Change search
Refine search result
1 - 16 of 16
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Frölander, Anders
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Tilliet, Mélanie
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Levacher, Vincent
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Bifunctional Pybox Ligands: Application in Cyanations of BenzaldehydeManuscript (Other academic)
  • 2.
    Hamberg, Anders
    et al.
    KTH, School of Biotechnology (BIO), Biochemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Penhoat, Maël
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Hult, Karl
    KTH, School of Biotechnology (BIO), Biochemistry.
    High-Throughput Enzymatic Method for Enantiomeric Excess Determination of O-Acetylated Cyanohydrins2006In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 128, no 7, p. 2234-2235Article in journal (Refereed)
  • 3.
    Hamberg, Anders
    et al.
    KTH, School of Biotechnology (BIO), Biochemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Wingstrand, Erica
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Hult, Karl
    KTH, School of Biotechnology (BIO), Biochemistry.
    High Throughput Synthesis and Analysis of Acylated Cyanohydrins2007In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 13, no 15, p. 4334-4341Article in journal (Refereed)
    Abstract [en]

    The yields and optical purities of products obtained from chiral Lewis acid/Lewis base-catalysed additions of alpha-ketonitriles to prochiral aldehydes could be accurately determined by an enzymatic method. The amount of remaining aldehyde was determined after its reduction to an alcohol, whilst the two product enantiomers were analysed after subsequent hydrolysis first by the (S)-selective Candida antarctica lipase B and then by the unselective pig liver esterase. The method could be used for analysis of products obtained from a number of aromatic aldehydes and aliphatic ketonitriles. Microreactor technology was successfully combined with high-throughput analysis for efficient catalyst optimization.

  • 4.
    Jönsson, Christina
    et al.
    KTH, Superseded Departments, Chemistry.
    Lundgren, Stina
    KTH, Superseded Departments, Chemistry.
    Haswell, S. J.
    Department of Chemistry, University of Hull.
    Moberg, Christina
    KTH, Superseded Departments, Chemistry.
    Asymmetric Catalysis in a Micro Reactor: Ce, Yb and Lu Catalysed Enantioselective Addition of Trimethylsilyl Cyanide to Benzaldehyde2004In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 60, no 46, p. 10515-10520Article in journal (Refereed)
    Abstract [en]

    A T-shaped micro reactor was used for the optimisation of reaction conditions for the enantioselective silyleyanation of benzaldehyde catalysed by lanthanide-pybox complexes. Compared to a conventional batch procedure, higher conversion was observed within shorter reaction time. The micro reactor process involving Lu(III) afforded essentially the same enantioselectivity as the batch process (73 vs 76% ee), whereas the enantioselectivity was lower in the micro reactor for catalysts containing Yb(III) (53 compared to 72%). Ce(III) provided very low selectivity in both types of processes (1 and 11 % ee, respectively). A study of the effect of additives showed that the enantioselectivity in the Yb catalysed reaction performed in the micro reactor could be increased to 66%, whereas only a minor improvement, to 78% ee, was observed in the reaction with Lu.

  • 5.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Efficient Synthesis and Analysis of Chiral Cyanohydrins2007Doctoral thesis, comprehensive summary (Other scientific)
    Abstract [en]

    This thesis deals with the development of new methods for efficient synthesis and analysis in asymmetric catalysis. It focuses on the preparation of chiral cyanohydrins by enantioselective addition of cyanide to prochiral aldehydes.

    The initial part of the thesis describes the development of a dual Lewis acid– Lewis base activation system for efficient synthesis of chiral O-acylated and Ocarbonylated cyanohydrins. This system was used for the preparation of a variety of cyanohydrins in high isolated yields and with up to 96% ee. Activation of the cyanide by nucleophilic attack of the Lewis base at the carbonyl carbon atom was supported experimentally.

    Secondly, convenient procedures for the synthesis of polymer-bound chiral YbCl3-pybox and Ti-salen complexes are described. The polymeric complexes were employed in cyanation of benzaldehyde.

    A T-shaped microreactor was used for screening of reaction conditions for the enantioselective cyanation of benzaldehyde using trimethylsilyl cyanide and acetyl cyanide as cyanide sources. A microreactor charged with the polymeric Tisalen complex was used for enantioselective cyanation of benzaldehyde.

    Finally, an enzymatic method for high throughput analysis of ee and conversion of products from chiral Lewis acid–Lewis base-catalysed additions of α- ketonitriles to prochiral aldehydes was developed. The method could be used for the analysis of a variety of O-acylated cyanohydrins. Microreactor technology was successfully combined with high throughput analysis for efficient catalyst optimisation.

  • 6.
    Lundgren, Stina
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Ihre, Henrik
    GE Healthcare, Uppsala.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Enantioselective Cyanation of Benzaldehyde: an Asymmetric Polymeric Catalyst in a Microreactor2008In: ARKIVOC, ISSN 1424-6376, Vol. 6, p. 73-80Article in journal (Refereed)
    Abstract [en]

    A chiral salen ligand containing a carboxylic acid group was attached to macroporous monosized polystyrene-divinylbenzene beads grafted with (4-hydroxybutyl) vinyl ether groups. A Ti(IV) complex of the beads was used for enantioselective cyanations of benzaldehyde using trimethylsilyl cyanide and acetyl cyanide as cyanide sources using both conventional batch techniques and a microreactor.

  • 7.
    Lundgren, Stina
    et al.
    KTH, Superseded Departments, Chemistry.
    Lutsenko, S.
    KTH, Superseded Departments, Chemistry.
    Jönsson, C.
    KTH, Superseded Departments, Chemistry.
    Moberg, Christina
    KTH, Superseded Departments, Chemistry.
    Polymer-Supported Pyridine-Bis(oxazoline). Application to Ytterbium Catalyzed Silylcyanation of Benzaldehyde2003In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 5, no 20, p. 3663-3665Article in journal (Refereed)
    Abstract [en]

    Terminal acetylenes containing hydroxy and carboxylic acid groups were subjected to Sonogashira coupling with 4-bromo-2,6-bis[(R)-4-phenyloxazolin-2-yl]pyridine and the resulting pybox derivatives were immobilized on Tentagel resins. Ytterbium(ill) chloride complexes of the polymeric ligands catalyzed the addition of trimethylsilyl cyanide to benzaldehyde with 80-81% ee. The ligands were reused more than 30 times without any loss in selectivity or activity, and the metal complexes could be recovered and reused at least four times, although with slightly decreasing activity.

  • 8.
    Lundgren, Stina
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Russom, Aman
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Jönsson, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Stemme, Göran
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Haswell, Stephen J.
    Andersson, Helene
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Moberg, Christina
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Micro reactors for the optimisation of reaction conditions in asymmetric metal catalysis2005In: Micro Total Analysis Systems 2004 / [ed] Laurell T; Nilsson J; Jensen K; Harrison DJ; Kutter JP, 2005, no 296, p. 445-447Conference paper (Refereed)
    Abstract [en]

    Two types of micro reactors were employed for enantioselective metal catalysed reactions. In the first type of reactor, an electroosmotic flow was used, whereas the second type of reactor used a pressure driven flow. The purpose of the study is to develop tools for rapid and efficient optimization of reactions, utilising minimum amounts of reagents.

  • 9.
    Lundgren, Stina
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Wingstrand, Erica
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Lewis acid-Lewis base-catalysed enantioselective addition of alpha-ketonitriles to aldehydes2007In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 349, no 3, p. 364-372Article in journal (Refereed)
    Abstract [en]

    Additions of structurally diverse alpha-ketonitriles to aromatic and aliphatic prochiral aldehydes yielding highly enantioenriched acylated cyanohydrins were achieved using a combination of a titanium salen dimer and an achiral or chiral Lewis base. In most cases high yields and high enantioselectivities were observed. The ee was moderate in the initial part of the reaction but increased over time. This could be avoided, and higher ees obtained, by keeping the titanium complex, in the presence or absence of aldehyde and ketonitrile, at -40 degrees C prior to the addition of the Lewis base. A mechanism initiated by nucleophilic attack of the tertiary amine at the carbonyl carbon atom of the ketonitile is supported by C-13 labelling experiments.

  • 10.
    Lundgren, Stina
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Wingstrand, Erica
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Penhoat, Maël
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Dual Lewis Acid–Lewis Base Activation in Enantioselective Cyanation of Aldehydes Using Acetyl Cyanide and Cyanoformate as Cyanide Sources2005In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 127, no 33, p. 11592-11593Article in journal (Refereed)
  • 11.
    Moberg, Christina
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Wingstrand, Erica
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    fei, Li
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Penhoat, Maël
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Enantioenriched cyanohydrins: Versatile insecticide intermediates2008In: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 236, p. 95-AGRO-Article in journal (Other academic)
    Abstract [en]

    Several pyrethroid insecticides contain cyanoester functions.  Many of these are today used in racemic form or, in case they contain more than a single stereocenter, even as a mixt. of several stereoisomers, although it is known that both aquatic toxicity and biodegrdn. may differ for the two enantiomers.  We have obtained enantioenriched O-acylated cyanohydrins by the addn. of ketonitriles to prochiral aldehydes catalyzed by a chiral Lewis acid and an achiral Lewis base.  By this procedure, (S)-O-acetyl 2-hydroxy-3-butenenitrile was prepd. from acrolein and acetyl cyanide in 67% yield and 73% ee.  This product can be used as an intermediate in the synthesis of glufosinate, (S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyric acid.

  • 12.
    Tilliet, Mélanie
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Frölander, Anders
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Levacher, Vincent
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Evaluation of new pyridine-bis(oxazoline) ligands in asymmetric catalysisManuscript (Other academic)
  • 13.
    Tilliet, Mélanie
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Levacher, Vincent
    Laboratoire de Chimie Organique Fine et Hétérocyclique, UMR 6014, Université et INSA de Rouen.
    Polymer-Bound Pyridine-Bis(oxazoline). Preparation through Click Chemistry and Evaluation in Asymmetric Catalysis2007In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 349, no 13, p. 2079-2084Article in journal (Refereed)
    Abstract [en]

    A pyridine-bis(oxazoline) ligand was efficiently immobilized by copper(I)-catalyzed azide-alkyne cycloaddition onto a polystyrene resin. The so obtained click-pybox resin 1a was associated with various metal salts (YbCl3, LuCl3, CuOTf) and the resulting resin-bound catalysts were explored in ring-opening of cyclohexene oxide, silylcyanation of benzaldehyde and alkynylation of imines. These new polymer-supported catalysts exhibit good to excellent performances in terms of catalytic activity, enantioselectivity and recyclability.

  • 14.
    Wingstrand, Erica
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Li, Fei
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    O-Acylated Cyanohydrins: Versatile Intermediates and Products2007In: Chimica Oggi, ISSN 0392-839X, Vol. 25, no 5, p. 14-15Article in journal (Refereed)
    Abstract [en]

    Addition of ketonitriles to prochiral aromatic or aliphatic aldehydes in the presence of a catalytic system consisting of a chiral Lewis acid and an achiral Lewis base gives access to chiral enantioenriched O-acylated cyanohydrins. The products are useful for diverse potential applications.

  • 15.
    Wingstrand, Erica
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Hamberg, Anders
    KTH, School of Biotechnology (BIO), Biochemistry.
    Hult, Karl
    KTH, School of Biotechnology (BIO), Biochemistry.
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    655-ORGN - Synthesis of highly enantioenriched cyanohydrins by dual Lewis acid - Lewis base activation2007In: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 234, p. 655-ORGN-Article in journal (Other academic)
    Abstract [en]

    Enantioenriched acylated cyanohydrins serve as versatile synthons and are themselves important synthetic targets.  By using our efficient catalytic dual Lewis acid - Lewis base activation system, a range of α-ketonitriles were added to both arom. and aliph. aldehydes affording highly enantioenriched O-acylated cyanohydrins in excellent yields.  The reactions proceeded smoothly in only one step with perfect atom economy.  Our recent results as well as the scope and limitations of the system will be presented together with mechanistic aspects.

  • 16.
    Wingstrand, Erica
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Lundgren, Stina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry.
    Penhoat, Maël
    KTH, School of Chemical Science and Engineering (CHE).
    Moberg, Christina
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Dual Lewis acid-Lewis base activation in enantioselective additions to aldehydes2006In: Pure and Applied Chemistry, ISSN 0033-4545, E-ISSN 1365-3075, Vol. 78, no 2, p. 409-414Article in journal (Refereed)
    Abstract [en]

    Reaction of benzaldehyde with ethyl cyanoformate in the presence of Lewis acidic Ti(IV) complexes of bispyridylamide or salen ligands and Lewis basic amines affords the O-alkoxycarbonylated cyanohydrin. In the presence of the salen-based catalytic system, acetyl cyanide can also be added to benzaldehyde, providing a highly enantioselective direct route to the O-acetylated cyanohydrin.

1 - 16 of 16
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf