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  • 1. He, Zehui
    et al.
    Lo Martire, Riccardo
    KTH, Skolan för teknikvetenskap (SCI), Farkost och flyg. Guangzhou University of Chinese Medicine Second Affiliated Hospital, China.
    Lu, Chuanjian
    Liu, Hongxia
    Ma, Lin
    Huang, Ying
    Li, Yongmei
    Sun, Liyun
    Bai, Yanping
    Liu, Wali
    Zha, Xushan
    Rasch Analysis of the Dermatology Life Quality Index Reveals Limited Application to Chinese Patients with Skin Disease2018Inngår i: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 98, nr 1, s. 59-64Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The objective of this study was to examine the psychometric properties of the Chinese version of the Dermatology Life Quality Index (DLQI) and to assess the invariance of its items with respect to several patient parameters via Rasch analysis. Data were aggregated from 9,845 patients with various skin diseases across 9 hospitals in different regions of China. The response structure, local independence, and reliability of the DLQI scale were analysed in a partial credit model, and differential item functioning (DIF) across region, disease, sex, and age were assessed with a Mantel-Haenszel procedure. Although acceptable scale reliability (Person Separation Index=2.3) was obtained, several problems were revealed, including disordered response thresholds, misfitting items, DIF by geographical region and disease, and mis-targeting patients with mild impairment regarding health-related quality of life (HRQL). In conclusion, the DLQI provides inadequate information on patients' impairments in HRQL, and the application of the DLQI in Chinese patients with skin disease is limited.

  • 2.
    Hedberg, Yolanda S.
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap. Karolinska Institutet, Sweden.
    Liden, Carola
    Lindberg, Magnus
    Chromium Dermatitis in a Metal Worker Due to Leather Gloves and Alkaline Coolant2016Inngår i: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 96, nr 1, s. 104-105Artikkel i tidsskrift (Fagfellevurdert)
  • 3.
    Hedberg, Yolanda S.
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi. Karolinska Institutet, Sweden .
    Liden, Carola
    Wallinder, Inger Odnevall
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Chromium released from leather - I: exposure conditions that govern the release of chromium(III) and chromium(VI)2015Inngår i: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 72, nr 4, s. 206-215Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background. Approximately 1-3% of the adult population in Europe is allergic to chromium (Cr). Anew restriction in REACH(Registration, Evaluation, Authorization and Restriction of Chemicals) based on the ISO 17075 standard has recently been adopted in the EU to limit Cr(VI) in consumer and occupational leather products. Objectives. The aim of this study was to critically assess key experimental parameters in this standard on the release of Cr(III) and Cr(VI) and their relevance for skin exposure. Material and methods. Four differently tanned, unfinished, leather samples were systematically investigated for their release of Cr(III) and Cr(VI) in relation to surface area, key exposure parameters, temperature, ultraviolet irradiation, and time. Results. Although the total release of Cr was largely unaffected by all investigated parameters, except exposure duration and temperature, the Cr oxidation state was highly dynamic, with reduced amounts of released Cr(VI) with time, owing to the simultaneous release of reducing agents from the leather. Significantly more Cr(III) than Cr(VI) was released from the Cr-tanned leather for all conditions tested, and it continued to be released in artificial sweat up to at least 1 week of exposure. Conclusions. Several parameters were identified that influenced the outcome of the ISO 17075 test.

  • 4.
    Hedberg, Yolanda
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.
    Uter, Wolfgang
    Univ Erlangen Nurnberg, Dept Med Informat Biometry & Epidemiol, Erlangen, Germany..
    Banerjee, Piu
    Guys Hosp, St Johns Inst Dermatol, London, England.;Lewisham & Greenwich NHS Trust, London, England..
    Lind, Marie-Louise
    Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden..
    Steengaard, Sanne Skovvang
    Univ Hosp Herlev Gentofte, Natl Allergy Res Ctr, Hellerup, Denmark..
    Teo, Ying
    Guys Hosp, St Johns Inst Dermatol, London, England..
    Liden, Carola
    Karolinska Inst, Inst Environm Med, Box 210, SE-17177 Stockholm, Sweden..
    Non-oxidative hair dye products on the European market: What do they contain?2018Inngår i: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 79, nr 5, s. 281-287Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Hair dyeing is very common and may cause allergic contact dermatitis. Oxidative (often termed permanent or semi-permanent) hair dye products have constituted the focus of market surveys and toxicological risk assessments, while non-oxidative (semi-permanent, temporary or direct) products have not been assessed. Objectives: To identify the hair dye substances presently used in non-oxidative hair dye products in Europe. Methods: Ingredient label data on eligible products in 5 European countries were collected, and 289 different non-oxidative hair dye products were included in this study. Results: Up to 9 hair dye substances were present in each product. Sixty-eight individual hair dye substances were identified on the 289 product labels, and their occurrence ranged from 0.3% to 34%. There were differences concerning substances used and their number per product between products of different consistency and colour. Conclusions: The hair dye substances in non-oxidative hair dye products are different from those in oxidative hair dye products, and are currently not covered by patch test series. The toxicological and skin-sensitizing profile of the substances in non-oxidative hair dye products, as well as their concentrations, should be further investigated.

  • 5. Julander, Anneli
    et al.
    Midander, Klara
    Herting, Gunilla
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Thyssen, Jacob P.
    White, Ian R.
    Odnevall Wallinder, Inger
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Liden, Carola
    New UK nickel-plated steel coins constitute an increased allergy and eczema risk2013Inngår i: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 68, nr 6, s. 323-330Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background. Nickel-plated steel coins have recently been introduced in the United Kingdom. Objectives. To compare the performance and allergy risk of the new nickel-plated coins (five and ten pence) with those of the cupro-nickel coins being replaced. Materials and methods. Coin handling studies with assessment of skin exposure and metal release in artificial sweat were performed. Six volunteers participated. Results. The amount of nickel deposited onto skin during the handling of nickel-plated coins for 1 hr was 7.5 mu g/cm(2), four times higher than that from cupro-nickel coins. The nickel content in the oxidized surface of nickel-plated coins was higher, explaining the higher skin dose. Initial nickel release rates were 10-27 times higher than 1-week rates, emphasizing that brief and repeated contact results in significant nickel exposure. Conclusions. Nickel-plated coins deposit higher levels of nickel onto skin than cupro-nickel coins, and hence pose an increased allergy risk. One-week release in artificial sweat is not suitable for determining the risk of handling items with high nickel release that come into short, repeated contact with the skin. The nickel skin dose is recommended for risk assessment. UK citizens are now, because of this change in coinage, unnecessarily exposed to higher levels of nickel on the skin. This is of public health concern.

  • 6. Malarstig, A.
    et al.
    Silveira, A.
    Wagsater, D.
    Ohrvik, J.
    Backlund, A.
    Samnegård, Ann
    Khademi, M.
    Hellenius, M. -L
    Leander, K.
    Olsson, T.
    Uhlén, Mathias
    KTH, Skolan för bioteknologi (BIO), Proteomik.
    de Faire, U.
    Eriksson, P.
    Hamsten, A.
    Plasma CD93 concentration is a potential novel biomarker for coronary artery disease2011Inngår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 270, nr 3, s. 229-236Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives. A common nonsynonymous single nucleotide polymorphism (SNP) in the CD93 gene (rs3746731, Pro541Ser) has been associated with risk of coronary artery disease (CAD). CD93 is a transmembrane glycoprotein, which is detectable in soluble form in human plasma. We investigated whether the concentration of soluble CD93 in plasma is related to risk of myocardial infarction (MI) and CAD, using a case-control study of premature MI (n = 764) and a nested case-control analysis of a longitudinal cohort study of 60-year-old subjects (analysis comprising 844 of 4232 subjects enrolled at baseline). In addition, SNPs in the CD93 gene were studied in relation to plasma CD93 concentration and CD93 mRNA expression. Methods and Results. A sensitive and specific enzyme-linked immunosorbent assay was established for determination of the plasma CD93 concentration. Subjects were divided into three groups according to tertiles of the distribution of CD93 concentration. Lower odds ratios for risk of MI and incidence of CAD were observed in the middle CD93 tertile (142-173 mu g L(-1)): odds ratio (95% confidence interval), 0.69 (0.49-0.97) and 0.61 (0.40-0.94), respectively. These associations were independent of traditional CAD risk factors. The minor allele of a SNP in the 3' untranslated region of CD93(rs2749812) was associated with increased plasma CD93 concentrations (P = 0.03) and increased CD93 mRNA expression levels (P = 0.02). Conclusion. The results of the present study suggest that the concentration of soluble CD93 in plasma is a potential novel biomarker for CAD, including MI.

  • 7.
    Mathiason, Frederik
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap.
    Liden, Carola
    Hedberg, Yolanda S.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap. Karolinska Institutet, Sweden .
    Chromium released from leather - II: the importance of environmental parameters2015Inngår i: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 72, nr 5, s. 275-285Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background. Approximately 1-3% of the adult population in Europe are allergic to chromium (Cr). A new restriction in Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) based on the ISO 17075 standard has recently been adopted in the EU to limit Cr(VI) in consumer and occupational leather products to < 3 mg/kg. Objectives. To investigate the influence of storage conditions [relative humidity, temperature, ultraviolet (UV) irradiation, and duration] on Cr release, and to assess several parameters relevant for occupational exposure (repeated exposure, wear, alkaline solutions, and sequential wet and dry exposures). Material and methods. A leather of relevance for work gloves was investigated for its release of Cr(III) and Cr(VI) under these different experimental conditions. Results. Relative humidity (water content in leather) during storage prior to Cr extraction was the single most important parameter. Cr(VI) levels could vary from non-detectable to levels significantly exceeding the restriction limit, depending on the relative humidity. Leather contact with alkaline solution and UV irradiation during storage could increase the Cr(VI) levels in subsequent extractions. Conclusions. The amount of Cr(VI) in leather is not an intrinsic property, but is influenced by environmental conditions of relevance for occupations and skin exposure.

  • 8.
    Ståhl, Patrik L.
    et al.
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för bioteknologi (BIO), Genteknologi.
    Stranneheim, Henrik
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för bioteknologi (BIO), Genteknologi.
    Asplund, Anna
    Berglund, Lisa
    KTH, Skolan för bioteknologi (BIO), Proteomik (stängd 20130101). KTH, Skolan för bioteknologi (BIO), Centra, Albanova VinnExcellence Center for Protein Technology, ProNova.
    Pontén, Fredrik
    Lundeberg, Joakim
    KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för bioteknologi (BIO), Genteknologi.
    Sun-Induced Nonsynonymous p53 Mutations Are Extensively Accumulated and Tolerated in Normal Appearing Human Skin2011Inngår i: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 131, nr 2, s. 504-508Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Here we demonstrate that intermittently sun-exposed human skin contains an extensive number of phenotypically intact cell compartments bearing missense and nonsense mutations in the p53 tumor suppressor gene. Deep sequencing of sun-exposed and shielded microdissected skin from mid-life individuals revealed that persistent p53 mutations had accumulated in 14% of all epidermal cells, with no apparent signs of a growth advantage of the affected cell compartments. Furthermore, 6% of the mutated epidermal cells encoded a truncated protein. The abundance of these events, not taking into account intron mutations and mutations in other genes that also may have functional implications, suggests an extensive tolerance of human cells to severe genetic alterations caused by UV light, with an estimated annual rate of accumulation of similar to 35,000 new persistent protein-altering p53 mutations in sun-exposed skin of a human individual.

  • 9. Tapia-Paez, I.
    et al.
    Asad, S.
    Taylan, F.
    Spalinskas, Rapolas
    KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Anandashankar, A.
    Nordenskjold, M.
    Wahlgren, C. F.
    Sahlén, Pelin
    KTH, Centra, Science for Life Laboratory, SciLifeLab.
    Bradley, M.
    Studies of keratinocyte-specific regulatory interactions by three-dimensional mapping with a focus on atopic dermatitis2018Inngår i: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 179, nr 1, s. E33-E33Artikkel i tidsskrift (Fagfellevurdert)
  • 10. Valentin, A.
    et al.
    Humphrey, J. D.
    Holzapfel, Gerhard A.
    KTH, Skolan för teknikvetenskap (SCI), Hållfasthetslära (Inst.).
    A Multi-Layered Computational Model of Coupled Elastin Degradation, Vasoactive Dysfunction, and Collagenous Stiffening in Aortic Aging2011Inngår i: Annals of Biomedical Engineering, ISSN 0090-6964, E-ISSN 1573-9686, Vol. 39, nr 7, s. 2027-2045Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Arterial responses to diverse pathologies and insults likely occur via similar mechanisms. For example, many studies suggest that the natural process of aging and isolated systolic hypertension share many characteristics in arteries, including loss of functional elastin, decreased smooth muscle tone, and altered rates of deposition, and/or crosslinking of fibrillar collagen. Our aim is to show computationally how these coupled effects can impact evolving aortic geometry and mechanical behavior. Employing a thick-walled, multi-layered constrained mixture model, we suggest that a coupled loss of elastin and vasoactive function are fundamental mechanisms by which aortic aging occurs. Moreover, it is suggested that collagenous stiffening, although itself generally an undesirable process, can play a key role in attenuating excessive dilatation, perhaps including the enlargement of abdominal aortic aneurysms.

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