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  • 1.
    Fredenberg, Erik
    et al.
    KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.
    Åslund, Magnus
    KTH, School of Engineering Sciences (SCI), Physics.
    Nillius, Peter
    KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.
    Danielsson, Mats
    KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.
    An efficient pre-object collimator based on an x-ray lens2009In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 36, no 2, p. 626-633Article in journal (Refereed)
    Abstract [en]

    A multiprism lens (MPL) is a refractive x-ray lens with one-dimensional focusing properties. If used as a pre-object collimator in a scanning system for medical x-ray imaging, it reduces the divergence of the radiation and improves on photon economy compared to a slit collimator. Potential advantages include shorter acquisition times, a reduced tube loading, or improved resolution. We present the first images acquired with a MPL in a prototype for a scanning mammography system. The lens showed a gain of flux of 1.32 compared to a slit collimator at equal resolution, or a gain in resolution of 1.31–1.44 at equal flux. We expect the gain of flux in a clinical setup with an optimized MPL and a custom-made absorption filter to reach 1.67, or 1.45–1.54 gain in resolution.

  • 2.
    Åslund, Magnus
    KTH, School of Engineering Sciences (SCI), Physics.
    Digital Mammography with a Photon Counting Detector in a Scanned Multislit Geometry2007Doctoral thesis, comprehensive summary (Other scientific)
    Abstract [en]

    Mammography screening aims to reduce the number of breast cancer deaths by early detection of the disease, which is one of the leading causes of deaths for middle aged women in the western world. The risk from the x-ray radiation in mammography is relatively low but still a factor in the benefit-risk ratio of screening. The characterization and optimization of a digital mammography system is presented in this thesis. The investigated system is shown to be highly dose efficient by employing a photon counting detector in a scanning multislit geometry.

    A novel automatic exposure control (AEC) is proposed and validated in clinical practise. The AEC uses the leading detector edge to measure the transmission of the breast. The exposure is modulated by altering the scan velocity during the scan. A W-Al anode-filter combination is proposed.

    The characterization of the photon counting detector is performed using the detective quantum efficiency. The effect of the photon counting detector and the multislit geometry on the measurement method is studied in detail. It is shown that the detector has a zero-frequency DQE of over 70\% and that it is quantum limited even at very low exposures.

    Efficient rejection of image-degrading secondary radiation is fundamental for a dose efficient system. The efficiency of the scatter rejection techniques currently used are quantified and compared to the multislit geometry.

    A system performance metric with its foundation in statistical decision theory is discussed. It is argued that a photon counting multislit system can operate at approximately half the dose compared to several other digital mammography techniques.

  • 3.
    Åslund, Magnus
    et al.
    KTH, School of Engineering Sciences (SCI), Physics.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics.
    Lundqvist, M
    Danielsson, M
    Optimized AEC for scanning digital mammography based on local variation of scan velocity2005In: Medical Imaging 2005: Physics of Medical Imaging, Pts 1 and 2 / [ed] Flynn, MJ, BELLINGHAM: SPIE-INT SOC OPTICAL ENGINEERING , 2005, Vol. 5745, p. 468-477Conference paper (Refereed)
    Abstract [en]

    In mammography, there is an optimal photon energy and current time product that produce the required image quality at the minimal dose. The task of an automatic exposure control (AEC), in full field digital mammography (FFDM) is to minimize the dose by using optimized exposure settings. Each point in a mammogram has different radiological thickness. A conventional AEC samples the thickness in some regions to set the current time product and possibly also the beam quality. We define an ideal AEC as one that optimizes the beam quality and exposure in each point to produce a constant contrast-to-noise ratio (CNR) of structures of interest throughout the image. This paper presents the results from a theoretical evaluation of an AEC proposed for a scanning photon-counting FFDM system. The geometry enables the AEC to use information from the leading detector line to adjust the scan velocity during the scan. Thus, the irradiation can be better optimized in the scanning-direction as compared to a conventional AEC. The scan time is further reduced by increased velocity over sections that contain no tissue. The results are quantified in terms of reduction of entrance dose and scan time. The presented AEC is compared to an ideal AEC, a conventional AEC and is also benchmarked against an ideal regulator. The effect of the detector width is evaluated. Compared to a conventional AEC, both evaluated on a set of 266 mammograms, the ideal AEC would reduce the entrance dose by 39% on average while the proposed AEC for scanning systems reduces the entrance dose by 10-20% and scan-time by 25-32% on average, depending on detector width.

  • 4.
    Åslund, Magnus
    et al.
    KTH, School of Engineering Sciences (SCI), Physics.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics.
    Lundqvist, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Danielsson, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    AEC for scanning digital mammography based on variation of scan velocity2005In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 32, no 11, p. 3367-3374Article in journal (Refereed)
    Abstract [en]

    A theoretical evaluation of nonuniform x-ray field distributions in mammography was conducted. An automatic exposure control (AEC) is proposed for a scanning full field digital mammography system. It uses information from the leading part of the detector to vary the scan velocity dynamically, thus creating a nonuniform x-ray field in the scan direction. Nonuniform radiation fields were also created by numerically optimizing the scan velocity profile to each breast's transmission distribution, with constraints on velocity and acceleration. The goal of the proposed AEC is to produce constant pixel signal-to-noise ratio throughout the image. The target pixel SNR for each image could be set based on the breast thickness, breast composition, and the beam quality as to achieve the same contrast-to-noise ratio between images for structures of interest. The results are quantified in terms of reduction in entrance surface air kerma (ESAK) and scan time relative to a uniform x-ray field. The theoretical evaluation was performed on a set of 266 mammograms. The performance of the different methods to create nonuniform fields decreased with increased detector width, from 18% to 11% in terms of ESAK reduction and from 30% to 25% in terms of scan time reduction for the proposed AEC and detector widths from 10 to 60 mm. Some correlation was found between compressed breast thickness and the projected breast area onto the image field. This translated into an increase of the ESAK and decrease of the scan time reduction with breast thickness. Ideally a nonuniform field in two dimensions could reduce the entrance dose by 39% on average, whereas a field nonuniform in only the scanning dimension ideally yields a 20% reduction. A benefit with the proposed AEC is that the risk of underexposing the densest region of the breast can be virtually eliminated.

  • 5.
    Åslund, Magnus
    et al.
    KTH, School of Engineering Sciences (SCI), Physics.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics.
    Lundqvist, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Danielsson, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Evaluation of an AEC system for scanning photon counting mammography based on variation of scan velocityIn: Medical physics (Lancaster), ISSN 0094-2405Article in journal (Other academic)
  • 6.
    Åslund, Magnus
    et al.
    KTH, School of Engineering Sciences (SCI), Physics.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics.
    Lundqvist, Mats
    Danielsson, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Optimization of operating conditions in photon counting multi-slit mammography based on Si-strip detectors - art. no. 61420A2006In: Medical Imaging 2006: Physics of Medical Imaging, Pts 1-3 / [ed] Flynn, MJ; Hsieh, J, 2006, Vol. 6142, p. A1420-A1420Conference paper (Refereed)
    Abstract [en]

    Measurements and simulations of the signal-difference-to-noise ratio (SDNR) and average glandular dose (AGD) have been performed on a photon counting full-field digital mammography system to determine the optimal operating conditions. Several beam qualities were experimentally evaluated by using different combinations of tube voltage, added filters and thickness of BR12 with a tungsten target x-ray tube. The SDNR and AGD were also calculated theoretically for an extended number of operating conditions and a more accurate breast model. As figure of merit for each operating condition, a spectral quantum efficiency (SQE) was calculated as the polychromatic SDNR squared over the optimal monochromatic SDNR squared at the same AGD. The theoretical model agreed within 4% relative the measured SDNR throughout the evaluated breast thickness (30-70 mm) and tube voltage range (26-38 kV). The optimization was performed with a constant SDNR-rate as compared to using a fixed filter thickness. The optimal combinations of tube voltage-filter material were: 32 kV-Ag, 34 kV-Cd, 36 kV-Sn for a breast thickness of 30, 50 and 70 mm respectively. These K-edge filter materials increased the SQE by less than 4% compared to the optimal Al filtration.

  • 7.
    Åslund, Magnus
    et al.
    KTH, School of Engineering Sciences (SCI), Physics.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics.
    Lundqvist, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Danielsson, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Physical characterization of a scanning photon counting digital mammography system based on Si-strip detectors2007In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 34, no 6, p. 1918-1925Article in journal (Refereed)
    Abstract [en]

    The physical performance of a scanning multislit full field digital mammography system was determined using basic image quality parameters. The system employs a direct detection detector comprised of linear silicon strip sensors in an edge-on geometry connected to photon counting electronics. The pixel size is 50 mu m and the field of view 24 x 26 cm(2). The performance was quantified using the presampled modulation transfer function, the normalized noise power spectrum and the detective quantum efficiency (DQE). Compared to conventional DQE methods, the scanning geometry with its intrinsic scatter rejection poses additional requirements on the measurement setup, which are investigated in this work. The DQE of the photon counting system was found to be independent of the dose level to the detector in the 7.6-206 mu Gy range. The peak DQE was 72% and 73% in the scan and slit direction, respectively, measured with a 28 kV W-0.5 mm Al anodefilter combination with an added 2 mm Al filtration.

  • 8.
    Åslund, Magnus
    et al.
    KTH, School of Engineering Sciences (SCI), Physics.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics.
    Lundqvist, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Danielsson, Mats
    KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.
    Scatter rejection in multislit digital mammography2006In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 33, no 4, p. 933-940Article in journal (Refereed)
    Abstract [en]

    The scatter to primary ratio (SPR) was measured on a scanning multislit full-field digital mammography system for different thickness of breast equivalent material and different tube voltages. Scatter within the detector was measured separately and was found to be the major source of scatter in the assembly. Measured total SPRs below 6% are reported for breast range 3-7 cm. The performance of the multislit assembly is compared to other imaging geometries with different scatter rejection schemes by using the scatter detective quantum efficiency.

  • 9.
    Åslund, Magnus
    et al.
    KTH, School of Engineering Sciences (SCI), Physics.
    Fredenberg, Erik
    KTH, School of Engineering Sciences (SCI), Physics.
    Cederström, Björn
    KTH, School of Engineering Sciences (SCI), Physics.
    Danielsson, Mats
    KTH, School of Engineering Sciences (SCI), Physics.
    Spectral shaping for photon counting digital mammography2007In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 580, no 2, p. 1046-1049Article in journal (Refereed)
    Abstract [en]

    The spectral shaping properties of conventional filters have been evaluated for a photon counting digital mammography system, and the result has been compared with the theoretical spectrum from a multi-prism X-ray lens (MPL). The absorption filters and the MPL were evaluated using a theoretical model of the system which has been verified experimentally. The spectral shaping performance is quantified with the spectral quantum efficiency (SQE), calculated as the polychromatic signal-difference-to-noise ratio (SDNR) squared over the optimal monochromatic SDNR squared at the same average glandular dose. The MPL increases the SQE by 25% compared to the investigated absorption filter when compared with a Tungsten anode. This translates into a potential dose reduction of 20% at maintained SDNR.

1 - 9 of 9
CiteExportLink to result list
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Cite
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  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
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  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
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