Change search
Refine search result
123 1 - 50 of 128
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Andrén, Oliver C. J.
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Ingverud, Tobias
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Hult, Daniel
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Håkansson, Joakim
    Bogestål, Yalda
    Caous, Josefin S.
    Blom, Kristina
    Zhang, Yuning
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Andersson, Therese
    Pedersen, Emma
    Björn, Camilla
    Löwenhielm, Peter
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Antibiotic-Free Cationic Dendritic Hydrogels as Surgical-Site-Infection-Inhibiting Coatings2019In: Advanced Healthcare Materials, ISSN 2192-2640, E-ISSN 2192-2659, Vol. 8, no 5Article in journal (Refereed)
    Abstract [en]

    Abstract A non-toxic hydrolytically fast-degradable antibacterial hydrogel is herein presented to preemptively treat surgical site infections during the first crucial 24 h period without relying on conventional antibiotics. The approach capitalizes on a two-component system that form antibacterial hydrogels within 1 min and consist of i) an amine functional linear-dendritic hybrid based on linear poly(ethylene glycol) and dendritic 2,2-bis(hydroxymethyl)propionic acid, and ii) a di-N-hydroxysuccinimide functional poly(ethylene glycol) cross-linker. Broad spectrum antibacterial effect is achieved by multivalent representation of catatonically charged ?-alanine on the dendritic periphery of the linear dendritic component. The hydrogels can be applied readily in an in vivo setting using a two-component syringe delivery system and the mechanical properties can accurately be tuned in the range equivalent to fat tissue and cartilage (G? = 0.5?8 kPa). The antibacterial effect is demonstrated both in vitro toward a range of relevant bacterial strains and in an in vivo mouse model of surgical site infection.

  • 2.
    Andrén, Oliver C. J.
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Walter, Marie V.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Yang, Ting
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Multifunctional Poly(ethylene glycol): Synthesis, Characterization, and Potential Applications of Dendritic-Linear-Dendritic Block Copolymer Hybrids2013In: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 46, no 10, p. 3726-3736Article in journal (Refereed)
    Abstract [en]

    Emerging dendritic-linear-dendritic (DLD) hybrids that possess synergetic properties of linear and highly functional branched dendritic polymers are becoming important macromolecular scaffolds in fields ranging from biomedicine to nanotechnology. By exploiting pseudo-one-step polycondensation reactions, a facile and scalable synthetic methodology for the construction of highly functional DLDs has been developed. A library of three sets of DLDs exhibiting a hydrophilic linear PEG core with covalently attached hyperbranched bis-MPA blocks was synthesized up to the seventh generation with 256 reactive peripheral hydroxyl groups. The degree of branching for the hybrids was found between 0.40 and 0.59 with dispersities ranging from 1.03 to 1.88. The introduction of hyperbranched components resulted in control over or even full disruption of the crystallinity of the PEG. Postfunctionalizations of the peripheral hydroxyl groups with azides, allyls, and ATRP initiators yielded reactive intermediates. These intermediates were successfully assessed through UV-initiated thiol-ene coupling reactions for the synthesis of charged hybrids. ATRP of styrene from the pheriphery afforded amphiphilic macromolecules. Finally, their scaffolding capacity was evaluated for the fabrication of 3D networks, i.e, novel dendritic hydrogels and highly ordered breath figures.

  • 3.
    Antoni, Per
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hed, Yvonne
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Nordberg, Axel
    KTH, School of Technology and Health (STH), Neuronic Engineering (Closed 20130701).
    Nyström, Daniel
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    von Holst, Hans
    KTH, School of Technology and Health (STH), Neuronic Engineering (Closed 20130701).
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications2009In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 48, no 12, p. 2126-2130Article in journal (Refereed)
  • 4.
    Antoni, Per
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hed, Yvonne
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Nordberg, Axel
    KTH, School of Technology and Health (STH), Neuronic Engineering.
    Nyström, Daniel
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    von Holst, Hans
    KTH, School of Technology and Health (STH), Neuronic Engineering.
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    One-pot dendritic growth and post-functionalization of multifunctional dendrimers: Synthesis and application2009Manuscript (preprint) (Other academic)
  • 5.
    Antoni, Per
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Vamvounis, George
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Nyström, Daniel
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Nyström, Andreas
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Lindgren, Mikael
    Norwegian Univ Sci & Technol, Dept Phys.
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Europium confined cyclen dendrimers with photophysically active triazoles2008In: Journal of Materials Chemistry, ISSN 0959-9428, E-ISSN 1364-5501, Vol. 18, no 22, p. 2545-2554Article in journal (Refereed)
    Abstract [en]

    Dendrimers up to the fourth generation (G1-G4) were successfully synthesized via the efficient copper catalyzed 1,3-dipolar cycloaddition between primary alkynes and azides (CuAAC), also referred to as a click reaction. The synthetic protocol involved the preparation of presynthesized dendron wedges that subsequently were attached to a tetra-valent alkyne functional cyclen core. These constructed structures integrated stable triazole groups "intra-locked'' between the cyclen and dendron wedges. The incorporation of a lanthanide metal ion, europium, into the interior of all cyclen dendrimers was monitored by FT-IR. Interestingly, the photophysical results showed that the proximate triazole not only acts as a stable linker but also as a sensitizers, transferring its singlet-singlet excitation in the ultraviolet region (270-290 nm) to the partially filled luminescent lanthanide 4f shell. An increase of luminescence decay time from the lanthanide D-5(0) -> F-7(2) emission was observed with increasing dendrimer size, indicating that the shielding effect of the dendron wedges is important for the relaxation of the photo-excitation and energy transfer. To the best of our knowledge, this is the first time a set of dendron wedges have successfully been attached to a cyclen metal ion cage via the versatile click reaction. Furthermore, the produced triazoles intra-locked in close proximity to the macrocycle core elucidated an interesting photophysical function.

  • 6.
    Antoni, Per
    et al.
    KTH, School of Chemical Science and Engineering (CHE).
    Nystrom, Daniel
    KTH, School of Chemical Science and Engineering (CHE). KTH, Royal Inst Technol, Sch Chem Sci & Engn, SE-10044 Stockholm, Sweden..
    Hawker, Craig J.
    Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA..
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE).
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE).
    POLY 558-Synthesis of click/ester and click/ether dendrimers based on AB2-and CD2-monomers2007In: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 234Article in journal (Other academic)
  • 7.
    Antoni, Per
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Nyström, Daniel
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hawker, Craig
    Univ Calif Santa Barbara, Mat Res Lab.
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    A chemoselective approach for the accelerated synthesis of well-defined dendritic architectures2007In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, no 22, p. 2249-2251Article in journal (Refereed)
    Abstract [en]

    A chemoselective and layered growth approach has been developed for the synthesis of dendrimers, combining Click chemistry with traditional esterification/etherification reactions, without the need for activation steps and with excellent overall yields.

  • 8.
    Antoni, Per
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Nyström, Daniel
    KTH, School of Chemical Science and Engineering (CHE).
    Ropponen, Jarmo
    KTH, School of Chemical Science and Engineering (CHE).
    Lundberg, Pontus
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malmström, Eva
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Click chemistry as a tool for accelerated and one-pot synthesis of dendrimers: thermal study and application2007Manuscript (preprint) (Other academic)
    Abstract [en]

    Dendrons, dendrimers and linear polymers have been synthesized using click chemistry in combination with anhydride chemistry and atom transfer radical polymerization, ATRP. Functional materials were obtained in multigram scale using these orthogonal chemistries simultaneous.

  • 9.
    Antoni, Per
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Robb, Maxwell J.
    Campos, Luis
    Montanez, Maria
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malmström, Eva
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hawker, Craig J.
    Pushing the Limits for Thiol-Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day2010In: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 43, no 16, p. 6625-6631Article in journal (Refereed)
    Abstract [en]

    Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB(2)-CD2 approach and having orthogonal, "clickable" groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.

  • 10.
    Arseneault, Mathieu
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Granskog, Viktor
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Khosravi, Sara
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Heckler, Ilona
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Antunez, Pablo Mesa
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Hult, Daniel
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Zhang, Yuning
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    The Dawn of Thiol-Yne Triazine Triones Thermosets as a New Material Platform Suited for Hard Tissue Repair2018In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 30, no 52, article id 1804966Article in journal (Refereed)
    Abstract [en]

    The identification of a unique set of advanced materials that can bear extraordinary loads for use in bone and tooth repair will inevitably unlock unlimited opportunities for clinical use. Herein, the design of high-performance thermosets is reported based on triazine-trione (TATO) monomers using light-initiated thiol-yne coupling (TYC) chemistry as a polymerization strategy. In comparison to traditional thiol-ene coupling (TEC) systems, TYC chemistry has yielded highly dense networks with unprecedented mechanical properties. The most promising system notes 4.6 GPa in flexural modulus and 160 MPa in flexural strength, an increase of 84% in modulus and 191% in strength when compared to the corresponding TATO system based on TEC chemistry. Remarkably, the mechanical properties exceed those of polylactide (PLA) and challenge poly(ether ether ketone) PEEK and today's methacrylate-based dental resin composites. All the materials display excellent biocompatibility, in vitro, and are successfully: i) molded into medical devices for fracture repair, and ii) used as bone adhesive for fracture fixation and as tooth fillers with the outstanding bond strength that outperform methacrylate systems used today in dental restoration application. Collectively, a new era of advanced TYC materials is unfolded that can fulfill the preconditions as bone fixating implants and for tooth restorations.

  • 11. Atlas, Salima
    et al.
    Raihane, Mustapha
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Lahcini, Mohammed
    Ameduri, Bruno
    Radical copolymerization of acrylonitrile with 2,2,2-trifluoroethyl acrylate for dielectric materials: Structure and characterization2013In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 51, no 18, p. 3856-3866Article, review/survey (Refereed)
    Abstract [en]

    Radical copolymerization based on acrylonitrile (AN) and 2,2,2-Trifluoroethyl acrylate (ATRIF) initited by AIBN was investigated in acetonitrile solution. The resulting poly(AN-co-ATRIF) copolymers were characterized by 1 H, 13 C, and 19 F NMR and IR spectroscopy, and size exclusion chromatography (SEC). Their compositions were assessed by 1 H NMR. The kinetics of radical copolymerization of AN with ATRIF was investigated from sereval experiments achieved at 70 degrees C from initial [AN](0)/[ATRIF](0) molar ratios ranging between 20/80 and 80/20 and was enabled to determine the reactivity ratios of both comonomers. From the monomer-polymer copolymerization curve, the Fineman-Ross and Kelen-Tudos laws enabled to assess the reactivity ratios (r(AN) = r(1) = 1.25 +/- 0.04 and r(ATRIF) = r(2) = 0.93 +/- 0.05 at 70 degrees C) while the revised patterns scheme led to r(12) = r(AN) = 1.03, and r(21) = r(ATRIF) = 0.78 at 70 degrees C. In all cases, rAN x rATRIF product was close to unity, which indicates that poly(AN-co-ATRIF) copolymers exhibit a random structure. This was also confirmed by the Igarashi's and Pyun's laws which revealed the presence of AN-ATRIF, AN-AN, and ATRIF-ATRIF dyads. The Q and e values for ATRIF were also assessed (Q(2) = 0.62 and e(2) = 0.93). The glass transition temperature values, Tg, of these copolymers increased from 17 to 61 degrees C as the molar percentage of ATRIF decreased from 77 to 16% in the copolymer. Thermogravimetry analysis of poly(AN-co-ATRIF) copolymers showed a good thermal stability compared to that of poly(ATRIF) homopolymer due to incorporation of AN comonomer.

  • 12. Auty, Sam E. R.
    et al.
    Andrén, Oliver C. J.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hern, Faye Y.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Rannard, Steven P.
    One-pot' sequential deprotection/functionalisation of linear-dendritic hybrid polymers using a xanthate mediated thiol/Michael addition2015In: Polymer Chemistry, ISSN 1759-9954, E-ISSN 1759-9962, Vol. 6, no 4, p. 573-582Article in journal (Refereed)
    Abstract [en]

    Thiol-Michael addition chemistry is a powerful tool for the preparation of functional materials. In this first report of xanthate-functional linear-dendritic polymer hybrids, the preparation of four generations of xanthate-functionalised dendron atom transfer radical polymerisation macroinitiators is described using an orthogonal chemical strategy. The controlled polymerisation of tertiary butyl methacrylate is demonstrated to high conversion and without interference from the xanthate surface groups. Modification of the peripheral xanthate groups of dendrons at the hybrid polymer chain-end has been studied using a one-pot deprotection/functionalisation strategy and a range of commercially available and bespoke acrylate monomers to form complex polymer architectures from feedstock polymers, differing in the number of modified end groups and the surface chemistry of the dendron chain end.

  • 13. Auty, Sam E. R.
    et al.
    Andrén, Oliver
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Rannard, Steven P.
    The first peripherally masked thiol dendrimers: a facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol-acrylate Michael addition reactions2014In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 50, no 50, p. 6574-6577Article in journal (Refereed)
    Abstract [en]

    Introducing multiple reactive functional groups at the periphery of dendrimer materials presents considerable challenges if the functionality is able to self-react. An efficient and facile approach to introducing masked thiols at the surface of polyester dendrimers is presented. One-pot, deprotection/thiol-acrylate Michael addition from the xanthate-functional dendritic substrates (generation zero to two) has been achieved for the first time, with high efficiency demonstrated using three acrylates of varying chemistry and avoiding disulfide formation.

  • 14. Berglin, M.
    et al.
    Elwing, H.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Löwenhielm, P.
    Kelly, J.
    Lundgren, A.
    Hybrid nanoparticle arrays for measuring the interaction between cell adhesion ligands and macromolecules using SPR2011In: European Cells and Materials, ISSN 1473-2262, E-ISSN 1473-2262, Vol. 21, no SUPPL.1, p. 44-Article in journal (Refereed)
  • 15. Bouit, Pierre-Antoine
    et al.
    Westlund, Robert
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Feneyrou, Patrick
    Maury, Olivier
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malmström, Eva
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Andraud, Chantal
    Dendron-decorated cyanine dyes for optical limiting applications in the range of telecommunication wavelengths2009In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 33, no 5, p. 964-968Article in journal (Refereed)
    Abstract [en]

    Cyanine dyes decorated with 2,2-bis(methylol) propionic acid (bis-MPA) based dendrons up to third generation were synthesized. Dendrons were attached to the chromophore using a "click chemistry'' reaction. Photophysical characterizations of these dyes show intense absorption and emission in the near-infrared (NIR), while nonlinear transmission experiments of the dendron-decorated chromophores indicate that properties in the IR of the parent dyes are conserved. This synthetic approach is a crucial preliminary step towards the preparation of solid functional materials for optical limiting (OL) applications in the IR.

  • 16.
    Carlborg, Carl Fredrik
    et al.
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Haraldsson, Tommy
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Öberg, Kim
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    van der Wijngaart, Wouter
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    BEYOND PDMS:: OFF-STOCHIOMETRY THIOL-ENE BASED SOFT LITHOGRAPHY FOR RAPID PROTOTYPING OF MICROFLUIDIC DEVICES2010In: 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (micro TAS 2010), 2010, p. 70-72Conference paper (Refereed)
    Abstract [en]

    We present an easy to use, rapid fabrication platform for microfluidic systems, based on micro-molding of novel thiolene based polymer formulations. The novel fabrication platform addresses major drawbacks of PDMS by allowing large freedom in material and surface properties, including: (photo)patterning of stable surface modifications, bonding without plasma treatment, rapid UV or thermal curing, variable E-modulus, minimized leaching of uncured components [1] and suppressed non-specific binding of biomolecules [2]. This process is potentially suited for both rapid prototyping in the laboratory and medium-scale commercial production, bridging the “development gap”.

  • 17.
    Carlborg, Carl Fredrik
    et al.
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Haraldsson, Tommy
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Öberg, Kim
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    van der Wijngaart, Wouter
    KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
    Beyond PDMS: off-stoichiometry thiol–ene (OSTE) based soft lithography for rapid prototyping of microfluidic devices2011In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 11, no 18, p. 3136-3147Article in journal (Refereed)
    Abstract [en]

    In this article we introduce a novel polymer platform based on off-stoichiometry thiol–enes (OSTEs), aiming to bridge the gap between research prototyping and commercial production of microfluidic devices. The polymers are based on the versatile UV-curable thiol–ene chemistry but takes advantage of off-stoichiometry ratios to enable important features for a prototyping system, such as one-step surface modifications, tuneable mechanical properties and leakage free sealing through direct UV-bonding. The platform exhibits many similarities with PDMS, such as rapid prototyping and uncomplicated processing but can at the same time mirror the mechanical and chemical properties of both PDMS as well as commercial grade thermoplastics. The OSTE-prepolymer can be cast using standard SU-8 on silicon masters and a table-top UV-lamp, the surface modifications are precisely grafted using a stencil mask and the bonding requires only a single UV-exposure. To illustrate the potential of the material we demonstrate key concepts important in microfluidic chip fabrication such as patterned surface modifications for hydrophobic stops, pneumatic valves using UV-lamination of stiff and rubbery materials as well as micromachining of chip-to-world connectors in the OSTE-materials.

  • 18.
    Carlmark, Anna
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Hawker, Craig J.
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    New methodologies in the construction of dendritic materials2009In: Chemical Society Reviews, ISSN 0306-0012, E-ISSN 1460-4744, Vol. 38, no 2, p. 352-362Article, review/survey (Refereed)
    Abstract [en]

    Dendritic polymers are highly branched polymer structures, with complex, secondary architectures and well-defined spatial location of functional groups. Due to their unique physical and chemical features, applications in areas such as targeted drug-delivery, macromolecular carriers, catalysis, sensors, light harvesting, surface engineering and biomimetic materials have been proposed. However, only a few dendritic materials have been exploited commercially due to time consuming syntheses and the generation of significant waste/presence of unreacted starting materials. This tutorial review describes traditional synthesis of dendritic materials as well as recent advances in synthetic strategies, for example the use of Click chemistry, as a tool to efficiently obtain complex, functional dendritic structures.

  • 19.
    Carlmark, Anna
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malmström, Eva
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research2013In: Chemical Society Reviews, ISSN 0306-0012, E-ISSN 1460-4744, Vol. 42, no 13, p. 5858-5879Article, review/survey (Refereed)
    Abstract [en]

    Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been suggested for dendritic polymers, including theranostics, biosensors, optics, adhesives and coatings. The transition from potential to real applications is strongly dictated by their commercial accessibility, scaffolding ability as well as biocompatibility. A dendritic family that fulfills these requirements is based on the 2,2-bismethylolpropionic acid (bis-MPA) monomer. This critical review is the first of its kind to cover most of the research activities generated on aliphatic polyester dendritic architectures based on bis-MPA. It is apparent that these scaffolds will continue to be in the forefront of cutting-edge research as their structural variations are endless including dendrons, dendrimers, hyperbranched polymers, dendritic-linear hybrids and their hybridization with inorganic surfaces.

  • 20. Coullerez, G.
    et al.
    Lundmark, S.
    Malkoch, Michael
    KTH, Superseded Departments, Polymer Technology.
    Magnusson, H.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
    Malmström, Eva
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
    Hult, Anders
    KTH, Superseded Departments, Polymer Technology.
    Mathieu, H. J.
    Insights into ToF-SIMS analysis of dendritic macromolecules: cationization and PCA to probe their molecular weight on surfaces2003In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 203, p. 620-624Article in journal (Refereed)
    Abstract [en]

    Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is utilized to study dendrons, dendrimers and hyperbranched derivatives prepared from the 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) or the 3-ethyl-3-(hydroxymethyl)oxetane (TMPO). We show that the cationization experiments of the intact molecules with alkali or metal ions such as Na+, Cu+ or Ag+ allow to detect whole molecular species up to 3000 Da (low generation). It allows to probe directly their molecular TM weight and end-functionality. However, when the molecule lift-off fails for series of hyperbranched polyesters Boltorn(TM), the fingerprint part of the SIMS spectra (m/z < 300 Da) is instead used. The low-mass fragments are mainly assigned to the bis-MP repeating unit. Ions due to the core molecule are also distinguished. Data treatment is combined with the principal component analysis (PCA) multivariate statistical method to highlight the main differences between the spectra. Only one principal component (PC1) is needed to describe most of the variance between the samples taking into account the generation effect. PC1 plotted as a function of the molecular weight gives a calibration curve. Normalization of the data set by ion intensities from the core molecule allows the linearization of the SIMS intensities vs. the molecular weight.

  • 21. Coullerez, G.
    et al.
    Mathieu, H. J.
    Lundmark, S.
    Malkoch, Michael
    KTH, Superseded Departments, Polymer Technology.
    Magnusson, H.
    Hult, Anders
    KTH, Superseded Departments, Polymer Technology.
    Cationization of dendritic macromolecule adsorbates on metals studied by time-of-flight secondary ion mass spectrometry2003In: Surface and Interface Analysis, ISSN 0142-2421, E-ISSN 1096-9918, Vol. 35, no 8, p. 682-692Article in journal (Refereed)
    Abstract [en]

    Time-of-flight secondary ion mass spectrometry (ToF-SIMS) was utilized to study dendritic macromolecules with various architectures, such as dendrons, dendrimers and hyperbranched polyesters prepared from bis-(hydroxymethyl)propionic acid (Bis-MPA) and a series of hyperbranched polyethers based on 3-ethyl-3(hydroxymethyl)oxetane. The measurements were performed on spin-coated thin films of the branched molecules (D) onto silicon, chemically etched copper foil and silver-coated wafers. They showed weak signatures of molecular ions by proton capture (D + H)(+) in the high mass range of the spectra (m/z > 400). On the contrary, cationization of the intact molecules with alkali or transition metal ions such as Na+, Cu+ or Ag+ was observed. High-intensity quasi-molecular ions (D + M)(+) (with M = Na+, Cu+ or Ag+) allowed the studied polymers to be identified. The whole molecular species were observed for Bis-MPA dendrons and dendrimers up to 3000 Da for hydroxyl or acetonide-terminated derivatives. The success of the so-called cationization experiments with metal substrates compared with analysis of molecular adsorbates on silicon is highlighted. The ToF-SIMS sensitivity appeared useful to provide information about the molecular end-groups or to highlight incomplete reaction occurring during some deprotection step of the synthesis. Only uncationized fragments of low masses were detected for the hyperbranched polyesters. This result suggested the effect of molecular asymmetry and/or flattening of the molecules on the substrates, which hampered the molecule lift-off efficiency. Nevertheless, the hyperbranched polyethers were characterized based on the peak distribution of intensities, which allowed estimation of their molecular weight average. This work was intended to illustrate the capabilities of ToF-SIMS to analyse dendritic polymers on surfaces.

  • 22. Dukette, Tiffany E
    et al.
    Mackay, Michael E
    Van Horn, Brooke
    Wooley, Karen L
    Drockenmuller, Eric
    Malkoch, Michael
    Hawker, Craig J
    Conformation of intramolecularly cross-linked polymer nanoparticles on solid substrates2005In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 5, no 9, p. 1704-1709Article in journal (Refereed)
    Abstract [en]

    The conformation of cross-linked, monomolecular, polystyrene nanoparticles on a solid substrate is considered as a function of cross-linking degree and substrate surface free energy. It is found that an extreme amount of cross-linking is necessary for the ca. 5-10 nm diameter nanoparticles to retain their original spherical shape, regardless of surface free energy. A lesser amount of cross-linking produces a nanoparticle that collapses to a pancake-like conformation on a high-energy substrate yet remains spherical on a low-energy surface. A simple model is developed to reveal the relationship between nanoparticle modulus and surface free energy to define the nanoparticle conformation.

  • 23.
    Engström, Joakim
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
    Asem, Heba
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Brismar, Hjalmar
    KTH, Superseded Departments (pre-2005), Physics. KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences (SCI), Applied Physics.
    Zhang, Yuning
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Malkoch, Michael
    KTH, Superseded Departments (pre-2005), Fibre and Polymer Technology. KTH, Superseded Departments (pre-2005), Polymer Technology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Malmström, Eva
    KTH, Superseded Departments (pre-2005), Fibre and Polymer Technology.
    In situ encapsulation of Nile red or Doxorubicinduring RAFT‐mediated emulsion polymerizationvia PISAManuscript (preprint) (Other academic)
  • 24.
    Erlandsson, Johan
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Fibre Technology.
    Pettersson, Torbjörn
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
    Ingverud, Tobias
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
    Granberg, H.
    Larsson, Per A.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center BiMaC Innovation.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Wågberg, Lars
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
    On the mechanism behind freezing-induced chemical crosslinking in ice-templated cellulose nanofibril aerogels2018In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 6, no 40, p. 19371-19380Article in journal (Refereed)
    Abstract [en]

    The underlying mechanism related to freezing-induced crosslinking of aldehyde-containing cellulose nanofibrils (CNFs) has been investigated, and the critical parameters behind this process have been identified. The aldehydes introduced by periodate oxidation allows for formation of hemiacetal bonds between the CNFs provided the fibrils are in sufficiently close contact before the water is removed. This is achieved during the freezing process where the cellulose components are initially separated, and the growth of ice crystals forces the CNFs to come into contact in the thin lamellae between the ice crystals. The crosslinked 3-D structure of the CNFs can subsequently be dried under ambient conditions after solvent exchange and still maintain a remarkably low density of 35 kg m-3, i.e. a porosity greater than 98%. A lower critical amount of aldehydes, 0.6 mmol g-1, was found necessary in order to generate a crosslinked 3-D CNF structure of sufficient strength not to collapse during the ambient drying. The chemical stability of the 3-D structure can be further enhanced by converting the hemiacetals to acetals by treatment with an alcohol under acidic conditions.

  • 25. Feliu, Neus
    et al.
    Walter, Marie Valérie
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Montañez, Maria I.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Kunzmann, Andrea
    Hult, Anders
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Nyström, Andreas
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Fadeel, Bengt
    Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers2012In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 33, no 7, p. 1970-1981Article in journal (Refereed)
    Abstract [en]

    Dendrimers can be designed for several biomedical applications due to their well-defined structure, functionality and dimensions. The present study focused on the in vitro biocompatibility evaluation of a library of aliphatic polyester dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) with an overall diameter of 0.5-2 nm. In addition, dendrimers with two different chemical surfaces (neutral with hydroxyl end group and anionic with carboxylic end group) and dendrons corresponding to the structural fragments of the dendrimers were evaluated. Commercial polyamidoamine dendrimers (PAMAM) with cationic (amine) or neutral (hydroxyl) end group were also included for comparison. Cell viability studies were conducted in human cervical cancer (HeLa) and acute monocytic leukemia cells (THP.1) differentiated into macrophage-like cells as well as in primary human monocyte-derived macrophages. Excellent biocompatibility was observed for the entire hydroxyl functional bis-MPA dendrimer library, whereas the cationic, but not the neutral PAMAM exerted dose-dependent cytotoxicity in cell lines and primary macrophages. Studies to evaluate material stability as a function of pH, temperature, and time, demonstrated that the stability of the 4th generation hydroxyl functional bis-MPA dendrimer increased at acidic pH. Taken together, bis-MPA dendrimers are degradable and non-cytotoxic to human cell lines and primary cells.

  • 26. Garcia Gallego, Sandra
    et al.
    Hult, Daniel
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Olsson, Johan V.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Fluoride-Promoted Esterification with Imidazolide-Activated Compounds: A Modular and Sustainable Approach to Dendrimers2015In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 54, no 8, p. 2416-2419Article in journal (Refereed)
    Abstract [en]

    Based on the growing demand for facile and sustainable synthetic methods to structurally perfect polymers, we herein describe a significant improvement of esterification reactions capitalizing on 1,1-carbonyldiimidazole (CDI). Cesium fluoride was shown to be an essential catalyst for these reactions to reach completion. This approach was successfully applied to the synthesis of structurally flawless and highly functional polyester dendrimers employing traditional and accelerated growth strategies. A sixth generation bis-MPA dendrimer with a molecular weight of 22.080Da and 192 peripheral hydroxy groups was isolated in less than one day of total reaction time. Large quantities of dendrimerswere obtained in high yields (>90%) using simple purification steps under sustainable conditions. The fluoride-promoted esterification (FPE) via imidazolide-activated compounds is wide in scope and constitutes a potentially new approach toward functional polymers and other materials.

  • 27.
    Garcia Gallego, Sandra
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Nyström, Andreas M.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications2015In: Progress in polymer science, ISSN 0079-6700, E-ISSN 1873-1619, Vol. 48, p. 85-110Article, review/survey (Refereed)
    Abstract [en]

    Polymers play an important role in the advancement of materials for use in cutting-edge applications. A direct consequence of an increased demand for more sophisticated materials has been a drive toward developing polymers that exhibit a higher level of structural control, especially in terms of the number and type of functionalities provided within the polymer framework. A family of polymers that meets such a challenge is based on the readily available AB2 monomer 2,2-bismethylolpropionic acid (bis-MPA) building block. Due to the ease with which the monomers can be synthesized, an array of multifunctional polymers have been produced including monodisperse dendrimers and dendrons and well-defined linear polymers as well as linear-dendritic hybridizations. This review outlines the evolution of the synthetic strategies for developing novel polymeric architectures based on bis-MPA and their assessment in both solution and substrate-based innovative applications.

  • 28. Ghirardello, Mattia
    et al.
    Öberg, Kim
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Staderini, Samuele
    Renaudet, Olivier
    Berthet, Nathalie
    Dumy, Pascal
    Hed, Yvonne
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Marra, Alberto
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Dondoni, Alessandro
    Thiol-Ene and Thiol-Yne-Based Synthesis of Glycodendrimers as Nanomolar Inhibitors of Wheat Germ Agglutinin2014In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 52, no 17, p. 2422-2433Article in journal (Refereed)
    Abstract [en]

    Alkene and alkyne functional polyester-based dendrimers of generation 1 to 4 have been prepared and reacted under free-radical conditions with 2-acetamido-2-deoxy-1-thio--D-glucose (GlcNAc-SH). As the alkene-dendrimers underwent the addition of one thiyl radical per ene group whereas each yne group of alkyne-dendrimers was saturated by two thiyl radicals, a collection of glycodendrimers with glycan density ranging from six to ninety-six GlcNAc per dendrimer was obtained. The recognition properties of the prepared glycodendrimers toward the wheat germ agglutinin (WGA) were evaluated by enzyme-linked lectin assay (ELLA). The eight glycodendrimers were excellent ligands showing IC50 values in the nanomolar range and relative potencies per sugar unit up to 2.27 e(6) when compared to monosaccharidic GlcNAc used as monovalent reference.

  • 29.
    Granskog, Viktor
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Fibre Technology.
    Garcia-Gallego, Sandra
    KTH.
    von Kieseritzky, Johanna
    Karolinska Inst, Stockholm, Sweden..
    Pettersson, Jennifer
    RISE Res Inst Sweden, Boras, Sweden..
    Stenlund, Patrik
    RISE Res Inst Sweden, Boras, Sweden..
    Zhang, Yuning
    KTH.
    Petronis, Sarunas
    RISE Res Inst Sweden, Boras, Sweden..
    Lyven, Benny
    RISE Res Inst Sweden, Boras, Sweden..
    Arner, Marianne
    Karolinska Inst, Stockholm, Sweden..
    Hakansson, Joakim
    RISE Res Inst Sweden, Boras, Sweden..
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    High-performance and biocompatible thiol-ene based adhesive for bone fracture fixation2018In: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 256Article in journal (Other academic)
  • 30.
    Granskog, Viktor
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Garcia-Gallego, Sandra
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Zhang, Yuning
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Adhesion-enhancing primer for high-performance bone adhesive2017In: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 253Article in journal (Other academic)
  • 31. Grayson, Scott M.
    et al.
    Myers, Brittany K.
    Bengtsson, Jonas
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Advantages of Monodisperse and Chemically Robust "SpheriCal" Polyester Dendrimers as a "Universal" MS Calibrant2014In: Journal of the American Society for Mass Spectrometry, ISSN 1044-0305, E-ISSN 1879-1123, Vol. 25, no 3, p. 303-309Article in journal (Refereed)
    Abstract [en]

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry.

  • 32. Hagberg, Erik C.
    et al.
    Malkoch, Michael
    Ling, Yibo
    Hawker, Craig J.
    Carter, Kenneth R.
    Effects of modulus and surface chemistry of thiol-ene photopolymers in nanoimprinting2007In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 7, no 2, p. 233-237Article in journal (Refereed)
    Abstract [en]

    Thiol-ene photopolymers were studied as patternable resins for nanocontact molding imprint lithography. Photopolymerizable thiol and ene monomer mixtures were used, and after molding, patterned thiol-ene polymer features the size and shape of the original molds were replicated. Adhesion and release were examined and controlled by manipulating the surface chemistry of the substrate and mold. A direct correlation between cured thiol-ene polymer modulus and pattern fidelity was observed.

  • 33.
    Heckler, Ilona
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Arseneault, Mathieu
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Granskog, Viktor
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Antunez, Pablo Mesa
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Zhang, Yuning
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Triazine trione based adhesive as potential materials for bone fracture fixation2018In: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 256Article in journal (Other academic)
  • 34.
    Hed, Yvonne
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Antoni, Per
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Montanez, Maria I.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Hult, Anders
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Bifunctional dendritic structures based on AB(2)C monomers2009In: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 238Article in journal (Other academic)
  • 35.
    Hed, Yvonne
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Zhang, Yuning
    Andrén, Olver C. J.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Zeng, Xianghui
    Nyström, Andreas M.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Side-by-side comparison of dendritic-linear hybrids and their hyperbranched analogs as micellar carriers of chemotherapeutics2013In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 51, no 19, p. 3992-3996Article in journal (Refereed)
    Abstract [en]

    Amphiphilic block copolymers are successfully synthesized possessing a hydrophobic dendritic component based on the bis-MPA monomer and a hydrophilic linear polyethylene glycol (PEG) component. The hybrids were either conjured in small scale using robust click reactions between perfect dendrons and linear PEG or multigram polycondensation of hyperbranched blocks from PEG. In all cases, the amphiphiles were assembled to micelles, were found nontoxic and successfully loaded with the chemotherapeutic doxorubicin.

  • 36.
    Hed, Yvonne
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Öberg, Kim
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Berg, Sandra
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Nordberg, Axel
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology. KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    von Holst, Hans
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Multipurpose heterofunctional dendritic scaffolds as crosslinkers towards functional soft hydrogels and implant adhesives in bone fracture applications2013In: Journal of Materials Chemistry B, ISSN 2050-7518, Vol. 1, no 44, p. 6015-6019Article in journal (Refereed)
    Abstract [en]

    Two sets of heterofunctional dendritic frameworks displaying an inversed and exact number of ene and azide groups have successfully been synthesized and post-functionalized with biorelevant molecules. Their facile scaffolding ability enabled the fabrication of soft and azide functional dendritic hydrogels with modulus close to muscle tissue. The dendritic scaffolds are furthermore shown to be promising primers for the development of novel bone fracture stabilization adhesives with shear strengths succeeding commercial Histroacryl (R).

  • 37. Hern, Faye Y.
    et al.
    Auty, Sam E. R.
    Andrén, Oliver C. J.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Rannard, Steve P.
    Model studies of the sequential and simultaneous statistical modification of dendritic functional groups and their implications within complex polymer architecture synthesis2017In: Polymer Chemistry, ISSN 1759-9954, E-ISSN 1759-9962, Vol. 8, no 10, p. 1644-1653Article in journal (Refereed)
    Abstract [en]

    Post-synthesis modification of polymers is a synthetically appealing approach to generate a range of samples from a single, well-characterised starting material. When partial or mixed-functionalisation is sought, an inevitable statistical distribution of modification outcomes will lead to considerable variation of chemical structures within the final sample. Here we have comprehensively investigated the postsynthesis sequential/partial and simultaneous mixed modification of xanthate-functional ideal dendrons and used this data to consider the implications for the more complex linear-dendritic hybrids and hyper-branched- polydendron analogues. Although H-1 NMR confirmed the potential to direct the reactions, it was clear from MALDI-TOF studies that very little of the actual targeted structures were generated in the statistical reactions.

  • 38.
    Hult, Anders
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Antoni, Per
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Dendrimers with interior and exterior functionalities comprising of azide or alkyne groups for post- functionalization by huisgen click cycloaddition2008Patent (Other (popular science, discussion, etc.))
    Abstract [en]

    Novelty: A dendritic polymer comprising a core and repeating units, is new. Every repeating unit is bound to other unit(s) with bond(s) consisting of an ester, amide, thioether, ether, urethane, amine or imine.Use: The dendritic polymer is used for drug delivery systems, tissue engineering, data storage devices, markers for imaging, diagnostics, vaccines, phototherapeutics, optical devices, semiconductor, bioactive hydrogels and/or catalysts; for manufacture of a particle and a hydrogel (claimed); and for coatings, polyfunctional initiators for controlled radical polymerization or living free-radical polymerization techniques, ring-opening metathesis polymerization and ring-opening polymerization, dental and other composite materials, additives to control viscosity, rheology, solubility and stabilizing capacity, hybrid organic-inorganic materials, water-soluble materials, amphiphilic architectures, well-defined building blocks for precise architectural control, deposition of dendrimers on solid surfaces, dispersing agents for nanoparticles, dendrimer vehicles for encapsulation and/or delivery, and dendrimer scaffolds. The particle is used in encapsulation of low molecular compounds such as potent drugs, chelating species and fluorescent dyes.Advantage: The dendritic polymer can be functionalized both in the interior and in the exterior. It is possible to use a one-pot growth of dendritic polymer. There is provided the possibility to have more functional groups in a dendritic polymer compared to conventional polymer. When comparing the number of functional groups of a dendrimer based on A'B' x C' y -monomers with a traditional dendrimer based A'B' x -monomers, it is evident that the intrinsic functionality provides a larger number of available functional groups for post-modification. There is provided the possibility of a synthesis which is very robust, can be performed in various solvents, performed at both ambient and elevated temperatures, performed at atmospheric pressure as well as elevated, performed in a variety of gases including oxygen, nitrogen or argon. The synthesis has a high yield making the manufacture economical. There is the possibility to exclude an activation step prior to post-functionalization of a dendritic polymer. There is provided the possibility to add different types of functional groups simultaneously both to inner layer and/or to the outer layer.

  • 39.
    Hult, Daniel
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Garcia-Gallego, Sandra
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Ingverud, Tobias
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Andrén, Oliver
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Degradable High Tg Sugar Derived Polycarbonates from Isosorbide and Dihydroxyacetone2018In: Polymer Chemistry, ISSN 1759-9954, E-ISSN 1759-9962, Vol. 9, no 17, p. 2238-2246Article in journal (Refereed)
    Abstract [en]

    Polycarbonates from isosorbide and dihydroxyacetone (DHA) have been synthesised using organocatalytic step-growth polymerization of their corresponding diols and bis-carbonylimidazolides monomers. By choice of feed ratio and monomer activation, either isosorbide or ketal protected DHA, random and alternating poly(Iso-co-DHA) carbonates have been formed. Thermal properties by DSC and TGA were herein strongly correlated to monomer composition. Dilution studies using 1H-NMR of a model compound DHA-diethyl carbonate in acetonitrile and deuterated water highlighted the influence of α-substituents on the keto/hydrate equilibrium of DHA. Further kinetics studies of in the pH* range of 4.7 to 9.6 serve to show the hydrolytic pH-profile of DHA-carbonates. The Hydrolytic degradation of deprotected polymer pellets show an increased degradation with increasing DHA content. Pellets with a random or alternating configuration show different characteristics in terms of mass loss and molecular weight loss profile over time.

  • 40.
    Ingverud, Tobias
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Wallenberg Wood Science Center.
    Erlandsson, Johan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Fibre Technology.
    Wågberg, Lars
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Fibre Technology.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    The combination of a dendritic polyampholyte and cellulose nanofibrils – a new type of functional materialManuscript (preprint) (Other academic)
  • 41.
    Ingverud, Tobias
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
    Larsson, Emma
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center BiMaC Innovation.
    Hemmer, Guillaume
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Rojas, Ramiro
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Carlmark, Anna
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center BiMaC Innovation.
    High water-content thermoresponsive hydrogels via electrostatic macrocrosslinking of cellulose nanofibrils2016In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 54, no 21, p. 3415-3424Article in journal (Refereed)
    Abstract [en]

    Atom transfer radical polymerization (ATRP) has been utilized to synthesize tri- and star-block copolymers of poly(di(ethylene glycol)methyl ether methacrylate) (PDEGMA) and quaternized poly(2-(dimethylamino)ethyl methacrylate) (qPDMAEMA). The block copolymers, all with a minimum of two cationically charged blocks, were sequentially used for electrostatic macrocrosslinking of a dilute dispersion of anionic TEMPO-oxidized cellulose nanofibrils (CNF, 0.3 wt%), forming free-standing hydrogels. The cationic block copolymers adsorbed irreversibly to the CNF, enabling the formation of ionically crosslinked hydrogels, with a storage modulus of up to 2.9 kPa. The ability of the block copolymers to adsorb to CNF was confirmed by quartz crystal microbalance with dissipation monitoring (QCM-D) and infrared spectroscopy (FT-IR), and the thermoresponsive properties of the hydrogels were investigated by rheological stress and frequency sweep, and gravimetric measurements. This method was shown to be promising for the facile production of thermoresponsive hydrogels based on CNF.

  • 42.
    Ingverud, Tobias
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Helux: A heterofunctional hyperbranched poly(amido amine) carboxylateManuscript (preprint) (Other academic)
  • 43.
    Ingverud, Tobias
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.
    Helux: A Heterofunctional Hyperbranched Poly(amido amine) Carboxylate2019In: ACS APPLIED POLYMER MATERIALS, ISSN 2637-6105, Vol. 1, no 7, p. 1845-1853Article in journal (Refereed)
    Abstract [en]

    Herein we present the first scientific report on the commercially available Helux 33/16 - a heterofunctional poly(amido amine carboxylate) hyperbranched polymer (Native Helux). The Native Helux, built from diethyl maleate (DEM) and diaminohexane (HMDA), was characterized, in part aided by reverse engineering of a similar scaffold with the same monomers. Different purification methods resulted in higher molecular weight polymers ranging from 8.4 to 51.7 kDa (M-w), and the Helux considered the purest, having 10 mmol (primary and secondary amines)/g as well as 2-4 mmol carboxylic/g Helux. Additionally, aqueous-mediated postmodifications of Helux were achieved including Michael addition, guanylation, and ring-opening of sultone, as well as water/ethyl acetate-mediated amidation of imidazole-activated pentenoic acid. The inherent heterofunctionality of Helux, amines and carboxylic groups, was further explored by a one-component self-cross-linking approach that yielded a dendritic poly(amido amine) network with autofluorescence-exhibiting properties and a T-g of 59 degrees C. The Helux network exhibited a storage modulus (G') of 7.9 MPa at 25 degrees C and in dry state, and 0.9 MPa (G') when plasticized by 50 wt % swelling (in water) of the network. Finally, dendritic hydrogels based on Helux were produced by a spontaneous NHS-amidation reaction with difunctional 10kPEG-NHS. The mechanical properties of the hydrogels were found to be dependent on the curing temperature for the hydrogel, yielding a G' of 8 and 14.5 kPa, a stress at break of 11.5 and 22.7 kPa, and a strain-at-break of 161 and 163%, at 25 and 37 degrees C, respectively.

  • 44.
    Jönsson, Christina
    et al.
    KTH, Superseded Departments, Chemistry.
    Hallman, Kristina
    KTH, Superseded Departments, Chemistry.
    Andersson, Helene
    KTH, Superseded Departments, Signals, Sensors and Systems.
    Stemme, Göran
    KTH, Superseded Departments, Signals, Sensors and Systems.
    Malkoch, Michael
    KTH, Superseded Departments, Polymer Technology.
    Malmström, Eva
    KTH, Superseded Departments, Polymer Technology.
    Hult, Anders
    KTH, Superseded Departments, Polymer Technology.
    Moberg, Christina
    KTH, Superseded Departments, Chemistry.
    Immobilized oxazoline-containing ligands in asymmetric catalysis - A review2002In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 12, no 14, p. 1857-1861Article, review/survey (Refereed)
    Abstract [en]

    Metal complexes of chiral oxazoline derivatives immobilized on soluble as well as insoluble supports serve as versatile asymmetric catalysts in a variety of applications. In a few cases recovery and reuse of the chiral ligands have been achieved.

  • 45. Kang, Taegon
    et al.
    Amir, Roey J.
    Khan, Anzar
    Ohshimizu, Kaoru
    Hunt, Jasmine N.
    Sivanandan, Kulandaivelu
    Montanez, Maria I.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Ueda, Mitsuru
    Hawker, Craig J.
    Facile access to internally functionalized dendrimers through efficient and orthogonal click reactions2010In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 46, no 9, p. 1556-1558Article in journal (Refereed)
    Abstract [en]

    A simple synthetic strategy has been developed for accessing internally functionalized dendrimers. The key feature of this approach is the use of two orthogonal and efficient reactions` epoxy-amine' and 'thiol-ene' coupling-for rapid growth of the dendritic scaffold. This sequence of reactions allows for the introduction of reactive hydroxyl groups at each dendritic layer.

  • 46. Khan, Anzar
    et al.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Montague, Martha F.
    Hawker, Craig J.
    Synthesis and characterization of hyperbranched polymers with increased chemical versatility for imprint lithographic resists2008In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 46, no 18, p. 6238-6254Article in journal (Refereed)
    Abstract [en]

    Hyperbranched polymers were prepared from a variety of mono- and difunctional monomers and used in the development of novel UV-imprint lithography (UV-IL) resists. The unique physical and chemical properties of these hyperbranched materials significantly increase the range of molecular systems that could be imprinted. Traditional challenges, such as the use of monomers that have low boiling points or the use of insoluble/highly crystalline momomers, are overcome by the preparation of hyperbranched polymers that incorporate these repeat units. In addition, the low viscosity of the hyperbranched macromolecules and the large number of reactive chain ends overcome many difficulties that are traditionally associated with the use of polymeric materials as imprint resists. Hyperbranched polymers containing up to 12 mol % pendant vinyl groups, needed for secondary crosslinking during imprinting, were prepared with a wide range of repeat unit structures and successfully imprinted with features from tens of microns to similar to 100 nm.

  • 47. Kikionis, Stefanos
    et al.
    Ioannou, Efstathia
    Andrén, Oliver C. J.
    Chronakis, Ioannis S.
    Fahmi, Amir
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Toskas, Georgios
    Roussis, Vassilios
    Nanofibrous nonwovens based on dendritic-linear-dendritic poly(ethylene glycol) hybrids2018In: Journal of Applied Polymer Science, ISSN 0021-8995, E-ISSN 1097-4628, Vol. 135, no 10, article id 45949Article in journal (Refereed)
    Abstract [en]

    Dendritic-linear-dendritic (DLD) hybrids are highly functional materials combining the properties of linear and dendritic polymers. Attempts to electrospin DLD polymers composed of hyperbranched dendritic blocks of 2,2-bis(hydroxymethyl) propionic acid on a linear poly(ethylene glycol) core proved unsuccessful. Nevertheless, when these DLD hybrids were blended with an array of different biodegradable polymers as entanglement enhancers, nanofibrous nonwovens were successfully prepared by electrospinning. The pseudogeneration degree of the DLDs, the nature of the co-electrospun polymer and the solvent systems used for the preparation of the electrospinning solutions exerted a significant effect on the diameter and morphology of the electrospun fibers. It is worth-noting that aqueous solutions of the DLD polymers and only 1% (w/v) poly(ethylene oxide) resulted in the production of smoother and thinner nanofibers. Such dendritic nanofibrous scaffolds can be promising materials for biomedical applications due to their bio-compatibility, biodegradability, multifunctionality, and advanced structural architecture.

  • 48.
    Larsson, Emma
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center BiMaC Innovation.
    Ingverud, Tobias
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
    Hemmer, Guillaume
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Rojas, Ramiro
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Carlmark, Anna
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center BiMaC Innovation. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
    Thermoresponsive hydrogels of cellulose nanofibrils and triblock copolymersManuscript (preprint) (Other academic)
    Abstract [en]

    Atom transfer radical polymerization (ATRP) has been utilized to synthesize triblock and star-block copolymers of quaternized poly(2-(dimethylamino)ethyl methacrylate) (qPDMAEMA) and poly(di(ethylene glycol) methyl ether methacrylate (PDEGMA). The block copolymers, that all contained a minimum of two charged blocks, were sequential adsorbed to negatively charged cellulose nanofibrils (CNF) in dilute water suspension, forming thermoresponsive hydrogels. The presence of more than one charge block allowed for the polymers to form permanent, physically crosslinked, gels when adsorbed to the CNF. The ability of the polymers to adsorb to CNF was confirmed by quartz crystal microbalance with dissipation monitoring (QCM-D), and the thermoresponsive properties of the gels were investigated by rheological measurements and gravimetric measurements. This method was shown to be promising for the facile, production of thermoresponsive hydrogels composed of CNF.

  • 49. Latorre-Sanchez, Alejandro
    et al.
    Johansson, Mats
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Zhang, Yuning
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Pomposo, Jose A.
    Active quinine-based films able to release antimicrobial compounds via melt quaternization at low temperature2018In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 6, no 1, p. 98-104Article in journal (Refereed)
    Abstract [en]

    The fabrication of antibacterial films based on renewable materials (e.g., chitosan) has attracted significant interest in fields such as food packaging, health care and medicine. However, exploiting the antibacterial properties of cinchona alkaloids to design active nanostructured films able to release quinine-based antimicrobial compounds has not been considered previously. Herein, we develop two different routes to produce active quinine-based nanostructured cross-linked films by exploiting the multiple reactive sites of quinine and, specifically, both the nitrogen atom and the vinyl group of the quinuclidine portion of the molecule, as well as their corresponding orthogonal quaternization and thiol-ene coupling reactions. The first synthetic strategy produces stiff and brittle nanostructured quinine-based films of limited utility for practical applications. Conversely, the second approach produces active, flexible and nanostructured quinine-based films (T-g = - 14 degrees C, Young's modulus = 1.3 GPa), which are able to release antimicrobial compounds against E. coli that, remarkably, are noncytotoxic against mouse macrophage and human dermal fibroblast cells. These kinds of active cinchona alkaloid-based coatings are easy to prepare by means of simple, solvent-free, melt quaternization/spreading procedures at a relatively low temperature (120 degrees C), making this second approach one of the most facile reported procedures to date to produce active nanostructured bio-based films.

  • 50. Lo Conte, Mauro
    et al.
    Robb, Maxwell J.
    Hed, Yvonne
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Marra, Alberto
    Malkoch, Michael
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
    Hawker, Craig J.
    Dondoni, Alessandro
    Exhaustive Glycosylation, PEGylation, and Glutathionylation of a [G4]-ene(48) Dendrimer via Photoinduced Thiol-ene Coupling2011In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 49, no 20, p. 4468-4475Article in journal (Refereed)
    Abstract [en]

    The use of free-radical thiol-ene coupling (TEC) for the introduction of carbohydrate, poly(ethylene glycol), and peptide fragments at the periphery of an alkene functional dendrimer has been reported in this article. Four different sugar thiols including glucose, mannose, lactose, and sialic acid, two PEGylated thiols, and the natural tripeptide glutathione were reacted with a fourth generation alkene functional dendrimer [G4]-ene(48) on irradiation at lambda(max) 365 nm. In all cases, the (1)H NMR spectra of the crude reaction mixture revealed the complete disappearance of alkene proton signals indicating the quantitative conversion of all 48 alkene groups of the dendrimer. With one exception only, all dendrimer conjugates were isolated in high yields (70-94%), validating the high efficiency of multiple TEC reactions on a single substrate. All isolated and purified compounds were analyzed by matrix assisted laser desorption ionization-time of flight (MALDI-TOF) spectrometry and gave spectra consistent with the assigned structure.

123 1 - 50 of 128
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf