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  • 1. Ahlberg, J
    et al.
    Claesson, L
    Nauwelarts de Agé, M
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Relationen mellan upplevelsemått och fysiologiska mått på fysisk ansträngning1980In: Information från Psykotekniska institutet, ISSN 0347-2795, no 115Article in journal (Other academic)
  • 2. Ahmed, Niaz
    et al.
    Näsman, Per
    KTH, Superseded Departments, Infrastructure.
    Wahlgren, Nils Gunnar
    Effect of intravenous nimodipine on blood pressure and outcome after acute stroke2000In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 31, no 6, p. 1250-1255Article in journal (Refereed)
    Abstract [en]

    Background and Purpose-The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustment for prognostic variables and to investigate outcome in subgroups with increasing levels of BP reduction. Methods-Patients with a clinical diagnosis of ischemic stroke (within 24 hours) were consecutively allocated to receive placebo (n=100), 1 mg/h (low-dose) nimodipine (n=101), or 2 mg/h (high-dose) nimodipine (n=94). The correlation between average BP change during the first 2 days and the outcome at day 21 was analysed. Results-Two hundred sixty-five patients were included in this analysis (n=92, 93, and 80 for placebo, low dose, and high dose. respectively). Nimodipine treatment resulted in a statistically significant reduction in systolic BP (SBP) and diastolic BP (DBP) from baseline compared with placebo during the first few days. In multivariate analysis, a significant correlation between DBP reduction and worsening of the neurological score was round for the high-close group (beta=0.49, P=0.048). Patients with a DBP reduction of greater than or equal to 20% in the high-dose group had a significantly increased adjusted OR for the compound outcome variable death or dependency (Barthel Index <60) (n/N=25/26, OR 10.16, 95% CI 1.02 to 101.74) and death alone (n/N=9/26, OR 4.3361 95% CI 1.131 16.619) compared with all placebo patients (n/N=62/92 and 14/92. respectively). There was no correlation between SEP change and outcome. Conclusions-DBP, but not SEP, reduction was associated with neurological worsening after the intravenous administration of high-dose nimodipine after acute stroke. For low-dose nimodipine, the results were not conclusive. These results do not confirm or exclude a neuroprotective property of nimodipine.

  • 3. Allgulander, Christer
    et al.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport and Economics, Safety Research.
    Regular hypnotic drug treatment in a sample of 32,679 Swedes: associations with somatic and mental health, inpatient psychiatricdiagnoses and suicide, derived with automated record-linkage1991In: Psychosomatic Medicine, ISSN 0033-3174, E-ISSN 1534-7796, Vol. 53, no 1, p. 101-108Article in journal (Refereed)
    Abstract [en]

    We studied Swedish survey responders who reported regular treatment with hypnotic drugs, to find associations to perceived health problems, inpatient psychiatric diagnoses, and subsequent suicide. Among 32,679 sampled Swedes, 26,952 (83%) participated, 500 of which (2%) reported regular hypnotic drug treatment. The rate of treatment was higher in women, and increased by age in both sexes. The major findings were high odds of concurrent psychoactive drug treatments, nervous symptoms and insomnia, as well as high rates of circulatory and musculoskeletal conditions in both sexes, with indicators of disability and sleep-disturbing symptoms. During a 15-year period, 35% of the men and 21% of the women who reported regular hypnotic drug treatment had also been admitted to inpatient psychiatric care. Substance abuse was diagnosed in 20% of the men and 4.3% of the women reporting hypnotic drug treatment. In multiple logistic regression models, the highest odds for regular hypnotic drug treatment were incurred by recent/current insomnia, nervous symptoms, and other psychoactive drug treatment. We conclude that therapy was principally given according to some current peer guidelines. Yet, further research is needed into the risk/benefit ratio of sustained hypnotic drug therapy in patients with qualifying somatic and psychiatric disorders to obtain a more uniformly based consensus.

