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  • 1.
    Hussein, Mohamed Ahmed Mohamady
    et al.
    Univ Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany.;Natl Res Ctr, Div Med Res, Dept Pharmacol, Cairo 12622, Egypt..
    Guler, Ece
    Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey..
    Rayaman, Erkan
    Marmara Univ, Dept Pharmaceut Microbiol, Istanbul, Turkey..
    Cam, Muhammet Emin
    Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey.;UCL, Dept Mech Engn, Torrington Pl, London W E 7JE, England..
    Sahin, Ali
    Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, TR-34722 Istanbul, Turkey..
    Grinholc, Mariusz
    Univ Gdansk, Intercollegiate Fac Biotechnol, Dept Biotechnol, Lab Mol Diagnost, Gdansk, Poland..
    Mansuroglu, Demet Sezgin
    Istanbul Arel Univ, Polymer Technol & Composite Applicat & Res Ctr Ar, TR-34537 Istanbul, Turkey..
    Sahin, Yesim Muge
    Istanbul Arel Univ, Polymer Technol & Composite Applicat & Res Ctr Ar, TR-34537 Istanbul, Turkey..
    Gunduz, Oguzhan
    Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey..
    Muhammed, Mamoun
    KTH.
    El-Sherbiny, Ibrahim M.
    Zewail City Sci & Technol, Ctr Mat Sci CMS, Nanomed Lab, Giza 12578, Egypt..
    Megahed, Mosaad
    Univ Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany..
    Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers2021In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 270, article id 118373Article in journal (Refereed)
    Abstract [en]

    Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.

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