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  • 1.
    Adriaens, Florian
    et al.
    University of Helsinki, Helsinki, Finland.
    Wang, Hongliang
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Theoretical Computer Science, TCS.
    Gionis, Aristides
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Theoretical Computer Science, TCS.
    Minimizing hitting time between disparate groups with shortcut edges2023In: KDD 2023: Proceedings of the 29th ACM SIGKDD Conference on Knowledge Discovery and Data Mining, Association for Computing Machinery (ACM) , 2023, p. 1-10Conference paper (Refereed)
    Abstract [en]

    Structural bias or segregation of networks refers to situations where two or more disparate groups are present in the network, so that the groups are highly connected internally, but loosely connected to each other. Examples include polarized communities in social networks, antagonistic content in video-sharing or news-feed platforms, etc. In many cases it is of interest to increase the connectivity of disparate groups so as to, e.g., minimize social friction, or expose individuals to diverse viewpoints. A commonly-used mechanism for increasing the network connectivity is to add edge shortcuts between pairs of nodes. In many applications of interest, edge shortcuts typically translate to recommendations, e.g., what video to watch, or what news article to read next. The problem of reducing structural bias or segregation via edge shortcuts has recently been studied in the literature, and random walks have been an essential tool for modeling navigation and connectivity in the underlying networks. Existing methods, however, either do not offer approximation guarantees, or engineer the objective so that it satisfies certain desirable properties that simplify the optimization task. In this paper we address the problem of adding a given number of shortcut edges in the network so as to directly minimize the average hitting time and the maximum hitting time between two disparate groups. The objectives we study are more natural than objectives considered earlier in the literature (e.g., maximizing hitting-time reduction) and the optimization task is significantly more challenging. Our algorithm for minimizing average hitting time is a greedy bicriteria that relies on supermodularity. In contrast, maximum hitting time is not supermodular. Despite, we develop an approximation algorithm for that objective as well, by leveraging connections with average hitting time and the asymmetric k-center problem.

  • 2.
    $$$Albertsson, Dagur I.
    et al.
    School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Kista, Sweden.
    $$$Rusu, Ana
    School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Kista, Sweden.
    Experimental Demonstration of Duffing Oscillator-Based Analog Ising Machines2024In: LASCAS 2024 - 15th IEEE Latin American Symposium on Circuits and Systems, Proceedings, Institute of Electrical and Electronics Engineers Inc. , 2024Conference paper (Refereed)
    Abstract [en]

    This paper presents a proof-of-concept analog Ising Machine, which can solve combinatorial optimization problems using bifurcations in networks of coupled Duffing oscillators. The proof-of-concept system consists of a network of four coupled Duffing oscillators implemented with low-cost components on a prototyping board. Experimental results demonstrate that the proposed prototype operates as an Ising Machine and it can solve various Max-Cut problems. This work provides the foundation towards realizing analog Ising Machines based on circuits that exhibit bifurcation properties, such as the Duffing oscillators, and that can be scaled to large networks.

  • 3.
    Backlund, Linus
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Electrical Engineering, Electronics and Embedded systems.
    Ngo, Kalle
    KTH, School of Electrical Engineering and Computer Science (EECS), Electrical Engineering, Electronics and Embedded systems.
    Gärtner, Joel
    KTH, School of Engineering Sciences (SCI), Mathematics (Dept.), Mathematics (Div.).
    Dubrova, Elena
    KTH, School of Electrical Engineering and Computer Science (EECS), Electrical Engineering, Electronics and Embedded systems.
    Secret Key Recovery Attack on Masked and Shuffled Implementations of CRYSTALS-Kyber and Saber2023In: Applied Cryptography and Network Security Workshops - ACNS 2023 Satellite Workshops, ADSC, AIBlock, AIHWS, AIoTS, CIMSS, Cloud S and P, SCI, SecMT, SiMLA, Proceedings, Springer Nature , 2023, p. 159-177Conference paper (Refereed)
    Abstract [en]

    Shuffling is a well-known countermeasure against side-channel attacks. It typically uses the Fisher-Yates (FY) algorithm to generate a random permutation which is then utilized as the loop iterator to index the processing of the variables inside the loop. The processing order is scrambled as a result, making side-channel attacks more difficult. Recently, a side-channel attack on a masked and shuffled implementation of Saber requiring 61,680 power traces to extract the long-term secret key was reported. In this paper, we present an attack that can recover the long-term secret key of Saber from 4,608 traces. The key idea behind the 13-fold improvement is to recover FY indexes directly, rather than by extracting the message Hamming weight and bit flipping, as in the previous attack. We capture a power trace during the execution of the decryption algorithm for a given ciphertext, recover FY indexes 0 and 255, and extract the corresponding two message bits. Then, we modify the ciphertext to cyclically rotate the message, capture a power trace, and extract the next two message bits with FY indexes 0 and 255. In this way, all message bits can be extracted. By recovering messages contained in k∗ l chosen ciphertexts constructed using a new method based on error-correcting codes of length l, where k is the module rank, we recover the long-term secret key. To demonstrate the generality of the presented approach, we also recover the secret key from a masked and shuffled implementation of CRYSTALS-Kyber, which NIST recently selected as a new public-key encryption and key-establishment algorithm to be standardized.

  • 4.
    Boon, Wietse M.
    et al.
    KTH, School of Engineering Sciences (SCI), Mathematics (Dept.), Numerical Analysis, NA.
    Nordbotten, J. M.
    Center for Modeling of Coupled Subsurface Dynamics, Department of Mathematics, University of Bergen, Bergen, Norway.
    Mixed-dimensional poromechanical models of fractured porous media2023In: Acta Mechanica, ISSN 0001-5970, E-ISSN 1619-6937, Vol. 234, no 3, p. 1121-1168Article in journal (Refereed)
    Abstract [en]

    We combine classical continuum mechanics with the recently developed calculus for mixed-dimensional problems to obtain governing equations for flow in, and deformation of, fractured materials. We present models in both the context of finite and infinitesimal strain, and discuss nonlinear (and non-differentiable) constitutive laws such as friction models and contact mechanics in the fracture. Using the theory of well-posedness for evolutionary equations with maximal monotone operators, we show well-posedness of the model in the case of infinitesimal strain and under certain assumptions on the model parameters.

  • 5.
    Cowgill, John
    et al.
    Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.
    Fan, Chen
    Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.
    Haloi, Nandan
    KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Tobiasson, Victor
    Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.
    Zhuang, Yuxuan
    Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.
    Howard, Rebecca J.
    Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.
    Lindahl, Erik
    KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics.
    Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor2023In: Neuron, ISSN 0896-6273, E-ISSN 1097-4199, Vol. 111, no 21, p. 5-3450Article in journal (Refereed)
    Abstract [en]

    The neurotransmitter γ-aminobutyric acid (GABA) drives critical inhibitory processes in and beyond the nervous system, partly via ionotropic type-A receptors (GABAARs). Pharmacological properties of ρ-type GABAARs are particularly distinctive, yet the structural basis for their specialization remains unclear. Here, we present cryo-EM structures of a lipid-embedded human ρ1 GABAAR, including a partial intracellular domain, under apo, inhibited, and desensitized conditions. An apparent resting state, determined first in the absence of modulators, was recapitulated with the specific inhibitor (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid and blocker picrotoxin and provided a rationale for bicuculline insensitivity. Comparative structures, mutant recordings, and molecular simulations with and without GABA further explained the sensitized but slower activation of ρ1 relative to canonical subtypes. Combining GABA with picrotoxin also captured an apparent uncoupled intermediate state. This work reveals structural mechanisms of gating and modulation with applications to ρ-specific pharmaceutical design and to our biophysical understanding of ligand-gated ion channels.

  • 6.
    Cui, Guo Dong
    et al.
    Department of Physics & Astronomy, Stony Brook University, Stony Brook, NY 11794-3800, USA.
    $$$Schweickert, Lucas
    Department of Applied Physics, Royal Institute of Technology, Albanova University Centre, Roslagstullsbacken 21, 106 91 Stockholm, Sweden, Roslagstullsbacken 21.
    $$$Jöns, Klaus D.
    Department of Applied Physics, Royal Institute of Technology, Albanova University Centre, Roslagstullsbacken 21, 106 91 Stockholm, Sweden, Roslagstullsbacken 21; Institute for Photonic Quantum Systems (PhoQS), Center for Optoelectronics and Photonics Paderborn (CeOPP), and Department of Physics, Paderborn University, 33098 Paderborn, Germany.
    Namazi, Mehdi
    Department of Physics & Astronomy, Stony Brook University, Stony Brook, NY 11794-3800, USA.
    Trotta, Rinaldo
    Institute of Semiconductor and Solid State Physics, Johannes Kepler University Linz, 4040, Austria; Dipartimento di Fisica, Sapienza Università di Roma, Piazzale A. Moro 1, I-00185 Roma, Italy, Piazzale A. Moro 1.
    Rastelli, Armando
    Institute of Semiconductor and Solid State Physics, Johannes Kepler University Linz, 4040, Austria.
    $$$Zwiller, Val
    Department of Applied Physics, Royal Institute of Technology, Albanova University Centre, Roslagstullsbacken 21, 106 91 Stockholm, Sweden, Roslagstullsbacken 21.
    Figueroa, Eden
    Department of Physics & Astronomy, Stony Brook University, Stony Brook, NY 11794-3800, USA; Brookhaven National Laboratory, Upton, NY, 11973, USA.
    Interfacing On-Demand Quantum Dot Single Photons with a Resonant Atomic Quantum Memory2023In: Quantum 2.0: Proceedings Optica Quantum 2.0 Conference and Exhibition, Optical Society of America , 2023Conference paper (Refereed)
    Abstract [en]

    We demonstrate coherent interactions between quantum dot single photons and a resonant 87Rb ensemble in the experiment and show an open quantum system analysis. These results could help build fast hybrid quantum networks.

  • 7.
    Deng, Yucheng
    et al.
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Guo, Qiang
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Xiang, Yan
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Fang, Di
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Komlev, Andrei A.
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Bechta, Sevostian
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Ma, Weimin
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    An experimental study on the effect of coolant salinity on steam explosion2024In: Annals of Nuclear Energy, ISSN 0306-4549, E-ISSN 1873-2100, Vol. 201, article id 110420Article in journal (Refereed)
    Abstract [en]

    The steam explosion plays an essential role in the safety analysis of light water reactors (LWRs). Some studies have demonstrated that the occurrence of steam explosions is dependent on many factors such as melt and coolant temperatures, melt and coolant properties, non -condensable gases, etc. After the Fukushima accident, seawater as an emergency coolant and its impact on fuel coolant interactions are receiving attention. However, there is still little knowledge on the impact of seawater on steam explosion. The present study is intended to examine the effect of coolant salinity on steam explosion through a series of tests with single molten droplet falling in different coolant pools (DI water, and seawater at different salinities from 7.7 g/kg to 35 g/kg). The experimental results reveal that the salinity of coolant significantly influences the probability of spontaneous steam explosion of molten tin droplets. The probability of steam explosion generally increases with increasing salinity from 0 to 17.5 g/kg. The molten droplet in seawater experiences more pronounced deformation at same depth before the vapor film of the droplet collapses. What's more, the peak pressure generated by steam explosion in seawater is notably higher than that in DI water. The fragmentation of molten tin droplet after the explosion is enhanced accordingly.

  • 8.
    $$$Edinger, Pierre
    et al.
    KTH Royal Institute of Technology, Stockholm, Sweden.
    Takabayashi, Alain Yuji
    Ecole Polytechnique Fédérale de Lausanne, Switzerland.
    Antony, Cleitus
    Tyndall National Institute of Technology, Cork, Ireland.
    Verheyen, Peter
    Interuniversity Microelectronics Centre, Leuven, Belgium.
    Khan, Umar
    Interuniversity Microelectronics Centre, Leuven, Belgium; Ghent University - IMEC, Dept. of Information Technology, Belgium.
    Bogaerts, Wim
    Interuniversity Microelectronics Centre, Leuven, Belgium; Ghent University - IMEC, Dept. of Information Technology, Belgium.
    Quack, Niels
    Ecole Polytechnique Fédérale de Lausanne, Switzerland.
    $$$Gylfason, Kristinn B.
    KTH Royal Institute of Technology, Stockholm, Sweden.
    A MEMS tunable phase monitor with integrated photodiode read-out for silicon photonic circuits2023In: Integrated Photonics Research, Silicon and Nanophotonics in Proceedings Advanced Photonics Congress 2023 - Part of Advanced Photonics Congress 2023, Optical Society of America , 2023Conference paper (Refereed)
    Abstract [en]

    Electrostatic MEMS provide low power consumption to programmable photonics. However, the scaling of programmable photonics also requires solutions for circuit monitoring. We demonstrate a MEMS tunable phase monitor with integrated read-out on a foundry platform.

  • 9.
    Ferrara, Vincenza
    et al.
    Vincenza Ferrara is an Early-Stage Researcher in the Department of Archaeology and Ancient History (Uppsala University) and the Department of Human Geography (Stockholm University).
    $$$Lindberg, Johan
    Johan Lindberg is a mechanical engineer from the Royal Institute of Technology (KTH, Sweden). He is an expert in traction motors, drive systems, programming, and statistics.
    CLIMATE AND ENVIRONMENTAL CHANGE PERCEPTIONS: A case from rural Sicily, Italy2023In: Routledge Handbook of Climate Change Impacts on Indigenous Peoples and Local Communities, Taylor and Francis , 2023, p. 109-123Chapter in book (Other academic)
    Abstract [en]

    In the middle of the Mediterranean sea, historically characterised by large spatial and temporal climate variability, the island of Sicily, a unique ethnic and cultural crossroad for millennia, has not been spared by global warming and environmental change. On the island, remote rural areas suffer today the severe progressive degradation of their biocultural heritage, accompanied by serious marginalisation due to contrasting and simultaneous processes of rural depopulation and land abandonment on the one side and agricultural intensification on the other. This chapter looks at climate and environmental changes as reported by locals in one of these remote areas, the Morello Valley, a fluvial system in central Sicily, and compares local observations with temperature and rainfall data collected by the nearest meteorological stations. Then, inspired by historical ecology, the chapter discusses the results of a longer-term reconstruction of the climatic, environmental, and societal past of this part of Sicily, covering the entire Holocene. Conclusions highlight the importance of taking into account both different spatial and temporal scales when approaching the climate discourse, cultural constructs derived from socio-cultural and historical events, and contemporary and place-based local perceptions.

  • 10.
    Frauenfelder, Arno
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS).
    Wiltz, Adrian
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Dimarogonas, Dimos V.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Decentralized Vehicle Coordination and Lane Switching without Switching of Controllers2023Conference paper (Refereed)
    Abstract [en]

    This paper proposes a controller for safe lane change manoeuvres of autonomous vehicles using high-order control barrier and Lyapunov functions. The inputs are calculated using a quadratic program (CLF-CBF-QP) which admits short calculation times. The controller allows for adaptive cruise control, lane following, lane switching and ensures collision avoidance at all times. The novelty of the controller is the decentralized approach to the coordination of vehicles without switching of controllers. In particular, vehicles indicate their manoeuvres which influences their own safe region and that of neighboring vehicles. This is achieved by introducing so-called coordination functions in the design of control barrier functions. In a relevant simulation example, the controller is validated and its effectiveness is demonstrated.

  • 11.
    Giorgini, L. T.
    et al.
    Nordita, Royal Institute of Technology and Stockholm University, Stockholm 106 91, Sweden.
    Eichhorn, Ralf
    KTH, Centres, Nordic Institute for Theoretical Physics NORDITA.
    Das, M.
    Indian Institute of Technology Mandi, Kamand, Himachal Pradesh 175075, India, Himachal Pradesh.
    Moon, W.
    Department of Environmental Atmospheric Sciences, Pukyong National University, 48513 Pusan, South Korea.
    Wettlaufer, John
    KTH, Centres, Nordic Institute for Theoretical Physics NORDITA.
    Thermodynamic cost of erasing information in finite time2023In: Physical Review Research, E-ISSN 2643-1564, Vol. 5, no 2, article id 023084Article in journal (Refereed)
    Abstract [en]

    The Landauer principle sets a fundamental thermodynamic constraint on the minimum amount of heat that must be dissipated to erase one logical bit of information through a quasistatically slow protocol. For finite time information erasure, the thermodynamic costs depend on the specific physical realization of the logical memory and how the information is erased. Here we treat the problem within the paradigm of a Brownian particle in a symmetric double-well potential. The two minima represent the two values of a logical bit, 0 and 1, and the particle's position is the current state of the memory. The erasure protocol is realized by applying an external time-dependent tilting force. We derive analytical tools to evaluate the work required to erase a classical bit of information in finite time via an arbitrary continuous erasure protocol, which is a relevant setting for practical applications. Importantly, our method is not restricted to the average work, but instead gives access to the full work distribution arising from many independent realizations of the erasure process. Using the common example of an erasure protocol that changes linearly with time acting on a double-parabolic potential, we explicitly calculate all relevant quantities and verify them numerically.

  • 12.
    Gulshan, Samina
    et al.
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering.
    Shafaghat, Hoda
    Division of Bioeconomy and Health, Department of Biorefinery and Energy, RISE Research Institutes of Sweden AB, SE-941 28 Piteå, Sweden, AB.
    Yang, Hanmin
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Evangelopoulos, Panagiotis
    Department of System Transition and Service Innovation, Unit of Resources from Waste, RISE Research Institutes of Sweden AB, SE-114 86 Stockholm, Sweden, AB.
    Yang, Weihong
    KTH, School of Industrial Engineering and Management (ITM), Energy Technology, Applied Thermodynamics and Refrigeration. KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Performance analysis and production of aromatics for ex situ catalytic pyrolysis of engineered WEEE2024In: Journal of Analytical and Applied Pyrolysis, ISSN 0165-2370, E-ISSN 1873-250X, Vol. 179, article id 106510Article in journal (Refereed)
    Abstract [en]

    Ex situ catalytic pyrolysis of engineered waste electrical and electronic equipment (WEEE) was conducted in a two-stage reactor using HZSM-5 catalyst. The effect of the catalysis temperature and the catalyst-to-feedstock (C/F) ratio on products yield, gas and oil composition, and products characterization were investigated in this study. Results indicated that lower reforming temperature and C/F ratio favored organic fractions production. The highest yield of organic fraction was obtained at a catalysis temperature of 450 °C and at a C/F ratio of 0.15, corresponding to 28.5 and 27.4 wt %, respectively. The highest selectivity toward aromatic hydrocarbons and the lowest TAN value of the organic fraction were obtained at a catalysis temperature of 450 °C and a C/F ratio of 0.2, respectively. Most of the alkali and transition metals and 23 % of Br remained in the solid residue after the catalytic pyrolysis of low-grade electronic waste (LGEW).

  • 13.
    $$$Gyger, Samuel
    et al.
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21; Current Address: Department of Applied Physics and Ginzton Laboratory, Stanford University, 348 Via Pueblo Mall, Stanford, California 94305, USA, 348 Via Pueblo Mall.
    $$$Zeuner, Katharina D.
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21.
    $$$Lettner, Thomas
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21.
    $$$Bensoussan, Sandra
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21; Ericsson AB, Torshamnsgatan 21, 164 40 Stockholm, Sweden, Torshamnsgatan 21.
    $$$Carlnäs, Martin
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21; Ericsson AB, Torshamnsgatan 21, 164 40 Stockholm, Sweden, Torshamnsgatan 21.
    $$$Ekemar, Liselott
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21; Ericsson AB, Torshamnsgatan 21, 164 40 Stockholm, Sweden, Torshamnsgatan 21.
    $$$Schweickert, Lucas
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21.
    $$$Hedlund, Carl Reuterskiöld
    Department of Electrical Engineering, KTH Royal Institute of Technology, 164 40 Kista, Sweden.
    $$$Hammar, Mattias
    Department of Electrical Engineering, KTH Royal Institute of Technology, 164 40 Kista, Sweden.
    Nilsson, Tigge
    Ericsson AB, Torshamnsgatan 21, 164 40 Stockholm, Sweden, Torshamnsgatan 21.
    Almlöf, Jonas
    Ericsson AB, Torshamnsgatan 21, 164 40 Stockholm, Sweden, Torshamnsgatan 21.
    $$$Steinhauer, Stephan
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21.
    Llosera, Gemma Vall
    Ericsson AB, Torshamnsgatan 21, 164 40 Stockholm, Sweden, Torshamnsgatan 21.
    $$$Zwiller, Val
    Quantum Nanophotonics, KTH Royal Institute of Technology, Roslagstullsbacken 21, 10691 Stockholm, Sweden, Roslagstullsbacken 21.
    Metropolitan Single-Photon Distribution at 1550 nm for Random Number Generation2023In: Quantum 2.0: Proceedings Optica Quantum 2.0 Conference and Exhibition, Optical Society of America , 2023Conference paper (Refereed)
    Abstract [en]

    Quantum communication networks are used for QKD and metrological applications. We present research connecting two nodes ˜ 20 kilometers apart over the municipal fiber network using semiconductor quantum dots emitting at 1550 nm.

  • 14.
    Hou, Yandong
    et al.
    School of Energy and Power Engineering, Northeast Electric Power University, Jilin, China.
    Chen, Tianbo
    School of Energy and Power Engineering, Northeast Electric Power University, Jilin, China.
    Li, Weichao
    School of Energy and Power Engineering, Northeast Electric Power University, Jilin, China.
    Gao, Chuntian
    School of Energy and Power Engineering, Northeast Electric Power University, Jilin, China.
    Chen, Bowen
    School of Energy and Power Engineering, Northeast Electric Power University, Jilin, China.
    Zhang, Chao
    School of Energy and Power Engineering, Northeast Electric Power University, Jilin, China.
    Xiang, Yan
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Numerical study on surface corrosion deposition of fuel elements and its influence on flow heat transfer2024In: Annals of Nuclear Energy, ISSN 0306-4549, E-ISSN 1873-2100, Vol. 201, article id 110458Article in journal (Refereed)
    Abstract [en]

    Corrosion of pressurized water reactors (PWR) in nuclear power plants can lead to serious safety hazards. This study aims to analyze the deposition of corrosion products using FLUENT software. Deposition models and thermal resistance models were developed, and the effects of deposits on the reactor's thermal–hydraulic characteristics were evaluated. Additionally, the impact of various parameters on deposition and thermal–hydraulic characteristics was examined. Results show that deposits accumulate extensively in the inlet section of the fuel cladding, while appearing as spot deposits in the outlet section. For deposit thicknesses below 30 μm, the surface temperature of the cladding gradually increases. However, when the thickness exceeds 30 μm, the surface temperature rapidly rises. Furthermore, the study reveals that the deposition amount decreases with increasing inlet flow velocity, exhibits an upward trend with higher inlet temperature, and increases with a higher wall heat flux density. This research provides important insights for understanding core deposition and thermal–hydraulic characteristics in nuclear reactor systems. It offers valuable guidance for enhancing safety and operational efficiency in nuclear power plants.

  • 15.
    Klarén, Ulf
    et al.
    ULF KLARÉN is Associate Professor in Visual Form and Color Theory at Konstfack, University College of Arts, Crafts and Design, Stockholm, Sweden ; he is Head of the Perception Studio—Competence Centre for Perception Studies. He does research on color, light, and space and has published the book Vad färgär [What color is] (Stockholm: HLS Förlag, 1996), a large number of articles, reports, and several anthology contributions on color and light perception and art education. He has been a guest teacher at the University of Art and Design in Helsinki, Finland, and invited lecturer at several universities in Scandinavia. He is a member of the board of the Swedish Color Foundation and Chairman of SE-RUM, the Society for Increased Knowledge about Color and Light. He was a member of the scientific committee for the AIC Conference in Stockholm in 2008. Klarén also works as an illustrator..
    $$$Anter, Karin Fridell
    KARIN FRIDELL ANTER is an architect SAR/MSA and PhD in architecture, specialized on color. She is Associate Professor at the Royal Institute of Technology and a researcher at University College of Arts, Crafts and Design, both in Stockholm. Her dissertation from 2000 is titled What Colour Is the Red House? Perceived Colour of Painted Façades. She has written several books in Swedish and numerous articles in Swedish and international journals. She is an active member of the International Colour Association (AIC) and led the scientific committee for its conference in Stockholm in 2008. She is internationally engaged as an academic examiner and guest lecturer, including invited speeches at several color conferences. During 2010–2011 she led the Nordic research project “SYN-TES. Colour and Light Synthesis: Towards a Coherent Field of Knowledge.” As a color consultant she works mainly with exterior color design and color selections for exterior use.; KARIN FRIDELL ANTER is an architect SAR/MSA and PhD in architecture, specialized on color. She is Associate Professor at the Royal Institute of Technology and a researcher at University College of Arts, Crafts and Design, both in Stockholm . Her dissertation from 2000 is titled What Colour Is the Red House? Perceived Colour of Painted Façades. She has written several books in Swedish and numerous articles in Swedish and international journals. She is an active member of the International Colour Association (AIC) and led the scientific committee for its conference in Stockholm in 2008. She is internationally engaged as an academic examiner and guest lecturer, including invited speeches at several color conferences. During 2010–2011 she led the Nordic research project “SYN-TES. Colour and Light Synthesis: Towards a Coherent Field of Knowledge.” As a color consultant she works mainly with exterior color design and color selections for exterior use.; KARIN FRIDELL ANTER is an architect SAR/MSA and PhD in architecture, specialized on color. She is Associate Professor at the Royal Institute of Technology and a researcher at University College of Arts, Crafts and Design, both in Stockholm. Her dissertation from 2000 is titled What Colour Is the Red House? Perceived Colour of Painted Façades. She has written several books in Swedish and numerous articles in Swedish and international journals. She is an active member of the International Colour Association (AIC) and led the scientific committee for its conference in Stockholm in 2008. She is internationally engaged as an academic examiner and guest lecturer, including invited speeches at several color conferences. During 2010–2011 she led the Nordic research project “SYN-TES. Colour and Light Synthesis: Towards a Coherent Field of Knowledge.” As a color consultant she works mainly with exterior color design and color selections for exterior use. Austria.
    Seeing Color2013In: Color and Design, Bloomsbury Publishing Plc. , 2013, p. 3-17Chapter in book (Other academic)
    Abstract [en]

    The goal of the chapter is to present a model for describing and analyzing color design, and to show its potential by discussing concrete examples from the fi eld of design and architecture. The model has been developed by Ulf Klarén as a pedogogical tool based on experience and on literature from the fi elds of perception psychology, cognitive science, philosophy, ethnology, and so forth. Color constructs our inner image of space. The world of colors is complex and dynamic and colors have many sensitive qualities, but nevertheless the experience of color has a nature of coherence. Just like the rest of our sensual experiences, color is perceived and understood on different levels, from the basics that are common to all humans to the most rapidly changing cultural trends.

  • 16.
    Kleeorin, Nathan
    et al.
    Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Turbulent Flows, Institute of Continuous Media Mechanics, Russian Academy of Sciences, Perm, Russia.
    Kuzanyan, Kirill
    Department of Turbulent Flows, Institute of Continuous Media Mechanics, Russian Academy of Sciences, Perm, Russia; Department of Solar Physics, Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radiowave Propagation (IZMIRAN), Russian Academy of Sciences, Moscow, Russia.
    $$$Rogachevskii, Igor
    Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Astrophysics, Nordic Institute for Theoretical Physics, KTH Royal Institute of Technology and Stockholm University, Stockholm, Sweden.
    Safiullin, Nikolai
    Department of Turbulent Flows, Institute of Continuous Media Mechanics, Russian Academy of Sciences, Perm, Russia; Department of Information Security, Ural Federal University, Ekaterinburg, Russia.
    Nonlinear Mean-Field Dynamos With Magnetic Helicity Transport and Solar Activity: Sunspot Number and Tilt2023In: Helicities in Geophysics, Astrophysics, and Beyond, wiley , 2023, p. 217-240Chapter in book (Other academic)
    Abstract [en]

    In this chapter, we discuss a mean field solar dynamo model with algebraic and dynamic nonlinearities, various mechanisms of sunspot formation, and prediction of solar activity. The algebraic nonlinearity describes the quenching of the alpha effect, turbulent magnetic diffusion, and the effective pumping velocity due to feedback from the growing large-scale magnetic field on the fluid motion. The dynamic nonlinearity is due to the evolution of the magnetic helicity of the small-scale magnetic field during the nonlinear stage of the dynamo; it is derived from conservation of the total (large-scale plus small-scale) magnetic helicity for very small microscopic magnetic diffusivity.We discuss observations of magnetic helicity in the Sun and their connection with the nonlinear mean field dynamo. We derive a budget equation for sunspot numbers taking into account sunspot formation mechanism due to the negative effective magnetic pressure instability. To predict solar activity, we use dynamo simulations as input to an artificial neural network that learns sunspot dynamics from available observations. Finally, we analyze the contribution of magnetic helicity transport to the formation of tilt in sunspot bipolar regions and compare the results with available observational data over the last 10 solar cycles (15-24).

  • 17.
    Kuhn, Tinka
    et al.
    Institute of Physical Geography and Landscape Ecology, Gottfried Wilhelm Leibniz University Hannover, Hannover, Germany.
    Vikström, Suvi
    Department of Sustainable Development, Environmental Science and Engineering, Finnish Environment Institute, Helsinki, Finland.
    Suškevičs, Monika
    Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, Tartu, Estonia.
    Storie, Joanna T.
    Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, Tartu, Estonia.
    Saikkonen, Liisa
    Department of Sustainable Development, Environmental Science and Engineering, Finnish Environment Institute, Helsinki, Finland.
    Rees, Rebecca
    UCL Institute of Education, University College London, London, UK.
    Håkansson, Cecilia
    KTH, School of Architecture and the Built Environment (ABE), Sustainable development, Environmental science and Engineering.
    Oinonen, Soile
    Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, Tartu, Estonia.
    Burkhard, Benjamin
    Institute of Physical Geography and Landscape Ecology, Gottfried Wilhelm Leibniz University Hannover, Hannover, Germany.
    Literature syntheses to inform marine ecosystem management: lessons learned from stakeholder participation2023In: Ecosystems and People, ISSN 2639-5908, E-ISSN 2639-5916, Vol. 19, no 1, article id 2188970Article in journal (Refereed)
    Abstract [en]

    Systematic literature syntheses are a key element in the scientific realm, considering the steadily growing amount of available knowledge. Involving stakeholders in the research process brings a wide range of advantages, like broadening the perspectives on the problem in question, increasing the relevance of results for policy- and decision-making, the public and other end-users and thus enhancing the impact and acceptance of research. While participatory approaches are on the rise, reflections on stakeholder involvement in systematic syntheses on environmental management are scarce. We reflect on the process of involving stakeholders with expertise also from outside academia during three literature syntheses with different foci of marine and coastal ecosystem services in the Baltic Sea. Our analysis is based on notes, e-mails, minutes and recordings of internal project meetings, interviews and workshops involving both researchers and stakeholders. We discuss the challenges the participatory approach introduced and develop lessons learned to support the planning of stakeholder engagement for future literature syntheses. We conclude that stakeholder identification, communication, collaboration and knowledge translation are highly time- and resource-intensive processes. Furthermore, appropriate training and experience are necessary for the design, execution and evaluation of participatory methods tailored to each project stage. Therefore, we underline the importance of adequate consideration of the required resources during project planning and implementation. To encourage and support valuable stakeholder engagement and knowledge exchange between the research community and actors of policy and practice, more appreciation of such efforts by funding institutions and within the wider scientific community is needed.

  • 18.
    Li, Yucheng
    et al.
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    Zhu, Liyu
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    Zhao, Jingyang
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    Qiu, Mengjie
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    Liu, Jing
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    He, Jing
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    Wang, Luying
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    Lei, Jiandu
    Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083 P. R. China.
    Tian, Weiqian
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Fibre Technology. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191 P. R. China.
    Rong, Long
    Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191 P. R. China.
    Facile synthesis of a high-efficiency NiFe bimetallic catalyst without pre-reduction for the selective hydrogenation reaction of furfural2022In: Catalysis Science & Technology, ISSN 2044-4753, E-ISSN 2044-4761, Vol. 13, no 2, p. 457-467Article in journal (Refereed)
    Abstract [en]

    A high-efficiency nickel-iron bimetallic catalyst (Ni3Fe1 alloy) was synthesized by a facile solvothermal reaction and directly used in furfural hydrogenation without pre-reduction. When the total metal acetate was 6 mmol (Ni : Fe = 4 : 2) with 2 mmol sodium acetate under reaction conditions of 1 MPa H2 pressure at 130 °C for 1 h, the conversion for furfural and selectivity for furfuryl alcohol were both more than 98%. XRD, BET, H2-TPD, SEM, HRTEM, EDS, ICP-MS and ex/in situ XPS were used to characterize the catalysts. Compared to the monometallic Ni catalyst, the introduction of Fe not only enhanced the hydrogen adsorption capacity of Ni but also forms NiFe2O4 on the surface of the catalyst to protect the internal crystals from further oxidation and maintain hydrogenation ability. Moreover, the introduction of Na increased the purity of the Ni3Fe1 crystal of the catalyst and reinforced the interaction between Ni and Fe, resulting in an improvement in hydrogenation performance. Based on density functional theory (DFT) calculations, the reaction mechanism was systematically investigated. The results of five recycling tests show excellent catalyst stability. The environmentally friendly synthetic process, high stability, catalytic efficiency and the ability to function without a pre-reduction step make the nickel-iron bimetallic catalyst an ideal, commercial candidate for the furfural hydrogenation reaction.

  • 19.
    Lindén, Pär A.
    et al.
    Wallenberg Wood Science Center, Department of Fiber and Polymer Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Royal Institute of Technology, Teknikringen 56-58, SE-100 44 Stockholm, Sweden, Teknikringen 56-58.
    Lindström, Mikael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Lawoko, Martin
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Henriksson, Gunnar
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology. Department of Fiber and Polymer Technology, KTH Royal Institute of Technology, 100 44, Stockholm, Sweden.
    Adapting the kraft cooking process in glycerol media. Studies of impregnation kinetics2023In: Nordic Pulp & Paper Research Journal, ISSN 0283-2631, E-ISSN 2000-0669, Vol. 38, no 1, p. 9-18Article in journal (Refereed)
    Abstract [en]

    Although organosolv processes using high-boiling solvents have been investigated in recent decades for developing novel industrial processes, there are potential benefits of using high-boiling point solvents for traditional sulphate-based cooking processes, both from an industrial perspective and from a laboratory perspective. Using high-boiling solvents, experiments can be done under atmospheric conditions, thus making it easier to continually monitor laboratory experiments and extracting aliquots at desired intervals. Using such a system, alkaline consumption was monitored during impregnation of spruce chips in glycerol media using chemical charges of 1 M NaOH and 0.1 M NaHS, i. e., kraft pulping conditions, and compared to a similar investigation of alkaline consumption in water media using steel autoclaves. The resulting data was fitted to a first order kinetic model, with an apparent activation energy of 22 kJ mol-1 in glycerol media. Finally, a "normal quality pulp"of kappa number 28 and a viscosity of 1113 ml g-1 was successful produced using a cooking process with an impregnation step at 140 °C for 3 h and a cooking step at 160 °C for 4 h. A nuclear magnetic resonance study on the dissolved lignin produced for said experiment showed characteristics typical of other kraft lignins.

  • 20.
    Litter, Marta Irene
    et al.
    Universidad Nacional de San Martín: San Martin, Buenos Aires, Argentina.
    Ahmad, Arslan
    KTH, School of Architecture and the Built Environment (ABE), Sustainable development, Environmental science and Engineering, Water and Environmental Engineering.
    Industrial applications of nanoparticles: A prospective overview2023Book (Other academic)
    Abstract [en]

    Nanotechnology is one of the most rapidly developing areas of science, with great potential to solve the developmental challenges in a wide range of industries such as aerospace, agriculture, bioengineering, cosmetics, chemicals, electronics, energy, renewables, surface coatings, textiles, medicine, materials manufacturing, military equipment, etc. To compile this book, distinguished scientists, engineers, and industrial professionals from different parts of the world have been invited. An array of 17 high-quality science-based chapters covering recent advancements, challenges, and future trends in industrial applications of nanotechnology is presented. The book is aimed at industrial professionals and graduate-level students and researchers.

  • 21.
    Mai, Vien V.
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Vejdemo-Johansson, Mikael
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Stability and Convergence of Stochastic Gradient Clipping: Beyond Lipschitz Continuity and Smoothness2021In: Proceedings of the 38th International Conference on Machine Learning, ICML 2021, ML Research Press , 2021, p. 7325-7335Conference paper (Refereed)
    Abstract [en]

    Stochastic gradient algorithms are often unstable when applied to functions that do not have Lipschitz-continuous and/or bounded gradients. Gradient clipping is a simple and effective technique to stabilize the training process for problems that are prone to the exploding gradient problem. Despite its widespread popularity, the convergence properties of the gradient clipping heuristic are poorly understood, especially for stochastic problems. This paper establishes both qualitative and quantitative convergence results of the clipped stochastic (sub)gradient method (SGD) for non-smooth convex functions with rapidly growing subgradients. Our analyses show that clipping enhances the stability of SGD and that the clipped SGD algorithm enjoys finite convergence rates in many cases. We also study the convergence of a clipped method with momentum, which includes clipped SGD as a special case, for weakly convex problems under standard assumptions. With a novel Lyapunov analysis, we show that the proposed method achieves the best-known rate for the considered class of problems, demonstrating the effectiveness of clipped methods also in this regime. Numerical results confirm our theoretical developments.

  • 22.
    Mishchenko, Yulia
    et al.
    KTH, School of Engineering Sciences (SCI), Centres, Centre for Nuclear Energy Technology, CEKERT. KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering. KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Structures.
    Patnaik, Sobhan
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering.
    Wallenius, Janne
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Power Safety.
    Lopes, Denise Adorno
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering. Westinghouse Electric Sweden AB, Västerås, Sweden.
    Thermophysical properties and oxidation behaviour of the U0.8Zr0.2N solid solution2023In: Nuclear Materials and Energy, E-ISSN 2352-1791, Vol. 35, article id 101459Article in journal (Refereed)
    Abstract [en]

    Thermophysical properties and oxidation behaviour of the composite pellet UN–20 vol%ZrN were investigated experimentally and compared with the behaviour of the pure UN pellet. A compound of a single phase, a solid solution of the average composition U0.8Zr0.2N, was obtained by Spark Plasma Sintering (SPS) of the powders UN and ZrN. Crystallographic and microstructural characterisation of the composite was performed using Scanning Electron Microscopy (SEM), standardised Energy Dispersive Spectroscopy (EDS) and Electron Backscatter Diffraction (EBSD). Nano hardness and Young's modulus were also measured by the nanoindentation method. High-Temperature X-ray diffraction (XRD) was applied to obtain the lattice expansion as a function of temperature (room temperature to 673 K). Thermogravimetric Analysis (TGA) was applied to evaluate oxidation behaviour in air. Results demonstrate that the fabrication method results in a matrix of solid solution with homogeneous composition averaged to U0.8Zr0.2N. The mechanical properties of such solution are uniform, with variation only due to the crystallographic orientation of the grains of the solution phase, similar to pure UN. The obtained value for the average linear thermal expansion coefficient is α¯ = 7.94 × 10-6/K, which compares well to UN (α¯ = 7.95 × 10-6/K) for the same temperature range. The degradation behaviour of the composite pellet UN-20 vol%ZrN in air shows a lower oxidation onset temperature, compared to pure UN, with the final product of oxidation being mainly U3O8. Smaller crystallites in the product of corrosion of the composite pellet indicate that the mechanism of degradation of the solid solution phase U0.8Zr0.2N is accompanied by the formation of two distinct oxides and their interaction.

  • 23.
    Oberdieck, Georg
    KTH, School of Engineering Sciences (SCI), Mathematics (Dept.).
    Marked relative invariants and GW/PT correspondences2024In: Advances in Mathematics, ISSN 0001-8708, E-ISSN 1090-2082, Vol. 439, article id 109472Article in journal (Refereed)
    Abstract [en]

    We introduce marked relative Pandharipande-Thomas (PT) invariants for a pair (X,D) of a smooth projective threefold and a smooth divisor. These invariants are defined by integration over the moduli space of r-marked stable pairs on (X,D), and appear naturally when degenerating diagonal insertions via the Li-Wu degeneration formula. We propose a Gromov-Witten (GW) / PT correspondence for marked relative invariants. We show compatibility of the conjecture with the degeneration formula and a splitting formula for relative diagonals. The results provide new tools to prove GW/PT correspondences for varieties with vanishing cohomology. As an application we prove the GW/PT correspondence for: (i) all Fano complete intersections, and (ii) the reduced theories of (S×C,S×{z1,…,zN}) where S is a K3 surface and C is a curve, for all curve classes which have divisibility at most 2 over the K3 surface. In the appendix we introduce a notion of higher-descendent invariants which can be seen as an analogue of the nodal Gromov-Witten invariants defined by Argüz, Bousseau, Pandharipande and Zvonkine in [3]. We show that the higher-descendent invariants reduce to marked relative invariants with diagonal insertions.

  • 24.
    Praveena, Rangasamy
    et al.
    Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam 638401, India.
    Balasankar, Athinarayanan
    Department of Physics, Gobi Arts & Science College, Gobichettipalayam 638453, India.
    Aruchamy, Kanakaraj
    School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
    Oh, Taehwan
    School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
    Polisetti, Veerababu
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Polymeric Materials. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
    Ramasundaram, Subramaniyan
    School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
    Anbazhakan, Kandasamy
    Department of Physics, Gobi Arts & Science College, Gobichettipalayam 638453, India.
    Structural Activity and HAD Inhibition Efficiency of Pelargonidin and Its Glucoside—A Theoretical Approach2022In: Molecules, ISSN 1431-5157, E-ISSN 1420-3049, Vol. 27, no 22, article id 8016Article in journal (Refereed)
    Abstract [en]

    Anthocyanins are an important pharmaceutical ingredient possessing diet regulatory, antioxidant, anticancer, antidiabetic, anti-obesity, antimicrobial, and anti-inflammatory properties. Pelargonidin is an important anthocyanin-based orange-red flavonoid compound used in drugs for treating hypoglycemia, retinopathy, skeletal myopathy, etc. The main sources of pelargonidin are strawberries and food products with red pigmentation. There is a lack of evidence for supporting its use as an independent supplement. In the present study, pelargonidin and pelargonidin-3-O-glucoside are studied for their structural properties using quantum chemical calculations based on density functional theory. The results confirmed that the parent compound and its glycosylated derivative acted as good electron donors. Electrostatic potential, frontier molecular orbitals, and molecular descriptor analyses also substantiated their electron donating properties. Furthermore, based on the probability, a target prediction was performed for pelargonidin and pelargonidin-3-O-glucoside. Hydroxyacyl-coenzyme A dehydrogenase was chosen as an enzymatic target of interest, since the presence work focuses on glucuronidated compounds and their efficacy over diabetes. Possible interactions between these compounds and a target with nominable binding energies were also evaluated. Further, the structural stability of these two compounds were also analyzed using a molecular dynamics simulation.

  • 25.
    Raghavan, Aneesh
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Sartori, Giacomo
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Johansson, Karl H.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Motion Planning for The Estimation of Functions2023In: 2023 62nd IEEE Conference on Decision and Control, CDC 2023, Institute of Electrical and Electronics Engineers (IEEE) , 2023, p. 7150-7155Conference paper (Refereed)
    Abstract [en]

    We consider the problem of estimation of an unknown real valued function with real valued input by an agent. The agent exists in 3D Euclidean space. It is able to traverse in a 2D plane while the function is depicted in a 2D plane perpendicular to the plane of traversal. By viewing the function from a given position, the agent is able to collect a data point lying on the function. By traversing through the plane while paying a control cost, the agent collects a finite set of data points. The set of data points are used by the agent to estimate the function. The objective of the agent is to find a control law which minimizes the control cost while estimating the function optimally. We formulate a control problem for the agent incorporating an inference cost and the control cost. The control problem is relaxed by finding a lower bound for the cost function. We present a kernel based linear regression model to approximate the cost-to-go and use the same in a control algorithm to solve the relaxed optimization problem. We present simulation results comparing the proposed approach with greedy algorithm based exploration.

  • 26.
    Saafi, Salwa
    et al.
    Brno University of Technology, Department of Telecommunications, Brno, Czech Republic, 61600; Tampere University, Unit of Electrical Engineering, Tampere, Finland, 33720.
    Vikhrova, Olga
    Brno University of Technology, Department of Telecommunications, Brno, Czech Republic, 61600.
    Fodor, Gabor
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control). Ericsson Research, Stockholm, Sweden.
    Hosek, Jiri
    Brno University of Technology, Department of Telecommunications, Brno, Czech Republic, 61600.
    Andreev, Sergey
    Tampere University, Unit of Electrical Engineering, Tampere, Finland, 33720.
    Cost- and Delay-Efficient Backhaul Selection for Time-Sensitive Maritime Communications2023In: IEEE Communications Letters, ISSN 1089-7798, E-ISSN 1558-2558, Vol. 27, no 4, p. 1235-1239Article in journal (Refereed)
    Abstract [en]

    Extending the existing near-shore terrestrial infrastructure with non-terrestrial network capabilities helps maritime operators alleviate the high costs of communication and meet the requirements imposed by time-sensitive applications. Recognizing that the deployment of terrestrial and non-terrestrial networks necessitates selecting from the available wireless backhaul solutions, which have dissimilar data transmission costs and communication link qualities, it is essential to propose an appropriate backhaul selection policy. Specifically, in this letter, we coin a backhaul selection policy that manages the inherent trade-off between data transmission expenses and timely throughput guarantees for maritime communications. We formulate the backhaul selection problem as a Markov decision process and show that the proposed solution is not only more cost-efficient, but also satisfies the timely throughput requirements in contrast to the currently used greedy strategies.

  • 27.
    Schäbitz, A.
    et al.
    Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
    Hillig, C.
    Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany, Ingolstädter Landstrasse 1.
    Mubarak, M.
    Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Jargosch, M.
    Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29; Department of Dermatology and Allergy, Technical University of Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Farnoud, A.
    Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany, Ingolstädter Landstrasse 1.
    Scala, E.
    Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Venerology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Kurzen, N.
    Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Pilz, A. C.
    Department of Dermatology and Allergy, Technical University of Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29; Department of Dermatology and Venerology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Bhalla, Nayanika
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Gene Technology.
    Thomas, J.
    Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Stahle, M.
    Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
    Biedermann, T.
    Department of Dermatology and Allergy, Technical University of Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Schmidt-Weber, C. B.
    Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Theis, F.
    Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany, Ingolstädter Landstrasse 1.
    Garzorz-Stark, N.
    Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Allergy, Technical University of Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Eyerich, K.
    Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Venerology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Dermatology and Venereology, Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden.
    Menden, M. P.
    Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany, Ingolstädter Landstrasse 1; Department of Biology, Ludwig-Maximilians University, Goßhadernerstrasse 2, Martinsried, 82152, Germany, Goßhadernerstrasse 2; German Center for Diabetes Research (DZD e.V.), Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany, Ingolstädter Landstrasse 1.
    Eyerich, S.
    Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Biedersteinerstrasse 29, 80802, Munich, Germany, Biedersteinerstrasse 29.
    Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases2022In: Nature Communications, E-ISSN 2041-1723, Vol. 13, no 1, article id 7729Article in journal (Refereed)
    Abstract [en]

    Abundant heterogeneous immune cells infiltrate lesions in chronic inflammatory diseases and characterization of these cells is needed to distinguish disease-promoting from bystander immune cells. Here, we investigate the landscape of non-communicable inflammatory skin diseases (ncISD) by spatial transcriptomics resulting in a large repository of 62,000 spatially defined human cutaneous transcriptomes from 31 patients. Despite the expected immune cell infiltration, we observe rather low numbers of pathogenic disease promoting cytokine transcripts (IFNG, IL13 and IL17A), i.e. >125 times less compared to the mean expression of all other genes over lesional skin sections. Nevertheless, cytokine expression is limited to lesional skin and presented in a disease-specific pattern. Leveraging a density-based spatial clustering method, we identify specific responder gene signatures in direct proximity of cytokines, and confirm that detected cytokine transcripts initiate amplification cascades of up to thousands of specific responder transcripts forming localized epidermal clusters. Thus, within the abundant and heterogeneous infiltrates of ncISD, only a low number of cytokine transcripts and their translated proteins promote disease by initiating an inflammatory amplification cascade in their local microenvironment.

  • 28.
    Sterling, Cody M.
    et al.
    Department of Physics, Stockholm University, AlbaNova University Center, SE-106 91 Stockholm, Sweden.
    Kamal, Chinnathambi
    Department of Physics, Stockholm University, AlbaNova University Center, SE-106 91 Stockholm, Sweden; Theory and Simulations Laboratory, Theoretical and Computational Physics Section, Raja Ramanna Centre for Advanced Technology, Indore 452013, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India, Anushakti Nagar.
    Garcia Fernandez, Alberto
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Applied Physical Chemistry.
    Man, Gabriel J.
    Condensed Matter Physics of Energy Materials, Division of X-ray Photon Science, Department of Physics and Astronomy, Uppsala University, Box 516, SE-75121 Uppsala, Sweden, Box 516; GJM Scientific Consulting, Fort Lee, New Jersey 07024, United States.
    Svanström, Sebastian
    Condensed Matter Physics of Energy Materials, Division of X-ray Photon Science, Department of Physics and Astronomy, Uppsala University, Box 516, SE-75121 Uppsala, Sweden, Box 516.
    Nayak, Pabitra K.
    Tata Institute of Fundamental Research, 36/P, Gopanpally Village, Serilingampally Mandal, Ranga Reddy District, Hyderabad 500046, India, 36/P, Gopanpally Village, Serilingampally Mandal, Ranga Reddy District.
    Butorin, Sergei M.
    Condensed Matter Physics of Energy Materials, Division of X-ray Photon Science, Department of Physics and Astronomy, Uppsala University, Box 516, SE-75121 Uppsala, Sweden, Box 516.
    Rensmo, Håkan
    Condensed Matter Physics of Energy Materials, Division of X-ray Photon Science, Department of Physics and Astronomy, Uppsala University, Box 516, SE-75121 Uppsala, Sweden, Box 516.
    Cappel, Ute B.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Applied Physical Chemistry. Division of Applied Physical Chemistry, Department of Chemistry, KTH - Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
    Odelius, Michael
    Department of Physics, Stockholm University, AlbaNova University Center, SE-106 91 Stockholm, Sweden.
    Electronic Structure and Chemical Bonding in Methylammonium Lead Triiodide and Its Precursor Methylammonium Iodide2022In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 126, no 47, p. 20143-20154Article in journal (Refereed)
    Abstract [en]

    A detailed examination of the electronic structures of methylammonium lead triiodide (MAPI) and methylammonium iodide (MAI) is performed with ab initio molecular dynamics (AIMD) simulations based on density functional theory, and the theoretical results are compared to experimental probes. The occupied valence bands of a MAPI single crystal and MAI powder are probed with X-ray photoelectron spectroscopy, and the conduction bands are probed from the perspective of nitrogen K-edge X-ray absorption spectroscopy. Combined, the theoretical simulations and the two experimental techniques allow for a dissection of the electronic structure unveiling the nature of chemical bonding in MAPI and MAI. Here, we show that the difference in band gap between MAPI and MAI is caused chiefly by interactions between iodine and lead but also weaker interactions with the MA+counterions. Spatial decomposition of the iodine p levels allows for analysis of Pb-I σ bonds and πinteractions, which contribute to this effect with the involvement of the Pb 6p levels. Differences in hydrogen bonding between the two materials, seen in the AIMD simulations, are reflected in nitrogen valence orbital composition and in nitrogen K-edge X-ray absorption spectra.

  • 29.
    Troubitsyna, Elena
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Theoretical Computer Science, TCS.
    Utilising Redundancy to Enhance Security of Safety-Critical Systems2023In: Computer Safety, Reliability, and Security: SAFECOMP 2023 Workshops, Springer Nature , 2023, p. 188-196Conference paper (Refereed)
    Abstract [en]

    For many safety-critical systems, implementing modern cybersecurity protection mechanisms is hindered by legacy design and high re-certification costs. Since such systems are typically designed to be highly reliable, they usually contain a large number of redundant components used to achieve fault tolerance. In this paper, we discuss challenges in utilising redundancy inherently present in the architectures of safety-critical systems to enhance system cybersecurity protection. We consider classic redundant architectures and analyse their ability to protect against cyberattacks. By evaluating the likelihood of a successful cyberattack on a redundant architecture under different implementation conditions, we conclude that redundancy in combination with diversity has better potential to be utilised for cybersecurity protection.

  • 30.
    Wang, Dan
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Chen, Wei
    Peking University, State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Engineering Science, Beijing, China.
    Johansson, Karl H.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Phase of Multivariable Systems: A Revisit via H2T-Dissipativity2023In: 2023 62nd IEEE Conference on Decision and Control, CDC 2023, Institute of Electrical and Electronics Engineers (IEEE) , 2023, p. 691-696Conference paper (Refereed)
    Abstract [en]

    A new notion of phase of multi-input multi-output (MIMO) systems was recently defined and studied, leading to new understandings in various fronts including a formulation of small phase theorem, a performance criterion named H∞ phase sector, and a sectored real lemma, etc. In this paper, we define a new notion of H2T-dissipativity and show the connection between the phase of a multivariable linear time-invariant (LTI) system and the H2T-dissipativity. The H2T-dissipativity, roughly speaking, is dissipativity restricted to the time-domain H2 space which consists of L2 signals with only positive frequency components. In addition, by exploiting the newly defined H2T- dissipativity, we also study the phase of a feedback system and provide a physical interpretation of the sectored real lemma.

  • 31.
    Wong, Kin Wing
    et al.
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering.
    Mickus, Ignas
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering.
    Vasudevan, Sumathi
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering.
    Li, Haipeng
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering.
    Grishchenko, Dmitry
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering.
    Kudinov, Pavel
    KTH, School of Engineering Sciences (SCI), Physics, Nuclear Engineering.
    CFD STUDIES OF SEPARATE EFFECT FLOW ACCELERATED CORROSION AND EROSION (SEFACE) FACILITY FOR HEAVY LIQUID METAL2023In: Proceedings of the 30th International Conference on Nuclear Engineering "Nuclear, Thermal, and Renewables: United to Provide Carbon Neutral Power", ICONE 2023, American Society of Mechanical Engineers (ASME) , 2023Conference paper (Refereed)
    Abstract [en]

    Long-term material compatibility in heavy liquid metal (HLM) remains a challenge for the successful deployment of HLM-based technologies. Flow-accelerated corrosion and erosion (FACE) phenomena can lead to continual material deterioration, which needs to be considered throughout the reactor design stage. Nonetheless, known experimental data are inadequate to cover all the prototypical flow regimes during LFR's operation. Modelling of the FAC/FACE phenomena remains mostly in lumped parameter/subchannel scales, where the FAC model is coupled to the bulk flow of the pipe or subchannel. These methodologies might produce a sufficient prediction for the core internals; however, this might not be suitable for the pump impeller due to comparatively greater relative velocity and the occurrence of transient flow patterns near the rotating impeller. To establish an understanding of the connection between turbulence and FACE, the liquid lead-based Separate Effect Flow Accelerated Corrosion and Erosion (SEFACE) facility is currently under design at KTH in the framework of the Sustainable Nuclear Energy Research In Sweden (SUNRISE) project. SEFACE attempts to investigate FACE phenomena in the liquid lead and produce quantifiable validation data for model development. The paper divides itself into two parts. Part I refers to the study of operational conditions in SEFACE via Reynolds Averaged Navier Stokes (RANS) simulation, while Part II deals with the recent attempt on modelling time-dependent flow shear on rotating disks based on large eddy simulation (LES). The paper begins with a brief review of prior studies on flow-accelerated corrosion. Following that, the SEFACE facility's design concept is laid out considering several physical and operational constraints. A periodic wedge of the SEFACE test chamber is chosen to examine the facility's time-averaged behaviour. The k-ω shear stress transport (SST) model was employed for the simulations. The torque prediction on the rotating disk system is verified with the empirical frictional factor prediction. The latest hydrodynamic design enables SEFACE to be spun at 1200 revolutions per minute (corresponding to a maximum velocity of 21 m/s) without causing free surface deformation or excessive pressure. SEFACE permits the collecting of experimental data under the effect of various relative velocities in a single experiment round. The second part of the paper focuses on a recent attempt to determine the wall shear stress distribution on a rotating disk using wall-modelled large eddy simulation (WMLES S-Omega). The obtained amplitude and frequency of wall shear stress fluctuations will aid model development in future.

  • 32.
    Wu, Xuyang
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control).
    Magnússon, Sindri
    Department of Computer and System Science, Stockholm University, Sweden.
    Vejdemo-Johansson, Mikael
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Robotics, Perception and Learning, RPL.
    Distributed safe resource allocation using barrier functions2023In: Automatica, ISSN 0005-1098, E-ISSN 1873-2836, Vol. 153, article id 111051Article in journal (Refereed)
    Abstract [en]

    Resource allocation plays a central role in networked systems such as smart grids, communication networks, and urban transportation systems. In these systems, many constraints have physical meaning and infeasible allocations can result in a system breakdown. Hence, algorithms with asymptotic feasibility guarantees can be insufficient since they cannot ensure that an implementable solution is found in finite time. This paper proposes a distributed feasible method (DFM) for resource allocation based on barrier functions. In DFM, every iterate is feasible and safe to implement since it does not violate the physical constraints. We prove that, under mild conditions, DFM converges to an arbitrarily small neighborhood of the optimum. Numerical experiments demonstrate the competitive performance of DFM.

  • 33.
    Yang, Hanmin
    et al.
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Zaini, Ilman Nuran
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Pan, Ruming
    School of Energy Science and Engineering, Harbin Institute of Technology, 150001, Harbin, China.
    Jin, Yanghao
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Wang, Yazhe
    KTH, School of Industrial Engineering and Management (ITM).
    Li, Lengwan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Biocomposites. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
    Bolívar Caballero, José Juan
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Shi, Ziyi
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Subasi, Yaprak
    Department of Chemistry - Ångström Laboratory, Structural Chemistry, Uppsala University, Lägerhyddsvägen 1, 751 21, Uppsala, Sweden, Lägerhyddsvägen 1.
    Nurdiawati, Anissa
    KTH, School of Industrial Engineering and Management (ITM), Industrial Economics and Management (Dept.), Sustainability, Industrial Dynamics & Entrepreneurship.
    Wang, Shule
    International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Longpan Road 159, 210037, Nanjing, China, Longpan Road 159; Jiangsu Province Key Laboratory of Biomass Energy and Materials, Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry (CAF), No. 16, Suojin Five Village, 210042, Nanjing, China, No. 16, Suojin Five Village.
    Shen, Yazhou
    Department of Mechanical Engineering, Imperial College London, SW7 2AZ, London, UK.
    Wang, Tianxiang
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Building Materials.
    Wang, Yue
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Building Materials.
    Sandström, Linda
    Department of Biorefinery and Energy, RISE Research Institutes of Sweden AB, Box 726, SE-941 28, Piteå, Sweden.
    Jönsson, Pär
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Yang, Weihong
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Han, Tong
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Process.
    Distributed electrified heating for efficient hydrogen production2024In: Nature Communications, E-ISSN 2041-1723, Vol. 15, no 1, article id 3868Article in journal (Refereed)
    Abstract [en]

    This study introduces a distributed electrified heating approach that is able to innovate chemical engineering involving endothermic reactions. It enables rapid and uniform heating of gaseous reactants, facilitating efficient conversion and high product selectivity at specific equilibrium. Demonstrated in catalyst-free CH4 pyrolysis, this approach achieves stable production of H2 (530 g h−1 L reactor−1) and carbon nanotube/fibers through 100% conversion of high-throughput CH4 at 1150 °C, surpassing the results obtained from many complex metal catalysts and high-temperature technologies. Additionally, in catalytic CH4 dry reforming, the distributed electrified heating using metallic monolith with unmodified Ni/MgO catalyst washcoat showcased excellent CH4 and CO2 conversion rates, and syngas production capacity. This innovative heating approach eliminates the need for elongated reactor tubes and external furnaces, promising an energy-concentrated and ultra-compact reactor design significantly smaller than traditional industrial systems, marking a significant advance towards more sustainable and efficient chemical engineering society.

  • 34.
    Zaugg, Judith Barbara
    et al.
    European Molecular Biology Laboratory, Heidelberg, Germany.
    Sahlén, Pelin
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Andersson, Robin
    Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
    Alberich-Jorda, Meritxell
    Department of Hemato-oncology, Institute of Molecular Genetics of the CAS, Prague, Czech Republic; Childhood Leukaemia Investigation Prague, Department of Pediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague, University Hospital Motol, Prague, Czech Republic.
    de Laat, Wouter
    Hubrecht Institute-KNAW, Oncode Institute and University Medical Center Utrecht, Utrech, Netherlands.
    Deplancke, Bart
    Laboratory of Systems Biology and Genetics, Institute of Bio-engineering, School of Life Sciences, EPFL, Lausanne, Switzerland.
    Ferrer, Jorge
    Centre for Genomic Regulation, the Barcelona Institute of Science and Technology, Barcelona, Spain; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Madrid, Spain; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
    Mandrup, Susanne
    The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
    Natoli, Gioacchino
    IEO, European Institute of Oncology – IRCCS, Milan, Italy.
    Plewczynski, Dariusz
    Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
    Rada-Iglesias, Alvaro
    Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC/University of Cantabria, Santander, Spain.
    Spicuglia, Salvatore
    TAGC, UMR 1090, Aix-Marseille University, INSERM, Marseille, France; Equipe Labellisée, LIGUE Contre le Cancer, Marseille, France.
    Current challenges in understanding the role of enhancers in disease2022In: Nature Structural & Molecular Biology, ISSN 1545-9993, E-ISSN 1545-9985, Vol. 29, no 12, p. 1148-1158Article in journal (Refereed)
    Abstract [en]

    Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing evidence that enhancer dysfunction due to genetic, structural or epigenetic mechanisms contributes to a broad range of human diseases referred to as enhanceropathies. Such mechanisms often underlie the susceptibility to common diseases, but can also play a direct causal role in cancer or Mendelian diseases. Despite the recent gain of insights into enhancer biology and function, we still have a limited ability to predict how enhancer dysfunction impacts gene expression. Here we discuss the major challenges that need to be overcome when studying the role of enhancers in disease etiology and highlight opportunities and directions for future studies, aiming to disentangle the molecular basis of enhanceropathies.

1 - 34 of 34
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