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  • 1.
    Janek Strååt, Sara
    et al.
    Karolinska Institutet and Stockholm University.
    Andreassen, Björn
    Karolinska Institutet and Stockholm University.
    Johansson, Cathrine
    Karolinska University Hospital Solna, Sweden.
    Noz, Marilyn E.
    New York University, Department of Radiology.
    Maguire Jr., Gerald Q.
    KTH, School of Information and Communication Technology (ICT), Communication Systems, CoS, Radio Systems Laboratory (RS Lab).
    Näfstadius, Peder
    Karolinska University Hospital.
    Näslund, Ingemar
    Karolinska Institutet.
    Schoenahl, Frederic
    University Hospital of Geneva, Geneva, Switzerland .
    Brahme, Anders
    Karolinska Institute.
    Clinical application of in vivo treatment delivery verification based on PET/CT imaging of positron activity induced at high energy photon therapy2013In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 58, no 16, p. 5541-5553Article in journal (Refereed)
    Abstract [en]

    The purpose of this study was to investigate in vivo verification of radiation treatment with high energy photon beams using PET/CT to image the induced positron activity. The measurements of the positron activation induced in a preoperative rectal cancer patient and a prostate cancer patient following 50 MV photon treatments are presented. A total dose of 5 and 8 Gy, respectively, were delivered to the tumors. Imaging was performed with a 64-slice PET/CT scanner for 30 min, starting 7 min after the end of the treatment. The CT volume from the PET/CT and the treatment planning CT were coregistered by matching anatomical reference points in the patient. The treatment delivery was imaged in vivo based on the distribution of the induced positron emitters produced by photonuclear reactions in tissue mapped on to the associated dose distribution of the treatment plan. The results showed that spatial distribution of induced activity in both patients agreed well with the delivered beam portals of the treatment plans in the entrance subcutaneous fat regions but less so in blood and oxygen rich soft tissues. For the preoperative rectal cancer patient however, a 2 +/- (0.5) cm misalignment was observed in the cranial-caudal direction of the patient between the induced activity distribution and treatment plan, indicating a beam patient setup error. No misalignment of this kind was seen in the prostate cancer patient. However, due to a fast patient setup error in the PET/CT scanner a slight mis-position of the patient in the PET/CT was observed in all three planes, resulting in a deformed activity distribution compared to the treatment plan. The present study indicates that the induced positron emitters by high energy photon beams can be measured quite accurately using PET imaging of subcutaneous fat to allow portal verification of the delivered treatment beams. Measurement of the induced activity in the patient 7 min after receiving 5 Gy involved count rates which were about 20 times lower than that of a patient undergoing standard F-18-FDG treatment. When using a combination of short lived nuclides such as O-15 (half-life: 2 min) and C-11 (half-life: 20 min) with low activity it is not optimal to use clinical reconstruction protocols. Thus, it might be desirable to further optimize reconstruction parameters as well as to address hardware improvements in realizing in vivo treatment verification with PET/CT in the future. A significant improvement with regard to O-15 imaging could also be expected by having the PET/CT unit located close to the radiation treatment room.

  • 2.
    Lundblad, Henrik
    et al.
    Karolinska Institute, Stockholm, Sweden.
    Karlsson-Thur, Charlotte
    Karolinska Institute, Stockholm, Sweden.
    Maguire Jr., Gerald Q.
    KTH, School of Information and Communication Technology (ICT), Communication Systems, CoS, Radio Systems Laboratory (RS Lab).
    Jonsson, Cathrine
    Karolinska University Hospital, Stockholm, Sweden.
    Noz, Marilyn E.
    New York University, Department of Radiology.
    Zeleznik, Michael P.
    University of Utah.
    Weidenhielm, Lars
    Karolinska Institutet at Karolinska University Hospital Solna.
    Can Spatiotemporal Fluoride (18F-ˆ’) Uptake be Used to Assess Bone Formation in the Tibia?: A Longitudinal Study Using PET/CT2017In: Clinical Orthopaedics and Related Research, ISSN 0009-921X, E-ISSN 1528-1132, Vol. 475, no 5, p. 1486-1498Article in journal (Refereed)
    Abstract [en]

    When a bone is broken for any reason, it is important for the orthopaedic surgeon to know how bone healing is progressing. There has been resurgence in the use of the fluoride (18F-ˆ’) ion to evaluate various bone conditions. This has been made possible by availability of positron emission tomography (PET)/CT hybrid scanners together with cyclotrons. Absorbed on the bone surface from blood flow, 18F-ˆ’ attaches to the osteoblasts in cancellous bone and acts as a pharmacokinetic agent, which reflects the local physiologic activity of bone. This is important because it shows bone formation indicating that the bone is healing or no bone formation indicating no healing. As 18F-ˆ’ is extracted from blood in proportion to blood flow and bone formation, it thus enables determination of bone healing progress.

  • 3.
    Lundblad, Henrik
    et al.
    Karolinska Institutet, Sweden.
    Maguire Jr., Gerald Q.
    KTH, School of Information and Communication Technology (ICT), Communication Systems, CoS, Radio Systems Laboratory (RS Lab).
    Karlsson-Thur, Charlotte
    Karolinska Institutet, Sweden.
    Jonsson, Cathrine
    Karolinska University Hospital Solna, Sweden.
    Noz, Marilyn E.
    New York University, USA.
    Zeleznik, Michael P.
    University of Utah, USA.
    Jacobsson, Hans
    Karolinska Institutet, Sweden.
    Weidenhielm, Lars
    Karolinska Institutet, Sweden.
    Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences2015In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, p. 1-11, article id 574705Article in journal (Refereed)
    Abstract [en]

    Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consentto undergo Na18F− PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curveeliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions werecompared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal)bone, and muscle. The SUV𝑚(𝑡) (𝑚 = max, mean) and a series of slopes were computed as (SUV𝑚(𝑡𝑖) − SUV𝑚(𝑡𝑗))/(𝑡𝑖 − 𝑡𝑗), forpairs of time values 𝑡𝑖 and 𝑡𝑗. A Patlak-like analysis was performed for the same time values by computing ((VOI𝑝(𝑡𝑖)/VOI𝑒(𝑡𝑖)) −(VOI𝑝(𝑡𝑗)/VOI𝑒(𝑡𝑗)))/(𝑡𝑖−𝑡𝑗), where p = broken bone, other bone, andmuscle and e = expected activity in aVOI. Paired comparisonsbetween Patlak-like and SUV𝑚 slopes showed good agreement by both linear regression and correlation coefficient analysis(𝑟 = 84%, 𝑟𝑠 = 78%-SUVmax, 𝑟 = 92%, and 𝑟𝑠 = 91%-SUVmean), suggesting static scans could substitute for dynamic studies.Patlak-like slope differences of 0.1 min−1 or greater between examinations and SUVmax differences of ∼5 usually indicated goodremodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in thiscohort.

  • 4.
    Lundblad, Henrik
    et al.
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden .
    Maguire Jr., Gerald Q.
    KTH, School of Information and Communication Technology (ICT), Communication Systems, CoS, Radio Systems Laboratory (RS Lab).
    Olivecrona, Henrik
    Karolinska Institute.
    Jonsson, Cathrine
    Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
    Jacobsson, Hans
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden .
    Noz, Marilyn E.
    New York University, Department of Radiology.
    Zeleznik, Michael P.
    University of Utah.
    Weidenhielm, Lars
    Karolinska Institutet at Karolinska University Hospital Solna.
    Sundin, Anders
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden .
    Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?2014In: Scientific World Journal, E-ISSN 1537-744X, Vol. 2014, p. 1-9Article in journal (Refereed)
    Abstract [en]

    Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent. Each patient was examined by (NaF)-F-18 PET/CT twice, at approximately six weeks and three months after the operation. A validated software tool was used for the following processing steps. The first and second CT volumes were aligned in 3D and the respective PET volumes were aligned accordingly. In the first PET volume spherical volumes of interest (VOIs) were delineated for the crural fracture and normal bone and transferred to the second PET volume for SUVmax evaluation. This method potentially provides clinical insight into questions such as, when has the bone remodeling progressed well enough to safely remove the TSF? and when is intervention required, in a timelier manner than current methods? For example, in two patients who completed treatment, the SUVmax between the first and second PET/CT examination decreased by 42% and 13%, respectively. Further studies in a larger patient population are needed to verify these preliminary results by correlating regional (NaF)-F-18 PET measurements to clinical and radiological findings.

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