget utöver kvalitetssäkringen utfördes en  ekonomisk analys. Enligt beräkningarna kunde valet av att automatisera  granskningen även motiveras ur ett ekonomiskt perspektiv.

    Fulltekst (pdf)
    Examensarbete
  • 50.
    Abraham, Saron
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
    High entropy oxide electrodes with ionic liquid electrolyte2022Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [en]

    Metal-based high entropy oxides are considered promising electrode materials for use in Li- ion batteries. In this work, the most widely studied high entropy oxide Mg0.2Ni0.2Cu0.2Co0.2Zn0.2O (M-HEO) with rock salt structure was successfully synthesized by Modified Pechini synthesis, characterized by X-ray diffraction analysis, and investigated as anode active material (negative electrode) in a coin cell. M-HEO has the concept of entropy stabilisation of crystal structure in oxide system with the configurational entropy value of 1,6R which confirmed that M-HEO classified as high entropy oxide. 

    To test the electrochemical performance, full cells comprising M-HEO as anode, lithium manganese oxide (LMO) as cathode together with ionic liquid electrolyte were assembled to explore their potential for practical applications. The electrochemical cycling performance was studied by two electrochemical experiments which are three-electrode cyclic voltammetry and galvanostatic charge/discharge. The cyclic voltammetry measurement was used to determine the behaviour of the system such as potential window and scan rate, while galvanostatic charge/discharge was used to determine the performance of the battery over time by applying constant current. 

    The results demonstrate that high entropy oxide possess a stable structure. This points out the direction for the preparation of M-HEOs with stable structure and excellent performance and provides a promising candidate for anode materials for LIBs.

    Fulltekst (pdf)
    fulltext
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