  • 4. Almquist, T.
    et al.
    Jacobson, S. H.
    Mobarrez, F.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis. KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Hjemdahl, P.
    Lipid-lowering treatment and inflammatory mediators in diabetes and chronic kidney disease2014In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 44, no 3, p. 276-284Article in journal (Refereed)
    Abstract [en]

    Background: Inflammation may contribute to the high cardiovascular risk in diabetes mellitus (DM) and chronic kidney disease (CKD). Monocyte chemoattractant protein-1 (MCP-1) facilitates the recruitment of monocytes into atherosclerotic lesions and is involved in diabetic nephropathy. Interferon gamma (IFNγ) is important in atherosclerosis and increases the synthesis of chemokines including MCP-1. Lipid-lowering treatment (LLT) with statins may have anti-inflammatory effects, and ezetimibe cotreatment provides additional cholesterol lowering. Methods: After a placebo run-in period, the effects of simvastatin alone (S) or simvastatin + ezetimibe (S+E) were compared in a randomized, double-blind, cross-over study on inflammatory parameters. Eighteen DM patients with estimated glomerular filtration rate (eGFR) 15-59 mL/min × 1·73 m2 (CKD stages 3-4) (DM-CKD) and 21 DM patients with eGFR &gt; 75 mL/min (DM only) were included. Results: At baseline, monocyte chemoattractant protein 1 (MCP-1) (P = 0·03), IFNγ (P = 0·02), tumour necrosis factor-α (TNFα) (P &lt; 0·01) and soluble vascular adhesion molecule (sVCAM) (P = 0·001) levels were elevated in DM-CKD compared with DM-only patients. LLT with S and S+E reduced MCP-1 levels (P &lt; 0·01 by anova) and IFNγ levels (P &lt; 0·01) in DM-CKD patients but not in DM-only patients. Reductions were most pronounced with the combination treatment. Conclusions: DM patients with CKD stages 3-4 had increased inflammatory activity compared with DM patients with normal GFR. Lipid-lowering treatment decreased the levels of MCP-1 and IFNγ in DM patients with concomitant CKD, which may be beneficial with regard to the progression of both atherosclerosis and diabetic nephropathy.

  • 5. Andreasson, J
    et al.
    Uttervall, K
    Liwing, J
    Alici, E
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Aschan, J
    Nahi, H
    Bortezomib, response and retreatment in 1st, 2nd, 3rd and 4th line of treatment in patients with multiple myeloma2012In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 97, no supplement 1, p. 610-610Article in journal (Refereed)
  • 6. Börjesson, M
    et al.
    Hamilton, C J
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Papaix, C
    Public opinion on congestion, free public transport and new roads investments in Stockholm, Helsinki and Lyon.2014Conference paper (Other academic)
  • 7.
    Börjesson, Maria
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport planning, economics and engineering. KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Hamilton, Carl J.
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport planning, economics and engineering.
    Papaix, Claire
    Factors driving public support for road congestion reduction policies: Congestion charging, free public transport and more roads in Stockholm, Helsinki and Lyon2015In: Transportation Research Part A: Policy and Practice, ISSN 0965-8564, E-ISSN 1879-2375, Vol. 78, p. 452-462Article in journal (Refereed)
    Abstract [en]

    Based on an across-the-board survey conducted among residents of Stockholm, Helsinki and Lyon, we explore the opinions on three policy measures to combat road congestion: congestion charging, free public transport and building more roads. The support for the two latter policies is substantially higher than the support for congestion charging, which is only supported by a majority in Stockholm. Self-interest is important for the formation of the opinion to all three policies. However, fundamental values and general political views, indicated by four attitudinal factors, are even more important in forming opinions towards the three transport policies. Of all attitudinal factors, the one indicating environmental concern most influences the support for all policies. Equity concerns, however, increase the support for free public transport and opposition to taxation increases the support for building more roads. Our results further suggest that the opinions towards free public transport and building more roads can be mapped along the left right political axis, where Environment and Equity are to the left and Pricing and Taxation are to the right. However, the opinion towards congestion charging cuts right through the political spectrum. The impact of the fundamental values and self-interest variables are similar for Stockholm and Helsinki, indicating that even if experience increases the overall support for charging, it does not change the relative strength of different political arguments to any major extent.

  • 8.
    Ceccato, Vania
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Urban Planning and Environment, Urban and Regional Studies.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Building and Real Estate Economics.
    Catherine, Sundling
    Langefors, Linda
    KTH.
    Trygghet i kollektivtrafiken i Stockholm i ett internationellt perspektiv: En handlingsplan mot sexuella trakasserier och brott i transitmiljöer2019Report (Other academic)
    Abstract [en]

    Safety and security are human rights - to feel free from risk and fear of danger is crucial for all people and a prerequisite for modern society. Safety promotes and encourages mobility, which is basic for an individual’s quality of life. This report presents Stockholm students' responses to a survey of experiences and perceptions of sexual harassment and sexual transit crimes in public transport conducted in May-June 2018 as part of an international study. The study contained 1,122 young people surveyed at the Royal Institute of Technology (KTH) in Stockholm and 309 students from Södertörn University in Huddinge. We investigated the victimization of sexual harassment and sexual crimes in transit environments, feelings of perceived security or lack thereof, and necessary improvements to make travel safer.

  • 9.
    Ekane, Nelson
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Urban Planning and Environment, Urban and Regional Studies. KTH, Stockholm.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Building and Real Estate Economics.
    ‘Carrots’, ‘Sticks’, and ‘Sermons’: Household perspectives on sanitation and hygiene behaviours in Rwanda and UgandaManuscript (preprint) (Other academic)
    Abstract [en]

    The appropriateness and effectiveness of different policy instruments in fostering improved sanitation and hygiene practices in different contexts is debated. ‘Sermons’ inform on recommended behaviours, ‘carrots’ initiate behaviours, and ‘sticks’ restrict, deter, and punish undesirable behaviours. Through the lens of ‘carrots’ ‘sticks’, and ‘sermons’, this article analyses two approaches to sanitation promotion as they have been implemented in Rwanda and Uganda. The Community Health Clubs (CHCs) approach is the policy choice in Rwanda whereas Community-Led Total Sanitation (CLTS) is predominantly promoted in Uganda. Building on a survey of 1173 households in both countries, this article contributes to the ongoing debate with insights on how target populations perceive the options promoted by the different approaches in influencing behaviour change outcomes, or not.  

    This study reveals significant differences regarding observed latrines, handwashing facilities, soap and water at the handwashing facility, and reported handwashing with soap and water between most of the study sites with CHC and CLTS intervention and those with no CHC and CLTS intervention. The observed differences are indications of the effectiveness of the interventions in changing behaviours. Similar differences are observed between best performing CLTS (ODF declared) and poor performing CLTS (ODF not yet declared), which underlines the importance of proper implementation. The study suggests support for using a combination of ‘carrots’, ‘sticks’, and ‘sermons’ which are all perceived as effective but for different reasons. Incentives for good sanitation practices and proper hygiene behaviour are perceived by respondents as a source of commitment and competition. Health messages are generally preferred for raising community awareness. However, the application of educational appeals - which are perceived as the most legitimate instruments and predominantly used in CHC and CLTS interventions – is insufficient for achieving universal compliance in the short-term. Other instruments can trigger short-term desired changes but may not be legitimate. This is the case with fines and naming and shaming which are perceived as effective but may compromise social relations and values. Findings also reveal that there is a common understanding among respondents that the responsibility for providing resources for construction and maintenance of sanitation facilities is a shared one. However, respondents’ ability to fulfil this responsibility is partly hampered by poverty and water availability related constraints.

  • 10. Ekengren Oscarsson, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Lagercrantz, A
    Analys av vallokasundersökning.2018Conference paper (Other academic)
  • 11. Ekengren Oscarsson, H
    et al.
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Landahl, E
    Holmberg, S
    Valu 2018 - SVT exit poll survey parliamentary election 20182018Report (Other academic)
  • 12. Ekengren Oscarsson, H
    et al.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Landahl, E
    Holmberg, S
    Valu 2018: SVT:s vallokalsundersökning Riksdagsvalet 2018.2018Report (Other academic)
  • 13. Ekstrand, E
    et al.
    Buhlin, K
    Holmer, J
    Kjellström, B
    Norhammar, A
    Näsman, Per
    Rathnayake, N
    Rydén, L
    Salonen, A
    Gustafsson, A
    Poor Agreement between Radiographic and Clinical Diagnosis of Periodontitis.2015In: IADR/AADR/CADR CongressArticle in journal (Other academic)
  • 14. Ekstrand, E. E.
    et al.
    Gustafsson, A. G.
    Norhammar, A. N.
    Näsman, Per N.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport Planning, Economics and Engineering.
    Ryden, L. R.
    Kjellstrom, B. K.
    Periodontal disease: A potential risk factor for myocardial infarction in younger women2016In: EUROPEAN HEART JOURNAL, ISSN 0195-668X, Vol. 37, p. 350-350Article in journal (Refereed)
  • 15. Ekstrand, E
    et al.
    Gustafsson, A
    Norhammar, A
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Ryden, L
    Kjellström, B
    Periodontal disease - a potential risk factor for myocardial infarction in younger women.2016In: Svenska Hjärtförbundet, no 128Article in journal (Other academic)
  • 16. Elofsson, S
    et al.
    Nauwelarts de Agé, M
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Lokala arbetsmarknadsförhållandens betydelse för sysselsättningen1981Report (Other academic)
  • 17. Elofsson, S
    et al.
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Nauwelarts de Agé, M
    Väderleksbaserade skördeprognoser, icke-linjära modeller1978Report (Other academic)
  • 18.
    Eriksson, B.
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Family Med, Huddinge, Sweden..
    Wandell, P.
    Karolinska Inst, Div Family Med, NVS, Solna, Sweden..
    Dahlstrom, U.
    Linkoping Univ, Dept Cardiol, Linkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Traffic Research, CTR.
    Lund, L. H.
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Cardiol, Stockholm, Sweden..
    Edner, M.
    Karolinska Inst, Dept Med, Cardiol Unit, N3 06, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden..
    Comorbidities, risk factors and outcomes in patients with heart failure and an ejection fraction of more than or equal to 40% in primary care- and hospital care-based outpatient clinics2018In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 36, no 2, p. 207-215Article in journal (Refereed)
    Abstract [en]

    Objective: The aim of this study is to describe patients with heart failure and an ejection fraction (EF) of more than or equal to 40%, managed in both Primary- and Hospital based outpatient clinks separately with their prognosis, comorbidities and risk factors. Further to compare the heart failure medication in the two groups. Design: We used the prospective Swedish Heart Failure Registry to include 9654 out-patients who had HF and EF >= 40%, 1802 patients were registered in primary care and 7852 in hospital care. Descriptive statistical tests were used to analyze base line characteristics in the two groups and multivariate logistic regression analysis to assess mortality rate in the groups separately. Setting: The prospective Swedish Heart Failure Registry. Setting: The prospective Swedish Heart Failure Registry. Subjects: Patients with heart failure and an ejection fraction (EF) of more than or equal to 40%. Main outcome measures: Comorbidities, risk factors and mortality. Results: Mean-age was 77.5 (primary care) and 70.3 years (hospital care) p < 0.0001, 46.7 vs. 36.3% women respectively (p < 0.0001) and EF >= 50% 26.1 vs. 13.4% (p < 0.0001). Co-morbidities were common in both groups (97.2% vs. 92.3%), the primary care group having more atrial fibrillation, hypertension, ischemic heart disease and COPD. According to the multivariate logistic regression analysis smoking, COPD and diabetes were the most important independent risk factors in the primary care group and valvular disease in the hospital care group. All-cause mortality during mean follow-up of almost 4 years was 315% in primary care and 27.8% in hospital care. One year-mortality rates were 7.8%, and 7.0% respectively. Conclusion: Any co-morbidity was noted in 97% of the HF-patients with an EF of more than or equal to 40% managed at primary care based out-patient clinics and these patients had partly other independent risk factors than those patients managed in hospital care based outpatients clinics. Our results indicate that more attention should be payed to manage COPD in the primary care group.

  • 19.
    Ferrannini, Giulia
    et al.
    Karolinska Inst, Dept Med, Cardiol Unit, Stockholm, Sweden.;Univ Turin, Postgrad Sch Internal Med, Dept Med Sci, Turin, Italy..
    Svenungsson, Elisabet
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Rheumatol Unit, Stockholm, Sweden..
    Kjellstrom, Barbro
    Karolinska Inst, Dept Med, Cardiol Unit, Stockholm, Sweden..
    Elvin, Kerstin
    Karolinska Inst, Dept Clin Immunol & Transfus Med, Unit Clin Immunol, Stockholm, Sweden..
    Grosso, Giorgia
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Rheumatol Unit, Stockholm, Sweden..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Building and Real Estate Economics.
    Ryden, Lars
    Karolinska Inst, Dept Med, Cardiol Unit, Stockholm, Sweden..
    Norhammar, Anna
    Karolinska Inst, Dept Med, Cardiol Unit, Stockholm, Sweden.;Capio St Gorans Hosp, Stockholm, Sweden..
    Dysglycaemic patients with antiphospholipid antibodies IgG: a neglected group at high cardiovascular risk?2019In: Lupus, ISSN 0961-2033, E-ISSN 1477-0962, Vol. 28, p. 42-42Article in journal (Other academic)
  • 20. Franzen-Dahlin, Asa
    et al.
    Billing, Ewa
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport and Economics, Safety Research.
    Martensson, Bjorn
    Wredling, Regina
    Murray, Veronica
    Post-stroke depression - effect on the life situation of the significant other2006In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 20, no 4, p. 412-416Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to describe the life situation among,significant others' to patients with post-stroke depression, and to identify associations between the life situation of the significant others and patient characteristics. Seventy-one dyads consisting of patients with a diagnosed post-stroke depression and their significant others were included. The patients were assessed for depression with the Montgomery-angstrom sberg Depression Rating Scale and diagnosed according to the DSM-IV. The assessments of significant others included their own life situation and proxy assessments of the patients' state of depression, anger, change of personality, and need of assistance. Significant others of male stroke patients reported a more negative impact on their life situation, than did significant others of female stroke patients (p = 0.04). There was a significant association between the patient's level of depression and physical function [activities of daily living (ADL)], with those with less impaired ADL having more major depression than those with more impaired ADL (p = 0.007). This study indicates that major post-stroke depression is more common among patients with limited functional deficits. This highlights the importance of assessment for depression also among seemingly recovered stroke patients in order to treat and support those in need. This study also stresses the importance of identifying different needs of the significant others in order to provide appropriate support in their caregiving role.

  • 21. Gerholm, TR
    et al.
    Meisels, S
    Brandell, L
    Thedéen, T
    Claesson, L
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Långsiktig energikonsumtionsutveckling1982Report (Other academic)
  • 22. Glimelius, B
    et al.
    Linné, T
    Hoffman, K
    Larsson, L
    Svensson, JH
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Svensson, B
    Helmers, C
    Epoetin Beta in the Treatment of Anemia in Patients With Advanced Gastrointestinal Cancer1998In: Journal of Clinical Oncology, ISSN 0732-183X, E-ISSN 1527-7755, Vol. 16, no 2, p. 434-440Article in journal (Refereed)
  • 23. Graham, C.
    et al.
    Lewis, S.
    Forbes, J.
    Mead, G.
    Hackett, M. L.
    Hankey, G. J.
    Gommans, J.
    Nguyen, H. T.
    Lundström, E.
    Isaksson, E.
    Näsman, Per
    KTH.
    Rudberg, A. -S
    Dennis, M.
    The FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: Statistical and health economic analysis plan for the trials and for the individual patient data meta-analysis2017In: Trials, ISSN 1745-6215, E-ISSN 1745-6215, Vol. 18, no 1, article id 627Article in journal (Refereed)
    Abstract [en]

    Background: Small trials have suggested that fluoxetine may improve neurological recovery from stroke. FOCUS, AFFINITY and EFFECTS are a family of investigator-led, multicentre, parallel group, randomised, placebo-controlled trials which aim to determine whether the routine administration of fluoxetine (20 mg daily) for six months after an acute stroke improves patients' functional outcome. Methods/Design: The core protocol for the three trials has been published (Mead et al., Trials 20:369, 2015). The trials include patients aged 18 years and older with a clinical diagnosis of stroke and persisting focal neurological deficits at randomisation 2-15 days after stroke onset. Patients are randomised centrally via each trials' web-based randomisation system using a common minimisation algorithm. Patients are allocated fluoxetine 20 mg once daily or matching placebo capsules for six months. The primary outcome measure is the modified Rankin scale (mRS) at six months. Secondary outcomes include: living circumstances; the Stroke Impact Scale; EuroQol (EQ5D-5 L); the vitality subscale of the 36-Item Short Form Health Survey (SF36); diagnosis of depression; adherence to medication; serious adverse events including death and recurrent stroke; and resource use at six and 12 months and the mRS at 12 months. Discussion: Minor variations have been tailored to the national setting in the UK (FOCUS), Australia, New Zealand and Vietnam (AFFINITY) and Sweden (EFFECTS). Each trial is run and funded independently and will report its own results. A prospectively planned individual patient data meta-analysis of all three trials will provide the most precise estimate of the overall effect and establish whether any effects differ between trials or subgroups. This statistical analysis plan describes the core analyses for all three trials and that for the individual patient data meta-analysis. Recruitment and follow-up in the FOCUS trial is expected to be completed by the end of 2018. AFFINITY and EFFECTS are likely to complete follow-up in 2020.

  • 24.
    Grosso, Giorgia
    et al.
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Unit Rheumatol, Stockholm, Sweden..
    Sippl, Natalie
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Kjellstrom, Barbro
    Karolinska Inst, Karolinska Univ Hosp, Cardiol Unit, Dept Med Solna, Stockholm, Sweden..
    Amara, Khaled
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    de Faire, Ulf
    Karolinska Inst, Div Cardiovasc Epidemiol IMM, Stockholm, Sweden..
    Elvin, Kerstin
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Unit Rheumatol, Stockholm, Sweden.;Karolinska Inst, Karolinska Univ Hosp, Unit Clin Immunol, Dept Clin Immunol & Transfus Med, Stockholm, Sweden..
    Lindahl, Bertil
    Uppsala Univ, Dept Med Sci, Uppsala, Sweden..
    Näsman, Per
    KTH.
    Ryden, Lars
    Karolinska Inst, Dept Med Solna, Cardiol Unit, Stockholm, Sweden..
    Norrhammar, Anna
    Karolinska Inst, Dept Med Solna, Cardiol Unit, Stockholm, Sweden.;Capio St Gorans Hosp, Stockholm, Sweden..
    Svenungsson, Elisabet
    Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden..
    IgG Antiphospholipid Antibodies, -a Common but Neglected Finding in Patients with Myocardial Infarction2018In: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Article in journal (Other academic)
  • 25.
    Grosso, Giorgia
    et al.
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Sippl, Natalie
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Kjellström, Barbro
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Amara, Khaled
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    de Faire, Ulf
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Elvin, Kerstin
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Lindahl, Bertil
    Uppsala Univ, Uppsala, Sweden..
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Building and Real Estate Economics.
    Ryden, Lars
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Norhammar, Anna
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden.;Capio St Gorans Hosp, Stockholm, Sweden..
    Svenungsson, Elisabet
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Antiphospholipid Antibodies in Patients With Myocardial Infarction2019In: Annals of Internal Medicine, ISSN 0003-4819, E-ISSN 1539-3704, Vol. 170, no 4, p. 277-280Article in journal (Refereed)
  • 26. Gustafsson, A
    et al.
    Buhlin, K
    de Faire, U
    Kjellström, B
    Klinge, B
    Lindahl, B
    Norhammar, A
    Nygren, Å
    Näsman, P
    Svenungsson, E
    Rydén, L
    The Relation between Cardiovascular and Periodontal Disease - the PAROKRANK study.2015Conference paper (Other academic)
  • 27. Gustafsson, T
    et al.
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS.
    Holmberg, S
    Senaste nytt ur SVT:s valundersökningar2015Conference paper (Other academic)
  • 28. Gustavsson, J
    et al.
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Some information about the activities at the Department of Statistics, Stockholm University, Sweden1990Conference paper (Other academic)
  • 29. Hedenus, M
    et al.
    Birgegård, G
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Ahlberg, L
    Karlsson, T
    Lauri, B
    Lundin, J
    Lärfars, G
    Österborg, A
    Adjuvant intravenous iron therapy potentiates epoetin beta treatment in anemic, non iron-depleted patients with lymphoproliferative disorders: Results of the NIFE study2006Conference paper (Other academic)
  • 30. Hedenus, M.
    et al.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport and Economics.
    Liwing, J.
    Economic evaluation in Sweden of epoetin beta with intravenous iron supplementation in anaemic patients with lymphoproliferative malignancies not receiving chemotherapy2008In: Journal of Clinical Pharmacy and Therapeutics, ISSN 0269-4727, E-ISSN 1365-2710, Vol. 33, no 4, p. 365-374Article in journal (Refereed)
    Abstract [en]

     Background and objective: Functional iron deficiency is one reason for lack of response to erythropoietin treatment. Concomitant intravenous (IV) iron supplementation has the potential to improve response to erythropoietin, allowing a decrease in erythropoietin dose requirements. In a recent study of anaemic, iron-replete patients with lymphoproliferative malignancies (Leukemia, 21, 2007, 627), the haemoglobin (Hb) increase and response rate were significantly greater in patients receiving epoetin beta with concomitant IV iron compared with patients receiving epoetin beta without IV iron (P < 0 05). The present analysis aimed to investigate whether a combination of epoetin beta and IV iron is cost-effective compared with epoetin beta without IV iron.

    Methods: This analysis was performed from a Swedish societal perspective as a within-trial evaluation of overall costs (based on differences in drug costs and resource use between groups) and effect (differences in Hb increases) during 16 weeks' treatment with epoetin beta with or without concomitant IV iron.

    Results and discussion: There was an improved response to epoetin beta with IV iron therapy and an almost 2-fold greater increase in Hb levels. Overall mean cost per patient in the epoetin beta with IV iron group was is an element of 5558 and in the epoetin beta without IV iron group was is an element of 6228. Thus, treatment with epoetin beta with IV iron resulted in overall cost savings of about 11% compared with epoetin beta without iron, mainly due to reduced erythropoietin dosages.

    Conclusion: Epoetin beta with concomitant IV iron in anaemic patients with lymphoproliferative malignancies not receiving chemotherapy resulted in better outcomes at lower cost compared with epoetin beta without iron. This suggests that epoetin beta with IV iron is a dominant therapy from a Swedish perspective.

  • 31. Hedenus, Michael
    et al.
    Birgegård, G.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport and Economics, Safety Research.
    Ahlberg, L.
    Karlsson, T.
    Lauri, B.
    Lundin, J.
    Lärfars, Gerd
    Österborg, A.
    Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study2007In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 21, no 4, p. 627-632Article in journal (Refereed)
    Abstract [en]

    This randomized study assessed if intravenous iron improves hemoglobin (Hb) response and permits decreased epoetin dose in anemic (Hb 9 - 11 g/dl), transfusion-independent patients with stainable iron in the bone marrow and lymphoproliferative malignancies not receiving chemotherapy. Patients (n = 67) were randomized to subcutaneous epoetin beta 30 000 IU once weekly for 16 weeks with or without concomitant intravenous iron supplementation. There was a significantly (P < 0.05) greater increase in mean Hb from week 8 onwards in the iron group and the percentage of patients with Hb increase >= 2 g/dl was significantly higher in the iron group (93%) than in the no-iron group (53%) (per-protocol population; P < 0.001). Higher serum ferritin and transferrin saturation in the iron group indicated that iron availability accounted for the Hb response difference. The mean weekly patient epoetin dose was significantly lower after 13 weeks of therapy (P < 0.029) and after 15 weeks approximately 10 000 IU (425%) lower in the iron group, as was the total epoetin dose (P = 0.051). In conclusion, the Hb increase and response rate were significantly greater with the addition of intravenous iron to epoetin treatment in iron-replete patients and a lower dose of epoetin was required.

  • 32. Hedenus, Michael
    et al.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport and Economics, Safety Research.
    Epoetin beta with intravenous iron results in overall cost savings in a population of anemic patients with lymphoid malignancies not receiving chemotherapy2007In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 110, no 11, p. 5179-Article in journal (Refereed)
  • 33. Hernborn, H
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu Swedish Exit Polls2002Report (Other academic)
  • 34. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Valu 2003. SVT:s vallokalundersökning EMU-valet 20032003Report (Other academic)
  • 35. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    SVT:s vallokalundersökning 19911991Report (Other academic)
  • 36. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu 2002. SVT:s vallokalundersökning 20022002Report (Other academic)
  • 37. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu Sveriges Televisions vallokalsundersökningar2003Report (Other academic)
  • 38. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu-94 SVT:s vallokalsundersökning 19941994Report (Other academic)
  • 39. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu-94EU SVT:s vallokalsundersökning Folkomröstningen 19941994Report (Other academic)
  • 40. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu-95 SVT:s vallokalsundersökning EU-parlamentsvalet 19951995Report (Other academic)
  • 41. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu-98 SVT:s vallokalsundersökning riksdagsvalet 19981998Report (Other academic)
  • 42. Hernborn, H
    et al.
    Holmberg, S
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Thedéen, T
    Valu-99 SVT:s vallokalsundersökning EU-parlamentsvalet 19991999Report (Other academic)
  • 43. Hernborn, H
    et al.
    Holmberg, S
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Safety Research.
    Valu 2006. Riksdagsvalet 20062006Other (Other academic)
  • 44. Hernborn, H
    et al.
    Holmberg, S
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Safety Research.
    Valu 2006. SVT:s vallokalundersökning riksdagsvalet 20062006Report (Other academic)
  • 45. Hernborn, H
    et al.
    Holmberg, S
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Safety Research.
    Valu i allmänhetens tjänst2006Report (Other academic)
  • 46. Hernborn, H
    et al.
    Holmberg, S
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Valu-vaka med besked! Inför rysarkvällen den 17 september 20062006Conference paper (Other (popular science, discussion, etc.))
  • 47. Hjemdahl, P.
    et al.
    Eriksson, S.V.
    Held, C.
    Forslund, L.
    Näsman, Per
    KTH, School of Architecture and the Built Environment (ABE), Transport and Economics, Safety Research.
    Rehnqvist, N.
    Favourable long term prognosis in stable angina pectoris:  an extended follow up of the angina prognosis study in Stockholm (APSIS)2006In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 92, no 2, p. 177-182Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate the long term prognosis of patients with stable angina pectoris.

    Design: Registry based follow up ( median 9.1 years) of patients participating in the APSIS ( angina prognosis study in Stockholm), which was a double blind, single centre trial of antianginal drug treatment.

    Patients: 809 patients (31% women) with stable angina pectoris < 70 ( mean (SD) 59 (7) years at inclusion) and an age and sex matched reference population from the same catchment area.

    Interventions: Double blind treatment with metoprolol or verapamil during 3.4 years ( median), followed by referral for usual care with open treatment. Main outcome measures: Cardiovascular ( CV) death and non-fatal myocardial infarction (MI) in the APSIS cohort and total mortality in comparison with reference subjects.

    Results: 123 patients died ( 41 MI, 36 other CV causes) and 72 had non-fatal MI. Mortality (19% v 6%, p< 0.001) and fatal MI (6.6% v 1.6%, p< 0.001) were increased among male compared with female patients. Diabetes, previous MI, hypertension, and male sex independently predicted CV mortality ( p, 0.001). Diabetes greatly increased the risk in a small subgroup of female patients. Male patients had higher mortality than men in the reference population during the first three years ( cumulative absolute difference 3.8%) but apparently not thereafter. Female patients had similar mortality to women in the reference population throughout the 9.1 years of observation.

    Conclusions: Female patients with stable angina had similar mortality to matched female reference subjects but male patients had an increased risk. Diabetes, previous MI, hypertension, and male sex were strong risk factors for CV death or MI.

    Objective: To evaluate the long term prognosis of patients with stable angina pectoris.

    Design: Registry based follow up ( median 9.1 years) of patients participating in the APSIS ( angina prognosis study in Stockholm), which was a double blind, single centre trial of antianginal drug treatment.

    Patients: 809 patients (31% women) with stable angina pectoris < 70 ( mean (SD) 59 (7) years at inclusion) and an age and sex matched reference population from the same catchment area.

    Interventions: Double blind treatment with metoprolol or verapamil during 3.4 years ( median), followed by referral for usual care with open treatment. Main outcome measures: Cardiovascular ( CV) death and non-fatal myocardial infarction (MI) in the APSIS cohort and total mortality in comparison with reference subjects.

    Results: 123 patients died ( 41 MI, 36 other CV causes) and 72 had non-fatal MI. Mortality (19% v 6%, p< 0.001) and fatal MI (6.6% v 1.6%, p< 0.001) were increased among male compared with female patients. Diabetes, previous MI, hypertension, and male sex independently predicted CV mortality ( p, 0.001). Diabetes greatly increased the risk in a small subgroup of female patients. Male patients had higher mortality than men in the reference population during the first three years ( cumulative absolute difference 3.8%) but apparently not thereafter. Female patients had similar mortality to women in the reference population throughout the 9.1 years of observation.

    Conclusions: Female patients with stable angina had similar mortality to matched female reference subjects but male patients had an increased risk. Diabetes, previous MI, hypertension, and male sex were strong risk factors for CV death or MI.

  • 48. Holmberg, S
    et al.
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Gustafsson, T
    Valu - hur väljer det svenska folket?2014Conference paper (Other academic)
  • 49. Holmberg, S
    et al.
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Gustafsson, T
    Valu 2014 - SVT exit poll survey parliamentary election 2014.2014Report (Other academic)
  • 50. Holmberg, S
    et al.
    Näsman, P
    KTH, School of Architecture and the Built Environment (ABE), Centres, Centre for Transport Studies, CTS. KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport and Location Analysis.
    Gustafsson, T
    Valu 2014 - SVT:s vallokalundersökning riksdagsvalet 2014.2014Report (Other academic)
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