Change search
Refine search result
1 - 23 of 23
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1. Andõn, F. T.
    et al.
    Kapralov, A. A.
    Yanamala, N.
    Feng, W.
    Baygan, Arjang
    Karolinska Institutet.
    Chambers, B. J.
    Hultenby, K.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Brandner, B. D.
    Fornara, Andrea
    Institute for Surface Chemistry, Stockholm.
    Klein-Seetharaman, J.
    Kotchey, G. P.
    Star, A.
    Shvedova, Anna A.
    West Virginia University, USA.
    Fadeel, B.
    Kagan, V. E.
    Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase2013In: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 9, no 16, p. 2721-2729Article in journal (Refereed)
    Abstract [en]

    Eosinophil peroxidase (EPO) is one of the major oxidant-producing enzymes during inflammatory states in the human lung. The degradation of single-walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O 2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H2O2 alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV-visible-NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials. Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant-generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.

  • 2. Barrefelt, Åsa
    et al.
    Saghafian, Maryam
    Kuiper, Raoul
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Egri, Gabriella
    Klickermann, Moritz
    Brismar, Torkel B.
    Aspelin, Peter
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Daehne, Lars
    Hassan, Moustapha
    Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat2013In: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 8, p. 3241-3254Article in journal (Refereed)
    Abstract [en]

    Background: In the present investigation, we studied the kinetics and biodistribution of a contrast agent consisting of poly(vinyl alcohol) (PVA) microbubbles containing superparamagnetic iron oxide (SPION) trapped between the PVA layers (SPION microbubbles). Methods: The biological fate of SPION microbubbles was determined in Sprague-Dawley rats after intravenous administration. Biodistribution and elimination of the microbubbles were studied in rats using magnetic resonance imaging for a period of 6 weeks. The rats were sacrificed and perfusion-fixated at different time points. The magnetic resonance imaging results obtained were compared with histopathologic findings in different organs. Results: SPION microbubbles could be detected in the liver using magnetic resonance imaging as early as 10 minutes post injection. The maximum signal was detected between 24 hours and one week post injection. Histopathology showed the presence of clustered SPION microbubbles predominantly in the lungs from the first time point investigated (10 minutes). The frequency of microbubbles declined in the pulmonary vasculature and increased in pulmonary, hepatic, and splenic macrophages over time, resulting in a relative shift from the lungs to the spleen and liver. Meanwhile, macrophages showed increasing signs of cytoplasmic iron accumulation, initially in the lungs, then followed by other organs. Conclusion: The present investigation highlights the biological behavior of SPION microbubbles, including organ distribution over time and indications for biodegradation. The present results are essential for developing SPION microbubbles as a potential contrast agent and/or a drug delivery vehicle for specific organs. Such a vehicle will facilitate the use of multimodality imaging techniques, including ultrasound, magnetic resonance imaging, and single positron emission computed tomography, and hence improve diagnostics, therapy, and the ability to monitor the efficacy of treatment.

  • 3.
    Dai, Jin
    et al.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics (Closed 20120101).
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics (Closed 20120101), Functional Materials, FNM (Closed 20120101).
    Chen, Yiting
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics (Closed 20120101).
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics (Closed 20120101), Functional Materials, FNM (Closed 20120101).
    Qiu, Min
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics (Closed 20120101).
    Yan, Min
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics (Closed 20120101).
    Light absorber based on nano-spheres on a substrate reflector2013In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 21, no 6, p. 6697-6706Article in journal (Refereed)
    Abstract [en]

    We systematically study a type of plasmonic light absorber based on a monolayer of gold nano-spheres with less than 30 nm in diameters deposited on top of a continuous gold substrate. The influences of particle size, inter-particle distance, particle-substrate spacer size etc on the resonance are studied thoroughly with a 3D finite-element method. We identified that the high-absorption resonance is mainly due to gap plasmon (coupled through particle bodies) when the separation between neighboring nano-spheres is small enough, such as close to 1 nm; at larger particle separations, the resonance is dominated by particle dipoles (coupled through the host dielectric). Experimentally, an absorber was fabricated based on chemically-synthesized gold nanoparticles coated with silica shell. The absorber shows a characteristic absorption band around 810 nm with a maximum absorbance of approximately 90%, which agrees reasonably well with our numerical calculation. The fabrication technique can be easily adapted for devising efficient light absorbers of large areas.

  • 4.
    Doddapaneni, Venkatesh
    et al.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Saleemi, Mohsin
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Gati, R.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    On the electrical arc interruption by using PMMA/iron oxide nanocomposites2016In: Materials Research Express, ISSN 2053-1591, Vol. 3, no 10, article id 105043Article in journal (Refereed)
    Abstract [en]

    An experimental study is undertaken on the fabrication of poly (methyl methacrylate) (PMMA)/iron oxide nanocomposites to determine their potential use for electrical arc interruption in the electrical switching applications such as circuit breakers. Monodisperse iron oxide nanoparticles of average size ¡«11 nmare synthesized via thermal decomposition method and then homogeneously dispersed in the PMMAmatrix by in situ polymerization.PMMA/iron oxide nanocomposites with different nanoparticle loading have been fabricated to study the effect of loading content on the thermal energy absorption. Detailed physicochemical characterizations on synthesized material are performed using X-ray powder diffraction, scanning electron microscopy, TEM, thermogravimetric analysis and differential scanning calorimetry at different processing stages. Atest-setup was designed to evaluate the quality of the nanocomposites for electric arc interruption capability. The results showed that PMMA/iron oxide nanocomposites have a clear impact on the electric arc interruption and therefore should be considered as promising candidates for electrical switching applications.

  • 5.
    Doddapaneni, Venkatesh
    et al.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Saleemi, Mohsin
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Gati, R.
    Toprak, Muhammet Sadaka
    KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
    Engineered PMMA-ZnO nanocomposites for improving the electric arc interruption capability in electrical switching applications: Unprecedented experimental insights2017In: Composites Science And Technology, ISSN 0266-3538, E-ISSN 1879-1050, Vol. 141, p. 113-119Article in journal (Refereed)
    Abstract [en]

    Polymer inorganic nanocomposites (PINCs) have been engineered for controlling the electrical arc and to improve the arc interruption capability of the electrical switching applications, like circuit breakers. Several PINCs are fabricated by formation of ZnO quantum dots (QDs) in a poly (methyl methacrylate) (PMMA) matrix via in-situ polymerization method to avoid agglomeration of QDs, leading to a good spatial distribution of QDs in the polymer matrix. These PINCs have been characterized in detail for the morphology of QDs, interaction between QDs and polymer matrix, and ultraviolet (UV) radiation absorption. ZnO QDs have been assessed to have particle diameter of 3.5 nm, and their presence in the PMMA is revealed by the unique luminescence characteristics of the QDs under UV light. The presence of ZnO QDs broadened the range of UV radiation absorption of PMMA and the absorption edge is gradually shifted from 270 nm to 338 nm with step-wise loading of ZnO QDs. The PINCs are tested to determine their reproducibility and impact on the electrical arcs of current 1.6 kA generated using a specially designed test-setup. Interaction of PINCs with the electrical arcs generates ablation of chemical species towards core of the electrical arc, resulting in increase of voltage leading to cool-down the arc temperature. This experimental study demonstrates for the first time that these PINCs are reproducible, reliable and provides superior arc interruption capability.

  • 6.
    Doddapaneni, Venkatesh
    et al.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Saleemi, Mohsin
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Gati, Rudolf
    ABB Switzerland.
    Toprak, Muhammet Sadaka
    KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
    New experimental insights for controlling the electrical arcs in electrical switching applications: a comparative study on PMMA nanocomposites of Au and ZnO2017In: Composites Science And Technology, ISSN 0266-3538, E-ISSN 1879-1050Article in journal (Other academic)
    Abstract [en]

    Polymer inorganic nanocomposites (PINCs) are developed, not only due to scientific interest but also improving theelectric arc interruption process in the electrical switching applications like circuit breakers. The novelty of this work isin integrating the current developments in PINCs into electrical switching application in order to extend the limits of thepower switching devices. Several PINCs are fabricated by using pre-synthesized Au nanoparticles (NPs) of size 2.75 ±0.4 nm and poly (methyl methacrylate) (PMMA) matrix via in-situ polymerization method. Six homogeneous PINCsamples with ultra-low wt% of Au NPs varying from 0.0003 to 0.005 wt% have been fabricated. We find that thepresence of Au NPs improved the convective heat transfer and visible optical radiation absorption of PMMA. Thefabricated PINCs are tested for their arc interruption performance and the results are compared with ZnO PINCs in ourearlier work. The results of the experiments insights demonstrate the impact of PINCs on the electrical arcs and theirpotential advantages of having PINCs for the electric arc interruption process in high power switching devices.

  • 7.
    Doddapaneni, Venkatesh
    et al.
    KTH, School of Electrical Engineering (EES), Electromagnetic Engineering.
    Zhao, Yichen
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Gati, R.
    Edin, Hans
    KTH, School of Electrical Engineering (EES), Electromagnetic Engineering.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Improving Uv Radiation Absorption by Copper Oxide NPs/PMMA Nanocomposites for Electrical Switching Applications2015In: Powder metallurgy and metal ceramics, ISSN 1068-1302, E-ISSN 1573-9066, Vol. 54, no 7-8, p. 397-401Article in journal (Refereed)
    Abstract [en]

    Nanocomposites based on the radiation absorbing polymer (PNCs) are of interest for a variety of applications including circuit breakers, UV-shielding windows, contact lenses, and glasses among others. Such PNCs can be made by incorporating suitable radiation absorbing nanoparticles into a polymeric matrix by in situ polymerization. In this study, spherical nanoparticles (5-6 nm) of oleic acid (OA) surface modified cupric oxide (CuO) are synthesized and used to improve the ultra-violet (UV) radiation absorption property of a polymer matrix, i.e., polymethylmethacrylate (PMMA). The synthesis of spherical CuO nanoparticles, surface modification using OA, dispersion of CuO nanoparticles with different concentrations in PMMA, and UV radiation absorption property of the resultant PNC are investigated. Two different PNCs are produced using OA modified CuO nanoparticles with different concentrations. As synthesized CuO nanoparticles and OA modified CuO nanoparticles are examined by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR) techniques. The UV absorption edges are evaluated from the UV-Vis absorption spectra by using UV-Visible absorption spectroscopy. The results show that the UV radiation absorption of the PNC with higher concentration of CuO nanoparticles is improved compared with PMMA and the absorption edge moved towards longer wavelengths i.e., from 271 to 281 nm. These PNCs are successful in arc interruption process by absorbing a broad range of radiation emitted from high-energy copper arcs produced in the circuit breakers.

  • 8.
    Dong, Lin
    et al.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Hu, Jun
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. Zhejiang University, China.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Popov, Sergei
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Friberg, Ari T.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. Helsinki University of Technology, Finland.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Influence of nanoparticles concentration on fluorescence quenching in gold/rhodamine 6G nanoassemblies2009In: 2009 Asia Communications and Photonics Conference and Exhibition, ACP 2009, Optical Society of America, 2009, p. 5377045-Conference paper (Refereed)
    Abstract [en]

    Fluorescence enhancement of dye solution doped with gold nanoparticles is a well-known effect. However, depending on size and concentration, nanoparticles can also deteriorate dye lasing properties due to increased quenching of the excited molecules. Here we report experimental results on such dependence of fluorescence degradation on the nanoparticle concentration.

  • 9.
    Dong, Lin
    et al.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Chughtai, Adnan
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Liuolia, Vytautas
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Popov, Sergei
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Friberg, Ari T.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Lasing From Water Solution of Rhodamine 6G/Gold Nanoparticles: Impact of SiO2-Coating on Metal Surface2012In: IEEE Journal of Quantum Electronics, ISSN 0018-9197, E-ISSN 1558-1713, Vol. 48, no 9, p. 1220-1226Article in journal (Refereed)
    Abstract [en]

    Gold nanoparticles embedded in an optical gain material, particularly in a water solution of Rhodamine 6G, used in dye lasers can both increase and damp dye flourescence, thus changing the laser output intensity. Simultaneously, such nanoparticles influence the gain material's resistance against photobleaching. In this paper, we report our study on the impact of the SiO2 coating of nanoparticles on the enhancement or quenching and photobleaching of the fluorescence. The investigation demonstrates a noticeable improvement of the gain material's photostability compared to uncoated gold nanoparticles when silicon dioxide coating is implemented.

  • 10.
    Dong, Lin
    et al.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Chughtai, Adnan
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Popov, Sergei
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Friberg, Ari T.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Enhanced photostability of aqueous solution of Rhodamine 6G with gold nanoparticles in lasing process by silica coating2012In: 2012 Conference on Lasers and Electro-Optics, CLEO 2012, IEEE , 2012, p. 6325399-Conference paper (Refereed)
    Abstract [en]

    Gold nanoparticles are mixed in aqueous solution of Rhodamine 6G to modify the lasing output intensity. The photostability deterioration of the gain medium by gold nanoparticles is successfully compensated by silica coating on the nanoparticles.

  • 11.
    Dong, Lin
    et al.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Chughtai, Adnan
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Popov, Sergei
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Friberg, Ari T.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Photostability of lasing process from water solution of Rhodamine 6G with gold nanoparticles2012In: Optics Letters, ISSN 0146-9592, E-ISSN 1539-4794, Vol. 37, no 1, p. 34-36Article in journal (Refereed)
    Abstract [en]

    We report the lasing performance and photobleaching of gain material containing a water solution of Rhodamine 6G dye and gold nanoparticles (NPs). In comparison to a pure dye solution, the investigated material demonstrated both enhancement and quenching of the lasing output, depending on the relative concentration of the gold NPs. Although the presence of NPs with an optimized concentration looks preferable in terms of the lasing output enhancement, such additives deteriorate the operational resource of the gain material; i.e., the photobleaching rate speeds up.

  • 12.
    Dong, Lin
    et al.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Hu, Jun
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Popov, Sergei
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Friberg, Ari T.
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fluorescence quenching and photobleaching in Au/Rh6G nanoassemblies: impact of competition between radiative and non-radiative decay2011In: JOURNAL OF THE EUROPEAN OPTICAL SOCIETY-RAPID PUBLICATIONS, ISSN 1990-2573, Vol. 6, p. 11019-Article in journal (Refereed)
    Abstract [en]

    We report the study of fluorescence quenching from nanoassemblies formed by Rhodamine 6G and gold nanoparticles (Au NPs) of 2.6 nm radius. The presence of Au NPs induces long-term degradation of the photostability (photobleaching) of Rhodamine 6G used as a gain medium in a Fabry-Perot laser cavity. We found that the degradation gets profound when the Au NPs concentration is significantly increased. Calculation of the radiative rate and direct time-resolved measurement of the fluorescence decay indicates that both the decrease of radiative decay rate and increase of non-radiative decay rate are responsible for the fluorescence quenching and photostability degradation. An energy transfer from the dye molecules to gold nanoparticles is dominating within small distance between them and suppresses the quantum efficiency of Rhodamine 6G drastically. In a long time scale, the photobleaching rate was slowing down, and the laser output intensity reached a stabilized level which depends on the gold nanoparticles concentration.

  • 13.
    Fornara, Andrea
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Recalenda, Alberto
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Sugunan, Abhilash
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fei, Ye
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Laurent, Sophie
    University of Mons.
    Muller, Robert
    University of Mons.
    Zou, Jing
    University of Tampere.
    Usama, Abo-RAmadan
    University of Helsinki.
    Toprak, Muhammet
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Polymeric/inorganic multifunctional nanoparticles for simultaneous drug delivery and visualization2010In: Materials Research Society Symposium Proceedings, ISSN 0272-9172, E-ISSN 1946-4274, Vol. 1257Article in journal (Refereed)
    Abstract [en]

    Nanoparticles consisting of different biocompatible materials are attracting a lot of interest in the biomedical area as useful tools for drug delivery, photo-therapy and contrast enhancement agents in MRI, fluorescence and confocal microscopy. This work mainly focuses on the synthesis of polymeric/inorganic multifunctional nanoparticles (PIMN) based on biocompatible di-block copolymer poly(L,L-lactide-co-ethylene glycol) (PLLA-PEG) via an emulsion-evaporation method. Besides containing a hydrophobic drug (Indomethacin), these polymeric nanoparticles incorporate different visualization agents such as superparamagnetic iron oxide nanoparticles (SPION) and fluorescent Quantum Dots (QDs) that are used as contrast agents for Magnetic Resonance Imaging (MRI) and fluorescence microscopy together. Gold Nanorods are also incorporated in such nanostructures to allow simultaneous visualization and photodynamic therapy. MRI studies are performed with different loading of SPION into PIMN, showing an enhancement in T2 contrast superior to commercial contrast agents. Core-shell QDs absorption and emission spectra are recorded before and after their loading into PIMN. With these polymeric/inorganic multifunctional nanoparticles, both MRI visualization and confocal fluorescence microscopy studies can be performed. Gold nanorods are also synthesized and incorporated into PIMN without changing their longitudinal absorption peak usable for lased excitation and phototherapy. In-vitro cytotoxicity studies have also been performed to confirm the low cytotoxicity of PIMN for further in-vivo studies.

  • 14.
    Kunzmann, Andrea
    et al.
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Andersson, Britta
    Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Vogt, Carmen
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Feliu, Neus
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Gabrielsson, Susanne
    Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Buerki-Thurnherr, Tina
    Labortory for Materials, Biology Interactions, Swiss Federal Laboratories of Materials Testing and Research, St. Gallen, Switzerland.
    Laurent, Sophie
    NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons, Belgium.
    Vahter, Marie
    Krug, Harald
    Division of Metals and Health, Institute of Environmental Medicine, Karolinska Insitutetet, Stockholm, Sweden.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Scheynius, Annika
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet and Universty Hospital Solan, Sweden.
    Fadeel, Bengt
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells2011In: Toxicology and Applied Pharmacology, ISSN 0041-008X, E-ISSN 1096-0333, Vol. 253, no 2, p. 81-93Article in journal (Refereed)
    Abstract [en]

    Engineered nanoparticles are being considered for a wide range of biomedical applications, from magnetic resonance imaging to "smart" drug delivery systems. The development of novel nanomaterials for biomedical applications must be accompanied by careful scrutiny of their biocompatibility. In this regard, particular attention should be paid to the possible interactions between nanoparticles and cells of the immune system, our primary defense system against foreign invasion. On the other hand, labeling of immune cells serves as an ideal tool for visualization, diagnosis or treatment of inflammatory processes, which requires the efficient internalization of the nanoparticles into the cells of interest. Here, we compare novel monodispersed silica-coated iron oxide nanoparticles with commercially available dextran-coated iron oxide nanoparticles. The silica-coated iron oxide nanoparticles displayed excellent magnetic properties. Furthermore, they were nontoxic to primary human monocyte-derived macrophages at all doses tested whereas dose-dependent toxicity of the smaller silica-coated nanoparticles (30 nm and 50 nm) was observed for primary monocyte-derived dendritic cells, but not for the similarly small dextran-coated iron oxide nanoparticles. No macrophage or dendritic cell secretion of pro-inflammatory cytokines was observed upon administration of nanoparticles. The silica-coated iron oxide nanoparticles were taken up to a significantly higher degree when compared to the dextran-coated nanoparticles, irrespective of size. Cellular internalization of the silica-coated nanoparticles was through an active, actin cytoskeleton-dependent process. We conclude that these novel silica-coated iron oxide nanoparticles are promising materials for medical imaging, cell tracking and other biomedical applications. (C) 2011 Elsevier Inc. All rights reserved.

  • 15.
    Li, Jiantong
    et al.
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Vaziri, Sam
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Lemme, Max C.
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Östling, Mikael
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    A simple route towards high-concentration surfactant-free graphene dispersions2012In: Carbon, ISSN 0008-6223, E-ISSN 1873-3891, Vol. 50, no 8, p. 3113-3116Article in journal (Refereed)
    Abstract [en]

    A simple solvent exchange method is introduced to prepare high-concentration and surfactant-free graphene liquid dispersion. Natural graphite flakes are first exfoliated into graphene in dimethylformamide (DMF). DMF is then exchanged by terpineol through distillation, relying on their large difference in boiling points. Graphene can then be concentrated thanks to the volume difference between DMF and terpineol. The concentrated graphene dispersions are used to fabricate transparent conductive thin films, which possess comparable properties to those prepared by more complex methods.

  • 16.
    Li, Jiantong
    et al.
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Vaziri, Sam
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Lemme, Max C.
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Östling, Mikael
    KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits.
    Efficient inkjet printing of graphene2013In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 25, no 29, p. 3985-3992Article in journal (Refereed)
    Abstract [en]

    An efficient and mature inkjet printing technology is introduced for mass production of coffee-ring-free patterns of high-quality graphene at high resolution (unmarked scale bars are 100 μm). Typically, several passes of printing and a simple baking allow fabricating a variety of good-performance electronic devices, including transparent conductors, embedded resistors, thin film transistors, and micro-supercapacitors.

  • 17.
    Vasileva, Elena
    et al.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Optics and Photonics, OFO.
    Fei, Ye
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Marinins, Aleksandrs
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Optics and Photonics, OFO.
    Etcheverry, Sebastián
    KTH, School of Engineering Sciences (SCI), Applied Physics.
    Toprak, Muhammet
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics.
    Popov, Sergei Yu
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Optics and Photonics, OFO.
    Optimization of optical gain in composite materials containing Rh6G dye and gold nanoparticles2015In: Asia Communications and Photonics Conference, ACPC 2015, 2015Conference paper (Refereed)
    Abstract [en]

    The existence of metal nanoparticles in a dye material can lead not only to quenching or enhancement of dye luminescence, or random lasing action, but also to the change of the fundamental material characteristic as optical gain. © 2015 OSA.

  • 18.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Chemically Synthesized Nano-Structured Materials for Biomedical and Photonic Applications2012Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Nanostructured materials have attracted a broad interest for applications in scientific and engineering fields due to their extraordinary properties stemming from the nanoscale dimensions. This dissertation presents the development of nanomaterials used for different applications, namely biomedicine and dye lasing.

    Various inorganic nanoparticles have been developed as contrast agents for non-invasive medical imaging, such as magnetic resonance imaging (MRI) and X-ray computed tomography (CT), owing to their unique properties for efficient contrasting effect. Superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized by thermo-decomposition method and phase-transferred to be hydrophilic used as MRI T2 (negative) contrast agents. Effects of surface modification of SPIONs by mesoporous silica (mSiO2) coating have been examined on the magnetic relaxivities. These contrast agents (Fe3O4@mSiO2) were found to have a coating-thickness dependent relaxation behavior and exhibit much higher contrast efficiency than that for the commercial ones. By growing thermo-sensitive poly(N-isopropylacrylamide -co-acrylamide) (P(NIPAAm-co-AAm)) as the outermost layer on Fe3O4@mSiO2 through free radical polymerization, a multifunctional core-shell nano-composite has been built up. Responding to the temperature change, these particles demonstrate phase transition behavior and were used for thermo-triggered magnetic separation. Their lower critical solution temperature (LCST) can be subtly tuned from ca. 34 to ca. 42 ˚C, suitable for further in vivo applications. An all-in-one contrast agent for MRI, CT and fluorescence imaging has been synthesized by depositing gadolinium oxide carbonate hydrate [Gd2O(CO3)2·H2O] shell on mSiO2-coated gold nanorod (Au NR), and then the particles were grafted with antibiofouling copolymer which can further link with the fluorescent dye. It shows both a higher CT and MRI contrast than the clinical iodine and gadolinium chelate contrast agent, respectively. Apart from the imaging application, owing to the morphology of Au NR, the particle has a plasmonic property of absorbing near-infrared (NIR) irradiation and suitable for future photothermal therapy. Cytotoxicity and biocompatibility of aforementioned nanoparticles have been evaluated and minor negative effects were found, which support their further development for medical applications.

    Gold nanoparticles embedded in the optical gain material, water solution of Rhodamine 6G (Rh6G) in particular, used in dye lasers can both increase and damp the dye fluorescence, thus, changing the laser output intensity. The studies of size effect and coating of gold nanoparticles on photostability of the gain media reveal that small sized (ca. 5.5 nm) gold nanoparticles are found detrimental to the photostability, while for the larger ones (ca. 25 nm) fluorescence enhancement rather than quenching is likely to occur. And a noticeable improvement of the photostability for the gain material is achieved when gold is coated with SiO2.

  • 19.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Synthesis of nanostructured and hierarchical materials for bio-applications2011Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    In recent years, nanostructured materials incorporated with inorganic particles and polymers have attracted attention for simultaneous multifunctional biomedical applications. This thesis summarized three works, which are preparation of mesoporous silica coated superparamagnetic iron oxide (Fe3O4@mSiO2) nanoparticles (NPs) as magnetic resonance imaging T2 contrast agents, polymer grafted Fe3O4@mSiO2 NPs response to temperature change, synthesis and biocompatibility evaluation of high aspect ratio (AR) gold nanorods.

    Monodisperse Fe3O4@mSiO2 NPs have been prepared through a sol-gel process. The coating thickness and particle sizes can be precisely controlled by varying the synthesis parameters. Impact of surface coatings on magnetometric and relaxometric properties of Fe3O4 NPs is studied. The efficiency of these contrast agents, evaluated by MR relaxivities ratio (r2/r1), is much higher than that of the commercial ones. This coating-thickness dependent relaxation behavior is explained due to the effects of mSiO2 coatings on water exclusion.

    Multifunctional core-shell composite NPs have been developed by growing thermo-sensitive poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAAm-co-AAm)) on Fe3O4@mSiO2 NPs through free radical polymerization. Their phase transition behavior is studied, and their lower critical solution temperature (LCST) can be subtly tuned from ca. 34 to ca. 42 °C, suitable for further in vivo applications.

    A seedless surfactant-mediated protocol has been applied for synthesis of high AR gold nanorods with the additive of HNO3. A growth mechanism based on the effect of nitrate ions on surfactant micelle elongation and Ostwald ripening process is proposed. The biocompatibility of high AR nanorods was evaluated on primary human monocyte derived dendritic cells (MDDCs). Their minor effects on viability and immune regulatory markers support further development for medical applications.

  • 20.
    Ye, Fei
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Brismar, Torkel
    Shi, Jingwen
    Lin, Dong
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Sayed, Ramy El
    Popov, Sergei
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics, Optics.
    Toprak, Muhammet
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Gold nanorod/mesoporoussilica/gadolinium oxide carbonate hydrate core/shell nanoparticles: A multimodalcontrast agent for MRI, CT and fluorescence imaging2012Manuscript (preprint) (Other academic)
  • 21.
    Ye, Fei
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Laurent, Sophie
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Astolfi, Laura
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Roch, Alain
    Martini, Alessandro
    Toprak, Muhammet
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muller, Robert N.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T2 contrast agent with tunable proton relaxivities2012In: Contrast Media & Molecular Imaging, ISSN 1555-4309, E-ISSN 1555-4317, Vol. 7, no 5, p. 460-468Article in journal (Refereed)
    Abstract [en]

    Monodisperse mesoporous silica (mSiO2) coated superparamagnetic iron oxide (Fe3O4@mSiO2) nanoparticles (NPs) have been developed as a potential magnetic resonance imaging (MRI) T2 contrast agent. To evaluate the effect of surface coating on MRI contrast efficiency, we examined the proton relaxivities of Fe3O4@mSiO2 NPs with different coating thicknesses. It was found that the mSiO2 coating has a significant impact on the efficiency of Fe3O4 NPs for MRI contrast enhancement. The efficiency increases with the thickness of mSiO2 coating and is much higher than that of the commercial contrast agents. Nuclear magnetic resonance (NMR) relaxometry of Fe3O4@mSiO2 further revealed that mSiO2 coating is partially permeable to water molecules and therefore induces the decrease of longitudinal relaxivity, r1. Biocompatibility evaluation of various sized (ca. 3595 nm) Fe3O4@mSiO2 NPs was tested on OC-k3 cells and the result showed that these particles have no negative impact on cell viability. The enhanced MRI efficiency of Fe3O4@mSiO2 highlights these coreshell particles as highly efficient T2 contrast agents with high biocompatibility.

  • 22.
    Ye, Fei
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Multifunctional core-shell nanoparticles: superparamagnetic, mesoporous, and thermosensitive2011In: Journal of nanoparticle research, ISSN 1388-0764, E-ISSN 1572-896X, Vol. 13, no 11, p. 6157-6167Article in journal (Refereed)
    Abstract [en]

    Multifunctional core-shell composite nanoparticles (NPs) have been developed by the combination of three functionalities into one entity, which is composed of a single Fe3O4 NP as the magnetic core, mesoporous silica (mSiO2) with cavities as the sandwiched layer, and thermosensitive poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAAm-co-AAm)) copolymer as the outer shell. The mSiO2-coated Fe3O4 NPs (Fe3O4@mSiO2) are monodisperse and the particle sizes were varied from 25 to 95 nm by precisely controlling the thickness of mSiO2-coating layer. The P(NIPAAm-co-AAm) were then grown onto surface-initiator-modified Fe3O4@mSiO2 NPs through free radical polymerization. These core-shell composite NPs (designated as Fe3O4@mSiO2@P(NIPAAm-co-AAm)) were found to be superparamagnetic with high r2 relaxivity. To manipulate the phase transition behavior of these thermosensitive polymer-coated NPs for future in vivo applications, the characteristic lower critical solution temperature (LCST) was subtly tuned by adjusting the composition of the monomers to be around the human body temperature (i.e. 37 °C), from ca. 34 to ca. 42 °C. The thermal response of the core-shell composite NPs to the external magnetic field was also demonstrated. Owing to their multiple functionality characteristics, these porous superparamagnetic and thermosensitive NPs may prove valuable for simultaneous magnetic resonance imaging (MRI), temperature-controlled drug release, and temperature-programed magnetic targeting and separation applications.

  • 23.
    Ye, Fei
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Vallhov, Helen
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institute and University Hospital Solna, Sweden.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Daskalaki, Evangelia
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet and Universty Hospital Solan, Sweden.
    abhilash, Sugunan
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Gabrielsson, Susanne
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet and Universty Hospital Solan, Sweden.
    Scheynius, Annika
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet and Universty Hospital Solan, Sweden.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Synthesis of high aspect ratio gold nanorods and their effects on human antigen presenting dendritic cells2011In: International Journal Of Nanotechnology, ISSN 1475-7435, Vol. 8, no 8-9, p. 631-652Article in journal (Refereed)
    Abstract [en]

    High aspect ratio (AR) gold nanorods (NRs) attract great interest for biomedical applications due to their novel physicochemical properties. Here, we report a facile method for preparation of high AR gold NRs through a seedless surfactant-mediated protocol with the additive of nitric acid. High-resolution transmission electron microscopy studies showed that the concentration of nitric acid has great effects on the crystal structures of the initially formed nuclei and consequently the growth of gold NRs. A mechanism based on the effect of nitrate ions on surfactant micelle elongation and Ostwald ripening process is proposed for the growth of high AR gold NRs. The biocompatibility of high AR NRs was evaluated on primary human monocyte derived dendritic cells (MDDCs), and compared with that of spherical gold nanoparticles (NPs) and low AR NRs. Low AR (similar to 4.5) gold NRs induced considerable cell death due to CTAB, while spherical gold NPs (7 nm) and high AR (similar to 21) gold NRs showed no or minor effects on viability and immune regulatory markers, which supports the further development of high AR gold NRs for medical applications.

1 - 23 of 23
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf