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  • 1.
    Abdel-Rehim, Mohamed
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet.
    Pedersen-Bjergaard, S.
    Abdel-Rehim, A.
    Lucena, R.
    Moein, M. M.
    Cárdenas, S.
    Miró, M.
    Microextraction approaches for bioanalytical applications: An overview2020Ingår i: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1616, artikel-id 460790Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Biological samples are usually complex matrices due to the presence of proteins, salts and a variety of organic compounds with chemical properties similar to those of the target analytes. Therefore, sample preparation is often mandatory in order to isolate the analytes from troublesome matrices before instrumental analysis. Because the number of samples in drug development, doping analysis, forensic science, toxicological analysis, and preclinical and clinical assays is steadily increasing, novel high throughput sample preparation approaches are calling for. The key factors in this development are the miniaturization and the automation of the sample preparation approaches so as to cope with most of the twelve principles of green chemistry. In this review, recent trends in sample preparation and novel strategies will be discussed in detail with particular focus on sorptive and liquid-phase microextraction in bioanalysis. The actual applicability of selective sorbents is also considered. Additionally, the role of 3D printing in microextraction for bioanalytical methods will be pinpointed.

  • 2.
    Ahmadi, Mazaher
    et al.
    Bu Ali Sina Univ, Fac Chem, Hamadan, Iran..
    Moein, Mohammad Mahdi
    Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.;Stockholm Cty Council, SE-17176 Stockholm, Sweden..
    Madrakian, Tayyebeh
    Bu Ali Sina Univ, Fac Chem, Hamadan, Iran..
    Afkhami, Abbas
    Bu Ali Sina Univ, Fac Chem, Hamadan, Iran..
    Bahar, Soleiman
    Univ Kurdistan, Fac Sci, Dept Chem, Sanandaj, Iran..
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik. Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.;Stockholm Cty Council, SE-17176 Stockholm, Sweden..
    Reduced graphene oxide as an efficient sorbent in microextraction by packed sorbent: Determination of local anesthetics in human plasma and saliva samples utilizing liquid chromatography-tandem mass spectrometry2018Ingår i: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 1095, s. 177-182Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Herein, reduced graphene oxide (RGO) has been utilized as an efficient sorbent in microextraction by packed sorbent (MEPS). The combination of MEPS and liquid chromatography-tandem mass spectrometry has been used to develop a method for the extraction and determination of three local anesthetics (i.e. lidocaine, prilocaine, and ropivacaine) in human plasma and saliva samples. The results showed that the utilization of RGO in MEPS could minimize the matrix effect so that no interfering peaks at the retention times of the analytes or internal standard was observed. The high extraction efficiency of this method was approved by mean recoveries of 97.26-106.83% and 95.21-105.83% for the studied analytes in plasma and saliva samples, respectively. Intra- and inter-day accuracies and precisions for all analytes were in good accordance with the international regulations. The accuracy values (as percentage deviation from the nominal value) of the quality control samples were between - 2.1 to 13.9 for lidocaine, - 4.2 to 11.0 for prilocaine and between - 4.5 to - 2.4 for ropivacaine in plasma samples while the values were ranged from - 4.6 to 1.6 for lidocaine, from - 4.2 to 15.5 for prilocaine and from - 3.3 to - 2.3 for ropivacaine in human saliva samples. Lower and upper limit of quantification (LLOQ, ULOQ) were set at 5 and 2000 nmol L-1 for all of the studied drugs. The correlation coefficients values were >= 0.995. The limit of detection values were obtained 4 nmol L-1 for lidocaine and prilocaine, and 2 nmol L-1 for ropivacaine.

  • 3.
    Bassyouni, Fatma
    et al.
    Natl Res Ctr, Pharmaceut Ind Res Div, Chem Nat & Microbial Prod Dept, Cairo 12622, Egypt..
    Tarek, Mohammad
    Armed Forces Coll Med AFCM, Bioinformat Dept, Cairo 12622, Egypt..
    Salama, Abeer
    Natl Res Ctr, Div Med, Dept Pharmacol, Cairo 12622, Egypt..
    Ibrahim, Bassant
    Natl Res Ctr, Div Med, Dept Pharmacol, Cairo 12622, Egypt..
    Salah El Dine, Sawsan
    Natl Res Ctr, Div Med, Dept Pharmacol, Cairo 12622, Egypt..
    Yassin, Nemat
    Natl Res Ctr, Div Med, Dept Pharmacol, Cairo 12622, Egypt..
    Hassanein, Amina
    Natl Res Ctr, Div Med, Dept Pathol, Cairo 12622, Egypt..
    Moharam, Maysa
    Natl Res Ctr, Biotechnol Res Div, Chem Dept Microbial Prod, Cairo 12622, Egypt..
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Promising Antidiabetic and Antimicrobial Agents Based on Fused Pyrimidine Derivatives: Molecular Modeling and Biological Evaluation with Histopathological Effect2021Ingår i: Molecules, ISSN 1431-5157, E-ISSN 1420-3049, Vol. 26, nr 8, artikel-id 2370Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Diabetes is the most common metabolic disorder in both developing and non-developing countries, and a well-recognized global health problem. The WHO anticipates an increase in cases from 171 million in 2000 to 366 million by 2030. In the present study, we focus on the preparation of pyrimidine derivatives as potential antidiabetic and antimicrobial agents. Thein vivoeffect on total serum glucose concentration, cholesterol and antioxidant activity was assessed in adult male albino Wister rats and compared to the reference drug glimperide. Promising results were observed for compound 5. The histopathological study confirms that compound 5 results in significant activity with liver maintenance. The antimicrobial activities were evaluated against several bacterial strains such as Salmonella typhimurium ATCC 25566, Bacillus cereus, Escherichia coli NRRN 3008, Pseudomonas aeruginosa ATCC 10145, Staphylococcus aureus ATCC 6538and fungi such as Rhizopus oligosporus, Mucor miehei and Asperillus niger. Compounds 4 and 5 showed a good inhibition of the bacterial zone compared to the reference drug cephradine. Finally, we suggest protein targets for these drugs based on computational analysis, and infer their activities from their predicted modes of binding using molecular modeling. The molecular modeling for compounds 4 and 5 resulted in improved docking scores and hydrogen bonding. The docking studies are in good agreement with the in vitro and in vivo studies.

  • 4.
    Chinnapaiyan, Maheswari
    et al.
    Muthayammal Coll Arts & Sci, Dept Math, Rasipuram 637408, Tamil Nadu, India.;Arignar Anna Govt Arts Coll, PG & Res Dept Math, Namakkal 637002, Tamil Nadu, India..
    Selvam, Yashika
    Sri Sarada Coll Women Autonomous, Dept Phys, Salem 636016, Tamil Nadu, India..
    Bassyouni, Fatma
    Natl Res Ctr, Dept Nat & Microbial Prod, Cairo 12662, Egypt..
    Ramu, Mathammal
    Muthayammal Coll Arts & Sci, Dept Math, Rasipuram 637408, Tamil Nadu, India..
    Sakkaraiveeranan, Chandrasekar
    Arignar Anna Govt Arts Coll, PG & Res Dept Math, Namakkal 637002, Tamil Nadu, India..
    Samickannian, Aravindan
    Govt Arts Coll Autonomous, Dept Phys, Salem 636007, Tamil Nadu, India..
    Govindan, Gobi
    Govt Arts Coll Autonomous, Dept Phys, Salem 636007, Tamil Nadu, India..
    Palaniswamy, Matheswaran
    Govt Arts Coll Autonomous, Dept Chem, Salem 636007, Tamil Nadu, India..
    Ramamurthy, Uthrakumar
    Govt Arts Coll Autonomous, Dept Phys, Salem 636007, Tamil Nadu, India..
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Nanotechnology, Green Synthesis and Biological Activity Application of Zinc Oxide Nanoparticles Incorporated Argemone Mxicana Leaf Extract2022Ingår i: Molecules, ISSN 1431-5157, E-ISSN 1420-3049, Vol. 27, nr 5, artikel-id 1545Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Nanomaterial is a rapidly growing area that is used to create a variety of new materials and nanotechnology applications from medical, pharmaceuticals, chemical, mechanical, electronics and several environmental industries including physical, chemical and biological nanoparticles are very important in our daily life. Nanoparticles with leaf extract from the healthy plant are important in the area of research using biosynthesis methods. Because of it's used as an environmentally ecofriendly, other than traditional physical and chemical strategies. In particular, biologically synthesized nanoparticles have become a key branch of nanotechnology. The present work presents a synthesis of zinc oxide nanoparticles using an extract from the Argemone leaf Mexicana. Biosynthetic nanoparticles are characterized by X-ray diffraction (XRD), Ultraviolet visible (UV-vis) spectroscopy analysis, a Fourier Transform Infrared Spectroscopy analysis (FTIR) and a scanning electron microcopy (SEM), X-ray analysis with dispersive energy (EDAX). XRD is used to examine the crystalline size of zinc oxide nanoparticles. The FTIR test consists in providing evidence of the presence of targeted teams. UV is used for optical properties and calculates the energy of the bandwidth slot. The scanning microscope emission reveals the morphology of the surface and the energy dispersive X-ray analysis confirms the basic composition of zinc oxide nanoparticles. It is found that zinc nanoparticles are capable of achieving high anti-fungal efficacy and therefore have a high potential antimicrobial activity of ZnO NPs, like antibacterial and high antioxidant. Zinc Oxide nanoparticles from the Argemone Mexicana leaf extract have several antimicrobial applications, such as medical specialty, cosmetics, food, biotechnology, nano medicine and drug delivery system. ZnO nanoparticles are important because they provide many practical applications in industry. The most important use of nanoparticles of ZnO would be strong antibacterial and antioxidant activity with a simple and efficient biosynthesis method may be used for future work applications.

  • 5. Daryanavard, S. M.
    et al.
    Zolfaghari, H.
    Abdel-Rehim, A.
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Recent applications of microextraction sample preparation techniques in biological samples analysis2021Ingår i: BMC Biomedical chromotography, ISSN 0269-3879, E-ISSN 1099-0801, Vol. 35, nr 7, artikel-id e5105Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Analysis of biological samples is affected by interfering substances with chemical properties similar to those of the target analytes, such as drugs. Biological samples such as whole blood, plasma, serum, urine and saliva must be properly processed for separation, purification, enrichment and chemical modification to meet the requirements of the analytical instruments. This causes the sample preparation stage to be of undeniable importance in the analysis of such samples through methods such as microextraction techniques. The scope of this review will cover a comprehensive summary of available literature data on microextraction techniques playing a key role for analytical purposes, methods of their implementation in common biological samples, and finally, the most recent examples of application of microextraction techniques in preconcentration of analytes from urine, blood and saliva samples. The objectives and merits of each microextration technique are carefully described in detail with respect to the nature of the biological samples. This review presents the most recent and innovative work published on microextraction application in common biological samples, mostly focused on original studies reported from 2017 to date. The main sections of this review comprise an introduction to the microextraction techniques supported by recent application studies involving quantitative and qualitative results and summaries of the most significant, recently published applications of microextracion methods in biological samples. This article considers recent applications of several microextraction techniques in the field of sample preparation for biological samples including urine, blood and saliva, with consideration for extraction techniques, sample preparation and instrumental detection systems.

  • 6.
    Karimiyan, Hanieh
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. Univ Mazandaran, Dept Chem, Babol Sar 4741695447, Iran.
    Hadjmohammadi, Mohammad Reza
    Univ Mazandaran, Dept Chem, Babol Sar 4741695447, Iran..
    Laxman, Karthik
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik.
    Moein, Mohammad Mahdi
    Karolinska Univ Hosp, Dept Radiopharm, S-17176 Stockholm, Sweden..
    Dutta, Joydeep
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik.
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
    Graphene Oxide/Polyethylene Glycol-Stick for Thin Film Microextraction of beta-Blockers from Human Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry2019Ingår i: Molecules, ISSN 1431-5157, E-ISSN 1420-3049, Vol. 24, nr 20Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A wooden stick coated with a novel graphene-based nanocomposite (Graphene oxide/polyethylene glycol (GO/PEG)) is introduced and investigated for its efficacy in solid phase microextraction techniques. The GO/PEG-stick was prepared and subsequently applied for the extraction of beta -blockers, acebutolol, and metoprolol in human oral fluid samples, which were subsequently detected by liquid chromatography tandem mass spectrometry (LC-MS/MS). Experimental parameters affecting the extraction protocol including sample pH, extraction time, desorption time, appropriate desorption solvent, and salt addition were optimized. Method validation for the detection from oral fluid samples was performed following FDA (Food and Drug Administration) guidelines on bioanalytical method validation. Calibration curves ranging from 5.0 to 2000 nmol L-1 for acebutolol and 25.0 to 2000 nmol L-1 for metoprolol were used. The values for the coefficient of determination (R-2) were found to be 0.998 and 0.996 (n = 3) for acebutolol and metoprolol, respectively. The recovery of analytes during extraction was 80.0% for acebutolol and 62.0% for metoprolol, respectively. The limit of detections (LODs) were 1.25, 8.00 nmol L-1 for acebutolol and metoprolol and the lower limit of quantifications (LLOQ) were 5.00 nmol L-1 for acebutolol and 25.0 nmol L-1 for metoprolol. Validation experiments conducted with quality control (QC) samples demonstrated method accuracy between 80.0% to 97.0% for acebutolol and from 95.0% to 109.0% for metoprolol. The inter-day precision for QC samples ranged from 3.6% to 12.9% for acebutolol and 9.5% to 11.3% for metoprolol. Additionally, the GO/PEG-stick was demonstrated to be reusable, with the same stick observed to be viable for more than 10 extractions from oral fluid samples.

  • 7.
    Karimiyan, Hanieh
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. Univ Mazandaran, Dept Chem, Babol Sar 4741695447, Iran..
    Uheida, Abdusalam
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik.
    Hadjmohammadi, Mohammadreza
    Univ Mazandaran, Dept Chem, Babol Sar 4741695447, Iran..
    Moein, Mohammad Mandi
    Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Solna, Sweden..
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Solna, Sweden..
    Polyacrylonitrile / graphene oxide nanofibers for packed sorbent microextraction of drugs and their metabolites from human plasma samples2019Ingår i: Talanta: The International Journal of Pure and Applied Analytical Chemistry, ISSN 0039-9140, E-ISSN 1873-3573, Vol. 201, s. 474-479Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    In the present study, a new graphene based nanofibers material (Polyacrylonitrile/Graphene Oxide (PAN/GO)) was used for microextraction by packed sorbent (MEPS). The PAN/GO nanofiber was synthesized using the electrospinning technique. MEPS online with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized for the extraction and determination of two local anesthetic drugs (lidocaine, prilocaine) and their major metabolites (2,6-xylidine, o-toluidine) in human plasma samples. Parameters affecting the extraction efficiency were investigated and optimized (including sample pH, washing solution and elution solution). The validation of the method was based on FDA (Food and Drug Administration) guidelines for bioanalytical methods. The calibration curve ranged from 2.00 to 2000 nmol/L for lidocaine and prilocaine, and from 10.0 to 2000 nmol/L for 2,6-xylidine and o-toluidine. The coefficient of determination (R-2) values were 0.996, 0.995, 0.995, 0.996 (n = 3) for lidocaine, prilocaine, 2,6-xylidine and o-toluidine, respectively. The extraction recovery was 93.0% for lidocaine, 96.0% for prilocaine, 68.0% for 2,6-xylidine and 69.0% for o-toluidine. The limits of detection (LODs) were 0.25, 0.50, 2.50, 1.25 nmol/L for lidocaine, prilocaine, 2,6-xylidine and o-toluidine, respectively. The lower limits of quantification (LLOQs) were 2.0 nmol/L for lidocaine and prilocaine, and 10 nmol/L for 2,6-xylidine and o-toluidine, respectively. The accuracy values for the quality control (QC) samples were in the range of 91.0-111% for lidocaine, 92.0-118% for prilocaine, 84.0-98.0% for 2,6-xylidine and 82.0-90.0% for o-toluidine. The inter-day precisions for QC samples ranged from 7.0% to 11.8% for lidocaine, from 8.6% to 11.7% for prilocaine, from 8.0% to 10.0% for 2,6-xylidine and from 8.0% to 9.0% for o-toluidine. The matrix effect values were in the range of - 2.3% to - 8.6% for lidocaine, - 2.7% to - 10.2% for prilocaine, 4.8%-5.2% for 2, 6-xylidine and - 8.2% to 9.4% for o-toluidine.

  • 8. Moein, M. M.
    et al.
    Abdel-Rehim, A.
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik.
    Nanomaterials for microextraction techniques in bioanalysis2019Ingår i: Handbook of Nanomaterials in Analytical Chemistry: Modern Trends in Analysis, Elsevier BV , 2019, s. 43-56Kapitel i bok, del av antologi (Övrigt vetenskapligt)
    Abstract [en]

    The analysis of biological samples (bioanalysis) always needs intensive sample cleanup (sample preparation) before it gets injected into the analytical instruments. In bioanalysis, sample preparation has an essential role because of the complexity of the biological matrix. Among popular sample preparation techniques, microextraction techniques received high attention because of needs of low volume of used solvent and sample. The sorbent may has high influence on the method selectivity and recovery. Because of their high surface area, ultra-small size, high physical and chemical stability properties, nanomaterials attained huge attention in sample preparation for analytical and bioanalytical trends. In this chapter, the different types and applications of nanomaterials in microextraction analysis and bioanalysis will be summarized and discussed. In addition, recently published papers on the relevance of nanomaterials as sorbents in microextraction for bioanalysis will be presented and the application of nanomaterials for online analysis procedures will be included.

  • 9.
    Moein, Mohammad Mahdi
    et al.
    Karolinska Univ Hosp, Dept Radiopharm, S-17176 Stockholm, Sweden..
    Abdel-Rehim, Abbi
    Univ Manchester, Fac Sci & Engn, Manchester M13 9PL, Lancs, England..
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. Karolinska Inst, Karolinska Hosp, Ctr Psychiat Res, Dept Clin Neurosci, S-17176 Stockholm, Sweden..
    Recent Applications of Molecularly Imprinted Sol-Gel Methodology in Sample Preparation2019Ingår i: Molecules, ISSN 1431-5157, E-ISSN 1420-3049, Vol. 24, nr 16, artikel-id 2889Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Due to their selectivity and chemical stability, molecularly imprinted polymers have attracted great interest in sample preparation. Imprinted polymers have been applied for the extraction and the enrichment of different sorts of trace analytes in biological and environmental samples before their analysis. Additionally, MIPs are utilized in various sample preparation techniques such as SPE, SPME, SBSE and MEPS. Nevertheless, molecularly imprinted polymers suffer from thermal (stable only up to 150 degrees C) and mechanical stability issues, improper porosity and poor capacity. The sol-gel methodology as a promising alternative to address these limitations allowing the production of sorbents with controlled porosity and higher surface area. Thus the combination of molecularly imprinted technology and sol-gel technology can create influential materials with high selectivity, high capacity and high thermal stability. This work aims to present an overview of molecularly imprinted sol-gel polymerization methods and their applications in analytical and bioanalytical fields.

  • 10. Suzaei, F. M.
    et al.
    Daryanavard, S. M.
    Abdel-Rehim, A.
    Bassyouni, F.
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Recent molecularly imprinted polymers applications in bioanalysis2023Ingår i: Chemické zvesti, ISSN 0366-6352, E-ISSN 1336-9075, Vol. 77, nr 2, s. 619-655Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Molecular imprinted polymers (MIPs) as extraordinary compounds with unique features have presented a wide range of applications and benefits to researchers. In particular when used as a sorbent in sample preparation methods for the analysis of biological samples and complex matrices. Its application in the extraction of medicinal species has attracted much attention and a growing interest. This review focus on articles and research that deals with the application of MIPs in the analysis of components such as biomarkers, drugs, hormones, blockers and inhibitors, especially in biological matrices. The studies based on MIP applications in bioanalysis and the deployment of MIPs in high-throughput settings and optimization of extraction methods are presented. A review of more than 200 articles and research works clearly shows that the superiority of MIP techniques lies in high accuracy, reproducibility, sensitivity, speed and cost effectiveness which make them suitable for clinical usage. Furthermore, this review present MIP-based extraction techniques and MIP-biosensors which are categorized on their classes based on common properties of target components. Extraction methods, studied sample matrices, target analytes, analytical techniques and their results for each study are described. Investigations indicate satisfactory results using MIP-based bioanalysis. According to the increasing number of studies on method development over the last decade, the use of MIPs in bioanalysis is growing and will further expand the scope of MIP applications for less studied samples and analytes.

  • 11.
    Suzaei, Foad Mashayekhi
    et al.
    Monitoring Human Hyg Condit & Stand Qeshm MHCS Co, Toxicol Labs, Qeshm Isl, Iran..
    Batista, Alex D.
    Ulm Univ, Inst Analyt & Bioanalyt Chem, Albert Einstein Allee 11, D-89081 Ulm, Germany..
    Mizaikoff, Boris
    Ulm Univ, Inst Analyt & Bioanalyt Chem, Albert Einstein Allee 11, D-89081 Ulm, Germany..
    Rahimi, Sima
    Payame Noor Univ, Fac Sci, Qeshm Isl, Iran..
    Daryanavard, Seyed Mosayeb
    Univ Hormozgan, Fac Sci, Dept Chem, Bandar Abbas, Iran..
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik. Med Solut, Stockholm, Sweden..
    Molecularly imprinted polymers for selective extraction/microextraction of cancer biomarkers: A review2022Ingår i: Microchimica Acta, ISSN 0026-3672, E-ISSN 1436-5073, Vol. 189, nr 7, artikel-id 255Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Over recent years, great efforts have been extensively documented in top scientific journals on the development of methods for early diagnosis, treatment, and monitoring of cancers which are prevalent critical diseases with a high mortality rate among men and women. The determination of cancer biomarkers using different optimum methodologies is one of the finest options for achieving these goals with more precision, speed, and at a lower cost than traditional clinical procedures. In this regard, while focusing on specific biomarkers, molecularly imprinted technology has enabled novel diagnostic techniques for a variety of diseases. Due to the well-known advantages of molecularly imprinted polymers (MIPs), this review focuses on the current trends of MIPs-based extraction/microextraction methods, specifically targeting cancer biomarkers from various matrices. These optimized methods have demonstrated high selectivity, accuracy, sorbent reusability, extraction recovery, and low limits of detection and quantification for a variety of cancer biomarkers, which are a powerful tool to provide early diagnosis, prognosis, and treatment monitoring, with potential clinical application expected soon. This review highlights the key progress, specific modifications, and strategies used for MIP synthesis. The future perspectives for cancer biomarkers purification and determination by fabricating MIP-based techniques are also discussed.

  • 12.
    Uheida, Abdusalam
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Mejía, Hugo Giraldo
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik. Advanced Mining Technology Center (AMTC) .
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet.
    Hamd, W.
    Dutta, Joydeep
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Visible light photocatalytic degradation of polypropylene microplastics in a continuous water flow system2021Ingår i: Journal of Hazardous Materials, ISSN 0304-3894, E-ISSN 1873-3336, Vol. 406, artikel-id 124299Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Microplastic pollution of water and ecosystem is attracting continued attention worldwide. Due to their small sizes (≤5 mm) microplastic particles can be discharged to the environment from treated wastewater effluents. As microplastics have polluted most of our aquatic ecosystems, often finding its way into drinking water, there is urgent need to find new solutions for tackling the menace of microplastic pollution. In this work, sustainable green photocatalytic removal of microplastics from water activated by visible light is proposed as a tool for the removal of microplastics from water. We propose a novel strategy for the elimination of microplastics using glass fiber substrates to trap low density microplastic particles such as polypropylene (PP) which in parallel support the photocatalyst material. Photocatalytic degradation of PP microplastics spherical particles suspended in water by visible light irradiation of zinc oxide nanorods (ZnO NRs) immobilized onto glass fibers substrates in a flow through system is demonstrated. Upon irradiation of PP microplastics for two weeks under visible light reduced led to a reduction of the average particle volume by 65%. The major photodegradation by-products were identified using GC/MS and found to be molecules that are considered to be mostly nontoxic in the literature.

