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  • 1.
    Hansson, Jonas
    et al.
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Quelennec, Aurore
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Yasuga, Hiroki
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Haraldsson, Tommy
    Van Der Wijngaart, Wouter
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Synthetic microfluidic paper allows controlled receptor positioning and improved readout signal intensity in lateral flow assays2015In: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2015, p. 284-286Conference paper (Refereed)
    Abstract [en]

    Synthetic Microfluidic Paper consists of slanted and interlocked polymer micropillars and can be used as a porous substrate in microfluidics and lateral flow assays. We here demonstrate single step manufacturing of multiple Synthetic Microfluidic Paper densities in the same device, and passive alignment of liquid spots in denser substrate regions, regardless of spotting position, allowing increased control of receptor positioning for lateral flow assays. We further demonstrate that the transparency of Synthetic Microfluidic Paper allows increasing readout signal intensity with increasing substrate thickness, to a value 3 times larger compared to nitrocellulose substrates.

  • 2.
    Hansson, Jonas
    et al.
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Quelennec, Aurore
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Yasuga, Hiroki
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Haraldsson, Tommy
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    van der Wijngaart, Wouter
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Synthetic Microfluidic Paper allows controlled receptor positioning and improvedreadout signal intensity in lateral flow assaysManuscript (preprint) (Other academic)
  • 3.
    Hansson, Jonas
    et al.
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Yasuga, Hiroki
    Basak, Sarthak
    Mercene Labs, Stockholm, SWEDEN.
    Carlborg, C. Fredrik
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    van der Wijngaart, Wouter
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Haraldsson, Tommy
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Direct Lithography of Rubbery OSTE+ Polymer2014In: Proceedings 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2014), 14CBMS , 2014, p. 123-125Conference paper (Refereed)
    Abstract [en]

    We present a Rubbery, Off-Stoichiometric Thiol-Ene-epoxy (OSTE+) polymer for direct lithography manufacturing, demonstrate its use in pneumatic pinch microvalves for lab-on-chip applications, test the lithography process achieving pillars of aspect-ratios (a.r.) 1:8, and characterize it’s surface as hydrophilic.

    Download full text (pdf)
    Hansson_2014_Direct Lithography of Rubbery OSTE+ Polymer.PDF
  • 4.
    Hansson, Jonas
    et al.
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Yasuga, Hiroki
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Haraldsson, Tommy
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    van der Wijngaart, Wouter
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Synthetic microfluidic paper2015In: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), IEEE conference proceedings, 2015, no February, p. 10-13Conference paper (Refereed)
    Abstract [en]

    We introduce a polymer synthetic microfluidic paper for lateral flow devices. The aim is to combine the high surface area of paper, or nitrocellulose, with the repeatability, controlled structure, and transparency of polymer micropillars. Our synthetic paper consists of a dense, high aspect ratio array of transparent pillars that are slanted and mechanically interlocked. We describe the manufacturing using multidirectional UV lithography and demonstrate successful capillary pumping of whole blood.

  • 5.
    Jonas, Hansson
    et al.
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Yasuga, Hiroki
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Haraldsson, Tommy
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    van der Wijngaart, Wouter
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Synthetic microfluidic paper: high surface area and high porosity polymer micropillar arrays2016In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 16, no 2, p. 298-304Article in journal (Refereed)
    Abstract [en]

    We introduce Synthetic Microfluidic Paper, a novel porous material for microfluidic applications that consists of an OSTE polymer that is photostructured in a well-controlled geometry of slanted and interlocked micropillars. We demonstrate the distinct benefits of Synthetic Microfluidic Paper over other porous microfluidic materials, such as nitrocellulose, traditional paper and straight micropillar arrays: in contrast to straight micropillar arrays, the geometry of Synthetic Microfluidic Paper was miniaturized without suffering capillary collapse during manufacturing and fluidic operation, resulting in a six-fold increased internal surface area and a three-fold increased porous fraction. Compared to commercial nitrocellulose materials for capillary assays, Synthetic Microfluidic Paper shows a wider range of capillary pumping speed and four times lower device-to-device variation. Compared to the surfaces of the other porous microfluidic materials that are modified by adsorption, Synthetic Microfluidic Paper contains free thiol groups and has been shown to be suitable for covalent surface chemistry, demonstrated here for increasing the material hydrophilicity. These results illustrate the potential of Synthetic Microfluidic Paper as a porous microfluidic material with improved performance characteristics, especially for bioassay applications such as diagnostic tests.

    Download full text (pdf)
    Hansson_2016_Synthetic-microfluidic-paper.pdf
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