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  • 1. Feliu, Neus
    et al.
    Walter, Marie Valérie
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Montañez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Kunzmann, Andrea
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Nyström, Andreas
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Fadeel, Bengt
    Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers2012Inngår i: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 33, nr 7, s. 1970-1981Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Dendrimers can be designed for several biomedical applications due to their well-defined structure, functionality and dimensions. The present study focused on the in vitro biocompatibility evaluation of a library of aliphatic polyester dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) with an overall diameter of 0.5-2 nm. In addition, dendrimers with two different chemical surfaces (neutral with hydroxyl end group and anionic with carboxylic end group) and dendrons corresponding to the structural fragments of the dendrimers were evaluated. Commercial polyamidoamine dendrimers (PAMAM) with cationic (amine) or neutral (hydroxyl) end group were also included for comparison. Cell viability studies were conducted in human cervical cancer (HeLa) and acute monocytic leukemia cells (THP.1) differentiated into macrophage-like cells as well as in primary human monocyte-derived macrophages. Excellent biocompatibility was observed for the entire hydroxyl functional bis-MPA dendrimer library, whereas the cationic, but not the neutral PAMAM exerted dose-dependent cytotoxicity in cell lines and primary macrophages. Studies to evaluate material stability as a function of pH, temperature, and time, demonstrated that the stability of the 4th generation hydroxyl functional bis-MPA dendrimer increased at acidic pH. Taken together, bis-MPA dendrimers are degradable and non-cytotoxic to human cell lines and primary cells.

  • 2.
    Hed, Yvonne
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Antoni, Per
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Montanez, Maria I.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Hult, Anders
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Malkoch, Michael
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Bifunctional dendritic structures based on AB(2)C monomers2009Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 238Artikkel i tidsskrift (Annet vitenskapelig)
  • 3. Kang, Taegon
    et al.
    Amir, Roey J.
    Khan, Anzar
    Ohshimizu, Kaoru
    Hunt, Jasmine N.
    Sivanandan, Kulandaivelu
    Montanez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Ueda, Mitsuru
    Hawker, Craig J.
    Facile access to internally functionalized dendrimers through efficient and orthogonal click reactions2010Inngår i: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 46, nr 9, s. 1556-1558Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A simple synthetic strategy has been developed for accessing internally functionalized dendrimers. The key feature of this approach is the use of two orthogonal and efficient reactions` epoxy-amine' and 'thiol-ene' coupling-for rapid growth of the dendritic scaffold. This sequence of reactions allows for the introduction of reactive hydroxyl groups at each dendritic layer.

  • 4.
    Lundberg, Pontus
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Walter, Valérie Marie
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Montañez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Hult, Daniel
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Linear dendritic polymeric amphiphiles with intrinsic biocompatibility: synthesis and characterization to fabrication of micelles and honeycomb membranes2011Inngår i: Polymer Chemistry, ISSN 1759-9954, Vol. 2, s. 394-402Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Linear dendritic hybrid materials enable a range of architectural variations which offers novel possibilities in the tailoring of polymeric materials. In this study dendrons based on the 2,2-bis(methylol)propionic acid (bis-MPA) building block, bearing click chemistry moieties in the core and peripheral hydroxyl functionalities, have been used as macroinitiators for ring opening polymerization of ε-caprolactone. A library of star branched polymers with poly(ε-caprolactone) chains was initially constructed using dendrons up to 4th generation. In a second step, the popular CuAAC or thiol–ene click reaction was efficiently used to attach poly(ethylene glycol) chains of different lengths to the core. Potential applications of the resulted amphiphilic linear dendritic hybrids were investigated. Both self-assembled micelles loaded with doxorubicin anticancer drug and ordered honeycomb membranes with enhanced surface area were successfully fabricated and characterized.

  • 5. Mahltig, Boris
    et al.
    Cheval, Nicolas
    Astachov, Vladimir
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Montanez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Haase, Hajo
    Fahmi, Amir
    Hydroxyl functional polyester dendrimers as stabilizing agent for preparation of colloidal silver particles-a study in respect to antimicrobial properties and toxicity against human cells2012Inngår i: Colloid and Polymer Science, ISSN 0303-402X, E-ISSN 1435-1536, Vol. 290, nr 14, s. 1413-1421Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The presented study concerns the preparation and investigation of silver particles in presence of hydroxylated polyester dendrimers used as stabilizing agent. Altogether a full series of water soluble and aliphatic bis-MPA dendrimers from first to fifth generation was used as to stabilize silver nanoparticles in situ. A special focus is set on the biological properties. The antibacterial properties of the dendrimer stabilized silver particles are tested against Escherichia coli and the toxicity against human cells is tested with the human epithelial cell line A549. Under the chosen testing arrangement, it was observed that the silver particles contain a significant antibacterial effect against E. coli. Silver particles stabilized in situ with dendrimers of higher generation seem to contain a stronger antibacterial property. No toxicity against human cells was observed for the silver particles even in case of the highest investigated silver concentration. Altogether the here prepared and investigated silver particles could offer a great potential for application as antibacterial agent with low human toxicity.

  • 6.
    Montanez, Maria I.
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Campos, Luis M.
    Antoni, Per
    Hed, Yvonne
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Walter, Marie Valerié
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Krull, Brandon T.
    Khan, Anzar
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Hawker, Craig J.
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Accelerated Growth of Dendrimers via Thiol-Ene and Esterification Reactions2010Inngår i: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 43, nr 14, s. 6004-6013Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    By taking advantage of the orthogonal nature of thiol-ene coupling and anhydride based esterification reactions, a facile and chemoselective strategy to dendritic macromolecules has been developed The ability to interchange growth steps based on thiol-ene and anhydride chemistry allows the synthesis of fifth-generation dendrimers in only five steps and under benign reaction conditions In addition, the presented coupling chemistries eliminate the traditional need for protection/deprotection steps and afford dendrimers in high yield and purity The modularity of this strategy coupled with the latent reactivity of the alkene/hydroxyl chain ends was demonstrated by using different cores (alkene and hydroxyl functional), various AB(2) and CD2 monomers and a range of chain end groups As a result, three dendritic libraries were prepared which exhibited tunability of both the chemical functionality and physical properties including the fabrication of PEG hydrogels.

  • 7.
    Montanez, Maria I.
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Hed, Yvonne
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Rapponnen, Jarmo
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Mayorga, Cristobalina
    Carlos Haya Hosp, Res Unit Allerg Res, Malaga 29010, Spain..
    Torres, Maria J.
    Carlos Haya Hosp, Res Unit Allerg Res, Malaga 29010, Spain..
    Blanca, Miguel
    Carlos Haya Hosp, Res Unit Allerg Res, Malaga 29010, Spain..
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Click chemistry: A highly robust methodology for the fabrication of bioactivate dendritic-cellulose surfaces2009Inngår i: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 238Artikkel i tidsskrift (Annet vitenskapelig)
  • 8.
    Montanez, Maria I.
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Ruiz-Sanchez, Antonio J.
    Perez-Inestrosa, Ezequiel
    A perspective of nanotechnology in hypersensitivity reactions including drug allergy2010Inngår i: Current Opinion in Allergy and Clinical Immunology, ISSN 1528-4050, E-ISSN 1473-6322, Vol. 10, nr 4, s. 297-302Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Purpose of review We provide an overview of the application of the concepts of nanoscience and nanotechnology as a novel scientific approach to the area of nanomedicine related to the domain of the immune system. Particular emphasis will be paid to studies on drug allergy reactions. Recent findings Several well defined chemical structures arranged in the dimension of the nanoscale are currently being studied for biomedical purposes. By interacting with the immune system, some of these show promising applications as vaccines, diagnostic tools and activators/effectors of the immune response. Even a brief listing of some key applications of nanostructured materials shows how broad and intense this area of nanomedicine is. Summary As a result of the development of nanoscience and nanotechnology applied to medicine, new approaches can be envisioned for problems related to the modulation of the immune response, as well as in immunodiagnosis, and to design new tools to solve related medical challenges. Nanoparticles offer unique advantages with which to exploit new properties and for materials to play a major role in new diagnostic techniques and therapies. Fullerene-C-60 and multivalent functionalized gold nanoparticles of various sizes have led to new tools and opened up new ways to study and interact with the immune system. Some of the most versatile nanostructures are dendrimers. In their interaction with the immune system they can naturally occurring macromolecules, taking advantage of the fact that dendrimers can be synthesized into nanosized structures. Their multivalence can be successfully exploited in vaccines and diagnostic tests for allergic reactions.

  • 9.
    Montañez, Maria I.
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik. KTH, Skolan för teknikvetenskap (SCI), Centra, VinnExcellens Centrum BiMaC Innovation.
    Hed, Yvonne
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Utsel, Simon
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Ropponen, Jarmo
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Malmström, Eva
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Wågberg, Lars
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Bifunctional Dendronized Cellulose Surfaces as Biosensors2011Inngår i: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 12, nr 6, s. 2114-2125Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Well-defined dendronized cellulose substrates displaying multiple representations of dual-functionality were constructed by taking advantage of the efficiency of the click reaction combined with traditional anhydride chemistry. First, activated cellulose surfaces were decorated with several generations of dendrons, and their peripheral reactive groups were subsequently reacted with a trifunctional orthogonal monomer. The generated substrate tool box was successfully explored by accurately tuning the surface function using a versatile orthogonal dual postfunctionalization approach. In general, the reactions were monitored by using a click-dye reagent or a quartz crystal microbalance (QCM) technique, and the resulting surfaces were well-characterized using XPS, and contact angle measurements. Utilizing this approach two different surfaces have been obtained; that is, triethylenglycol oligomers and amoxicillin molecules were efficiently introduced to the dendritic surface. As a second example, mannose-decorated hydroxyl functional surfaces illustrated their potential as biosensors by multivalent detection of lectin protein at concentration as low as 5 nM.

  • 10.
    Neus, Feliu Torres
    et al.
    Karolinska Inst, Stockholm, Sweden .
    Walter, Marie V.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Montanez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Kunzmann, Andrea
    Karolinska Inst, Stockholm, Sweden .
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Nyström, Andreas
    Karolinska Inst, Stockholm, Sweden .
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Fadeel, Bengt
    Karolinska Inst, Stockholm, Sweden .
    Biocompatibility of polyester dendrimers in comparison to polyamidoamine dendrimers2012Inngår i: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 211, s. S203-S204Artikkel i tidsskrift (Annet vitenskapelig)
  • 11.
    Nordberg, Axel
    et al.
    KTH, Skolan för teknik och hälsa (STH), Neuronik.
    Antoni, Per
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Montanez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    von Holst, Hans
    KTH, Skolan för teknik och hälsa (STH), Neuronik.
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Highly Adhesive Phenolic Compounds as Interfacial Primers for Bone Fracture Fixations2010Inngår i: ACS APPLIED MATERIALS & INTERFACES, ISSN 1944-8244, Vol. 2, nr 3, s. 654-657Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Bone fractures are today scabilized with screws and metal plates. More complicated Fractures require alternative treatments that exclude harsh surgical conditions. By adapting the benign and UV initiated thiol-ene reaction, we efficiently fabricated triazine-based, fiber-reinforced adhesive patches within 2 s. To enhance their bone adhesion properties, we found that a pre-treatment step of bone surfaces with phenolic dopamine and poly(parahydroxystyrene) compounds was successful. The latter display the greatest E-module of 3.4 MPa in shear strength. All patches exhibited low cytotoxicity and can therefore find potential use in future treatments of bone fractures.

  • 12.
    Nordberg, Axel
    et al.
    KTH, Skolan för teknik och hälsa (STH), Neuronik.
    Montañez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Ramakrishnan, Subashiyni
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Malkoch, Michael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik, Ytbehandlingsteknik.
    von Holst, Hans
    KTH, Skolan för teknik och hälsa (STH), Neuronik.
    Higly adhesive DOPA primers for fibre reinforced Thiol-Ene patch fixation of bone fractures.Manuskript (preprint) (Annet vitenskapelig)
  • 13.
    Porsch, Christian
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi, Ytbehandlingsteknik.
    Zhang, Yuning
    Montanez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi, Ytbehandlingsteknik.
    Malho, Jani-Markus
    Kostiainen, Mauri A.
    Nyström, Andreas M.
    Malmström, Eva
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi, Ytbehandlingsteknik.
    Disulfide-Functionalized Unimolecular Micelles as Selective Redox-Responsive Nanocarriers2015Inngår i: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Redox-sensitive hyperbranched dendritic-linear polymers (HBDLPs) were prepared and stabilized individually as unimolecular micelles with diameters in the range 25–40 nm. The high molecular weight (500–950 kDa), core–shell amphiphilic structures were synthesized through a combination of self-condensing vinyl copolymerization (SCVCP) and atom transfer radical polymerization (ATRP). Cleavable disulfide bonds were introduced, either in the backbone, or in pendant groups, of the hyperbranched core of the HBDLPs. By triggered reductive degradation, the HBDLPs showed up to a 7-fold decrease in molecular weight, and the extent of degradation was tuned by the amount of incorporated disulfides. The HBDLP with pendant disulfide-linked functionalities in the hyperbranched core was readily postfunctionalized with a hydrophobic dye, as a mimic for a drug. An instant release of the dye was observed as a response to a reductive environment similar to the one present intracellularly. The proposed strategy shows a facile route to highly stable unimolecular micelles, which attractively exhibit redox-responsive degradation and cargo release properties.

  • 14.
    Utsel, Simon
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Montañez, Maria I.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Hed, Yvonne
    Ropponen, Jarmo
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Wågberg, Lars
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Hult, Anders
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknik.
    Malkoch, Michael
    Tunable Bifunctional Dendronized Cellulose SurfacesManuskript (preprint) (Annet vitenskapelig)
1 - 14 of 14
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