Change search
Refine search result
1 - 1 of 1
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Maniatis, Silas
    et al.
    New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA..
    Aijo, Tarmo
    Flatiron Inst, Ctr Computat Biol, New York, NY 10010 USA..
    Vickovic, Sanja
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Braine, Catherine
    New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA.;Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10032 USA..
    Kang, Kristy
    New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA..
    Mollbrink, Annelie
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Fagegaltier, Delphine
    New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA..
    Andrusivova, Zaneta
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Saarenpaa, Sami
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Saiz-Castro, Gonzalo
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Cuevas, Miguel
    Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10032 USA..
    Watters, Aaron
    Flatiron Inst, Ctr Computat Biol, New York, NY 10010 USA..
    Lundeberg, Joakim
    KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Gene Technology.
    Bonneau, Richard
    Flatiron Inst, Ctr Computat Biol, New York, NY 10010 USA.;NYU, Ctr Data Sci, New York, NY 10011 USA..
    Phatnani, Hemali
    New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA.;Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10032 USA..
    Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis2019In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 364, no 6435, p. 89-+Article in journal (Refereed)
    Abstract [en]

    Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS. We identify pathway dynamics, distinguish regional differences between microglia and astrocyte populations at early time points, and discern perturbations in several transcriptional pathways shared between murine models of ALS and human postmortem spinal cords.

1 - 1 of 1
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf