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  • 1.
    Kajko-Mattsson, Mira
    et al.
    KTH, School of Information and Communication Technology (ICT), Computer and Systems Sciences, DSV.
    Ta, Mi
    KTH, School of Information and Communication Technology (ICT), Computer and Systems Sciences, DSV.
    Wilczek, Lukas
    KTH, School of Information and Communication Technology (ICT), Computer and Systems Sciences, DSV.
    State of modernization practice in four Swedish organizations2007In: COMPSAC 2007: The Thirty-First Annual International Computer Software And Applications Conference, Vol I, Proceedings, 2007, p. 549-556Conference paper (Refereed)
    Abstract [en]

    Little is known about the industrial practice of modernising legacy systems. To be able to study it, we have created RaMoLeS - an end-to-end process model for modernising legacy systems. It consists of four sub-models: (1) Assessment, (2) Retirement, (3) Reengineering, and (4) Renovation. It provides guidelines for making decisions on how to approach ageing systems. In addition, it designates activities for each of its sub-models. In this paper, we evaluate the state of modernising practice in four major Swedish organisations using RaMoLeS. Our results show that most of the organisations studied do not have any defined end-to-end modernisation process model to follow. However, they conduct most of the activities as designated in the RaMoLeS framework.

  • 2.
    Åsberg, M
    et al.
    Karolinska Institutet.
    Nygren, A
    Karolinska Institutet.
    Leopardi, Rosario
    Karolinska Institutet.
    Rylander, Gunnar
    Peterson, Ulla
    Wilczek, Lukas
    Karolinska Institutet.
    Källmén, Håkan
    Ekstedt, Mirjam
    Karolinska Institutet.
    Åkerstedt, Torbjörn
    Karolinska Institutet.
    Lekander, Mats
    Karolinska Institutet.
    Ekman, Rolf
    Novel biochemical markers of psychosocial stress in women2009In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 4, no 1, p. e3590-Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women.

    METHODS: Plasma concentrations of interleukin (IL) 1-alpha, IL1-beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women.

    RESULTS: We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill.

    CONCLUSIONS: MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress.

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