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  • 1. Andõn, F. T.
    et al.
    Kapralov, A. A.
    Yanamala, N.
    Feng, W.
    Baygan, Arjang
    Karolinska Institutet.
    Chambers, B. J.
    Hultenby, K.
    Ye, Fei
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Materials- and Nano Physics, Functional Materials, FNM.
    Brandner, B. D.
    Fornara, Andrea
    Institute for Surface Chemistry, Stockholm.
    Klein-Seetharaman, J.
    Kotchey, G. P.
    Star, A.
    Shvedova, Anna A.
    West Virginia University, USA.
    Fadeel, B.
    Kagan, V. E.
    Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase2013In: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 9, no 16, p. 2721-2729Article in journal (Refereed)
    Abstract [en]

    Eosinophil peroxidase (EPO) is one of the major oxidant-producing enzymes during inflammatory states in the human lung. The degradation of single-walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O 2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H2O2 alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV-visible-NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials. Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant-generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.

  • 2.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Magnetic nanostructured materials for advanced bio-applications2008Licentiate thesis, comprehensive summary (Other scientific)
    Abstract [en]

    In the recent years, nanostructured magnetic materials and their use in biomedical and biotechnological applications have received a lot of attention. In this thesis, we developed tailored magnetic nanoparticles for advanced bio-applications, such as direct detection of antibodies in biological samples and stimuli responsive drug delivery system.

    For sensitive and selective detection of biomolecules, thermally blocked iron oxide nanoparticles with specific magnetic properties are synthesized by thermal hydrolysis to achieve a narrow size distribution just above the superparamagnetic limit.  The prepared nanoparticles were characterized and functionalized with biomolecules for use in a successful biosensor system. We have demonstrated the applicability of this type of nanoparticles for the detection of Brucella antibodies as model compound in serum samples and very low detection limits were achieved (0.05 mg/mL).

    The second part is concerning an in-depth investigation of the evolution of the thermally blocked magnetic nanoparticles. In this study, the formation of the nanoparticles at different stages during the synthesis was investigated by high resolution electron microscopy and correlated to their magnetic properties.  At early stage of the high temperature synthesis, small nuclei of 3.5 nm are formed and the particles size increases successively until they reach a size of 17-20 nm. The small particles first exhibit superparamagnetic behavior at the early stage of synthesis and then transform to thermally blocked behavior as their size increases and passes the superparamagnetic limit.

    The last section of the Thesis is related to the development of novel drug delivery system based on magnetically controlled release rate. The system consists of hydrogel of Pluronic FP127 incorporating superparamagnetic iron oxide nanoparticles to form a ferrogel. The sol to gel formation of the hydrogel could be tailored to be solid at body temperature and thus have the ability to be injected inside living biological tissues.

    In order to evaluate the drug loading and release, the hydrophobic drug indomethacin was selected as a model compound. The drug could be loaded in the ferrogel owning to the oil in water micellar structure. We have studied the release rate from the ferrogel in the absence and presence of magnetic field. We have demonstrated that the drug release rate can be significantly enhanced by use of external magnetic field decreasing the half time of the release to more than 50% (from 3200 to 1500 min) upon the application of the external magnetic field.

    This makes the developed ferrogel a very promising drug delivery system that does not require surgical implant procedure for medical treatment and gives the possibility of enhancing the rate of release by external magnetic field.

  • 3.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Multifunctional nanomaterials for diagnostic and therapeutic applications2010Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In the past few years, the use of nanostructured materials in medical applications hasdramatically increased, both in the research phase and for clinical purposes, due to thepeculiar properties and the ability of such materials to interact at a similar scale withbiological entities. In this thesis, we developed tailored magnetic multifunctionalnanoparticles for diagnostic and therapeutic applications, such as detection ofbiomolecules, simultaneous enhanced magnetic resonance imaging (MRI), fluorescentvisualization and controlled drug release.For sensitive and selective detection of specific biomolecules, thermally blocked ironoxide nanoparticles with tailored magnetic properties were developed. The formation ofsuch nanoparticles has been studied both in terms of size and magnetic behavior in liquidsuspension or in polymer matrixes. These particles with narrow size distribution (averagediameter of 19 nm) were surface functionalized by antigen molecules and were used forthe detection of Brucella antibodies in biological samples. The binding of biomoleculesresults in an increase in the particle’s hydrodynamic diameter, affecting the relaxationbehavior that was monitored by magnetic measurements. This sensing system is a fastand sensitive biosensor with very low detection limits (0.05 μg/mL).Superparamagnetic iron oxide nanoparticles (SPION) have been synthesized withaverage diameter of 10-12 nm, narrow size distribution, high crystallinity and superiormagnetic properties as liquid suspensions or embedded in a bulk transparent magneticnanocomposite. These nanoparticles were synthesized in organic solvents and, after phasetransfer with Pluronic F127 amphiphilic copolymer, show excellent relaxivity properties(high r2/r1 ratio) and great contrast enhancement in T2 weighted MRI, confirmed by invivostudies of rat inner ear.SPION have been used as a component for different multifunctional nanostructures. Thefirst system based on poly (L,L lactide)-methoxy polyethylene glycol (PLLA-mPEG)copolymer has been prepared by an emulsion/evaporation process that lead to polymericnanoparticles containing several imaging agents, such as SPION, quantum dots (QDs)and gold nanorods as well as indomethacin (IMC) as therapeutic payload. With a similarprocedure, but using poly (lactide-co-glycolide) (PLGA-PEG-NH2) copolymer, a secondtype of multifunctional nanoparticles has been obtained. Their size can be tailored from70 to 150 nm varying synthesis parameters, such as the surfactant concentration or waterto oil ratio. Both these polymer-based multifunctional nanoparticles can be visualized byfluorescence microscopy (QDs photoemission) and MRI (SPION magnetization) and theycan be used for photothermal therapy (gold nanorods) and drug delivery. The last systemconsists of SPION nanoparticles coated with PLLA directly on the surface by an in-situpolymerization process. A hydrophobic drug was loaded before the phase transfer withPluronic F127 and these nanoparticles show simultaneous MRI T2 contrast enhancementas well as high drug loading and sustained delivery.Controlling the drug release rate is also a critical parameter for tailored therapeutictreatments, and for this reason we developed a novel drug delivery system based on theintegration of SPION and Pluronic F127 gels. IMC was loaded in the ferrogel (with atailored gelation temperature) and its release rate was triggered by applying an externalmagnetic field owing to the SPION magnetic properties.

  • 4.
    Fornara, Andrea
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Chiavarino, Annalisa
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    PLGA-PEG multifunctional nanoparticles for simultaneous drug delivery and visualizationIn: Journal of nanoparticle research, ISSN 1388-0764, E-ISSN 1572-896XArticle in journal (Other academic)
  • 5.
    Fornara, Andrea
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Chiavarino, Annalisa
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    PLGA-PEG multifunctional nanoparticles for simultaneous drug delivery and imaging by MRI and fluorescence microscopy2012In: Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012, 2012, p. 4-7Conference paper (Refereed)
    Abstract [en]

    This work deals with the synthesis of multifunctional nanoparticles based on biocompatible di-block copolymer (PLGA-PEG) via an emulsion-evaporation method. To enable their visualization, these nanoparticles can be loaded with iron oxide nanoparticles for Magnetic Resonance Imaging (MRI) and/or quantum dots for fluorescent microscopy. A therapeutic agent, Indomethacin, can also be loaded and released. The influence of synthesis parameters on nanoparticle size (in the range 70-150 nm) has been controlled to achieve specific cellular interactions avoiding possible immuno-response. These multifunctional nanoparticles possess excellent photoemission properties for fluorescent microscopy and enhanced contrast efficiency for T 2 MRI imaging compared to available agents used today. In-vitro experiments confirm the low cytotoxicity of such nanoparticles and their excellent visualization properties by MRI and fluorescence microscopy in cells and biological tissues.

  • 6.
    Fornara, Andrea
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics (Closed 20120101), Functional Materials, FNM (Closed 20120101).
    Johansson, Petter
    Petersson, Karolina
    Gustafsson, Stefan
    Qin, Jian
    Olsson, Eva
    Ilver, Dag
    Krozer, Anatol
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics (Closed 20120101), Functional Materials, FNM (Closed 20120101).
    Johansson, Christer
    KTH, School of Information and Communication Technology (ICT), Material Physics (Closed 20120101), Functional Materials, FNM (Closed 20120101).
    Tailored Magnetic Nanoparticles for Direct and Sensitive Detection of Biomolecules in Biological Samples2008In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 8, no 10, p. 3423-3428Article in journal (Refereed)
    Abstract [en]

    We developed nanoparticles with tailored magnetic properties for sensitive detection of biomolecules directly in biological samples in a single step. Thermally blocked nanoparticles obtained by thermal hydrolysis are mixed with sample solutions and the variation of the magnetic relaxation due to surface binding is used to detect the presence of biomolecules. The binding events significantly increase the hydrodynamic volume of nanoparticles, thus changing their Brownian relaxation frequency which is measured by a specifically developed AC-susceptometer.

    The system was tested for the presence of Brucella antibodies in serum samples from infected cows and the surface of the nanoparticles was functionalized with lipopolysaccarides (LPS) from Brucella abortus. The hydrodynamic volume of functionalized particles increased by 25-35% as a result of the binding of the antibodies, as measured by changes in the susceptibility in an alternating magnetic field. The method has shown high sensitivity, with detection limit of 7 nmol·L-1 in serum without any pre-treatment of the biological samples.

    The detection method is very sensitive, cost-efficient and versatile, giving a direct indication if the animal is infected or not, making it suitable for point-of care applications. The functionalization of tailored magnetic nanoparticles can be modified to suit numerous homogenous assays for a wide range of applications.

  • 7.
    Fornara, Andrea
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Laurent, Sophie
    University of Mons.
    Muller, Robert
    University of Mons.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Bifunctional polylactide coated iron oxide nanoparticles for drug delivery and MRI contrast enhancementIn: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095Article in journal (Other academic)
  • 8.
    Fornara, Andrea
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Recalenda, Alberto
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Sugunan, Abhilash
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fei, Ye
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Laurent, Sophie
    University of Mons.
    Muller, Robert
    University of Mons.
    Zou, Jing
    University of Tampere.
    Usama, Abo-RAmadan
    University of Helsinki.
    Toprak, Muhammet
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Polymeric/inorganic multifunctional nanoparticles for simultaneous drug delivery and visualization2010In: Materials Research Society Symposium Proceedings, ISSN 0272-9172, E-ISSN 1946-4274, Vol. 1257Article in journal (Refereed)
    Abstract [en]

    Nanoparticles consisting of different biocompatible materials are attracting a lot of interest in the biomedical area as useful tools for drug delivery, photo-therapy and contrast enhancement agents in MRI, fluorescence and confocal microscopy. This work mainly focuses on the synthesis of polymeric/inorganic multifunctional nanoparticles (PIMN) based on biocompatible di-block copolymer poly(L,L-lactide-co-ethylene glycol) (PLLA-PEG) via an emulsion-evaporation method. Besides containing a hydrophobic drug (Indomethacin), these polymeric nanoparticles incorporate different visualization agents such as superparamagnetic iron oxide nanoparticles (SPION) and fluorescent Quantum Dots (QDs) that are used as contrast agents for Magnetic Resonance Imaging (MRI) and fluorescence microscopy together. Gold Nanorods are also incorporated in such nanostructures to allow simultaneous visualization and photodynamic therapy. MRI studies are performed with different loading of SPION into PIMN, showing an enhancement in T2 contrast superior to commercial contrast agents. Core-shell QDs absorption and emission spectra are recorded before and after their loading into PIMN. With these polymeric/inorganic multifunctional nanoparticles, both MRI visualization and confocal fluorescence microscopy studies can be performed. Gold nanorods are also synthesized and incorporated into PIMN without changing their longitudinal absorption peak usable for lased excitation and phototherapy. In-vitro cytotoxicity studies have also been performed to confirm the low cytotoxicity of PIMN for further in-vivo studies.

  • 9.
    Fornara, Andrea
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Vogt, Carmen
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Khartsev, Sergiy
    KTH, School of Information and Communication Technology (ICT), Material Physics, Material Physics, MF.
    Li, Shanghua
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Grishin, Alexander
    KTH, School of Information and Communication Technology (ICT), Material Physics, Material Physics, MF.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Synthesis, characterization and magneto-optical properties of transparent magnetic PMMA/nanoparticles compositeManuscript (preprint) (Other academic)
  • 10.
    Gustafsson, Stefan
    et al.
    Department of Applied Physics, Chalmers University of Technology.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Petersson, Karolina
    Imego AB.
    Johansson, Christer
    Imego AB.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Olsson, Eva
    Department of Applied Physics, Chalmers University of Technology.
    Evolution of Structural and Magnetic Properties of Magnetite Nanoparticles for Biomedical Applications2010In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 10, no 5, p. 2278-2284Article in journal (Refereed)
    Abstract [en]

    We have investigated the evolution of microstructure and magnetic properties of thermally blocked magnetite nanoparticles, aimed for immunoassay applications, during their synthesis. High-resolution transmission electron microscopy (HRTEM) investigations of the size, size distribution, morphology, and crystal structure of particles reveal that particles at an early stage of the reaction process are either single crystals or polycrystals containing planar faults and they grow via a combination of reactant (monomer) consumption and oriented attachment at specific crystallographic surfaces because of the strong dipolar character of the < 111 > surfaces of magnetite. At a later stage of the synthesis reaction, the magnetic attraction strives to align contacting particles with their < 111 > axis of easy magnetization in parallel and this may also be an active driving force for crystal growth. At latter stages, the crystal growth is dominated by Ostwald ripening leading to smoother crystalline particles with a mean diameter of 16.7 +/- 3.5 nm and a narrow size distribution. The magnetic properties of the particles measured using static and dynamic magnetic fields are consistent with the evolution of particle size and structure and show the transition from superparamagnetic to thermally blocked behavior needed for magnetic relaxation-based immunoassay applications.

  • 11.
    Li, Shanghua
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Kim, Do Kyung
    Synthesis and magnetic properties of bulk transparent PMMA/Fe-oxide nanocomposites2009In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 20, no 18Article in journal (Refereed)
    Abstract [en]

    PMMA/Fe-oxide nanocomposites are fabricated by a chemical method. Monodispersed Fe-oxide nanoparticles are well dispersed in the PMMA matrix by in situ polymerization, resulting in a bulk transparent polymeric nanocomposite. The magnetic behavior of the PMMA/Fe-oxide nanocomposites is investigated. The transparent PMMA/Fe-oxide nanocomposite has potentially interesting magneto-optic applications without compromising the advantages of a lightweight, noncorrosive polymeric material with very high transparency even for bulk samples.

  • 12.
    Okoli, Chuka
    et al.
    KTH, School of Biotechnology (BIO), Environmental Microbiology. KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Dalhammar, Gunnel
    KTH, School of Biotechnology (BIO), Environmental Microbiology.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Rajarao, Gunaratna
    KTH, School of Biotechnology (BIO), Environmental Microbiology.
    Characterization of Superparamagnetic Iron Oxide Nanoparticles and Its Application in Protein Purification2011In: Journal of Nanoscience and Nanotechnology, ISSN 1533-4880, E-ISSN 1533-4899, Vol. 11, no 11, p. 10201-10206Article in journal (Refereed)
    Abstract [en]

    The application of surface modified magnetic adsorbent particles in combination with magnetic separation techniques has received considerable awareness in recent years. There is a particular need in protein purification and analysis for specific, functional and generic methods of protein binding on solid supports. Nanoscale superparamagnetic iron oxide particles have been used to purify a natural coagulant protein extracted from Moringa oleiferaseeds. Spectrophotometric analysis of the coagulant protein was performed using synthetic clay solution as substrate. Protein binding with carboxyl and silica surface modified superparamagnetic iron oxide nanoparticles (SPION) were compared with the known carboxyl methyl cellulose (CMC) beads of ∼1 m. SPION modified with carboxyl surface showed higher binding capacity towards the coagulant protein compared to the CMC beads. The high surface area to volume ratio of the carboxyl-coated SPION resulted in high binding capacity and rapid adsorption kinetics of the crude protein extract. The purification and molecular weight of coagulant protein is analyzed by SDS-PAGE. This approach utilizes the most efficient, feasible and economical method of coagulant protein purification and it can also be applicable to other proteins that possess similar properties.

  • 13. Poe, Dennis
    et al.
    Zou, Jing
    Zhang, Weikai
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Ramadan, Usama Abo
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Pyykkö, Ilmari
    MRI of the Cochlea with Superparamagnetic Iron Oxide Nanoparticles Compared to Gadolinium Chelate Contrast Agents in a Rat Mode2009In: European Journal of Nanomedicine, ISSN 1662-5986, Vol. 2, no 2, p. 29-36Article in journal (Refereed)
  • 14.
    Qin, Jian
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Asempah, Isaac
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Laurent, Sophie
    Department of General Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muller, Robert N.
    Department of General Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Injectable Superparamagnetic Ferrogels for Controlled Release of Hydrophobic Drugs2009In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 21, no 13, p. 1354-1357Article in journal (Refereed)
    Abstract [en]

    A ferrogel for magnetically controlled release of drugs is prepared by integration of superparamagnetic iron oxide nanoparticles and Pluronic F127 gels. The hydrophobic drug indomethacin is loaded in the ferrogel owing to the oil-in-water micellar structure. The characteristic solgel transition property renders the ferrogel an injectable drug carrier that will be, in principle, free from surgical implant procedure.

  • 15. Thaler, M.
    et al.
    Soumen, R.
    Fornara, A.
    Bitsche, M.
    Qin, J.
    Muhammed, M.
    Salvenmoser, W.
    Rieger, G.
    Schrott-Fischer, A.
    Glueckert, R.
    Investigation of Superparamagnetic Iron Oxide Nanoparticles across Scales in the Inner Ear2011In: Molecular Biology of the Cell, ISSN 1059-1524, E-ISSN 1939-4586, Vol. 22Article in journal (Other academic)
  • 16. Thaler, Marlene
    et al.
    Roy, Soumen
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Bitsche, Mario
    Glueckert, Rudolf
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Salvenmoser, Willi
    Rieger, Gunde
    Visualization and Analysis of Superparamagnetic Ferrogels in the Inner Ear by Light Microscopy and Energy Filtred TEM: a promising approach for advanced local drug deliveryIn: Journal of Microscopy, ISSN 0022-2720, E-ISSN 1365-2818Article in journal (Other academic)
  • 17.
    Thaler, Marlene
    et al.
    Carl Zeiss NTS GmbH.
    Roy, Suomen
    Medical University of Innsbruck.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Bitsche, Mario
    Medical University of Innsbruck.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Salvenmoser, Willi
    University of Innsbruck.
    Rieger, Gunde
    Medical University of Innsbruck.
    Schrott Fischer, Anneliese
    Medical University of Innsbruck.
    Glueckert, Rudolf
    Medical University of Innsbruck.
    Visualization and Analysis of Superparamagnetic Iron Oxide Nanoparticles in the Inner Ear by Light Microscopy and Energy Filtered TEM2011In: Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, Vol. 7, no 3, p. 360-369Article in journal (Refereed)
    Abstract [en]

    Nanoparticles as potential carriers for local drug transfer are an alternative to systemic drug delivery into the inner ear. We report on the first in vitro tests of a new ferrogel consisting of superparamagnetic iron oxide nanoparticles (SPIONs) and a Pluronic (R) F127 (PF127) copolymer. Pluronic copolymers possess a unique viscosity-adjustable property that makes PF127 gels easy to handle compared to conventional cross-linked hydrogels. This ferrogel was successfully tested in cadaver human temporal bones as well as in organotypic explant cultures of mouse inner ears. SPIONs were identified by light microscopy and localized with different imaging modes in energy-filtered transmission electron microscopy. Our approach shows a promising possibility to use iron oxide nanoparticles, which are suitable for visualization and characterization at both the light- and electron-microscopic levels.

    From the Clinical Editor: The authors report the first in vitro tests of a new ferrogel consisting of superparamagnetic iron oxide nanoparticles (SPIONs) and a Pluronic (R) F127 (PF127) copolymer for drug delivery in the inner ear, demonstrasting a promising possibility to use iron oxide nanoparticles, which are suitable for visualization and characterization at both the light- and electron-microscopic levels.

  • 18.
    Ye, Fei
    et al.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Vallhov, Helen
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institute and University Hospital Solna, Sweden.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Daskalaki, Evangelia
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet and Universty Hospital Solan, Sweden.
    abhilash, Sugunan
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Toprak, Muhammet S.
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Gabrielsson, Susanne
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet and Universty Hospital Solan, Sweden.
    Scheynius, Annika
    Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet and Universty Hospital Solan, Sweden.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Synthesis of high aspect ratio gold nanorods and their effects on human antigen presenting dendritic cells2011In: International Journal Of Nanotechnology, ISSN 1475-7435, Vol. 8, no 8-9, p. 631-652Article in journal (Refereed)
    Abstract [en]

    High aspect ratio (AR) gold nanorods (NRs) attract great interest for biomedical applications due to their novel physicochemical properties. Here, we report a facile method for preparation of high AR gold NRs through a seedless surfactant-mediated protocol with the additive of nitric acid. High-resolution transmission electron microscopy studies showed that the concentration of nitric acid has great effects on the crystal structures of the initially formed nuclei and consequently the growth of gold NRs. A mechanism based on the effect of nitrate ions on surfactant micelle elongation and Ostwald ripening process is proposed for the growth of high AR gold NRs. The biocompatibility of high AR NRs was evaluated on primary human monocyte derived dendritic cells (MDDCs), and compared with that of spherical gold nanoparticles (NPs) and low AR NRs. Low AR (similar to 4.5) gold NRs induced considerable cell death due to CTAB, while spherical gold NPs (7 nm) and high AR (similar to 21) gold NRs showed no or minor effects on viability and immune regulatory markers, which supports the further development of high AR gold NRs for medical applications.

  • 19.
    Zhou, Jing
    et al.
    University of Tampere.
    Zhang, Weikai
    University of Tampere.
    Poe, Dennis
    University of Tampere.
    Qin, Jian
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Fornara, Andrea
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Zhang, Ya
    University of Tampere.
    Ramadan, Usama
    University of Helsinki.
    Muhammed, Mamoun
    KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
    Pyykkö, Ilmari
    University of Tampere.
    MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear2010In: Nanomedicine, ISSN 1743-5889, Vol. 5, no 5, p. 739-754Article in journal (Refereed)
    Abstract [en]

    Aim: Superparamagnetic iron oxide nanoparticles hierarchically coated with oleic acid and Pluronic F127 copolymers (POA@SPION) have shown exceptional 12 contrast enhancement. The aim of the present work was to investigate the MRI manifestation of POA@SPION in the inner ear. Materials & methods: A total of 26 male Wister rats were selected for testing POA@SPION administered through intracochlear, intratympanic and intravenous routes. MRI was performed with a 4.7 T MR scanner. Results & conclusion: POA@SPION can be introduced into the perilymph space, after which it becomes widely distributed and can demonstrate the integrity of the perilymph-endolymph barrier. Positive highlighting of the endolymph compartment against the darkened perilymph was visualized for the first time. POA@SPION passed through the middle-inner ear barriers in only small amounts, but stayed in the perilymph for 3 days. They did not traverse the blood-perilymph barrier or blood-endolymph barrier. The inner ear distribution of POA@SPION was confirmed by histology. POA@SPION is a promising T2 negative contrast agent.

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