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  • 1.
    Llorens, Vicente Charcos
    et al.
    KTH, Superseded Departments (pre-2005), Numerical Analysis and Computer Science, NADA.
    Fransén, Erik
    KTH, Superseded Departments (pre-2005), Numerical Analysis and Computer Science, NADA.
    Intrinsic desynchronization properties of neurons containing dendritic rapidly activating K-currents2004In: Neurocomputing, ISSN 0925-2312, E-ISSN 1872-8286, Vol. 58, p. 137-143Article in journal (Refereed)
    Abstract [en]

    In this work, we investigate the role of the potassium A-current (K-A) in linking network synchrony to cellular excitability and firing frequency. We present an analysis of the notion of synchrony and we describe its conceptual and modeling implications. An full synchronization, K-A enables a control over the timing, or even a suppression, of spikes. For completely desynchronized activity, we show how K-A affects fast changes in amplitude of the summed EPSPs as well as amount of depolarization caused by the input. Simulations at intermediate levels of synchrony suggest that activity resulting from the interaction between cellular excitability and network synchrony could be altered through K-A modulation.

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