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  • 1.
    Akay, Altug
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Dragomir, A.
    Department of Biomedical Engineering, University of Houston, Houston, TX, US.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    A novel data-mining approach leveraging social media to monitor and respond to outcomes of diabetes drugs and treatment2013In: 2013 IEEE Point-of-Care Healthcare Technologies (PHT), New York: IEEE , 2013, p. 264-266Conference paper (Refereed)
    Abstract [en]

    A novel data-mining method was developed to gauge the experiences of medical devices and drugs by patients with diabetes mellitus. Self-organizing maps were used to analyze forum posts numerically to better understand user opinion of medical devices and drugs. The end-result is a word list compilation that correlates certain positive and negative word cluster groups with medical drugs and devices. The implication of this novel data-mining method could open new avenues of research into rapid data collection, feedback, and analysis that would enable improved outcomes and solutions for public health.

  • 2.
    Akay, Altug
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Dragomir, A
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    A Novel Data-Mining Approach Leveraging Social Media to Monitor Consumer Opinion of Sitagliptin2015In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 19, no 1, p. 389-396Article in journal (Refereed)
    Abstract [en]

    A novel data mining method was developed to gauge the experience of the drug Sitagliptin (trade name Januvia) by patients with diabetes mellitus type 2. To this goal, we devised a two-step analysis framework. Initial exploratory analysis using self-organizing maps was performed to determine structures based on user opinions among the forum posts. The results were a compilation of user's clusters and their correlated (positive or negative) opinion of the drug. Subsequent modeling using network analysis methods was used to determine influential users among the forum members. These findings can open new avenues of research into rapid data collection, feedback, and analysis that can enable improved outcomes and solutions for public health and important feedback for the manufacturer.

  • 3.
    Akay, Altug
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Dragomir, A.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    A novel data-mining platform leveraging social media to monitor outcomes of Januvia2013In: Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, IEEE conference proceedings, 2013, p. 7484-7487Conference paper (Refereed)
    Abstract [en]

    A novel data-mining method was developed to gauge the experiences of the diabetes mellitus drug Januvia. Self-organizing maps were used to analyze forum posts numerically to infer user opinion of drug Januvia. Graph theory was used to discover influential users. The result is a word list compilation correlating positive and negative word cluster groups and a web of influential users on Januvia. The implications could open new research avenues into rapid data collection, feedback, and analysis that would enable improved solutions for public health.

  • 4.
    Akay, Altug
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Dragomir, A
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Network-Based Modeling and Intelligent Data Mining of Social Media for Improving Care2015In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 19, no 1, p. 210-218Article in journal (Refereed)
    Abstract [en]

    Intelligently extracting knowledge from social media has recently attracted great interest from the Biomedical and Health Informatics community to simultaneously improve healthcare outcomes and reduce costs using consumer-generated opinion. We propose a two-step analysis framework that focuses on positive and negative sentiment, as well as the side effects of treatment, in users' forum posts, and identifies user communities (modules) and influential users for the purpose of ascertaining user opinion of cancer treatment. We used a self-organizing map to analyze word frequency data derived from users' forum posts. We then introduced a novel network-based approach for modeling users' forum interactions and employed a network partitioning method based on optimizing a stability quality measure. This allowed us to determine consumer opinion and identify influential users within the retrieved modules using information derived from both word-frequency data and network-based properties. Our approach can expand research into intelligently mining social media data for consumer opinion of various treatments to provide rapid, up-to-date information for the pharmaceutical industry, hospitals, and medical staff, on the effectiveness (or ineffectiveness) of future treatments.

  • 5.
    Akay, Altug
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Dragomir, Andrei
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    A Novel-Data Mining Platform to Monitor the Outcomes of Erlontinib (Tarceva) using Social Media2014In: XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013, Springer, 2014, p. 1394-1397Conference paper (Refereed)
    Abstract [en]

    A novel data-mining method was developed to gauge the experiences of the oncology drug Tarceva. Self-organizing maps were used to analyze forum posts numerically to infer user opinion of drug Tarceva. The result is a word list compilation correlating positive and negative word cluster groups and a web of influential users on Tarceva. The implica-tions could open new research avenues into rapid data collec-tion, feedback, and analysis that would enable improved solu-tions for public health.

  • 6.
    Akay, Altug
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Dragomir, Andrei
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Assessing Antidepressants Using Intelligent Data Monitoring and Mining of Online Fora2016In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 20, no 4, p. 977-986Article in journal (Refereed)
    Abstract [en]

    Depression is a global health concern. Social networks allow the affected population to share their experiences. These experiences, when mined, extracted, and analyzed, can be converted into either warnings to recall drugs (dangerous side effects), or service improvement (interventions, treatment options) based on observations derived from user behavior in depression-related social networks. Our aim was to develop a weighted network model to represent user activity on social health networks. This enabled us to accurately represent user interactions by relying on the data's semantic content. Our three-step method uses the weighted network model to represent user's activity, and network clustering and module analysis to characterize user interactions and extract further knowledge from user's posts. The network's topological properties reflect user activity such as posts' general topic as well as timing, while weighted edges reflect the posts semantic content and similarities among posts. The result, a synthesis from word data frequency, statistical analysis of module content, and the modeled health network's properties, has allowed us to gain insight into consumer sentiment of antidepressants. This approach will allow all parties to participate in improving future health solutions of patients suffering from depression.

  • 7.
    Akay, Altug
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Dragomir, Andrei
    University of Houston, Biomedical Engineering.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Mining Social Media Big Data for Health2015In: IEEE PulseArticle, review/survey (Refereed)
    Abstract [en]

    Advances in information technology (IT) and big data are affecting nearly every facet of the public and private sectors. Social media platforms are one example of such advances: its nature allows users to connect, collaborate, and debate on any topic with comparative ease. The result is a hefty volume of user-generated content that, if properly mined and analyzed, could help the public and private health care sectors improve the quality of their products and services while reducing costs. The users of these platforms are the key to these improvements, as their valuable feedback will help improve health solutions.

  • 8.
    Elinder, Goran
    et al.
    Karolinska Inst, Dept Pediat, Stockholm, Sweden..
    Eriksson, Anders
    Umea Univ, Dept Community Med & Rehabil, Forens Med, Umea, Sweden.;Natl Board Forens Med, Stockholm, Sweden..
    Hallberg, Boubou
    Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Pediat & Neonatol, Stockholm, Sweden..
    Lynoe, Niels
    Karolinska Inst, Med Eth, Stockholm, Sweden..
    Sundgren, Pia Maly
    Lund Univ, Diagnost Radiol, Lund, Sweden.;Skane Univ Hosp, Dept Neuroradiol, Lund, Sweden..
    Rosen, Mans
    Karolinska Inst, Hlth Technol Assessment, Stockholm, Sweden..
    Engstrom, Ingemar
    Univ Orebro, Univ Hlth Care Res Ctr, Fac Med & Hlth, Child & Adolecent Psychiat, Orebro, Sweden..
    Erlandsson, Björn-Erik
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Human Communication Science.
    Traumatic shaking: The role of the triad in medical investigations of suspected traumatic shaking2018In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, p. 3-23Article, review/survey (Refereed)
    Abstract [en]

    The Swedish Agency for Health Technology Assessment and Assesment of Social Services (SBU) is an independent national authority, tasked by the government with assessing methods used in health, medical and dental services and social service interventions from a broad perspective, covering medical, economic, ethical and social aspects. The language in SBU's reports are adjusted to a wide audience. SBU's Board of Directors has approved the conclusions in this report. The systematic review showed the following graded results: There is limited scientific evidence that the triad (Three components of a whole. The triad associated with SBS usually comprises subdural haematoma, retinal haemorrhages and encephalopathy.) and therefore, its components can be associated with traumatic shaking (low-quality evidence). There is insufficient scientific evidence on which to assess the diagnostic accuracy of the triad in identifying traumatic shaking (very low-quality evidence). Limited scientific evidence (low-quality evidence) represents a combined assessment of studies of high or moderate quality which disclose factors that markedly weaken the evidence. It is important to note that limited scientific evidence for the reliability of a method or an effect does not imply complete lack of scientific support. Insufficient scientific evidence (very low-quality evidence) represents either a lack of studies or situations when available studies are of low quality or show contradictory results. Evaluation of the evidence was not based on formal grading of the evidence according to GRADE but on an evaluation of the total scientific basis.

  • 9.
    Emrani, Zahra
    et al.
    Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Karbalaie, Abdolamir
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Fatemi, Alimohammad
    Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
    Etehad Tavakol, Mahnaz
    Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Capillary density: An important parameter in nailfold capillaroscopy2017In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 109, p. 7-18Article in journal (Refereed)
    Abstract [en]

    Nailfold capillaroscopy is one of the various noninvasive bioengineering methods used to investigate skin microcirculation. It is an effective examination for assessing microvascular changes in the peripheral circulation; hence it has a significant role for the diagnosis of Systemic sclerosis with the classic changes of giant capillaries as well as the decline in capillary density with capillary dropout. The decline in capillary density is one of microangiopathic features existing in connective tissue disease. It is detectable with nailfold capillaroscopy. This parameter is assessed by applying quantitative measurement. In this article, we reviewed a common method for calculating the capillary density and the relation between the number of capillaries as well as the existence of digital ulcers, pulmonary arterial hypertension, autoantibodies, scleroderma patterns and different scoring system.

  • 10.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Overview of international standardization in informatics2013Conference paper (Other academic)
  • 11.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Overview on international standards activities related to software2013Conference paper (Refereed)
  • 12.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Safety Management and Accident Forensics2013Conference paper (Other academic)
  • 13.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Säkerhetsbegrepp och krav på informationssäkerhet vid användning av medicintekniska produkter inom vård och omsorg2015Report (Refereed)
    Abstract [sv]

    Syftet med innevarande forskningsaktivitet är att analysera och jämföra säkerhetsbegrepp och krav på informationssäkerhet i EN 80001-1:2011 (11) och ISO 27000 serien (12). Analysen skall belysa hur EN 80001-1:2011 kan tillämpas vid CE-märkning och hur den påverkar informationssäkerheten. Målet är att resultaten skall vara en bas för hur säkerhetsarbetet enligt de två standarderna påverkar verksamheten.

  • 14.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Varför köper vi sämre alternativ då det finns billigare och bättre?2013Conference paper (Other academic)
  • 15.
    Erlandsson, Björn-Erik
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Brodin, Lars-Åke
    KTH, School of Technology and Health (STH), Medical Engineering.
    Medicinsk säkerhet2016In: Anestesi / [ed] Sten GE Lindahl, Ola Winsö, Jonas Åkeson, Stockholm: Liber AB , 2016, 3, p. 168-173Chapter in book (Other academic)
  • 16.
    Erlandsson, Björn-Erik
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    et al.,
    Slutrapport RO 2013:02: Dödsfall på hjärtklinikens hjärtintensivavdelning N25 vid Karolinska Universitetssjukhuset i Solna, den 17 oktober 20102013Report (Other academic)
  • 17.
    Erlandsson, Björn-Erik
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Waldenström, A
    Adverse Events In Healthcare: How do we take into account the experience for safer care?2014In: Medical Physics in Radiation Oncology and Imaging, 2014Conference paper (Refereed)
  • 18.
    Erlandsson, Björn-Erik
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Waldenström, Anders
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Olyckor och tillbud inom vården: Erfarenheter för en säkrare vård2014In: MTD, 2014Conference paper (Refereed)
    Abstract [sv]

    I oktober 2010 en patient dog vid enheten för hjärtintensivvård vid Karolinska Universitetssjukhuset i Stockholm. StatensHaverikommission (SHK) beslutade att för första gången någonsin att utreda en negativ händelse som inträffade inom vården.

  • 19.
    Etehad Tavakol, Mahnaz
    et al.
    Isfahan University of Medical Sciences, Iran.
    Fatemi, Alimohammad
    Isfahan University of Medical Sciences, Iran.
    Karbalaie, Abdolamir
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Emrani, Zahra
    Isfahan University of Medical Sciences, Iran.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Nailfold Capillaroscopy in Rheumatic Diseases: Which Parameters Should Be Evaluated?2015In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, article id 974530Article in journal (Refereed)
    Abstract [en]

    Video nailfold capillaroscopy (NFC), considered as an extension of the widefield technique, allows a more accurate measuring andstoring of capillary data and a better defining, analyzing, and quantifying of capillary abnormalities. Capillaroscopic study is oftenperformed on the patients suspected of having microcirculation problems such as Raynaud’s phenomenon as the main indicationfor nailfold capillaroscopy. Capillaroscopic findings based on microcirculation studies can provide useful information in the fieldsof pathophysiology, differential diagnosis, and monitoring therapy. Nailfold capillaroscopy provides a vital assessment in clinicalpractices and research; for example, its reputation in the early diagnosis of systemic sclerosis is well established and it is also usedas a classification criterion in this regard. This review focuses on the manner of performing video nailfold capillaroscopy and on acommon approach for measuring capillary dimensions in fingers and toes.

  • 20.
    Fatemi, Alimohammad
    et al.
    Isfahan Univ Med Sci, Sch Med, Dept Internal Med, Rheumatol Sect, Esfahan, Iran..
    Erlandsson, Björn-Erik
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems.
    Emrani, Zahra
    Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran..
    Etehadtavakol, Mahnaz
    Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran..
    Smiley, Abbas
    Indiana Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Bloomington, IN USA..
    Karbalaie, Abdolamir
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems.
    Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors2019In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 126, article id UNSP 103910Article in journal (Refereed)
    Abstract [en]

    Objectives: The aim of this study was to determine capillaroscopic changes in patients with systemic lupus erythematosus (SLE) and their predictors. Methods: Fifty-nine SLE patients and 31 controls were enrolled in a cross-sectional study. Nailfold capillaroscopy examinations were performed, and qualitative semi-quantitative and quantitative parameters were evaluated in all fingers. Demographic features and lupus characteristics, such as renal involvement, medications, laboratory data, disease activity (SLEDAI) and damage, were recorded. The predictors of capillaroscopic abnormalities were obtained by backward stepwise regression analysis. Results: Capillary numbers of right hands were significantly lower in patients than in controls [8.74 (1.66) vs. 9.63 (1.80), P = 0.0001]. Capillaries were wider in patients than in controls in right [56.32 pm (16.76) vs. 50.43 mu m (10.16), P = 0.002] and left hands [54.40 (15.02) vs. 49.71 (9.77), P = 0.005]. Capillaries were shorter in SLE patients than in controls. Multivariate analysis revealed that the main associative factors of microvascular abnormalities were gender, drinking tea and hydroxychloroquine use for giant capillaries, SLEDAI and low C3 for avascularity and age, lupus nephritis and corticosteroid use for ramification. Conclusion: Most nailfold capillaroscopic abnormalities were more common in SLE patients than in controls. Hydroxychloroquine, corticosteroids, SLEDAI, low complement and lupus nephritis may be the major prognostic factors for microvascular changes in SLE patients.

  • 21.
    Fatemi, Alimohammad
    et al.
    Rheumatology Section, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Karbalaie, Abdolamir
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH). KTH.
    Zahra, Emrani
    Isfahan University of Medical Sciences, Isfahan, Iran.
    Etehadtavakol, Mahnaz
    Isfahan University of Medical Sciences, Isfahan, Iran.
    Smiley, Abbas
    School of Public Health, Indiana University, Bloomington, IN, USA.
    Erlandsson, Björn-Erik
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH).
    Nailfold microvascular changes in patients with systemic lupus erythematosus and their predictorsManuscript (preprint) (Other academic)
  • 22.
    Karbalaie, Abdolamir
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Abtahi, Farhad
    Fatemi, A.
    Etehadtavakol, M.
    Emrani, Z.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Elliptical broken line method for calculating capillary density in nailfold capillaroscopy: Proposal and evaluation2017In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 113, p. 1-8Article in journal (Refereed)
    Abstract [en]

    Nailfold capillaroscopy is a practical method for identifying and obtaining morphological changes in capillaries which might reveal relevant information about diseases and health. Capillaroscopy is harmless, and seems simple and repeatable. However, there is lack of established guidelines and instructions for acquisition as well as the interpretation of the obtained images; which might lead to various ambiguities. In addition, assessment and interpretation of the acquired images are very subjective. In an attempt to overcome some of these problems, in this study a new modified technique for assessment of nailfold capillary density is introduced. The new method is named elliptic broken line (EBL) which is an extension of the two previously known methods by defining clear criteria for finding the apex of capillaries in different scenarios by using a fitted elliptic. A graphical user interface (GUI) is developed for pre-processing, manual assessment of capillary apexes and automatic correction of selected apexes based on 90° rule. Intra- and inter-observer reliability of EBL and corrected EBL is evaluated in this study. Four independent observers familiar with capillaroscopy performed the assessment for 200 nailfold videocapillaroscopy images, form healthy subject and systemic lupus erythematosus patients, in two different sessions. The results show elevation from moderate (ICC = 0.691) and good (ICC = 0.753) agreements to good (ICC = 0.750) and good (ICC = 0.801) for intra- and inter-observer reliability after automatic correction of EBL. This clearly shows the potential of this method to improve the reliability and repeatability of assessment which motivates us for further development of automatic tool for EBL method.

  • 23.
    Karbalaie, Abdolamir
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Emrani, Zahra
    Isfahan Univ Med Sci, Med Image & Signal Proc Res Ctr, Esfahan, Iran..
    Fatemi, Alimohammad
    Isfahan Univ Med Sci, Sch Med, Dept Internal Med, Rheumatol Sect, Esfahan, Iran..
    Etehadtavakol, Mahnaz
    Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran..
    Erlandsson, Björn-Erik
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems.
    Practical issues in assessing nailfold capillaroscopic images: a summary2019In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 38, no 9, p. 2343-2354Article, review/survey (Refereed)
    Abstract [en]

    Nailfold capillaroscopy (NC) is a highly sensitive, safe, and non-invasive technique to assess involvement rate of microvascularity in dermatomyositis and systemic sclerosis. A large number of studies have focused on NC pattern description, classification, and scoring system validation, but minimal information has been published on the accuracy and precision of the measurement. The objective of this review article is to identify different factors affecting the reliability and validity of the assessment in NC. Several factors can affect the reliability of the examination, e.g., physiological artifacts, the nailfold imaging instrument, human factors, and the assessment rules and standards. It is impossible to avoid all artifacts, e.g., skin transparency, physically injured fingers, and skin pigmentation. However, minimization of the impact of some of these artifacts by considering some protocols before the examination and by using specialized tools, training, guidelines, and software can help to reduce errors in the measurement and assessment of NC images. Establishing guidelines and instructions for automatic characterization and measurement based on machine learning techniques also may reduce ambiguities and the assessment time.

  • 24.
    Karbalaie, Abdolamir
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems.
    Etehadtavakol, Mahnaz
    Isfahan University of Medical Sciences, Isfahan, Iran.
    Abtahi, Farhad
    Fatemi, Alimohammad
    Rheumatology Section, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Emrani, Zahra
    Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Erlandsson, Björn-Erik
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH).
    Image Enhancement Effect on Inter and Intra-observer Reliability of Nailfold Capillary Assessment2018In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319Article in journal (Refereed)
    Abstract [en]

    Background: Nailfold capillaroscopy (NC) is a diagnostic imaging technique that is used to assess the blood capillary network in the nailfold area. NC is routinely used for patients with microcirculation problems, such as systemic sclerosis and other connective tissue diseases.  Experts commonly use subjective evaluation as a reference point in images of nailfold video capillaroscopy, so it is important to reduce the inherent ambiguities in human judgment and diagnosis. Image quality is an important factor that affects measurement error and assessment time of NC images.

    Objective: In this study, a new image enhancement technique was introduced and evaluated subjectively.

    Methods: In total, 475 nailfold video capillaroscopy images from 18 healthy subjects and 41 systemic lupus erythematosus patients were used. The images were randomly divided into two sets, one each with 275 and 200. Eight independent observers who were familiar with the capillaroscopy technique participated in this study. The set of 275 images was evaluated by three observers with the forced–choice pairwise comparison method. Elliptic broken line (EBL) was used to count the number of capillaries. The intra- and inter-observer reliability of the original and enhanced images was evaluated on 200 images by five observers.

    Result: Except for eight images, all observers preferred the enhanced images in the visual quality comparison method. The intra-class correlation coefficient (ICC) of intra- and inter-observer reliability increased from 0.76-0.84 to 0.82-0.89, respectively, when using the enhancement method.

    Conclusion: By improving the image quality, more capillary details will be visible, and an observer can document more details that may not be visible in the original image and can do so more efficiently.

  • 25.
    Karbalaie, Abdolamir
    et al.
    KTH, School of Technology and Health (STH).
    Fatemi, Alimohammad
    Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences.
    Etehadtavakol, Mahnaz
    Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences.
    Abtahi, Farhad
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics. Department of Clinical Science, Intervention and Technology, Karolinska Institute (KI).
    Emrani, Zahra
    Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Counting Capillaries in Nailfold Capillaroscopy:State of the Art and a Proposed Method2016In: 2016 IEEE EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES), IEEE, 2016, , p. 5p. 170-174Conference paper (Refereed)
    Abstract [en]

    Capillaries play a crucial role in the microcirculatory system by exchanging metabolic substrates and waste products between blood and various tissues. The behavior of capillaries is affiliated with the number of capillaries per unit volume of tissue. Among the various noninvasive techniques available for analyzing skin microcirculation, nailfold capillaroscopyis considered to be a simple and easy-to-perform technique that allows a direct in-vivo visualization of the capillary network.Capillary density is one of the most important parameters in the studies involving capillaroscopy images. Capillary density in most of studies is defined as the number of capillaries in a one-millimeter span of the distal row in each finger or toe. This definition is silent about counting or excluding the number of the capillary with different shapes. However, there is no single standard for counting the number of capillaries in a span of one millimeter. In this paper, a novel method is proposed for determining the nailfold capillary density. This method is a modified combination of two existing techniques: the direct observation and the 90◦ method.Compared to the two existing approaches, the proposed method is more straightforward and easy to use for cases in which the capillaries have different shapes and sizes. Through different examples, we have shown how this method can be used to select the apex point of the capillary and subsequently count the number of capillaries with several papillae.

  • 26.
    Karbalaie, Abdolamir
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Hamid Muhammed, Hamed
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Using Homo-Separation of Variables for Solving Systems of Nonlinear Fractional Partial Differential Equations2013In: International journal of mathematics and mathematical sciences, ISSN 0161-1712, E-ISSN 1687-0425, Vol. 2013, p. 8-Article in journal (Refereed)
    Abstract [en]

    A new method proposed and coined by the authors as the homo-separation of variables method is utilized to solve systems oflinear and nonlinear fractional partial differential equations (FPDEs). The new method is a combination of two well-establishedmathematical methods, namely, the homotopy perturbation method (HPM) and the separation of variables method. Whencompared to existing analytical and numerical methods, the method resulting from our approach shows that it is capable ofsimplifying the target problem at hand and reducing the computational load that is required to solve it, considerably.The efficiencyand usefulness of this new general-purposemethod is verified by several examples, where different systems of linear and nonlinearFPDEs are solved.

  • 27.
    Karbalaie, Abdolamir
    et al.
    KTH, School of Technology and Health (STH), Informatics, logistics and management (Closed 20130701).
    MONTAZERI, MOHAMMAD MEHDI
    Khomeinishahr Branch Islamic Azad University Khomeinishahr, Isfahan.
    SHABANI, MARYAM
    Naghsh Jahan Intelligent and Communication Engineering Sahin Shahr, Isfahan IRAN.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Informatics, logistics and management (Closed 20130701). Royal Institute of Technology KTH.
    Application of Homo-separation of variables method on nonlinearsystem of PDEs2014In: WSEAS Transactions on Mathematics, ISSN 1109-2769, E-ISSN 2224-2880, Vol. 13, p. 992-1000Article in journal (Refereed)
    Abstract [en]

    In this study, the Homo-Separation of Variables method is introduced to find the exact solution of somecoupled nonlinear partial differential equations. This analytical method is a new combination of two powerfuland popular methods; namely the homotopy perturbation method (HPM) and the separation of variables method.The exact solution is constructed by choosing an appropriate initial approximation in addition to retaining onlythe first term of the series obtained by HPM. The proposed method is capable of reducing the computational loadconsiderably when compared to other classical method.

  • 28.
    Mridha, Mannan
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Improving patient care and safety using medical devices and ICT tools-examples from Bangladesh2014Conference paper (Refereed)
  • 29.
    Mridha, Mannan
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    To Increase Access E-Health and Improve Quality of Care for Rural Patients Developing Smart and Affordable Diagnostic Devices2014In: Medical Physics in Radiation Oncology and Imaging, 2014Conference paper (Refereed)
  • 30.
    Mridha, Mannan
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    et al,
    E-Learning for empowering the rural people in Bangladesh opportunities and challenges2013In: The Second International Conference on E-Learning and E-Technologies in Education (ICEEE2013), 2013, p. 323-328Conference paper (Refereed)
    Abstract [en]

    AbstractInadequate educational resources,insufficient and unqualified teachers and health care providers,and lack of community involvement, are some of the causes that contribute to the oor state of education and health in rural Bangladesh. This is although, it is well known that,access to quality education and scientific knowledge is essential for creating economic rowth and sustainable human development, including poverty alleviation and improvement of human health. In all countries and in the developing countries in particular, there is a need to mploy Information and Communication Technology, ICT to gain global access to learning. ICT an address issues of educational equity, social exclusion and can deliver a more effective and ccessible educational opportunities. It can also reduce cost of reaching and educating many ural students who are deprived of creative education due to lack of qualified teaching force.

    In Bangladesh, the education curriculum has been modernized to meet an international standard. For various reasons, qualified teachers are not keen to move to rural areas. The same is true in areas of health sectors where qualified medical doctors are not willing to move to rural areas. Therefore, we find enormous potentials for contribution of e-Learning and e-Health in empowering the rural educators as well as health care providers. A pilot project to test the potentials of e-Learning is implemented at a village Nohata in Magura district in Bangladesh (www.nuhat.org). Started in 2006, it has been using ICT tools to communicate, learn, and access international quality educational content. International quality teachers have been conducting teaching using videoconference system. Various relevant e-Learning aids have been developed to meet the local needs and conditions, you tube programmes covering different topics are carefully selected to meet the appropriate requirement of different target groups. The links are downloaded so that the students, the teachers, health workers, patients can follow the links off line, as many times as they want and discuss among themselves. The ICT tools are also being used to improve access to health care; enhance the quality of service delivery; improve the effectiveness of public health and primary care interventions; improve the shortage of health professionals through collaboration and training. ICT tools are offering solutions for emergency medical assistance, long-distance consultation, supervision quality assurance, and education and training for healthcare professionals and providers. The main challenges are to empower the rural people through creating locally relevant content for improving proficiency in English language, Mathematics, Science and Health care application and services considering the sociocultural factors, to achieve health, education and economic development. Through careful selection and creation of relevant e-Learning materials, we intend to develop the rural community using the potential of rural people and adopting participatory approaches for building  knowledge, skills and capacity.

    Keywords: e-learning in developing countries, rural empowerment, relevant content, e-health, rural health quality improvement

  • 31.
    Mridha, Mannan
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Islam, Mohammad
    BSM Medical University, Dhaka, Bangladesh.
    Srinivas, Mandalika B
    Birla Institute of Technology and Sciences, BITS, Hyderabad, India.
    E-Health in Developing Countries to Manage illnesses through Patient Education and Empowerment of Rural Health Workers2013In: Medicinteknikdagarna i Stockholm, 2013Conference paper (Refereed)
  • 32.
    Waldenström, Anders
    et al.
    Umeå universitet.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Incidenter i vården: Hur tar vi tillvara erfarenheterna för en säkrare vård?2014Conference paper (Refereed)
    Abstract [sv]

    Sjukvården blir alltmer komplicerad. Möjligheterna ökar med även riskerna. Mångåriga neddragningar i delar av vården kan inte ske utan risk att påverka säkerheten. Samhället har ett ansvar att minimera dessa risker. Med erfarenhet av ett fall utrett av Statens Haverikommission vill vi ventilera dessa frågor för att skapa debatt om hur detta arbete bäst kan bedrivas.

  • 33.
    Xu, Xiayu
    et al.
    School of Life Science and Technology,Xián University, Xián, China.
    Akay, Altug
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Wei, Huilin
    Wang, ShuQi
    Pingguan-Murphy, Belinda
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Li, Xiujun
    Lee, Wongu
    Hu, Jie
    Wang, Lin
    Xu, Feng
    Advances in Smartphone-Based Point-of-Care Diagnostics: This paper reviews the state-of-the-art advances in smartphone-based point-of-care diagnostic technologies and their applications in medicine and biology.2015In: Proceedings of the IEEE, ISSN 0018-9219, E-ISSN 1558-2256, Vol. 103, no 2, p. 236-247Article in journal (Refereed)
    Abstract [en]

    Point-of-care (POC) diagnostics is playing an increasingly important role in public health, environmental monitoring, and food safety analysis. Smartphones, alone or in conjunction with add-on devices, have shown great capability of data collection, analysis, display, and transmission, making them popular in POC diagnostics. In this article, the state-ofthe- art advances in smartphone-based POC diagnostic technologies and their applications in the past few years are outlined, ranging from in vivo tests that use smartphone’s built-in/external sensors to detect biological signals to in vitro tests that involves complicated biochemical reactions. Novel techniques are illustrated by a number of attractive examples, followed by a brief discussion of the smartphone’s role in telemedicine. The challenges and perspectives of smartphonebased POC diagnostics are also provided.

  • 34. Elinder, Göran (Contributor)
    Eriksson, Anders (Contributor)
    Hallberg, Boubou (Contributor)
    Lynøe, Niels (Contributor)
    Sundgren, Pia Maly (Contributor)
    Rosén, Måns (Contributor)
    Erlandsson, Björn-Erik (Contributor)
    KTH, School of Technology and Health (STH), Medical Engineering.
    Skakvåld: Triadens roll vid medicinsk utredning av misstänkt skakvåld2016Report (Other academic)
    Abstract [sv]

    Den systematiska litteraturöversikten visar följande evidensgraderade resultat:

    1. Det finns begränsat vetenskapligt underlag för att triaden1 och därmed dess delkomponenter kan förekomma vid skakvåld.
    2. Det finns otillräckligt vetenskapligt underlag för att bedöma den diagnostiska träffsäkerheten av triaden1 för att identifiera skakvåld.

    Begränsat vetenskapligt underlag bygger på studier med hög eller medelhög kvalitet med kraftigt försvagande faktorer vid en samlad bedömning. Det är viktigt att klargöra att även begränsat vetenskapligt stöd för en metods tillförlitlighet eller effekt inte innebär avsaknad av vetenskapligt stöd.

    Otillräckligt vetenskapligt underlag föreligger då studier saknas, tillgängliga studier har låg kvalitet eller där studier av likartad kvalitet visar motsägande resultat.

    Evidensvärderingen bygger inte på en formell evidensgradering med GRADE utan på en sammanlagd värdering av det vetenskapliga underlaget.

1 - 34 of 34
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