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  • 1.
    Alijagic, Andi
    et al.
    Örebro Univ, Man Technol Environm Res Ctr MTM, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Inflammatory Response & Infect Susceptibil Ctr iRi, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden..
    Scherbak, Nikolai
    Örebro Univ, Man Technol Environm Res Ctr MTM, SE-70182 Örebro, Sweden..
    Kotlyar, Oleksandr
    Örebro Univ, Man Technol Environm Res Ctr MTM, SE-70182 Örebro, Sweden.;Örebro Univ, Ctr Appl Autonomous Sensor Syst AASS, Mobile Robot & Olfact Lab MRO, SE-70182 Örebro, Sweden..
    Karlsson, Patrik
    Örebro Univ, Dept Mech Engn, SE-70182 Örebro, Sweden..
    Wang, Xuying
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, AIMES Ctr Advancement Integrated Med & Engn Sci, SE-10044 Stockholm, Sweden.;KTH Royal Inst Technol, SE-10044 Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Benada, Oldrich
    Czech Acad Sci, Inst Microbiol, SE-68385 Prague, Czech Republic..
    Amiryousefi, Ali
    Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden..
    Andersson, Lena
    Örebro Univ, Fac Med & Hlth, Inflammatory Response & Infect Susceptibil Ctr iRi, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden.;Örebro Univ Hosp, Dept Occupat & Environm Med, SE-70185 Örebro, Sweden..
    Persson, Alexander
    Örebro Univ, Fac Med & Hlth, Inflammatory Response & Infect Susceptibil Ctr iRi, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden..
    Felth, Jenny
    Andersson, Henrik
    Larsson, Maria
    Örebro Univ, Man Technol Environm Res Ctr MTM, SE-70182 Örebro, Sweden..
    Hedbrant, Alexander
    Örebro Univ, Fac Med & Hlth, Inflammatory Response & Infect Susceptibil Ctr iRi, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden..
    Salihovic, Samira
    Örebro Univ, Man Technol Environm Res Ctr MTM, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Inflammatory Response & Infect Susceptibil Ctr iRi, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden..
    Hyoetylaeinen, Tuulia
    Örebro Univ, Man Technol Environm Res Ctr MTM, SE-70182 Örebro, Sweden..
    Repsilber, Dirk
    Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden..
    Saerndahl, Eva
    Örebro Univ, Fac Med & Hlth, Inflammatory Response & Infect Susceptibil Ctr iRi, SE-70182 Örebro, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, SE-70182 Örebro, Sweden..
    Engwall, Magnus
    Örebro Univ, Man Technol Environm Res Ctr MTM, SE-70182 Örebro, Sweden..
    A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles2023Ingår i: Cells, E-ISSN 2073-4409, Vol. 12, nr 2, artikel-id 281Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Additive manufacturing (AM) or industrial 3D printing uses cutting-edge technologies and materials to produce a variety of complex products. However, the effects of the unintentionally emitted AM (nano)particles (AMPs) on human cells following inhalation, require further investigations. The physicochemical characterization of the AMPs, extracted from the filter of a Laser Powder Bed Fusion (L-PBF) 3D printer of iron-based materials, disclosed their complexity, in terms of size, shape, and chemistry. Cell Painting, a high-content screening (HCS) assay, was used to detect the subtle morphological changes elicited by the AMPs at the single cell resolution. The profiling of the cell morphological phenotypes, disclosed prominent concentration-dependent effects on the cytoskeleton, mitochondria, and the membranous structures of the cell. Furthermore, lipidomics confirmed that the AMPs induced the extensive membrane remodeling in the lung epithelial and macrophage co-culture cell model. To further elucidate the biological mechanisms of action, the targeted metabolomics unveiled several inflammation-related metabolites regulating the cell response to the AMP exposure. Overall, the AMP exposure led to the internalization, oxidative stress, cytoskeleton disruption, mitochondrial activation, membrane remodeling, and metabolic reprogramming of the lung epithelial cells and macrophages. We propose the approach of integrating Cell Painting with metabolomics and lipidomics, as an advanced nanosafety methodology, increasing the ability to capture the cellular and molecular phenotypes and the relevant biological mechanisms to the (nano)particle exposure.

  • 2.
    Alinejadian, Navid
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Tallinn Univ Technol, Dept Mech & Ind Engn, Ehitajate Tee 5, EE-19086 Tallinn, Estonia..
    Kazemi, S. H.
    Inst Adv Studies Basic Sci, Dept Chem, Zanjan 4513766731, Iran..
    Grossberg-Kuusk, M.
    Tallinn Univ Technol, Dept Mat & Environm Technol, Ehitajate Tee 5, EE-19086 Tallinn, Estonia..
    Kollo, L.
    Odnevall, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, AIMES Ctr Advancement Integrated Med & Engn Sci, Stockholm, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Prashanth, K. G.
    Tallinn Univ Technol, Dept Mech & Ind Engn, Ehitajate Tee 5, EE-19086 Tallinn, Estonia.;Austrian Acad Sci, Erich Schmid Inst Mat Sci, Jahnstr 12, A-8700 Leoben, Austria.;Vellore Inst Technol, Sch Mech Engn, CBCMT, Vellore 632014, India..
    Importance of the micro-lattice structure of selective laser melting processed Mo/Mo(x)S(x+1) composite: Corrosion studies on the electrochemical performance in aqueous solutions2022Ingår i: Materials Today Chemistry, E-ISSN 2468-5194, Vol. 26, artikel-id 101219Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Selective laser melting (SLM) based processing of Mo-based samples is challenging due to solidification cracking. We here demonstrate that the addition of 2 wt% MoS2 to the Mo feedstock markedly improves crack mitigation of SLM-processed Mo/MoS2/Mo2S3 composite micro-lattice structures (SLM-Mo/ Mo(x)S(x+1)). Crack inhibition is suggested to be a result of Mo2S3 formation, decreased lattice strain (0.04 4%), and a decrease in accumulated residual stresses. The increased values of polarization resistance from 42.3 and 19.2 kU cm2 to 437 and 78.2 kU cm2, respectively verified the hindering effect of the composition on stress corrosion cracking (SCC) and surface oxidation cracking. However, an increased corrosion current density, from 1.22 to 10.2 mA/cm2, and cathodic Tafel constant, from 175 to 260.5 mV, confirmed the decreased polarization resistance and occurrence of different types of corrosion such as SCC and pitting. The strategy to add 2 wt% MoS2 to the Mo feedstock enables the fabrication of hightemperature micro-lattice structure components with improved corrosion resistance properties applicable in e.g., electronic, power semiconductor heat sinks, offshore-, aerospace-, defense-, or particularly novel sodium-ion energy storage applications.

  • 3.
    Alinejadian, Navid
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Tallinn Univ Technol TalTech, Dept Mech & Ind Engn, EE-19086 Tallinn, Estonia..
    Kazemi, Sayed Habib
    Inst Adv Studies Basic Sci, Dept Chem, Zanjan 4513766731, Iran..
    Nasirpouri, Farzad
    Sahand Univ Technol, Fac Mat Engn, Sahand New Town 5331811111, East Azerbaijan, Iran..
    Odnevall, Inger
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, AIMES Ctr Advancement Integrated Med & Engn Sci, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Electro-deposited nano-Ni/reduced graphene oxide composite film of corrugated surface for high voltammetric sensitivity2023Ingår i: Materials Chemistry and Physics, ISSN 0254-0584, E-ISSN 1879-3312, Vol. 297, s. 127288-, artikel-id 127288Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Reduced graphene oxide (rGO) is an ideal candidate in nanostructured metallic materials to enhance their electrochemical performance. However, few studies exist on the effects of rGO on the crystallographic, physical, and topological properties of co-electrodeposited Ni/rGO nanocomposites. In this study, the morphology and normalized electro-active specific surface (NESS) of a Ni/rGO nanocomposite were correlated with its crystal-lographic properties by varying the applied co-electrodeposition current density (0.01-0.1 A cm(-2)) and rGO concentration (0.5-2 mg mL(-1)). Tuning was done to achieve the best physical and electrochemical properties of the nanocomposite at alkaline (NaOH) conditions in terms of the highest NESS (12.3 x 10(-4)) and electro-active sensitivity (17.3 mu A mM(-1) cm(-2)) possible. The findings of the study show a possible approach to enhance the performance of electro-active components such as electrochemical devices, sensors, and actuators.

  • 4.
    Alinejadian, Navid
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Department of Mechanical and Industrial Engineering, Tallinn University of Technology, Tallinn, 19086, Estonia.
    Kazemi, Sayed Habib
    Inst Adv Studies Basic Sci, Dept Chem, Zanjan 4513766731, Iran..
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. AIMES-Center for the Advancement of Integrated Medical and Engineering Sciences; Department of Neuroscience, Karolinska Institutet, Stockholm, 171 77, Sweden.
    SLM-processed MoS2/Mo2S3 nanocomposite for energy conversion/storage applications2022Ingår i: Scientific Reports, E-ISSN 2045-2322, Vol. 12, nr 1, artikel-id 5030Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    MoS2-based nanocomposites have been widely processed by a variety of conventional and 3D printing techniques. In this study, selective laser melting (SLM) has for the first time successfully been employed to tune the crystallographic structure of bulk MoS2 to a 2H/1T phase and to distribute Mo2S3 nanoparticles in-situ in MoS2/Mo2S3 nanocomposites used in electrochemical energy conversion/storage systems (EECSS). The remarkable results promote further research on and elucidate the applicability of laser-based powder bed processing of 2D nanomaterials for a wide range of functional structures within, e.g., EECSS, aerospace, and possibly high-temperature solid-state EECSS even in space.

  • 5.
    Alinejadian, Navid
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Tallinn Univ Technol TalTech, Dept Mech & Ind Engn, Ehitajate Tee 5, EE-19086 Tallinn, Estonia..
    Kollo, Lauri
    Tallinn Univ Technol TalTech, Dept Mech & Ind Engn, Ehitajate Tee 5, EE-19086 Tallinn, Estonia..
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Progress in additive manufacturing of MoS2-based structures for energy storage applications - A review2022Ingår i: Materials Science in Semiconductor Processing, ISSN 1369-8001, E-ISSN 1873-4081, Vol. 139, artikel-id 106331Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Investigation of next-generation manufacturing methods for the processing of functional materials and offering products with improved performance/functionalities has always been a challenge in terms of energy efficiency, cost-effectiveness, and eco-friendliness. Additive manufacturing (AM) attributes to rapid prototyping techniques that provide new opportunities to test new concepts and design complex 3D structures from metals, ceramics, and composites. Moreover, as a well-known transition metal dichalcogenide, Molybdenum disulfide (MoS2) is a two-dimensional (2D) material with outstanding electrochemical, physical, and mechanical properties that make it a potential candidate for energy storage electrodes via intercalation of different H+, Li+, Na+, and K+ cations. In this review, we discuss the existing conventional MoS2-processing methodologies and compare them with the novel additive manufacturing processes (especially laser-based powder bed fusion). The authors are convinced that the processing of prominent MoS2-based functional structures by the novel additive manufacturing processes can provide complex structures for different electrochemical applications, particularly for energy conversion/ storage systems.

  • 6.
    Atapour, Masoud
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Hedberg, Yolanda
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Stainless steel in simulated milk and whey protein solutions - Influence of grade on corrosion and metal release2020Ingår i: Electrochimica Acta, ISSN 0013-4686, E-ISSN 1873-3859, Vol. 331, artikel-id 135428Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Reactions at the biointerfaces between stainless steel and protein-rich dairy products, which contain whey proteins, are important to consider in terms of food safety and material grade selection. Changes in corrosion behavior, metal release, and surface composition of austenitic (AISI 316 L), ferritic (AISI 430), and lean duplex (LDX 2101) stainless steels in simulated milk (SMS) and whey protein solution were investigated. The amount of released metals and the corrosion susceptibility increased according to 2101 < 316 L < 430. All grades revealed low corrosion rates in the whey protein solution without any sign of active/metastable corrosion. Pitting corrosion was evident for 430 in SMS. The total amount of released metals (iron, chromium, and nickel) was significantly higher in whey protein solution compared with SMS. This suggests the metal release process to be mainly governed by complexation reactions. Nickel was preferentially released compared to its bulk composition fraction for both 316 L and 2101 in the highly complexing SMS. Reduced metal release rates with time correlated with the enrichment of chromium in the surface oxide. The extent of metal release was for all metals substantially lower than release limits of metals stipulated in health regulations related to the use of alloys and metals in food-related environments.

  • 7.
    Atapour, Masoud
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Isfahan Univ Technol, Dept Mat Engn, Esfahan 8415683111, Iran..
    Wang, Xuying
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Farnlund, Kim
    AMEXCI AB, Gammelbackavagen 2, S-69151 Karlskoga, Sweden..
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Hedberg, Yolanda
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Corrosion and metal release investigations of selective laser melted 316L stainless steel in a synthetic physiological fluid containing proteins and in diluted hydrochloric acid2020Ingår i: Electrochimica Acta, ISSN 0013-4686, E-ISSN 1873-3859, Vol. 354, artikel-id 136748Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The corrosion and metal release characteristics of additively manufactured stainless steels are key factors for their applicability in biomedical applications. The effect of building direction on the microstructure, corrosion behavior and metal release of selective laser melted (SLM) AISI 316L stainless steel were therefore investigated in a protein-rich synthetic body fluid (PBS+BSA, pH 7.3) and in diluted hydrochloric acid (HCl, pH 1.5). A multi-analytical approach was applied to characterize SLM 316L surfaces printed in different building directions (denoted XY and XZ) and a post heat treated SLM surface (XZ-HT) compared with wrought surfaces. All SLM specimens revealed an austenitic microstructure without any amounts of delta-ferrite and without large-angled grain boundaries in contrast to the wrought 316L surface. The building direction strongly affected the grain size distribution due to the temperature gradients in the melt pools. The SLM 316L specimens released initially slightly less Fe, Cr and Ni compared with the wrought 316L specimen. Slightly less metal was released from the heat treated SLM specimen (XZ-HT) specimen compared to the other SLM specimens. Relatively high amounts of released Cr were observed in PBS+BSA, most probably attributed to protein-bound Cr, whereas substantially more Ni was released in HCl compared to PBS+BSA due to pitting corrosion and a reduced surface oxide thickness. The surface oxide composition of as-printed SLM specimens was strongly dependent on the building direction and the post heat treatment, whereas no differences were observed after abrasion either among the SLM specimens or compared with the wrought 316L specimen. Cr became in all cases enriched within the outermost surface oxide in PBS+BSA and strongly enriched in the HCl solution, coupled to a strongly reduced amount of released metals with time. The heat treated SLM specimen (XZ-HT) gained a superior charge transfer resistance, the lowest passive current density, and the highest OCP value among all specimens. In HCl, the SLM specimens showed a lower pitting susceptibility compared to the wrought specimens. No pitting was observed in PBS+BSA. No differences in corrosion or metal release characteristics were observed related to the building direction of abraded SLM specimens.

  • 8.
    Atapour, Masoud
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
    Wang, Xuying
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Persson, M.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Hedberg, Yolanda
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Electrochemical Society Member..
    Corrosion of Binder Jetting Additively Manufactured 316L Stainless Steel of Different Surface Finish2020Ingår i: Journal of the Electrochemical Society, ISSN 0013-4651, E-ISSN 1945-7111, Vol. 167, nr 13, artikel-id 131503Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    One technique of additive manufacturing is the binder-jetting technique that has the advantages of low costs, printing at room temperature and in air, and no need of a support structure. The aim of this study was to investigate the corrosion behavior of printed 316L surfaces with and without different post surface treatments of blasting and superfinishing. Comparative studies were performed on abraded wrought 316L. Surface topography, porosity, surface oxide composition, and electrochemical characteristics, including pitting corrosion, were investigated at room temperature as a function of post surface treatments in diluted hydrochloric acid at pH 1.5. The blasting and superfinishing treatment significantly reduced the surface roughness and level of surface porosity. Blasting detrimentally affected on the pitting corrosion resistance. The superfinishing process induced an enrichment of chromium in the surface oxide and improved the pitting corrosion resistance. All surfaces revealed slightly reduced susceptibility to pit initiation and metastable pitting as compared to wrought 316L, possibly explained by the absence of inclusions. Once pitting propagation was induced, repassivation was hindered for all surfaces compared with the wrought surface. The pitting corrosion resistance of the as-superfinished 316L was improved compared with wrought 316L.

  • 9.
    Atapour, Masoud
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Wei, Zheng
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Chaudhary, Himanshu
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi.
    Lendel, Christofer
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Hedberg, Yolanda
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Metal release from stainless steel 316L in whey protein - And simulated milk solutions under static and stirring conditions2019Ingår i: Food Control, ISSN 0956-7135, E-ISSN 1873-7129, Vol. 101, s. 163-172Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Stainless steel is an important transport and processing contact material for bovine milk and dairy products. Release (migration) of metals, ions, complexes or wear debris/particles, and metal-induced protein aggregation in such environments are hence important to consider both from a corrosion and food safety perspective. This study aims on investigating the release of iron (Fe), chromium (Cr), and nickel (Ni) from AISI 316L stainless steel in contact with whey protein solutions relevant for protein drinks, and on how the whey proteins are influenced by stirring with a magnetic stir bar and metal release. Mechanistic insight is gained by parallel investigations of metal release from two reference non-protein containing solutions, a metal-complexing (citrate-containing) simulated milk solution (SMS) and a low complexing phosphate buffered saline solution (PBS). All immersion exposures were conducted at pH 6.8 for 0.5, 4, 24 and 48 hat room temperature at static and stirring conditions. All solutions and samples were investigated using different chemical, spectroscopic, microscopic, and electrochemical methods. Significantly higher amounts of Fe, Cr, and Ni were released into the whey protein solution (80 g/L) as compared to SMS and PBS. Strong enrichment of Cr in the surface oxide and reduction of the surface oxide thickness were associated with a higher amount of Ni release in the metal-complexing solutions (SMS and whey protein) compared with PBS. Stirring conditions resulted in higher amounts of metal release, enrichment of Cr in the surface oxide, and clear signs of wear of the 316L surface in all solutions compared to static conditions. The wear mechanism in the whey protein solution was different as compared to corresponding processes in SMS and PBS, involving an etching-like process and larger-sized wear debris. Electrochemical measurements at static conditions confirmed observed differences between the solutions, with the lowest corrosion resistance observed for coupons exposed in the whey protein solution, followed by SMS and PBS. Released metals in solution from the 316L coupons in contact with the whey protein solution resulted in enhanced rates of protein aggregation and precipitation of protein aggregates from solution. Further studies should be made to investigate other relevant test conditions and assess toxicological risks.

  • 10. Bahar, B.
    et al.
    Herting, G.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Hakkila, K.
    Leygraf, Christofer
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Virta, M.
    The interaction between concrete pavement and corrosion-induced copper runoff from buildings2008Ingår i: Environmental Monitoring & Assessment, ISSN 0167-6369, E-ISSN 1573-2959, Vol. 140, nr 1-3, s. 175-189Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Changes in chemical speciation of copper and the capacity of concrete pavement to retain copper in runoff water from external buildings have been investigated at urban field conditions, and in parallel laboratory experiments simulating outdoor scenarios. The research study showed the concrete surface to form a copper rich surface layer (approximate to 50 mu m thick) upon exposure, and a high capacity to significantly reduce the bioavailable fraction of released copper (20-95%). The retention capacity of copper varied between 5 and 20% during single runoff events in the laboratory, and between 10 and 40% of the total copper release during single natural runoff events. The capacity to retain and reduce the bioavailable fraction of non-retained copper increased with increasing wetness of the concrete surfaces, increasing pH of the runoff water and decreasing flow rates. Bioassay testing with bacterial and yeast bioreporters showed the bioavailable fraction of non-retained copper to be significantly lower than the total copper concentration in the runoff water, between 22 and 40% for bacteria and between 8 and 31% for yeast. The application of generated data to simulate a fictive outdoor scenario, suggests a significant reduction of bioavailable and total copper to background values during environmental entry as a result of dilution, and the interaction with solid surfaces, organic matter and complexing agents already in the drainage system.

  • 11.
    Bahar, Babak
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Leygraf, Christofer
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Corrosion-induced copper release from rain gutters2008Ingår i: Metall (Berlin. 1947), ISSN 0026-0746, Vol. 62, nr 3, s. 129-135Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    While runoff rates from copper roofs have been extensively studied during the last years, corresponding studies from copper rain gutters have been missing. A laboratory investigation has been undertaken to examine the influence of important runoff water parameters on the copper runoff from rain gutters. At a given rainfall quantity, the release rate of copper increases with decreasing runoff water intensity and decreasing degree of gutter inclination, and with increasing runoff acidity and increasing Cu2+-ion concentration in the runoff water. A comparison of the predicted long-term copper release from the gutter-system compared to the roof on a real building suggests that less than 5% of the total copper runoff originates from the gutter. However, single rain events may result in higher release rates, especially during the initial rain portion.

  • 12. Bender, R.
    et al.
    Féron, D.
    Mills, D.
    Ritter, S.
    Bäßler, R.
    Bettge, D.
    De Graeve, I.
    Dugstad, A.
    Grassini, S.
    Hack, T.
    Halama, M.
    Han, E. -H
    Harder, T.
    Hinds, G.
    Kittel, J.
    Krieg, R.
    Leygraf, Christopher
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Martinelli, L.
    Mol, A.
    Neff, D.
    Nilsson, J. -O
    Odnevall, Inger
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Paterson, S.
    Paul, S.
    Prošek, T.
    Raupach, M.
    Revilla, R. I.
    Ropital, F.
    Schweigart, H.
    Szala, E.
    Terryn, H.
    Tidblad, J.
    Virtanen, S.
    Volovitch, P.
    Watkinson, D.
    Wilms, M.
    Winning, G.
    Zheludkevich, M.
    Corrosion challenges towards a sustainable society2022Ingår i: Materials and corrosion - Werkstoffe und Korrosion, ISSN 0947-5117, E-ISSN 1521-4176, Vol. 73, nr 11, s. 1730-1751Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A global transition towards more sustainable, affordable and reliable energy systems is being stimulated by the Paris Agreement and the United Nation's 2030 Agenda for Sustainable Development. This poses a challenge for the corrosion industry, as building climate-resilient energy systems and infrastructures brings with it a long-term direction, so as a result the long-term behaviour of structural materials (mainly metals and alloys) becomes a major prospect. With this in mind “Corrosion Challenges Towards a Sustainable Society” presents a series of cases showing the importance of corrosion protection of metals and alloys in the development of energy production to further understand the science of corrosion, and bring the need for research and the consequences of corrosion into public and political focus. This includes emphasis on the limitation of greenhouse gas emissions, on the lifetime of infrastructures, implants, cultural heritage artefacts, and a variety of other topics. 

  • 13. Berggren, D.
    et al.
    Bertling, Sofia
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Heijerick, D.
    Herting, Gunilla
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Koundakjian, P.
    Leygraf, Christofer
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Odnevall Wallinder, Inger
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Release of Chromium, Nickel and Iron from Stainless Steel Exposed under Atmospheric Conditions and The Environmental Interaction of these Metals: A Combined Field and Laboratory Investigation2004Rapport (Övrigt vetenskapligt)
  • 14.
    Bertling, Sofia
    et al.
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Degryse, F.
    Laboratory for Soil and Water Management, Catholic University of Leuven.
    Odnevall Wallinder, Inger
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Smolders, E.
    Laboratory for Soil and Water Management, Catholic University of Leuven.
    Leygraf, Christofer
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Model studies of corrosion induced copper runoff fate in soil2006Ingår i: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 25, nr 3, s. 683-691Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Laboratory experiments have been performed with 3-cm soil columns simulating the fate of corrosion-induced copper runoff in contact with soil. The investigation simulates approximately 30 years (assuming an infiltration surplus of 25 cm/year) of continuous percolation of copper containing runoff water of a concentration realistic at the immediate release situation (4.8 mg/L) into four soils representative of urban conditions. Two of the three investigated topsoils reached their breakthrough of copper within the simulated time, while the third topsoil did not show a breakthrough. The subsoil reached a breakthrough after approximately 10 years of simulated exposure. To simulate more realistic outdoor scenarios, the laboratory-obtained breakthrough curves were modeled with Hydrus-1D (R) using a Langmuir-Freundlich model to describe copper sorption, the parameters of which were estimated from soil properties (pH, organic carbon content). The model predicts longer breakthrough times with increasing pH and organic content of the soil and with decreasing concentrations of copper and dissolved organic carbon in the runoff water. The time span for copper in runoff water (at concentrations of 0.01-10 mg/L) to reach a soil depth of 50 cm varied between 170 and more than 8,000 years for the predicted field scenarios.

  • 15.
    Bertling, Sofia
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Berggren Kleja, Daniel
    Department of Soil Sciences, Swedish University of Agricultural Sciences, SLU, Uppsala, Sweden.
    Leygraf, Christofer
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Long-term corrosion-induced copper runoff from natural and artificial patina and its environmental impact2006Ingår i: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 25, nr 3, s. 891-898Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The overall objective of this paper is to present an extensive set of data for corrosion-induced copper dispersion and its environmental interaction with solid surfaces in the near vicinity of buildings. Copper dispersion is discussed in terms of total copper flows, copper speciation and bioavailability at the immediate release situation, and its changes during transport from source to recipient. Presented results are based on extensive field exposures (eight years) at an urban site, laboratory investigations of the runoff process, published field data, generated predictive site-specific runoff rate models, and reactivity investigations toward various natural and manmade surfaces, such as those in soil, limestone, and concrete. Emphasis is placed on the interaction of copper-containing runoff water with different soil systems through long-term laboratory column investigations. The fate of copper is discussed in terms of copper retention, copper chemical speciation, breakthrough capacities, and future mobilization based on changes in copper concentrations in the percolate water, computer modeling using the Windermere Humic Aqueous Model, and sequential extractions. The results illustrate that, for scenarios where copper comes in extensive contact with solid surfaces, such as soil and limestone, a large fraction of released copper is retained already in the immediate vicinity of the building. In all, both the total copper concentration in runoff water and its bioavailable part undergo a significant and rapid reduction.

  • 16.
    Bertling, Sofia
    et al.
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Odnevall Wallinder, Inger
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Leygraf, Christofer
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Immobilization of copper in runoff water from roofing materials by limestone, soil and concrete2002Ingår i: 15th Internatioal Corrosion Conference: Granada, Spain, 2002Konferensbidrag (Refereegranskat)
  • 17.
    Bertling, Sofia
    et al.
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Odnevall Wallinder, Inger
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Leygraf, Christofer
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    The capacity of limestone to immobilize copper in runoff water: a laboratory investigation2002Ingår i: 15th International Corrosion Conference: Granada, Spain, 2002Konferensbidrag (Refereegranskat)
  • 18.
    Bertling, Sofia
    et al.
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Odnevall Wallinder, Inger
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Leygraf, Christofer
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Berggren, D.
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Environmental effects of zinc runoff from roofing materials: a new multidisciplinary approach2002Ingår i: Outdoor Atmospheric Corrosion / [ed] Townsend HE, 2002, Vol. 1421, s. 200-215Konferensbidrag (Refereegranskat)
    Abstract [en]

    The objective of this work is to study changes in concentration and bioavailability of zinc-containing runoff water, released from roofing materials, upon passage through soil. The experimental approach is based on simulating the interaction between zinc in artificial runoff water and soil in a column system.

    The total zinc concentration of runoff was substantially reduced when passing through the soil and suggests marked zinc retention, During a constant flow and supply of zinc into the soil, equivalent to three and a half years of precipitation in Stockholm, a zinc retention capacity of approximately 99% was recorded, Not only the total concentration, but also the bio-available portion of the total zinc concentration was reduced after passage through soil, Most of the retained zinc was located in top 3 cm of the soil core and suggests the total capacity for zinc retention of the investigated soil to be about 140 years per kilogram soil in an isolated system in real systems, changes of temperature, pH, microbial activity, weathering of minerals and deposition of new organic material must be considered.

    The results form part of the effect assessment, preceding future risk assessment of the environmental effects of dispersed zinc.

  • 19.
    Bertling, Sofia
    et al.
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Leygraf, Christofer
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Berggren, Kleja D.
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Occurrence and fate of corrosion-induced zinc in runoff water from external structures2006Ingår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 367, nr 2-3, s. 908-923Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This paper comprises data from an extensive cross-disciplinary research project aiming to elucidate the environmental fate of corrosion-induced zinc release from external structures. It includes an exposure assessment that provide long-term runoff rates, concentrations and chemical speciation of zinc, from 14 zinc-based materials exposed during 5 years in Stockholm, Sweden, and an effect assessment including bioavailability and ecotoxicity measurements, both at the immediate release situation and after soil interaction.Runoff rates of total zinc ranged from 0.07 to 2.5g Znm(-2) yr(-1) with zinc primarily released as the free ion for all materials investigated. The average effect concentration, causing a 50% growth reduction after 72h to the green algae Raphidocelis subcapitata, was at the immediate release situation 69 mu g ZnL-1. Upon interaction of runoff water with soil, which simulated 18 to 34years of exposure, the total zinc concentration was significantly reduced, from milligram per litre to microgram per litre levels. Simultaneously, the most bioavailable fraction of zinc in runoff, the hydrated zinc(II)-ion, decreased from more than 95% to about 30%. The major fraction, 98-99%, of the introduced total zinc concentration in the runoff water was retained within the soil. As long as the soil retention capacity was not reached, this resulted in zinc concentrations in the percolate water transported through the soil layer, close to background values and below growth inhibition concentrations for the green algae investigated. Zinc retained in soil was to a large extent (85-99.9%) extractable with EDTA, and available for plant uptake after 5 to 7months of ageing.

  • 20.
    Besharat, Zahra
    et al.
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Material- och nanofysik, Materialfysik, MF.
    Wakeham, Deborah
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Johnson, C. Magnus
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Göthelid, Mats
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Material- och nanofysik, Materialfysik, MF.
    Rutland, Mark W.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Mixed monolayers of alkane thiols with polar terminal group on gold: Investigation of structure dependent surface properties2016Ingår i: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 484, nr 279, s. 279-290, artikel-id j.jcis.2016.08.053Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Adsorption of thiols with cationic or anionic terminal group on gold has been studied from mixed solutions of 11-Amino-1-undecanethiol (AUT) and 3-Mercaptopropionic acid (MPA) using Quartz Crystal Microbalance with Dissipation (QCM-D), X-ray Photoelectron Spectroscopy (XPS), atomic force microscopy (AFM) and contact angles. The goal is to probe the nature of such layers, and the additivity or otherwise of the pH responsiveness, with a view to evaluate their suitability as smart materials. For each of the two pure (unmixed) cases, ordered molecular monolayers are formed with sulfur binding to gold and the alkane chain pointing out from the surface as expected. Adsorption from the thiol mixtures, however, leads to a more complex behaviour. The surface concentration of thiols from the mixtures, as determined by QCM-D, is considerably lower than for the pure cases and it reaches a minimum at a 3:1 MPA/AUT relative concentration in the solution. The XPS results confirm a reduction in adsorbed amount in mixtures with the lowest overall intensity for the 3:1 ratio. Monolayers formed from mixtures display a wettability which is much lower and less pH sensitive. Collectively these results confirm that for adsorption from mixed systems, the configuration is completely different. Complex formation in the mixed solutions leads to the adsorption of molecules parallel to the surface in an axially in-plane configuration. This parallel layer of thiols is mechanically relatively robust to nano-shaving based on AFM measurements. These results will have a significant impact on the design of biomimetic surface coatings particularly when mixtures of oppositely charged molecules are present on the surface, as is commonly the case in biological, proteinaceous surfaces (e.g. hair and skin).

  • 21.
    Blomberg, Eva
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Herting, Gunilla
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Kuttuva Rajarao, G
    Mehtiö, T
    Uusinoka, M
    Ahonen, M
    Mäkinen, R
    Mäkitalo, T
    Odnevall, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. AIMES—Center for the Advancement of Integrated Medical and Engineering Sciences; Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Weathering and Antimicrobial Properties of Laminate and Powder Coatings Containing Silver Phosphate Glass Used as High-Touch Surfaces2022Ingår i: Sustainability, E-ISSN 2071-1050, Vol. 14, nr 12, s. 7102-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Increasing the use of hygienic high-touch surfaces with antimicrobial properties in health care and public spaces is one way to hinder the spread of bacteria and infections. This study investigates the antimicrobial efficacy and surface reactivity of commercial laminate and powder coated surfaces treated with silver-doped phosphate glass as antimicrobial additive towards two model bacterial strains, Escherichia coli and Bacillus subtilis, in relation to surface weathering and repeated cleaning. High-touch conditions in indoor environments were simulated by different extents of pre-weathering (repeated daily cycles in relative humidity at constant temperature) and simplified fingerprint contact by depositing small droplets of artificial sweat. The results elucidate that the antimicrobial efficacy was highly bacteria dependent (Gram-positive or Gram-negative), not hampered by differences in surface weathering but influenced by the amount of silver-doped additive. No detectable amounts of silver were observed at the top surfaces, though silver was released into artificial sweat in concentrations a thousand times lower than regulatory threshold values stipulated for materials and polymers in food contact. Surface cleaning with an oxidizing chemical agent was more efficient in killing bacteria compared with an agent composed of biologically degradable constituents. Cleaning with the oxidizing agent resulted further in increased wettability and presence of residues on the surfaces, effects that were beneficial from an antimicrobial efficacy perspective.

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  • 22.
    Cappellini, Francesca
    et al.
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden..
    Di Bucchianico, Sebastiano
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.;Helmholtz Zentrum Munchen, Comprehens Mol Analyt, D-81379 Munich, Germany..
    Karri, Venkatanaidu
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden..
    Latvala, Siiri
    Stockholm Univ, Dept Environm Sci, S-11418 Stockholm, Sweden..
    Malmlof, Maria
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.;Inhalat Sci, Halsovagen 7-9, S-14157 Huddinge, Sweden..
    Kippler, Maria
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden..
    Elihn, Karine
    Stockholm Univ, Dept Environm Sci, S-11418 Stockholm, Sweden..
    Hedberg, Jonas
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Gerde, Per
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.;Inhalat Sci, Halsovagen 7-9, S-14157 Huddinge, Sweden..
    Karlsson, Hanna L.
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden..
    Dry Generation of CeO2 Nanoparticles and Deposition onto a Co-Culture of A549 and THP-1 Cells in Air-Liquid Interface-Dosimetry Considerations and Comparison to Submerged Exposure2020Ingår i: Nanomaterials, E-ISSN 2079-4991, Vol. 10, nr 4, artikel-id 618Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Relevant in vitro assays that can simulate exposure to nanoparticles (NPs) via inhalation are urgently needed. Presently, the most common method employed is to expose lung cells under submerged conditions, but the cellular responses to NPs under such conditions might differ from those observed at the more physiological air-liquid interface (ALI). The aim of this study was to investigate the cytotoxic and inflammatory potential of CeO2 NPs (NM-212) in a co-culture of A549 lung epithelial cells and differentiated THP-1 cells in both ALI and submerged conditions. Cellular dose was examined quantitatively using inductively coupled plasma mass spectrometry (ICP-MS). The role of serum and LPS-priming for IL-1 beta release was further tested in THP-1 cells in submerged exposure. An aerosol of CeO2 NPs was generated by using the PreciseInhale (R) system, and NPs were deposited on the co-culture using XposeALI (R). No or minor cytotoxicity and no increased release of inflammatory cytokines (IL-1 beta, IL-6, TNF alpha, MCP-1) were observed after exposure of the co-culture in ALI (max 5 mu g/cm(2)) or submerged (max 22 mu g/cm(2)) conditions. In contrast, CeO2 NPs cause clear IL-1 beta release in monocultures of macrophage-like THP-1, independent of the presence of serum and LPS-priming. This study demonstrates a useful approach for comparing effects at various in-vitro conditions.

  • 23.
    Cappellini, Francesca
    et al.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Hedberg, Yolanda
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    McCarrick, Sarah
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Hedberg, Jonas
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Derr, Remco
    Toxys, Leiden, Netherlands..
    Hendriks, Giel
    Toxys, Leiden, Netherlands..
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Karlsson, Hanna L.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides2018Ingår i: Nanotoxicology, ISSN 1743-5390, E-ISSN 1743-5404, Vol. 12, nr 6, s. 602-620Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An increasing use of cobalt (Co)-based nanoparticles (NPs) in different applications and exposures at occupational settings triggers the need for toxicity assessment. Improved understanding regarding the physiochemical characteristics of Co metal NPs and different oxides in combination with assessment of toxicity and mechanisms may facilitate decisions for grouping during risk assessment. The aim of this study was to gain mechanistic insights in the correlation between NP reactivity and toxicity of three different Co-based NPs (Co, CoO, and Co3O4) by using various tools for characterization, traditional toxicity assays, as well as six reporter cell lines (ToxTracker) for rapid detection of signaling pathways of relevance for carcinogenicity. The results showed cellular uptake of all NPs in lung cells and induction of DNA strand breaks and oxidative damage (comet assay) by Co and CoO NPs. In-depth studies on the ROS generation showed high reactivity of Co, lower for CoO, and no reactivity of Co3O4 NPs. The reactivity depended on the corrosion and transformation/dissolution properties of the particles and the media highlighting the role of the surface oxide and metal speciation as also confirmed by in silico modeling. By using ToxTracker, Co NPs were shown to be highly cytotoxic and induced reporters related to oxidative stress (Nrf2 signaling) and DNA strand breaks. Similar effects were observed for CoO NPs but at higher concentrations, whereas the Co3O4 NPs were inactive at all concentrations tested. In conclusion, our study suggests that Co and CoO NPs, but not Co3O4, may be grouped together for risk assessment.

  • 24.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. KKTH Royal Inst Technol, AIMES Ctr Adv Integrated Med & Engn Sci, Karolinska Inst, SE-17177 Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Babu, Prasath
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Zhao, Weijie
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Johnson, C. Magnus
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Hedström, Peter
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap, Strukturer.
    Odnevall, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. AIMES Ctr Adv Integrated Med & Engn Sci, Karolinska Inst, SE-17177 Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Leygraf, Christofer
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    High-Resolution Microscopical Studies of Contact Killing Mechanisms on Copper-Based Surfaces2021Ingår i: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 13, nr 41, s. 49402-49413Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The mechanisms of bacterial contact killing induced by Cu surfaces were explored through high-resolution studies based on combinations of the focused ion beam (FIB), scanning transmission electron microscopy (STEM), high-resolution TEM, and nanoscale Fourier transform infrared spectroscopy (nano-FTIR) microscopy of individual bacterial cells of Gram-positive Bacillus subtilis in direct contact with Cu metal and Cu5Zn5Al1Sn surfaces after high-touch corrosion conditions. This approach permitted subcellular information to be extracted from the bioinorganic interface between a single bacterium and Cu/Cu5Zn5Al1Sn surfaces after complete contact killing. Early stages of interaction between individual bacteria and the metal/alloy surfaces include cell leakage of extracellular polymeric substances (EPSs) from the bacterium and changes in the metal/alloy surface composition upon adherence of bacteria. Three key observations responsible for Cu-induced contact killing include cell membrane damage, formation of nanosized copper-containing particles within the bacteria cell, and intracellular copper redox reactions. Direct evidence of cell membrane damage was observed upon contact with both Cu metal and Cu5Zn5Al1Sn surfaces. Cell membrane damage permits copper to enter into the cell interior through two possible routes, as small fragmentized Cu2O particles from the corrosion product layer and/or as released copper ions. This results in the presence of intracellular copper oxide nanoparticles inside the cell. The nanosized particles consist primarily of CuO with smaller amounts of Cu2O. The existence of two oxidation states of copper suggests that intracellular redox reactions play an important role. The nanoparticle formation can be regarded as a detoxification process of copper, which immobilizes copper ions via transformation processes within the bacteria into poorly soluble or even insoluble nanosized Cu structures. Similarly, the formation of primarily Cu(II) oxide nanoparticles could be a possible way for the bacteria to deactivate the toxic effects induced by copper ions via conversion of Cu(I) to Cu(II).

  • 25.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. AIMES - Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet and KTH Royal Institute of Technology, Stockholm, Sweden; Department of Neuroscience, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
    Butina, Karen
    Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Herting, Gunilla
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Rajarao, Gunaratna Kuttuva
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Industriell bioteknologi.
    Richter-Dahlfors, Agneta
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi. Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden; Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden.
    Blomberg, Eva
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden..
    Leygraf, Christofer
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    The interplay between atmospheric corrosion and antimicrobial efficiency of Cu and Cu5Zn5Al1Sn during simulated high-touch conditions2021Ingår i: Corrosion Science, ISSN 0010-938X, E-ISSN 1879-0496, Vol. 185, artikel-id 109433Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The interplay between atmospheric corrosion and antimicrobial efficiency of bare Cu and Cu5Zn5Al1Sn was studied upon exposures simulating high-touch surface conditions. The survival of the bacteria Bacillus subtilis during surface contact with Cu and Cu5Zn5Al1Sn was examined under different degrees of surface oxidation, tarnishing, wettability and copper ion release. Depending on surface conditions complete bacteria inhibition was obtained within 4 min on Cu and within 6-10 min on Cu5Zn5Al1Sn. The antibacterial efficiency increases slightly with copper release rate and is governed by complex interactions between the corroded metal surface, bacteria and extracellular polymeric substances produced by the bacteria.

  • 26.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Herting, Gunilla
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Goidanich, S.
    Sánchez Amaya, J. M.
    Arenas, M. A.
    Le Bozec, N.
    Jin, Y.
    Leygraf, Christopher
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    The role of Sn on the long-term atmospheric corrosion of binary Cu-Sn bronze alloys in architecture2019Ingår i: Corrosion Science, ISSN 0010-938X, E-ISSN 1879-0496, Vol. 149, s. 54-67Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The role of Sn on the atmospheric corrosion performance of binary Cu-Sn bronze alloys (4–6 wt.% Sn) compared with Cu metal used in outdoor architecture is elucidated in terms of microstructure, native surface oxide composition, patina evolution, corrosion rates, appearance and metal release. Results are presented for non-exposed surfaces and surfaces exposed at different urban and marine sites in Europe up to 5 years and based on multi-analytical findings from microscopic, spectroscopic, electrochemical and chemical investigations. Alloying influenced the corrosion, aesthetic appearance and patina evolution, differently for urban and marine sites, whereas no effects were observed on the release pattern.

  • 27.
    Chang, Tingru
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap. Univ Sci & Technol Beijing, Natl Ctr Mat Serv Safety, Beijing 100083, Peoples R China.
    Herting, Gunilla
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Jin, Ying
    Univ Sci & Technol Beijing, Natl Ctr Mat Serv Safety, Beijing 100083, Peoples R China..
    Leygraf, Christofer
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    The golden alloy Cu5Zn5Al1Sn: Patina evolution in chloride-containing atmospheres2018Ingår i: Corrosion Science, ISSN 0010-938X, E-ISSN 1879-0496, Vol. 133, s. 190-203Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The influence of chloride deposition on the formation, evolution and barrier properties of the patina formed on CuSZn5Al1Sn used for architectural cladding is explored via long-term marine field exposures and laboratory investigations. The presence of Cu2O, ZnO, Al2O3 and SnO2 within the inner part of the patina and intercalation of SnO2, Zn-5(CO3)(2)(OH)(6), Zn6Al2(OH)(16)CO3 center dot 4H(2)O, Zn-5(OH)(8)Cl-2 center dot H2O within its outer part, predominantly composed of Cu-2(OH)(3)Cl, significantly reduce the chloride-induced corrosion compared with Cu metal. The intercalation of zinc-rich corrosion products within the patina and not at the top-surface explain their marginal influence on the runoff process that mainly occurs at the outmost surface.

  • 28.
    Chang, Tingru
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap. Univ Sci & Technol Beijing, Peoples R China.
    Jin, Ying
    Wen, Lei
    Zhang, Chensheng
    Leygraf, Christofer
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Zhang, Junping
    Synergistic effects of gelatin and convection on copper foil electrodeposition2016Ingår i: Electrochimica Acta, ISSN 0013-4686, E-ISSN 1873-3859, Vol. 211, s. 245-254Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Copper foil electrodeposition has been explored using a pure titanium rotating disk electrode (RDE) in acidic electrolytes containing gelatin and/or chloride ions under different convection conditions. In the plating bath without gelatin, the results indicate that stronger convection promotes hydrogen evolution, which reduces the current efficiency during copper plating. Gelatin restrains the growth of copper grains in the lateral direction parallel to the surface. This results in grain refinement on the shiny side, an increase in local grain misorientation and in internal stresses on both the shiny and the matte side, and a reduction in their internal stress difference. At strong convection conditions and with gelatin present, copper deposits as strip-like grains along the centrifugal direction of the cross section, and finally forms a spiral-shaped pattern on the matte side. The causes of these features are discussed in detail. The combined influences of hydrogen and gelatin adsorption are further elaborated in a model for a copper deposition. The current investigation suggests that a moderate convection (somewhat lower than 1000 rpm) and a concentration of 2 ppm gelatin in the plating bath are sufficient for copper foil fabrication in the presence of chloride ions (20 ppm).

  • 29.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Khort, Aliaksandr
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Saeed, Anher
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Blomberg, Eva
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Nielsen, Maria Bille
    Hansen, Steffen Foss
    Odnevall, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. AIMES - Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska, Institutet and KTH Royal Institute of Technology, Stockholm, Sweden; Karolinska Institutet, Department of Neuroscience, SE-171 77 Stockholm, Sweden.
    Effects of interactions between natural organic matter and aquatic organism degradation products on the transformation and dissolution of cobalt and nickel-based nanoparticles in synthetic freshwater2023Ingår i: Journal of Hazardous Materials, ISSN 0304-3894, E-ISSN 1873-3336, Vol. 445, s. 130586-130586, artikel-id 130586Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Expanding applications and production of engineered nanoparticles lead to an increased risk for their environmental dispersion. Systematic knowledge of surface transformation and dissolution of nanoparticles is essential for risk assessment and regulation establishment. Such aspects of Co- and Ni-based nanoparticles including metals, oxides, and solution combustion synthesized metal nanoparticles (metal cores with carbon shells) were investigated upon environmental interaction with organic matter, simulated by natural organic matter (NOM) and degradation products from zooplankton and algae (eco-corona biomolecules, EC) in freshwater (FW). The presence of NOM and EC in FW results in negative surface charges of the nanoparticles reduces the extent of nanoparticles agglomeration, and increases concentration, mainly due to the surface adsorption of carboxylate groups of the organic matter. The dissolution of the Co-based nanoparticles was for all conditions (FW, FW with NOM or EC) higher than the Ni-based, except for Co3O4 being nearly non-soluble. The surface transformation and dissolution of nanoparticles are highly exposure and time-dependent, and surface- and environment specific. Therefore, no general correlation was observed between dissolution and, particle types, surface conditions, or EC/NOM adsorption. This underlines the importance of thorough investigations of nanoparticles adsorption/desorption, degradation, and exposure scenarios for developing regulatory relevant protocols and guidelines.

  • 30.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. KTH, Centra, Center for the Advancement of Integrated Medical and Engineering Sciences, AIMES. Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Leygraf, Christopher
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Herting, Gunilla
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Fan, Yanmiao
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Ytbehandlingsteknik.
    Babu, Prasath
    KTH, Skolan för industriell teknik och management (ITM), Materialvetenskap.
    Malkoch, Michael
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Ytbehandlingsteknik.
    Blomberg, Eva
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Ytbehandlingsteknik. KTH, Centra, Center for the Advancement of Integrated Medical and Engineering Sciences, AIMES. Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Effect of blue light illumination on atmospheric corrosion and bacterial adhesion on copper2024Ingår i: Corrosion Science, ISSN 0010-938X, E-ISSN 1879-0496, Vol. 230, artikel-id 111909Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The effect of blue light on atmospheric corrosion of Cu and on the antimicrobial properties was explored upon exposure mimicking the condition of hygienic surface disinfection. The results show that blue light illumination enhanced the formation of Cu2O, resulting in a slightly increased corrosion resistance of Cu without pre-deposited NaCl, whereas the enhanced formation of Cu2O, CuCl and/or Cu(OH)3Cl on copper with pre-deposited NaCl caused concomitant corrosion product flaking and a reduced corrosion resistance. The blue light induced enhancement of Cu corrosion led to increased surface roughness and more pronounced integration of bacteria within the corrosion products.

  • 31.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Leygraf, Christopher
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Jin, Ying
    Univ Sci & Technol Beijing, Natl Ctr Mat Serv Safety, Beijing 100083, Peoples R China..
    Understanding the Barrier Layer Formed via Adding BTAH in Copper Film Electrodeposition2019Ingår i: Journal of the Electrochemical Society, ISSN 0013-4651, E-ISSN 1945-7111, Vol. 166, nr 2, s. D10-D20Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The influence of surface adsorption of benzotriazole (BTAH) and of chloride ions (Cl-) on the kinetics of copper electrodeposition/dissolution in copper sulfate solutions and on copper deposit characteristics have been investigated using electrochemical quartz crystal microbalance (EQCM) combined with cyclic voltammetry (CV). The addition of BTAH alone increases the overpotential of copper deposition, whereas a Cu(I)BTA complex forms at potentials higher than 0.08 V (vs. SCE) accompanied with the occurrence of copper anodic dissolution. With simultaneous addition of BTAH and Cl-, surface adsorption of Cl- competes with that of BTAH during the initial stage of copper nucleation. Different cuprous reaction intermediates form in the examined potential range -0.4 to 0.3 V (vs. SCE), which partly eliminate the favorable effect of BTAH on the deposited copper. A BTAH-containing adsorbed layer formed on the matte side of electrodeposited copper film in the presence of BTAH with or without Cl-, exhibiting a barrier surface property and an improved corrosion resistance compared with the copper film electrodeposited in the electrolyte without addition of BTAH.

  • 32.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Maltseva, Alina
    PSL Univ, Chim ParisTech, CNRS, IRCP, F-75005 Paris, France..
    Volovitch, Polina
    PSL Univ, Chim ParisTech, CNRS, IRCP, F-75005 Paris, France..
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Leygraf, Christopher
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    A mechanistic study of stratified patina evolution on Sn-bronze in chloride-rich atmospheres2020Ingår i: Corrosion Science, ISSN 0010-938X, E-ISSN 1879-0496, Vol. 166, artikel-id 108477Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The complex stratified patina formed on Sn-bronze in chloride-rich atmospheres has been explored through long-term field exposures and short-term laboratory investigations using a multi-analytical approach. The stratified patina is composed of Cu2O- and Cu-2(OH)(3)Cl-rich sublayers intercalated by Sn-oxides, mainly SnO2. The stratification is triggered by events of high chloride deposition, resulting in repeated dissolution and solidification of sublayers, whereby redox reactions between the intermediate products of Sn- and Cu-chlorides play a crucial role. Sn-induced patina stratification is a major reason for enhanced patina flaking on Sn-bronze and its accelerated corrosion rate compared to Cu metal in marine environments.

  • 33.
    Chang, Tingru
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    de la Fuente, D.
    Chico, B.
    Morcillo, M.
    Welter, J. -M
    Leygraf, Christopher
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Analysis of historic copper patinas. Influence of inclusions on patina uniformity2017Ingår i: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 10, nr 3, artikel-id 298Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The morphology and elemental composition of cross sections of eight historic copper materials have been explored. The materials were taken from copper roofs installed in different middle and northern European environments from the 16th to the 19th century. All copper substrates contain inclusions of varying size, number and composition, reflecting different copper ores and production methods. The largest inclusions have a size of up to 40 μm, with most inclusions in the size ranging between 2 and 10 μm. The most common element in the inclusions is O, followed by Pb, Sb and As. Minor elements include Ni, Sn and Fe. All historic patinas exhibit quite fragmentized bilayer structures, with a thin inner layer of cuprite (Cu2O) and a thicker outer one consisting mainly of brochantite (Cu4SO4(OH)6). The extent of patina fragmentation seems to depend on the size of the inclusions, rather than on their number and elemental composition. The larger inclusions are electrochemically nobler than the surrounding copper matrix. This creates micro-galvanic effects resulting both in a profound influence on the homogeneity and morphology of historic copper patinas and in a significantly increased ratio of the thicknesses of the brochantite and cuprite layers. The results suggest that copper patinas formed during different centuries exhibit variations in uniformity and corrosion protection ability.

  • 34.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, Stockholm, Sweden..
    Sepati, M.
    Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, Milan, Italy..
    Herting, Gunilla
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Leygraf, Christopher
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Rajarao, Gunaratna Kuttuva
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Industriell bioteknologi.
    Butina, K.
    Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, Stockholm, Sweden..
    Richter-Dahlfors, Agneta
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi. Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, Stockholm, Sweden..
    Blomberg, Eva
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, AIMES Ctr Adv Integrated Med & Engn Sci, Stockholm, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, Stockholm, Sweden..
    A novel methodology to study antimicrobial properties of high-touch surfaces used for indoor hygiene applications-A study on Cu metal2021Ingår i: PLOS ONE, E-ISSN 1932-6203, Vol. 16, nr 2, artikel-id e0247081Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Metal-based high-touch surfaces used for indoor applications such as doorknobs, light switches, handles and desks need to remain their antimicrobial properties even when tarnished or degraded. A novel laboratory methodology of relevance for indoor atmospheric conditions and fingerprint contact has therefore been elaborated for combined studies of both tarnishing/corrosion and antimicrobial properties of such high-touch surfaces. Cu metal was used as a benchmark material. The protocol includes pre-tarnishing/corrosion of the high touch surface for different time periods in a climatic chamber at repeated dry/wet conditions and artificial sweat deposition followed by the introduction of bacteria onto the surfaces via artificial sweat droplets. This methodology provides a more realistic and reproducible approach compared with other reported procedures to determine the antimicrobial efficiency of high-touch surfaces. It provides further a possibility to link the antimicrobial characteristics to physical and chemical properties such as surface composition, chemical reactivity, tarnishing/corrosion, surface roughness and surface wettability. The results elucidate that bacteria interactions as well as differences in extent of tarnishing can alter the physical properties (e.g. surface wettability, surface roughness) as well as the extent of metal release. The results clearly elucidate the importance to consider changes in chemical and physical properties of indoor hygiene surfaces when assessing their antimicrobial properties.

  • 35.
    Chang, Tingru
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. University of Science and Technology Beijing, China.
    Wallinder, Inger Odnevall
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Jin, Ying
    Leygraf, Christofer
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    The golden alloy Cu-5Zn-5Al-1Sn: A multi-analytical surface characterization2018Ingår i: Corrosion Science, ISSN 0010-938X, E-ISSN 1879-0496, Vol. 131, s. 94-103Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The golden alloy Cu-5Zn-5Al-1Sn has found many applications because of its appearance and resistance to tarnishing. The microstructure and multi-component surface oxide of Cu-5Zn-5Al-1Sn have been investigated through a multi-analytical approach. Compared to commercial Cu metal, Cu-5Zn-5Al-1Sn has significantly smaller grains and higher fraction of coherent twin boundaries. The 5-10 nm thick oxide formed after diamond polishing has four identified sub-oxides all contributing to the overall corrosion resistance. Cu2O is mainly located in the outer part, followed by ZnO, SnO2 and Al2O3 closer to the alloy substrate. The latter three possess barrier properties, while Cu2O exhibits a more complex structure.

  • 36. Chico, B.
    et al.
    Fuente, D. D. L.
    Jiménez, J. A.
    Chang, Tingru
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Leygraf, Christopher
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Morcillo, M.
    Analysis of historic copper patinas 2: Characterization of 400 year old patina from Royal Summer Palace in Prague2017Ingår i: EUROCORR 2017 - The Annual Congress of the European Federation of Corrosion, 20th International Corrosion Congress and Process Safety Congress 2017, Asociace koroznich inzenyru z.s.- AKI - Czech Association of Corrosion Engineers , 2017Konferensbidrag (Refereegranskat)
    Abstract [en]

    This paper presents an in-depth characterisation study of the patina formed on a copper tile taken from the roof of Queen Anne's Summer Palace in Prague after close to 400 years of exposure to the action of the atmosphere. A wide variety of techniques have been performed, including metallographic and chemical analysis (electrogravimetry, AAS, XRF) of the copper matrix, and spectroscopic and microscopic investigations (GIXRD, TEM/EDS and SEM/EDS) to determine the composition and structure of the patina. The major conclusions of the study are: (a) the base copper contains abundant inclusions mainly of rosiaite (PbSb2O6); (b) the patina is formed by an inner sublayer of cuprite (Cu2O) and an outer sublayer of brochantite [Cu4SO4(OH)6] and antlerite [Cu3SO4(OH)4] and traces of azurite [Cu3(CO3)2(OH)2]; and (c) the brochantite/antlerite crystals are randomly doped with Fe and C.

  • 37. Cronholm, Pontus
    et al.
    Karlsson, Hanna L.
    Hedberg, Jonas
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Lowe, Troy A.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Winnberg, Lina
    Elihn, Karine
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Möller, Lennart
    Intracellular Uptake and Toxicity of Ag and CuO Nanoparticles: A Comparison Between Nanoparticles and their Corresponding Metal Ions2013Ingår i: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 9, nr 7, s. 970-982Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An increased understanding of nanoparticle toxicity and its impact on human health is essential to enable a safe use of nanoparticles in our society. The aim of this study is to investigate the role of a Trojan horse type mechanism for the toxicity of Ag-nano and CuO-nano particles and their corresponding metal ionic species (using CuCl2 and AgNO3), i.e., the importance of the solid particle to mediate cellular uptake and subsequent release of toxic species inside the cell. The human lung cell lines A549 and BEAS-2B are used and cell death/membrane integrity and DNA damage are investigated by means of trypan blue staining and the comet assay, respectively. Chemical analysis of the cellular dose of copper and silver is performed using atomic absorption spectroscopy. Furthermore, transmission electron microscopy, laser scanning confocal microscopy, and confocal Raman microscopy are employed to study cellular uptake and particle-cell interactions. The results confirm a high uptake of CuO-nano and Ag-nano compared to no, or low, uptake of the soluble salts. CuO-nano induces both cell death and DNA damage whereas CuCl2 induces no toxicity. The opposite is observed for silver, where Ag-nano does not cause any toxicity, whereas AgNO3 induces a high level of cell death. In conclusion: CuO-nano toxicity is predominantly mediated by intracellular uptake and subsequent release of copper ions, whereas no toxicity is observed for Ag-nano due to low release of silver ions within short time periods.

  • 38.
    Cronholm, Pontus
    et al.
    Karolinska Inst, Stockholm, Sweden.
    Karlsson, Hanna L.
    Karolinska Inst, Stockholm, Sweden.
    Hedberg, Jonas
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Lowe, Troy
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Elihn, Karine
    Stockholm Univ, Stockholm, Sweden .
    Wallinder, Inger Odnevall
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Möller, Lennart
    Karolinska Inst, Stockholm, Sweden.
    A Trojan Horse type mechanism: Cellular dose and toxicity of Ag and CuO nanoparticles2012Ingår i: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 211, s. S201-S201Artikel i tidskrift (Övrigt vetenskapligt)
  • 39. Cronholm, Pontus
    et al.
    Midander, Klara
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Karlsson, Hanna L.
    Elihn, Karine
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Möller, Lennart
    Effect of sonication and serum proteins on copper release from copper nanoparticles and the toxicity towards lung epithelial cells2011Ingår i: Nanotoxicology, ISSN 1743-5390, Vol. 5, nr 2, s. 269-281Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Different methodological settings can influence particle characteristics and toxicity in nanotoxicology. The aim of this study was to investigate how serum proteins and sonication of Cu nanoparticle suspensions influence the properties of the nanoparticles and toxicological responses on human lung epithelial cells. This was investigated by using methods for particle characterization (photon correlation spectroscopy and TEM) and Cu release (atomic absorption spectroscopy) in combination with assays for analyzing cell toxicity (MTT-, trypan blue- and Comet assay). The results showed that sonication of Cu nanoparticles caused decreased cell viability and increased Cu release compared to non-sonicated particles. Furthermore, serum in the cell medium resulted in less particle agglomeration and increased Cu release compared with medium without serum, but no clear difference in toxicity was detected. Few cells showed intracellular Cu nanoparticles due to fast release/dissolution processes of Cu. In conclusion; sonication can affect the toxicity of nanoparticles.

  • 40.
    Di Bucchianico, Sebastiano
    et al.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Gliga, Anda R.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Åkerlund, Emma
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Skoglund, Sara
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Fadeel, Bengt
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Karlsson, Hanna L.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells2018Ingår i: Particle and Fibre Toxicology, E-ISSN 1743-8977, Vol. 15, artikel-id 32Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Genotoxicity is an important toxicological endpoint due to the link to diseases such as cancer. Therefore, an increased understanding regarding genotoxicity and underlying mechanisms is needed for assessing the risk with exposure to nanoparticles (NPs). The aim of this study was to perform an in-depth investigation regarding the genotoxicity of well-characterized Ni and NiO NPs in human bronchial epithelial BEAS-2B cells and to discern possible mechanisms. Comparisons were made with NiCl2 in order to elucidate effects of ionic Ni. Methods: BEAS-2B cells were exposed to Ni and NiO NPs, as well as NiCl2, and uptake and cellular dose were investigated by transmission electron microscopy (TEM) and inductively coupled plasma mass spectrometry (ICP-MS). The NPs were characterized in terms of surface composition (X-ray photoelectron spectroscopy), agglomeration (photon cross correlation spectroscopy) and nickel release in cell medium (ICP-MS). Cell death (necrosis/apoptosis) was investigated by Annexin VFITC/PI staining and genotoxicity by cytokinesis-block micronucleus (cytome) assay (OECD 487), chromosomal aberration (OECD 473) and comet assay. The involvement of intracellular reactive oxygen species (ROS) and calcium was explored using the fluorescent probes, DCFH-DA and Fluo-4. Results: NPs were efficiently taken up by the BEAS-2B cells. In contrast, no or minor uptake was observed for ionic Ni from NiCl2. Despite differences in uptake, all exposures (NiO, Ni NPs and NiCl2) caused chromosomal damage. Furthermore, NiO NPs were most potent in causing DNA strand breaks and generating intracellular ROS. An increase in intracellular calcium was observed and modulation of intracellular calcium by using inhibitors and chelators clearly prevented the chromosomal damage. Chelation of iron also protected against induced damage, particularly for NiO and NiCl2. Conclusions: This study has revealed chromosomal damage by Ni and NiO NPs as well as Ni ionic species and provides novel evidence for a calcium-dependent mechanism of cyto- and genotoxicity.

  • 41.
    Ekvall, Mikael T.
    et al.
    Lund Univ, Dept Biol, Aquat Ecol, Ecol Bldg, S-22362 Lund, Sweden.;Lund Univ, Ctr Mol Prot Sci, Dept Biochem & Struct Biol, POB 124, S-22100 Lund, Sweden.;Lund Univ, NanoLund, POB 118, S-22100 Lund, Sweden..
    Hedberg, Jonas
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Univ Western Ontario, Surface Sci Western, 999 Collip Circle, London, ON N6G 0J3, Canada..
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Malmendal, Anders
    Lund Univ, Ctr Mol Prot Sci, Dept Biochem & Struct Biol, POB 124, S-22100 Lund, Sweden.;Lund Univ, NanoLund, POB 118, S-22100 Lund, Sweden.;Roskilde Univ, Dept Sci & Environm, POB 260, DK-4000 Roskilde, Denmark..
    Hansson, Lars-Anders
    Lund Univ, Dept Biol, Aquat Ecol, Ecol Bldg, S-22362 Lund, Sweden.;Lund Univ, NanoLund, POB 118, S-22100 Lund, Sweden..
    Cedervall, Tommy
    Lund Univ, Ctr Mol Prot Sci, Dept Biochem & Struct Biol, POB 124, S-22100 Lund, Sweden.;Lund Univ, NanoLund, POB 118, S-22100 Lund, Sweden..
    Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna2021Ingår i: Scientific Reports, E-ISSN 2045-2322, Vol. 11, nr 1, artikel-id 10784Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP's) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC-Co) and cobalt (Co) on the crustacean Daphnia magna is postponed in the presence of natural biological degradation products (eco-corona biomolecules). For Daphnia exposed to WC-Co NPs the survival time increased with 20-25% and for Co NPs with 30-47% after mixing the particles with a solution of eco-corona biomolecules before exposure. This suggests that an eco-corona, composed of biomolecules always present in natural ecosystems, reduces the toxic potency of both studied NPs. Further, the eco-coronas did not affect the particle uptake, suggesting that the reduction in toxicity was related to the particle-organism interaction after eco-corona formation. In a broader context, this implies that although the increasing use and production of NPs may constitute a novel, global environmental threat, the acute toxicity and long-term effects of some NPs will, at least under certain conditions, be reduced as they enter natural ecosystems.

  • 42. Ekvall, Mikael T.
    et al.
    Hedberg, Jonas
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Wallinder, Inger Odnevall
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Hansson, Lars-Anders
    Cedervall, Tommy
    Long-term effects of tungsten carbide (WC) nanoparticles in pelagic and benthic aquatic ecosystems2018Ingår i: Nanotoxicology, ISSN 1743-5390, E-ISSN 1743-5404, Vol. 12, nr 1, s. 79-89Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    As the production and usage of nanomaterials are increasing so are the concerns related to the release of the material into nature. Tungsten carbide (WC) is widely used for its hard metal properties, although its use, in for instance tyre studs, may result in nano-sized particles ending up in nature. Here, we evaluate the potential long-term exposure effects of WC nanoparticles on a pelagic (Daphnia magna) and a benthic (Asellus aquaticus) organism. No long-term effects were observed in the benthic system with respect to population dynamics or ecosystem services. However, long-term exposure of D. magna resulted in increased time to first reproduction and, if the particles were resuspended, strong effects on survival and reproductive output. Hence, the considerable differences in acute vs. long-term exposure studies revealed here emphasize the need for more long-term studies if we are to understand the effects of nanoparticles in natural systems.

  • 43. Elihn, Karine
    et al.
    Cronholm, Pontus
    Karlsson, Hanna L.
    Midander, Klara
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Möller, Lennart
    Cellular Dose of Partly Soluble Cu Particle Aerosols at the Air-Liquid Interface Using an In Vitro Lung Cell Exposure System2013Ingår i: Journal of Aerosol Medicine, ISSN 1941-2711, E-ISSN 1941-2703, Vol. 26, nr 2, s. 84-93Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: There is currently a need to develop and test in vitro systems for predicting the toxicity of nanoparticles. One challenge is to determine the actual cellular dose of nanoparticles after exposure. Methods: In this study, human epithelial lung cells (A549) were exposed to airborne Cu particles at the air-liquid interface (ALI). The cellular dose was determined for two different particle sizes at different deposition conditions, including constant and pulsed Cu aerosol flow. Results: Airborne polydisperse particles with a geometric mean diameter (GMD) of 180nm [geometric standard deviation (GSD) 1.5, concentration 10(5) particles/mL] deposited at the ALI yielded a cellular dose of 0.4-2.6 mu g/cm(2) at pulsed flow and 1.6-7.6 mu g/cm(2) at constant flow. Smaller polydisperse particles in the nanoregime (GMD 80 nm, GSD 1.5, concentration 10(7) particles/mL) resulted in a lower cellular dose of 0.01-0.05 mu g/cm(2) at pulsed flow, whereas no deposition was observed at constant flow. Exposure experiments with and without cells showed that the Cu particles were partly dissolved upon deposition on cells and in contact with medium. Conclusions: Different cellular doses were obtained for the different Cu particle sizes (generated with different methods). Furthermore, the cellular doses were affected by the flow conditions in the cell exposure system and the solubility of Cu. The cellular doses of Cu presented here are the amount of Cu that remained on the cells after completion of an experiment. As Cu particles were partly dissolved, Cu (a nonnegligible contribution) was, in addition, present and analyzed in the nourishing medium present beneath the cells. This study presents cellular doses induced by Cu particles and demonstrates difficulties with deposition of nanoparticles at the ALI and of partially soluble particles.

  • 44. Eriksson, P.
    et al.
    Carlsson, B.
    Odnevall Wallinder, Inger
    KTH, Tidigare Institutioner (före 2005), Materialvetenskap.
    Design of accelerated corrosion tests for electronic components in automotive applications2001Ingår i: IEEE transactions on components and packaging technologies (Print), ISSN 1521-3331, E-ISSN 1557-9972, Vol. 24, nr 1, s. 99-107Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Two new accelerated laboratory corrosion tests for electronic components in automotive applications have been developed, based on the use of metallic copper as a meter for corrosivity. The accelerated tests are designed so that they reproduce the same kind of corrosion effects as observed with exposure of copper in real vehicle environments. The test cycle that best simulates the corrosion characteristics of an engine compartment is composed of the following steps: a) exposure to neutral salt spray for 2 h; b) drying at 23 degreesC and 50% RH for 22 h; c) exposure to a test atmosphere of 1.5 ppm NO2 and 0.5 ppm SO2 at 25 degreesC and 95% RH for five days; d) drying at 23 degreesC and 50% RH for one day. The predominating corrosion products of copper, formed both during service exposure and in the accelerated test, are Cu2O and Cu2Cl(OH)(3), with a small amount of sulphur-containing corrosion products in the form of sulphates, In terms of corrosivity of copper, a test duration of six weeks corresponds to 7.5 years of exposure in the reference engine compartment selected for this study. The test cycle designed for the passenger compartment contains the steps: a) exposure for five days to a test atmosphere of 10 ppm NO2 and 95% RH at 35 degreesC, followed by b) drying at 23 degreesC and 50% RH for two days. In this case, Cu2O is the predominating corrosion product. Zn terms of corrosivity of copper, a test duration of four weeks corresponds to 7.5 years of exposure in the reference passenger compartment of this study.

  • 45. Ferraris, M.
    et al.
    Perero, S.
    Ferraris, S.
    Miola, M.
    Verne, E.
    Skoglund, Sara
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Blomberg, Eva
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap. SP Technical Research Institute of Sweden, Sweden.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Antibacterial silver nanocluster/silica composite coatings on stainless steel2017Ingår i: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 396, s. 1546-1555Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A coating made of silver nanocluster/silica composites has been deposited, Via a radio frequency (RF) co-sputtering technique, for the first time onto stainless steel (AISI 304L) with the aim to improve its antibacterial properties. Different thermal treatments after coating deposition have been applied in order to optimize the coating adhesion, cohesion and its antibacterial properties. Its applicability has been investigated at realistic conditions in a cheese production plant. The physico-chemical characteristics of the coatings have been analyzed by means of different bulk and surface analytical techniques. Field emission scanning electron microscopy (FESEM), X-ray Photoelectron Spectroscopy (XPS), contact angle measurements and atomic force microscopy (AFM) were employed to assess coating morphology, composition, surface roughness, wetting properties, size and local distribution of the nanoparticles within the coating. Tape tests were used to determine the adhesion/cohesion properties of the coating. The amount and time-dependence of released silver in solutions of acetic acid, artificial water, artificial tap water and artificial milk were determined by means of Atomic Absorption Spectroscopy (AAS). The antibacterial effect of the coating was evaluated at different experimental conditions using a standard bacterial strain of Staphylococcus aureus in compliance with National Committee for Clinical Laboratory Standards (NCCLS) and AATCC 147 standards. The Ahearn test was performed to measure the adhesion of bacteria to the coated stainless steel surface compared with a control surface. The antibacterial coating retained its antibacterial activity after thermal treatment up to 450 degrees C and after soaking in common cleaning products for stainless steel surfaces used for e.g. food applications. The antibacterial capacity of the coating remained at high levels for 1-5 days, and showed a good capacity to reduce the adhesion of bacteria up to 30 days. Only a few percent of silver in the coating was released into acetic acid, even after 10 days of exposure at 40 degrees C. Most silver (> 90%) remained also in the coating even after 240 h of continuous exposure. Similar observations were made after repeated exposure at 100 degrees C. Very low levels of released silver in solution were observed in artificial milk. No release of silver nanoparticles was observed either in synthetic tap water or in artificial milk at given conditions. The coating further displayed good antibacterial properties also when tested during working conditions in a cheese production plant.

  • 46.
    Ferraris, Sara
    et al.
    Politecnico di Torino.
    Perero, S.
    Politecnico di Torino.
    Miola, M.
    Politecnico di Torino.
    Vernè, E.
    Politecnico di Torino.
    Rosiello, A.
    Aero Sekur S.p.A.
    Ferrazzo, V.
    Aero Sekur S.p.A.
    Valletta, G.
    Aero Sekur S.p.A.
    Sanchez, Javier
    Bactiguard AB.
    Ohrlander, Mattias
    Bactiguard AB.
    Tjörnhammar, Staffan
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Laserfysik.
    Fokine, Michael
    Laurell, Fredrik
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Laserfysik.
    Blomberg, Eva
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap. SP Technical Research Institute of Sweden, Chemistry, Materials and Surfaces, Sweden.
    Skoglund, Sara
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Ferraris, M.
    Politecnico di Torino.
    Chemical, mechanical and antibacterial properties of silver nanocluster/silica composite coated textiles for safety systems and aerospace applications2014Ingår i: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 317, s. 131-139Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This work describes the chemical, mechanical and antibacterial properties of a novel silver nanocluster/silica composite coating, obtained by sputtering, on textiles for use in nuclear bacteriological and chemical (NBC) protection suites and for aerospace applications.

    The properties of the coated textiles were analyzed in terms of surface morphology, silver concentration and silver release in artificial sweat and synthetic tap water, respectively. No release of silver nanoparticles was observed at given conditions.

    The water repellency, permeability, flammability and mechanical resistance of the textiles before and after sputtering demonstrated that the textile properties were not negatively affected by the coating.

    The antibacterial effect was evaluated at different experimental conditions using a standard bacterial strain of Staphylococcus aureus and compared with the behavior of uncoated textiles.

    The coating process conferred all textiles a good antibacterial activity. Optimal deposition conditions were elaborated to obtain sufficient antibacterial action without altering the aesthetical appearance of the textiles.

    The antibacterial coating retained its antibacterial activity after one cycle in a washing machine only for the Nylon based textile.

  • 47.
    Gliga, Anda R.
    et al.
    Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, Div Mol Toxicol, Stockholm, Sweden..
    De Loma, Jessica
    Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden..
    Di Bucchianico, Sebastiano
    Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden..
    Skoglund, Sara
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Keshavan, Sandeep
    Karolinska Inst, Inst Environm Med, Div Mol Toxicol, Stockholm, Sweden..
    Odnevall Wallinder, Inger
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Karlsson, Hanna L.
    Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden..
    Fadeel, Bengt
    Karolinska Inst, Inst Environm Med, Div Mol Toxicol, Stockholm, Sweden..
    Silver nanoparticles modulate lipopolysaccharide-triggered Toll-like receptor signaling in immune-competent human cell lines2020Ingår i: Nanoscale Advances, E-ISSN 2516-0230, Vol. 2, nr 2, s. 648-658Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Silver (Ag) nanoparticles are commonly used in consumer products due to their antimicrobial properties. Here we studied the impact of Ag nanoparticles on immune responses by using cell lines of monocyte/macrophage and lung epithelial cell origin, respectively. Short-term experiments (24 h) showed that Ag nanoparticles reduced the lipopolysaccharide (LPS)-induced secretion of pro-inflammatory cytokines in THP-1 cells under serum-free conditions. ICP-MS analysis revealed that cellular uptake of Ag was higher under these conditions. Long-term exposure (up to 6 weeks) of BEAS-2B cells to Ag nanoparticles also suppressed pro-inflammatory cytokine production following a brief challenge with LPS. Experiments using reporter cells revealed that Ag nanoparticles as well as AgNO3 inhibited LPS-triggered Toll-like receptor (TLR) signaling. Furthermore, RNA-sequencing of BEAS-2B cells indicated that Ag nanoparticles affected TLR signaling pathways. In conclusion, Ag nanoparticles reduced the secretion of pro-inflammatory cytokines in response to LPS, likely as a result of the release of silver ions leading to an interference with TLR signaling. This could have implications for the use of Ag nanoparticles as antibacterial agents. Further in vivo studies are warranted to study this.

  • 48. Gliga, Anda R.
    et al.
    Skoglund, Sara
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Fadeel, Bengt
    Karlsson, Hanna L.
    Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release2014Ingår i: Particle and Fibre Toxicology, E-ISSN 1743-8977, Vol. 11, nr 1, s. 11-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Silver nanoparticles (AgNPs) are currently one of the most manufactured nanomaterials. A wide range of toxicity studies have been performed on various AgNPs, but these studies report a high variation in toxicity and often lack proper particle characterization. The aim of this study was to investigate size-and coating-dependent toxicity of thoroughly characterized AgNPs following exposure of human lung cells and to explore the mechanisms of toxicity. Methods: BEAS-2B cells were exposed to citrate coated AgNPs of different primary particle sizes (10, 40 and 75 nm) as well as to 10 nm PVP coated and 50 nm uncoated AgNPs. The particle agglomeration in cell medium was investigated by photon cross correlation spectroscopy (PCCS); cell viability by LDH and Alamar Blue assay; ROS induction by DCFH-DA assay; genotoxicity by alkaline comet assay and gamma H(2)AX foci formation; uptake and intracellular localization by transmission electron microscopy (TEM); and cellular dose as well as Ag release by atomic absorption spectroscopy (AAS). Results: The results showed cytotoxicity only of the 10 nm particles independent of surface coating. In contrast, all AgNPs tested caused an increase in overall DNA damage after 24 h assessed by the comet assay, suggesting independent mechanisms for cytotoxicity and DNA damage. However, there was no gamma H(2)AX foci formation and no increased production of intracellular reactive oxygen species (ROS). The reasons for the higher toxicity of the 10 nm particles were explored by investigating particle agglomeration in cell medium, cellular uptake, intracellular localization and Ag release. Despite different agglomeration patterns, there was no evident difference in the uptake or intracellular localization of the citrate and PVP coated AgNPs. However, the 10 nm particles released significantly more Ag compared with all other AgNPs (approx. 24 wt% vs. 4-7 wt%) following 24 h in cell medium. The released fraction in cell medium did not induce any cytotoxicity, thus implying that intracellular Ag release was responsible for the toxicity. Conclusions: This study shows that small AgNPs (10 nm) are cytotoxic for human lung cells and that the toxicity observed is associated with the rate of intracellular Ag release, a 'Trojan horse' effect.

  • 49. Goidanich, S.
    et al.
    Brunk, Jon
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Herting, Gunilla
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Arenas, M. A.
    Wallinder, Inger Odnevall
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Atmospheric corrosion of brass in outdoor applications Patina evolution, metal release and aesthetic appearance at urban exposure conditions2011Ingår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 412, s. 46-57Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Short (days, weeks) and long-term (months, years) non-sheltered field exposures of brass (15, and 20 wt.% Zn) and copper sheet have been conducted in three European cities (Milan, Stockholm, Madrid) to generate an in-depth time-dependent understanding of patina evolution, corrosion rates, aesthetic appearance, metal release and degree of dezincification in relation to detailed bulk and surface characteristics prior to exposure. This has been accomplished by using a multitude of surface and bulk analytical tools, chemical analysis and colorimetric investigations. Small differences in surface finish and local variations in nobility observed for the non-exposed brass alloys resulted in slight differences in corrosion initiation. Despite different kinetic behaviour and relative surface distributions of zinc- and copper-rich patina constituents, similar phases were identified with copper-rich phases rapidly dominating the outermost patina layer in Milan, compared to Madrid and Stockholm showing both copper- and zinc-rich phases. As a consequence of differences in surface coverage of copper- and zinc-rich corrosion products at the different sites, the release ratios of copper to zinc varied concordantly. The released amount of zinc to copper (Zn/Cu) was for both alloys and test sites always higher compared to the bulk composition showing a preferential release of zinc. The amount of released copper from the brass alloys was on an average 30-40% lower compared to copper sheet at all test sites investigated. Significantly lower annual total release rates of copper and zinc compared with annual corrosion rates were evident for both brass alloys at all sites.

  • 50. Goidanich, S.
    et al.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Korrosionslära.
    Arenas, M. A.
    De Damborenea, J.
    Ormellese, M.
    Sánchez Amaya, J. M.
    Botana, F. J.
    Le Bozec, N.
    Effect of the environment on the metal release and corrosion behaviour of different copper-based alloys: Field exposures at 5 different test sites in Europe2008Konferensbidrag (Refereegranskat)
    Abstract [en]

    Diffuse emissions and dispersion of metals from different sources in the society have lately received an increased concern from an environmental perspective. Large research efforts have been initiated and undertaken by the division of Corrosion Science at KTH to fill knowledge gaps on corrosion-induced metal release from external constructions and buildings. The generation of such data is of paramount importance for the on-going assessment of flows and potential adverse environmental effects caused by released metals. Generated information is also essential for an improved understanding of prevailing atmospheric corrosion processes of importance for the preservation of our cultural heritage, e.g. bronze statues exposed to the atmosphere. This paper summarizes and compares long-term metal release data from pure copper, bronze (6%wt Sn) and brass (20%wt Zn) exposed at unsheltered conditions in five European environments of significantly different climatic and pollutant conditions; three urban sites (Stockholm-Sweden, Milan-Italy and Madrid-Spain) and two marine sites (Brest-France, Cadiz-Spain). Generated data are interpreted with respect to parallel multi-analytical studies of changes in patina characteristics, corrosion rates and differences in prevailing environmental conditions.

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