  • 13.
    Zohdi, Zeynab
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, SE-17176 Solna, Sweden ; Univ Bu Ali Sina, Dept Chem, Hamadan 65174, Iran.
    Hashemi, Mahdi
    Univ Bu Ali Sina, Dept Chem, Hamadan 65174, Iran..
    Uheida, Abdusalam
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik.
    Moein, Mohammad Mahdi
    Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, SE-17176 Solna, Sweden..
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik. Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, SE-17176 Solna, Sweden Dept Appl Phys, SE-16440 Stockholm, Sweden..
    Graphene Oxide Tablets for Sample Preparation of Drugs in Biological Fluids: Determination of Omeprazole in Human Saliva for Liquid Chromatography Tandem Mass Spectrometry2019Ingår i: Molecules, ISSN 1431-5157, E-ISSN 1420-3049, Vol. 24, nr 7, artikel-id 1191Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this study, a novel sort of sample preparation sorbent was developed, by preparing thin layer graphene oxide tablets (GO-Tabs) utilizing a mixture of graphene oxide and polyethylene glycol on a polyethylene substrate. The GO-Tabs were used for extraction and concentration of omeprazole (OME) in human saliva samples. The determination of OME was carried out using liquid chromatography-tandem mass spectrometry (LC-MS/MS) under gradient LC conditions and in the positive ion mode (ESI+) with mass transitions of m/z 346.3 -> 198.0 for OME and m/z 369.98 -> 252.0 for the internal standard. Standard calibration for the saliva samples was in the range of 2.0-2000 nmol L-1. Limits of detection and quantification were 0.05 and 2.0 nmol L-1, respectively. Method validation showed good method accuracy and precision; the inter-day precision values ranged from 5.7 to 8.3 (%RSD), and the accuracy of determinations varied from -11.8% to 13.3% (% deviation from nominal values). The extraction recovery was 60%, and GO-Tabs could be re-used for more than ten extractions without deterioration in recovery. In this study, the determination of OME in real human saliva samples using GO-Tab extraction was validated.

  • 14.
    Zohdijamil, Zeynab
    et al.
    Karolinska institutet.
    Hashemi, M.
    Abdel-Rehim, A.
    Laxman, Karthik
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Uheida, Abdusalam
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Dutta, Joydeep
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Abdel-Rehim, Mohamed
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik.
    Functionalized graphene oxide tablets for sample preparation of drugs in biological fluids: Extraction of ritonavir, a HIV protease inhibitor, from human saliva and plasma using LC–MS/MS2021Ingår i: BMC Biomedical chromotography, ISSN 0269-3879, E-ISSN 1099-0801, Vol. 35, nr 12, artikel-id e5111Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this work, graphene oxide–based tablets (GO-Tabs) were prepared by applying a thin layer of functionalized GO on a polyethylene substrate. The GO was functionalized with amine groups (–NH2) by poly(ethylene glycol)bis(3-aminopropyl) terminated (GO-NH2-PEG-NH2). The functionalized GO-Tabs were used for the extraction of ritonavir (RTV) in human saliva samples. RTV in plasma and saliva samples was analyzed using LC–MS/MS. Gradient LC system with MS/MS in the positive-ion mode [electrospray ionization (ESI+)] was used. The transitions m/z 721 → 269.0 and m/z 614 → 421 were used for RTV and the internal standard indinavir, respectively. This study determined the human immunodeficiency virus protease inhibitor RTV in human saliva samples using functionalized GO-Tab and LC–MS/MS, and the method was validated. The standard calibration curve for plasma and saliva samples was constructed from 5.0 to 2000 nmol L−1. The limit of detection was 0.1 nmol L−1, and the limit of quantification was 5.0 nmol L−1 in both plasma and saliva matrices. The intra- and inter-assay precision values were found to be between 1.5 and 5.8%, and the accuracy values ranged from 88.0 to 108% utilizing saliva and plasma samples. The extraction recovery was more than 80%, and the presented functionalized GO-Tabs could be reused for more than 10 extractions without deterioration in recovery.

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