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  • 1.
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Aspects of Electrical Bioimpedance Spectrum Estimation2014Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Electrical bioimpedance spectroscopy (EBIS) has been used to assess the status or composition of various types of tissue, and examples of EBIS include body composition analysis (BCA) and tissue characterisation for skin cancer detection. EBIS is a non-invasive method that has the potential to provide a large amount of information for diagnosis or monitoring purposes, such as the monitoring of pulmonary oedema, i.e., fluid accumulation in the lungs. However, in many cases, systems based on EBIS have not become generally accepted in clinical practice. Possible reasons behind the low acceptance of EBIS could involve inaccurate models; artefacts, such as those from movements; measurement errors; and estimation errors. Previous thoracic EBIS measurements aimed at pulmonary oedema have shown some uncertainties in their results, making it difficult to produce trustworthy monitoring methods. The current research hypothesis was that these uncertainties mostly originate from estimation errors. In particular, time-varying behaviours of the thorax, e.g., respiratory and cardiac activity, can cause estimation errors, which make it tricky to detect the slowly varying behaviour of this system, i.e., pulmonary oedema.

    The aim of this thesis is to investigate potential sources of estimation error in transthoracic impedance spectroscopy (TIS) for pulmonary oedema detection and to propose methods to prevent or compensate for these errors.   This work is mainly focused on two aspects of impedance spectrum estimation: first, the problems associated with the delay between estimations of spectrum samples in the frequency-sweep technique and second, the influence of undersampling (a result of impedance estimation times) when estimating an EBIS spectrum. The delay between frequency sweeps can produce huge errors when analysing EBIS spectra, but its effect decreases with averaging or low-pass filtering, which is a common and simple method for monitoring the time-invariant behaviour of a system. The results show the importance of the undersampling effect as the main estimation error that can cause uncertainty in TIS measurements.  The best time for dealing with this error is during the design process, when the system can be designed to avoid this error or with the possibility to compensate for the error during analysis. A case study of monitoring pulmonary oedema is used to assess the effect of these two estimation errors. However, the results can be generalised to any case for identifying the slowly varying behaviour of physiological systems that also display higher frequency variations.  Finally, some suggestions for designing an EBIS measurement system and analysis methods to avoid or compensate for these estimation errors are discussed.

  • 2.
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Towards Heart Rate Variability Tools in P-Health: Pervasive, Preventive, Predictive and Personalized2016Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [sv]

    Hjärtfrekvensvariabilitet (HRV) har senaste tiden rönt en hel del uppmärksamhet och flera teknikerför analys av HRV i tids- resp. frekvensområdet samt medels icke-linjära metoder har utvecklats.Det har visats att HRV kan användas för att övervaka det autonoma nervsystemet (ANS) blandannat för att upptäcka särskilt vagala störningar inom ANS. Minskad HRV förknippas med flerasjukdomar såsom diabetes, reumatoid artrit, depression, kronisk hjärtsjukdom och har ävenföreslagits som prediktor för dålig prognos och plötslig hjärtdöd. HRV är dock ännu inte allmäntaccepterat som ett kliniskt verktyg utan används främst inom forskning. Framsteg inomneuroimmunitetsområdet med ökad förståelse för sambandet mellan nerv- och immunsystem, haröppnat en nytt potentiell område för HRV-applikationer. Ett exempel är när systemiskinflammationoch autoimmun sjukdom primärt orsakas av låg vagal aktivitet, vilket kan upptäckas ochprognostiseras via minskad HRV. Denna avhandling är resultatet av flera tekniska utvecklingsstegoch explorativ forskning där HRV tillämpas i syfte att utveckla ett prognostiskt diagnostiskt verktygmed förebyggande potential. Huvudsyften har varit: 1) att utveckla ett prisvärt verktyg för eneffektiv och enkel analys av HRV 2) att studera sambandet mellan HRV och pro-inflammatoriskamarkörer och därigenom potentiellt återspegla graden av aktivitet i den kolinergaantiinflammatoriska effektorvägen 3) att utveckla datorprogramvara för ett biologisktåterkopplingssystem där individen med egen träning ökar sin vagala aktivitet vilket sedanåterspeglas i en ökad HRV. I denna sammanläggningsavhandling finns utförlig beskrivning av varjeingående studies metod och resultat artikar I-VI. I ramberättelsen presenteras en kortsammanfattning av metoder och resultat, grupperade efter ämne och sammanhang.Sammanfattningsvis visar resultaten att de utvecklade verktygen adekvat registrerar och analyserarHRV korrekt enkelt , samt att HRV kan påverkas av spel-träning. HRV i framtaget koncept harpotential att användas som ett skarpt prognostiskt verktyg, inte bara för traditionell vård med fokuspå sjukdom, utan också inom friskvård. Framtagna verktyg möjliggör tidig upptäckt av minskadHRV, snabb intervention och prevention. Spelifiering med seriöst spelande utgör en potentiellplattform som motiverar en träningsrutin och som genom återkoppling kan öka HRV och därmedvälmåendet.

  • 3.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Berndtsson, Andreas
    Abtahi, Shirin
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Development and preliminary evaluation of an Android based heart rate variability biofeedback system2014Ingår i: Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE, IEEE conference proceedings, 2014, s. 3382-3385Konferensbidrag (Refereegranskat)
    Abstract [en]

    The reduced Heart Rate Variability (HRV) is believed to be associated with several diseases such as congestive heart failure, diabetes and chronic kidney diseases (CKD). In these cases, HRV biofeedback may be a potential intervention method to increase HRV which in turn is beneficial to these patients. In this work, a real-time Android biofeedback application based on a Bluetooth enabled ECG and thoracic electrical bioimpedance (respiration) measurement device has been developed. The system performance and usability have been evaluated in a brief study with eight healthy volunteers. The result demonstrates real-time performance of system and positive effects of biofeedback training session by increased HRV and reduced heart rate. Further development of the application and training protocol is ongoing to investigate duration of training session to find an optimum length and interval of biofeedback sessions to use in potential interventions.

  • 4.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Karolinska Institutet, Sweden.
    Hilderman, Marie
    Bruchfeld, Annette
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Borås, Sweden.
    Janerot-Sjöberg, Birgitta
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinsk bildteknik. Karolinska Institutet, Sweden.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Karolinska Institutet, Sweden.
    Pro-inflammatory Blood Markers and Heart Rate Variability in Apnoea as a Reflection of Basal Vagal ToneManuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Pro-inflammatory cytokines play a crucial role in inflammatory response, which istightly regulated by the nervous system to avoid the damage caused by inflammation. There isevidence for a cholinergic anti-inflammatory pathway that includes afferent and efferent vagalnerves that sense the inflammation and stimulate the anti-inflammatory response. Non-functionalanti-inflammatory response might lead to excessive and chronic inflammation e.g., rheumatoidarthritis (RA), inflammatory bowel disease (IBD), and poor outcome. Heart rate variability(HRV) has been proposed as a potential tool to monitor the level of anti-inflammatory activitythrough the monitoring of vagal activity. In this paper, the association of pro-inflammatorymarkers with HRV indices is evaluated. We used a database called “Heart Biomarker Evaluationin Apnea Treatment (HeartBEAT)” that consists of 6±2 hours of Electrocardiogram (ECG)recordings during nocturnal sleep from 318 patients at baseline and 301of them at 3 monthsfollow-up. HRV indices are calculated from ECG recordings of 5-360 minutes. The results showa statistically significant correlation between heart rate (HR) and pro-inflammatory cytokines,independent of duration of ECG analysis. HRV indices e.g., standard deviation of all RRintervals (SDNN) show an inverse relation to the pro-inflammatory cytokines. Longer ECGrecordings show a higher potential to reflect the level of anti-inflammatory response. In light oftheories for the cholinergic anti-inflammatory pathway, a combination of HR and HRV as areflection of basal vagal activity might be a potential prognostic tool for interventional guidance.

  • 5.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Ji, Guangchao
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lu, Ke
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Rodby, Kristian
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    A knitted garment using intarsia technique for Heart Rate Variability biofeedback: Evaluation of initial prototype2015Ingår i: Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, IEEE , 2015, Vol. 2015, s. 3121-3124Konferensbidrag (Refereegranskat)
    Abstract [en]

    Heart rate variability (HRV) biofeedback is a method based on paced breathing at specific rate called resonance frequency by giving online feedbacks from user respiration and its effect on HRV. Since the HRV is also influence by different factors like stress and emotions, stress related to an unfamiliar measurement device, cables and skin electrodes may cover the underling effect of such kind of intervention. Wearable systems are usually considered as intuitive solutions which are more familiar to the end-user and can help to improve usability and hence reducing the stress. In this work, a prototype of a knitted garment using intarsia technique is developed and evaluated. Results show the satisfactory level of quality for Electrocardiogram and thoracic electrical bioimpedance i.e. for respiration monitoring as a part of HRV biofeedback system. Using intarsia technique and conductive yarn for making the connection instead of cables will reduce the complexity of fabrication in textile production and hence reduce the final costs in a final commercial product. Further development of garment and Android application is ongoing and usability and efficiency of final prototype will be evaluated in detail.

  • 6.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Ji, Guangchao
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lu, Ke
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Rödby, Kristian
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Björlin, Anders
    Kiwok AB.
    Östlund, Anders
    Kiwok AB.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Högskolan i Borås, Akademin för vård, arbetsliv och välfärd.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Textile-Electronic Integration in Wearable Measurement Garments for Pervasive Healthcare Monitoring2015Konferensbidrag (Övrigt vetenskapligt)
  • 7.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Aslamy, Benjamin
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Boujabir, Imaneh
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    An Affordable ECG and Respiration Monitoring System Based on Raspberry PI and ADAS1000: First Step towards Homecare Applications2015Ingår i: 16th Nordic-Baltic Conference on Biomedical Engineering: 16. NBC & 10. MTD 2014 joint conferences. October 14-16, 2014, Gothenburg, Sweden, Springer, 2015, s. 5-8Konferensbidrag (Refereegranskat)
    Abstract [en]

    Homecare is a potential solution for problems associated with an aging population. This may involve several physiological measurements, and hence a flexible but affordable measurement device is needed. In this work, we have designed an ADAS1000-based four-lead electrocardiogram (ECG) and respiration monitoring system. It has been implemented using Raspberry PI as a platform for homecare applications. ADuM chips based on iCoupler technology have been used to achieve electrical isolation as required by IEC 60601 and IEC 60950 for patient safety. The result proved the potential of Raspberry PI for the design of a compact, affordable, and medically safe measurement device. Further work involves developing a more flexible software for collecting measurements from different devices (measuring, e.g., blood pressure, weight, impedance spectroscopy, blood glucose) through Bluetooth or user input and integrating them into a cloud-based homecare system.

  • 8.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lu, Ke
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Dizon, M
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Johansson, M
    KTH-School of Technology and Health.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Högskolan i Borås.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Data- och elektroteknik. Högskolan i Borås, Akademin för vård, arbetsliv och välfärd.
    Evaluating Atrial Fibrillation Detection Algorithm based on Heart Rate Variability analysis2015Ingår i: Medicinteknikdagarna, Uppsala: Svensk förening för medicinsk teknik och fysik , 2015Konferensbidrag (Refereegranskat)
  • 9.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lu, Ke
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Dizon, M
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Johansson, M
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Högskolan i Borås, Akademin för vård, arbetsliv och välfärd.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Evaluation of Atrial Fibrillation Detection by using Heart Rate Variability analysis2015Konferensbidrag (Övrigt vetenskapligt)
  • 10.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lu, Ke
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Guangchao, Li
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Rödby, Kristian
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Högskolan i Borås.
    A Knitted Garment using Intarsia Technique for Heart Rate Variability Biofeedback: Evaluation of Initial Prototype.2015Konferensbidrag (Övrigt vetenskapligt)
  • 11.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Electrical bioimpedance spectroscopy in time-variant systems: Is undersampling always a problem?2014Ingår i: Journal of Electrical Bioimpedance, ISSN 1891-5469, Vol. 5, nr 1, s. 28-33Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    During the last decades, Electrical Bioimpedance Spectroscopy (EBIS) has been applied mainly by using the frequency-sweep technique, across a range of many different applications. Traditionally, the tissue under study is considered to be time-invariant and dynamic changes of tissue activity are ignored by treating the changes as a noise source. A new trend in EBIS is simultaneous electrical stimulation with several frequencies, through the application of a multi-sine, rectangular or other waveform. This method can provide measurements fast enough to sample dynamic changes of different tissues, such as cardiac muscle. This high sampling rate comes at a price of reduction in SNR and the increase in complexity of devices. Although the frequency-sweep technique is often inadequate for monitoring the dynamic changes in a variant system, it can be used successfully in applications focused on the time-invariant or slowly-variant part of a system. However, in order to successfully use frequency-sweep EBIS for monitoring time-variant systems, it is paramount to consider the effects of aliasing and especially the folding of higher frequencies, on the desired frequency e.g. DC level. This paper discusses sub-Nyquist sampling of thoracic EBIS measurements and its application in the case of monitoring pulmonary oedema. It is concluded that by considering aliasing, and with proper implementation of smoothing filters, as well as by using random sampling, frequency-sweep EBIS can be used for assessing time-invariant or slowly-variant properties of time-variant biological systems, even in the presence of aliasing. In general, undersampling is not always a problem, but does always require proper consideration.

  • 12.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Löfgren, Nils
    Elimination of ECG Artefacts in Foetal EEG Using Ensemble Average Subtraction and Wavelet Denoising Methods: A Simulation2014Ingår i: XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013, Springer, 2014, s. 551-554Konferensbidrag (Refereegranskat)
    Abstract [en]

    Biological signals recorded from surface electrodes contain interference from other signals which are not desired and should be considered as noise. Heart activity is especially present in EEG and EMG recordings as a noise. In this work, two ECG elimination methods are implemented; ensemble average subtraction (EAS) and wavelet denoising methods. Comparison of these methods has been done by use of simulated signals achieved by adding ECG to neonates EEG. The result shows successful elimination of ECG artifacts by using both methods. In general EAS method which remove estimate of all ECG components from signal is more trustable but it is also harder for implementation due to sensitivity to noise. It is also concluded that EAS behaves like a high-pass filter while wavelet denoising method acts as low-pass filter and hence the choice of one method depends on application.

  • 13.
    Abtahi, Farhad
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Snäll, Jonatan
    KTH, Skolan för teknik och hälsa (STH).
    Aslamy, Benjamin
    KTH, Skolan för teknik och hälsa (STH).
    Abtahi, Shirin
    KTH, Skolan för teknik och hälsa (STH).
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Boras, Sweden.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Karolinska Institute, Sweden.
    Biosignal PI, an Affordable Open-Source ECG and Respiration Measurement System2014Ingår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 15, nr 1, s. 93-109Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Bioimedical pilot projects e.g., telemedicine, homecare, animal and human trials usually involve several physiological measurements. Technical development of these projects is time consuming and in particular costly. A versatile but affordable biosignal measurement platform can help to reduce time and risk while keeping the focus on the important goal and making an efficient use of resources. In this work, an affordable and open source platform for development of physiological signals is proposed. As a first step an 8–12 leads electrocardiogram (ECG) and respiration monitoring system is developed. Chips based on iCoupler technology have been used to achieve electrical isolation as required by IEC 60601 for patient safety. The result shows the potential of this platform as a base for prototyping compact, affordable, and medically safe measurement systems. Further work involves both hardware and software development to develop modules. These modules may require development of front-ends for other biosignals or just collect data wirelessly from different devices e.g., blood pressure, weight, bioimpedance spectrum, blood glucose, e.g., through Bluetooth. All design and development documents, files and source codes will be available for non-commercial use through project website, BiosignalPI.org.

  • 14.
    Atefi, Seyed Reza
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Electrical Bioimpedance Cerebral Monitoring: From Hypothesis and Simulation to First Experimental Evidence in Stroke Patients2015Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Stroke is amongthe leading causes of death worldwide and requires immediate care to prevent death or permanent disability. Unfortunately, the current stateof stroke diagnosis is limited to fixed neuroimaging facilities that do not allow rapid stroke diagnosis. Hence, a portable stroke-diagnosis device could assist in the pre-hospital triage of patients. Moreover, such a portable device could also be useful for bedside stroke monitoring of patients in the Neuro Intensive Care Unit (Neuro-ICU) to avoid unnecessary neuroimaging. Recent animal studies and numerical simulations have supported the idea of implementing Electrical Bioimpedance (EBI) in a portable device, allowing non-invasive assessment as a useful tool for the pre-hospital triage of stroke and Traumatic Brain Injury (TBI) patients. Unfortunately, these studies have not reported any results from human subjects in the acute phase of the stroke. The numerical simulations are also based on simple models that sometimes lack necessary details.

    Finite Element Method (FEM) simulations on a realistic numerical head model as well as experimental Bioimpedance Spectroscopy (BIS) measurements from human subjectsin the acute, subacute and chronic phasesof stroke were used to answer the following research questions: (i) Does stroke modify the electrical properties of brain tissue in a way that is detectable via EBI? (ii) Would it be possible to detect stroke via EBI as early as in the acute and sub-acute phase?(iii) Is EBI sensitive enough to monitor changes caused by stroke pathogenesis?

    Using FEM to simulate electrical current injection on the head and study the resulting distribution of electrical potential on the scalp, it was shown that Intra-Cranial Hemorrhage (ICH) affects the quasi-symmetric scalp potential distribution,creating larger left-right potential asymmetry when compared to the healthy head model. Proof-of-concept FEM simulations were also tested in a small cohort of 6ICH patients and 10 healthy controls, showing that the left-right potential difference in the patients is significantly (p<0.05) larger than in the controls. Using bioimpedance measurements in the acute,  subacute and chronic phasesof stroke and examining simple features, it was also shown that the head EBI measurements of patients suffering stroke are different from controls, enabling the discrimination of healthy controls and stroke patients at any stage of the stroke. The absolute change in test-retest resistance measurements of the control group (~5.33%) was also found to be significantly (p<0.05) smaller than the EBI measurements of patients obtained 24 hours and 72 hours after stroke onset (20.44%). These results suggested that scalp EBI is sensitive to stroke pathogenesis changesand thususeful for bedside monitoring in the Neuro-ICU. These results suggested that EBI is a potentially useful tool for stroke diagnosis and monitoring.

    Finally, the initial observations based on a small number of patients, addressing the proposed future work of this thesis, suggested that the average head resistance amplitude of hemorrhagic stroke patients is smaller than in healthy controls, while ischemic stroke patients show a larger resistance amplitude than the controls. Scalp potential asymmetry analysis of healthy, hemorrhagic and ischemic stroke subjects also suggests that these three groups can be separated. However, these results are based on a small number of patients and need to be validated using a larger cohort. Initial observations also showed that the resistance of the EBI measurements of controls is robust between test and retest measurements, showing no significant difference (less than 2% and p>0.05). Subject position during EBI recording (supine or sitting) did not seem to affect the resistance of the EBI measurements (p>0.05). However, age, sex and head size showed significant effects on the resistance measurements. These initial observations are encouraging for further research on EBI for cerebral monitoring and stroke diagnosis. However, at this stage, considering the uncertainties in stroke type differentiation, EBI cannot replace CT but has the potential to be used as a consultation tool.

  • 15.
    Atefi, Seyed Reza
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Kamalian, Shervin
    Rosenthal, Eric
    Lev, Michael
    Bonmassar, Giorgio
    Intracranial haemorrhage alters scalp potential distributions in bioimpedance cerebral monitoring applications: preliminary results from FEM simulation on a realistic head model and human subjects2016Ingår i: Medical Physics, ISSN 2473-4209, Vol. 43, nr 2, s. 675-686Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: Current diagnostic neuroimaging for detection of intracranial hemorrhage (ICH) is limited to fixed scanners requiring patient transport and extensive infrastructure support. ICH diagnosis would therefore benefit from a portable diagnostic technology, such as electrical bioimpedance (EBI). Through simulations and patient observation, the authors assessed the influence of unilateral ICH hematomas on quasisymmetric scalp potential distributions in order to establish the feasibility of EBI technology as a potential tool for early diagnosis. Methods: Finite element method (FEM) simulations and experimental leftright hemispheric scalp potential differences of healthy and damaged brains were compared with respect to the asymmetry caused by ICH lesions on quasisymmetric scalp potential distributions. In numerical simulations, this asymmetry was measured at 25 kHz and visualized on the scalp as the normalized potential difference between the healthy and ICH damaged models. Proof-of-concept simulations were extended in a pilot study of experimental scalp potential measurements recorded between 0 and 50 kHz with the authors custom-made bioimpedance spectrometer. Mean leftright scalp potential differences recorded from the frontal, central, and parietal brain regions of ten healthy control and six patients suffering from acute/subacute ICH were compared. The observed differences were measured at the 5% level of significance using the two-sample Welch ttest. Results: The 3D-anatomically accurate FEM simulations showed that the normalized scalp potential difference between the damaged and healthy brain models is zero everywhere on the head surface, except in the vicinity of the lesion, where it can vary up to 5%. The authors preliminary experimental results also confirmed that the leftright scalp potential difference in patients with ICH (e.g., 64 mV) is significantly larger than in healthy subjects (e.g., 20.8 mV; P < 0.05). Conclusions: Realistic, proof-of-concept simulations confirmed that ICH affects quasisymmetric scalp potential distributions. Pilot clinical observations with the authors custom-made bioimpedance spectrometer also showed higher leftright potential differences in the presence of ICH, similar to those of their simulations, that may help to distinguish healthy subjects from ICH patients. Although these pilot clinical observations are in agreement with the computer simulations, the small sample size of this study lacks statistical power to exclude the influence of other possible confounders such as age, ex, and electrode positioning. The agreement with previously published simulation-based and clinical results, however, suggests that EBI technology may be potentially useful for ICH detection. © 2016 American Association of Physicists in Medicine.

  • 16.
    Atefi, Seyed Reza
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Study of the dynamics of transcephalic cerebral impedance data during cardio-vascular surgery2013Ingår i: XV International Conference on Electrical Bio-Impedance (ICEBI) & XIV Conference on Electrical Impedance Tomography (EIT), Institute of Physics (IOP), 2013, Vol. 434, nr 1, s. 012045-Konferensbidrag (Refereegranskat)
    Abstract [en]

    Postoperative neurological deficits are one of the risks associated with cardio vascular surgery, necessitating development of new techniques for cerebral monitoring. In this study an experimental observation regarding the dynamics of transcephalic Electrical Bioimpedance (EBI) in patients undergoing cardiac surgery with and without extracorporeal circulation (ECC) was conducted to investigate the potential use of electrical Bioimpedance for cerebral monitoring in cardio vascular surgery. Tetrapolar transcephalic EBI measurements at single frequency of 50 kHz were recorded prior to and during cardio vascular surgery. The obtained results show that the transcephalic impedance decreases in both groups of patients as operation starts, however slight differences in these two groups were also observed with the cerebral impedance reduction in patients having no ECC being less common and not as pronounced as in the ECC group. Changes in the cerebral impedance were in agreement with changes of haematocrit and temperature. The origin of EBI changes is still unexplained however these results encourage us to continue investigating the application of electrical bioimpedance cerebral monitoring clinically.

  • 17.
    Atefi, Seyed Reza
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Thorlin, Thorleif
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Stroke Damage Detection Using Classification Trees on Electrical Bioimpedance Cerebral Spectroscopy Measurements2013Ingår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 13, nr 8, s. 10074-10086Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    After cancer and cardio-vascular disease, stroke is the third greatest cause of death worldwide. Given the limitations of the current imaging technologies used for stroke diagnosis, the need for portable non-invasive and less expensive diagnostic tools is crucial. Previous studies have suggested that electrical bioimpedance (EBI) measurements from the head might contain useful clinical information related to changes produced in the cerebral tissue after the onset of stroke. In this study, we recorded 720 EBI Spectroscopy (EBIS) measurements from two different head regions of 18 hemispheres of nine subjects. Three of these subjects had suffered a unilateral haemorrhagic stroke. A number of features based on structural and intrinsic frequency-dependent properties of the cerebral tissue were extracted. These features were then fed into a classification tree. The results show that a full classification of damaged and undamaged cerebral tissue was achieved after three hierarchical classification steps. Lastly, the performance of the classification tree was assessed using Leave-One-Out Cross Validation (LOO-CV). Despite the fact that the results of this study are limited to a small database, and the observations obtained must be verified further with a larger cohort of patients, these findings confirm that EBI measurements contain useful information for assessing on the health of brain tissue after stroke and supports the hypothesis that classification features based on Cole parameters, spectral information and the geometry of EBIS measurements are useful to differentiate between healthy and stroke damaged brain tissue.

  • 18.
    Atefi, Seyed Reza
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Tomner, Jens
    Kostulas, Konstantinos
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Bonmassar, Giorgio
    Stroke Pathogenesis Alters Dielectric Properties of Brain Tissue Supporting Electrical Bioimpedance Technology as a tool for Cerebral MonitoringManuskript (preprint) (Övrigt vetenskapligt)
  • 19. Ayllnon, David
    et al.
    Gil-Pita, Roberto
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Detection and Classification of Measurement Errors in Bioimpedance Spectroscopy2016Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, nr 6, artikel-id e0156522Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Bioimpedance spectroscopy (BIS) measurement errors may be caused by parasitic stray capacitance, impedance mismatch, cross-talking or their very likely combination. An accurate detection and identification is of extreme importance for further analysis because in some cases and for some applications, certain measurement artifacts can be corrected, minimized or even avoided. In this paper we present a robust method to detect the presence of measurement artifacts and identify what kind of measurement error is present in BIS measurements. The method is based on supervised machine learning and uses a novel set of generalist features for measurement characterization in different immittance planes. Experimental validation has been carried out using a database of complex spectra BIS measurements obtained from different BIS applications and containing six different types of errors, as well as error-free measurements. The method obtained a low classification error (0.33%) and has shown good generalization. Since both the features and the classification schema are relatively simple, the implementation of this pre-processing task in the current hardware of bioimpedance spectrometers is possible.

  • 20.
    Buendia, Rubén
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Bosaeus, I.
    Gil-Pita, R.
    Johannsson, G.
    Ellegård, L.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Robustness study of the different immittance spectra and frequency ranges in bioimpedance spectroscopy analysis for assessment of total body composition2014Ingår i: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 35, nr 7, s. 1373-1395Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The estimation of body fluids is a useful and common practice for assessment of disease status and therapy outcomes. Electrical bioimpedance spectroscopy (EBIS) methods are noninvasive, inexpensive and efficient alternatives for determination of body fluids. One of the main source of errors in EBIS measurements in the estimation of body fluids is capacitive coupling. In this paper an analysis of capacitive coupling in EBIS measurements was performed and the robustness of the different immittance spectra against it tested. On simulations the conductance (G) spectrum presented the smallest overall error, among all immittance spectra, in the estimation of the impedance parameters used to estimate body fluids. Afterwards the frequency range of 10-500 kHz showed to be the most robust band of the G spectrum. The accuracy of body fluid estimations from the resulting parameters that utilized G spectrum and parameters provided by the measuring device were tested on EBIS clinical measurements from growth hormone replacement therapy patients against estimations performed with dilution methods. Regarding extracellular fluid, the correlation between each EBIS method and dilution was 0.93 with limits of agreement of 1.06 +/- 2.95 l for the device, 1.10 +/- 2.94 l for G [10-500 kHz] and 1.04 +/- 2.94 l for G [5-1000 kHz]. Regarding intracellular fluid, the correlation between dilution and the device was 0.91, same as for G [10-500 kHz] and 0.92 for G [5- 1000 kHz]. Limits of agreement were 0.12 +/- 4.46 l for the device, 0.09 +/- 4.45 for G [10- 500 kHz] and 0.04 +/- 4.58 for G [5-1000 kHz]. Such close results between the EBIS methods validate the proposed approach of using G spectrum for initial Cole characterization and posterior clinical estimation of body fluids status.

  • 21.
    Cuba-Gyllensten, Illapha
    et al.
    KTH, Skolan för teknik och hälsa (STH). Philips Research Europe, High Tech. Campus 34, 5656AE, Eindhoven, Netherlands; ACTLab., Signal Processing Systems, TU Eindhoven, 5600MB Eindhoven, Netherlands.
    Abtahi, Farhad
    Philips Research Europe, High Tech. Campus 34, 5656AE, Eindhoven, Netherlands.
    Bonomi, Alberto G.
    KTH, Skolan för teknik och hälsa (STH).
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Borås, Sweden.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Karolinska Institute, Sweden.
    Amft, O.
    ACTLab., Signal Processing Systems, TU Eindhoven, 5600MB Eindhoven, Netherlands.
    Removing respiratory artefacts from transthoracic bioimpedance spectroscopy measurements2013Ingår i: XV International Conference on Electrical Bio-Impedance (ICEBI) & XIV Conference on Electrical Impedance Tomography (EIT), Institute of Physics Publishing (IOPP), 2013, Vol. 434, nr 1Konferensbidrag (Refereegranskat)
    Abstract [en]

    Transthoracic impedance spectroscopy (TIS) measurements from wearable textile electrodes provide a tool to remotely and non-invasively monitor patient health. However, breathing and cardiac processes inevitably affect TIS measurements, since they are sensitive to changes in geometry and air or fluid volumes in the thorax. This study aimed at investigating the effect of respiration on Cole parameters extracted from TIS measurements and developing a method to suppress artifacts. TIS data were collected from 10 participants at 16 frequencies (range: 10 kHz - 1 MHz) using a textile electrode system (Philips Technologie Gmbh). Simultaneously, breathing volumes and frequency were logged using an electronic spirometer augmented with data from a breathing belt. The effect of respiration on TIS measurements was studied at paced (10 and 16 bpm) deep and shallow breathing. These measurements were repeated for each subject in three different postures (lying down, reclining and sitting). Cole parameter estimation was improved by assessing the tidal expiration point thus removing breathing artifacts. This leads to lower intra-subject variability between sessions and a need for less measurements points to accurately assess the spectra. Future work should explore algorithmic artifacts compensation models using breathing and posture or patient contextual information to improve ambulatory transthoracic impedance measurements.

  • 22. Cunico, F. J.
    et al.
    Marquez, Juan Carlos
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Hilke, H.
    Skrifvars, M.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Studying the performance of conductive polymer films as textile electrodes for electrical bioimpedance measurements2013Ingår i: XV International Conference on Electrical Bio-Impedance (ICEBI) & XIV Conference on Electrical Impedance Tomography (EIT), 2013, Vol. 434, nr 1, s. 012027-Konferensbidrag (Refereegranskat)
    Abstract [en]

    With the goal of finding novel biocompatible materials suitable to replace silver in the manufacturing of textile electrodes for medical applications of electrical bioimpedance spectroscopy, three different polymeric materials have been investigated. Films have been prepared from different polymeric materials and custom bracelets have been confectioned with them. Tetrapolar total right side electrical bioimpedance spectroscopy (EBIS) measurements have been performed with polymer and with standard gel electrodes. The performance of the polymer films was compared against the performance of the gel electrodes. The results indicated that only the polypropylene 1380 could produce EBIS measurements but remarkably tainted with high frequency artefacts. The influence of the electrode mismatch, stray capacitances and large electrode polarization impedance are unclear and they need to be clarified with further studies. If sensorized garments could be made with such biocompatible polymeric materials the burden of considering textrodes class III devices could be avoided.

  • 23. Ferreira, J.
    et al.
    Seoane, Fernando
    School of Engineering, University of Borås, Borås 501 90, Sweden .
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Portable bioimpedance monitor evaluation for continuous impedance measurements: Towards wearable plethysmography applications2013Ingår i: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2013, s. 559-562Konferensbidrag (Refereegranskat)
    Abstract [en]

    Personalised Health Systems (PHS) that could benefit the life quality of the patients as well as decreasing the health care costs for society among other factors are arisen. The purpose of this paper is to study the capabilities of the System-on-Chip Impedance Network Analyser AD5933 performing high speed single frequency continuous bioimpedance measurements. From a theoretical analysis, the minimum continuous impedance estimation time was determined, and the AD5933 with a custom 4-Electrode Analog Front-End (AFE) was used to experimentally determine the maximum continuous impedance estimation frequency as well as the system impedance estimation error when measuring a 2R1C electrical circuit model. Transthoracic Electrical Bioimpedance (TEB) measurements in a healthy subject were obtained using 3M gel electrodes in a tetrapolar lateral spot electrode configuration. The obtained TEB raw signal was filtered in MATLAB to obtain the respiration and cardiogenic signals, and from the cardiogenic signal the impedance derivative signal (dZ/dt) was also calculated. The results have shown that the maximum continuous impedance estimation rate was approximately 550 measurements per second with a magnitude estimation error below 1% on 2R1C-parallel bridge measurements. The displayed respiration and cardiac signals exhibited good performance, and they could be used to obtain valuable information in some plethysmography monitoring applications. The obtained results suggest that the AD5933-based monitor could be used for the implementation of a portable and wearable Bioimpedance plethysmograph that could be used in applications such as Impedance Cardiography. These results combined with the research done in functional garments and textile electrodes might enable the implementation of PHS applications in a relatively short time from now.

  • 24.
    Ferreira, Javier
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Álvarez, L.
    Buendía, R.
    Ayllón, D.
    Llerena, C.
    Gil-Pita, R.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Bioimpedance-based wearable measurement instrumentation for studying the autonomic nerve system response to stressful working conditions2013Ingår i: XV International Conference on Electrical Bio-Impedance (ICEBI) & XIV Conference on Electrical Impedance Tomography (EIT), 2013, Vol. 434, nr 1, s. 012015-Konferensbidrag (Refereegranskat)
    Abstract [en]

    The assessment of mental stress on workers under hard and stressful conditions is critical to identify which workers are not ready to undertake a mission that might put in risk their own life and the life of others. The ATREC project aims to enable Real Time Assessment of Mental Stress of the Spanish Armed Forces during military activities. Integrating sensors with garments and using wearable measurement devices, the following physiological measurements were recorded: heart and respiration rate, skin galvanic response as well as peripheral temperature. The measuring garments are the following: a sensorized glove, an upper-arm strap and a repositionable textrode chest strap system with 6 textrodes. The implemented textile-enabled instrumentation contains: one skin galvanometer, two temperature sensors, for skin and environmental, and an Impedance Cardiographer/Pneumographer containing a 1 channel ECG amplifier to record cardiogenic biopotentials. The implemented wearable systems operated accordingly to the specifications and are ready to be used for the mental stress experiments that will be executed in the coming phases of the project in healthy volunteers.

  • 25. Garcia-Molina, G.
    et al.
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lagares-Lemos, M.
    Automated NREM sleep staging using the Electro-oculogram: A pilot study2012Ingår i: Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE, IEEE , 2012, s. 2255-2258Konferensbidrag (Refereegranskat)
    Abstract [en]

    Automatic sleep staging from convenient and unobtrusive sensors has received considerable attention lately because this can enable a large range of potential applications in the clinical and consumer fields. In this paper the focus is on achieving non-REM (NREM) sleep staging from ocular electrodes. From these signals, specific patterns related to sleep such as slow eye movements, K-complexes, eye blinks, and spectral features are estimated. Although such patterns are characteristic of the Electroencephalogram, they can also be visible to a lesser extent on signals from ocular electrodes. Automatic sleep staging was implemented using two approaches: i) based on a state-machine and ii) using a neural network. The first one relied on the recommendations of the American Academy of Sleep Medicine, and the second one used a multilayer perceptron which was trained on manually sleep-staged data. Results were obtained on the data of five volunteers who participated in a nap experiment. Manual sleep staging of this data, performed by an expert, was used as reference. Five stages were considered, namely wake with eyes open, wake with eyes closed, and sleep stages N1, N2, and N3. The results were characterized in terms of confusion matrices from which the Cohen's κ coefficients were estimated. The values of κ for both the state-machine and neural-network based automatic sleep staging approaches were 0.79 and 0.59 respectively. Thus, the state-machine based approach shows a very good agreement with manual staging of sleep-data.

  • 26. Hilderman, Marie
    et al.
    Qureshi, Abdul R
    Al-Abed, Yousef
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Lindecrantz, Kaj
    Anderstam, Björn
    Bruchfeld, Annette
    Cholinergic anti-inflammatory pathway activity in dialysis patients: a role for neuroimmunomodulation?2015Ingår i: Clinical Kidney Journal, ISSN 2048-8505, E-ISSN 2048-8513, Vol. 8, nr 5Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: The cholinergic anti-inflammatory pathway (CAP) modulates inflammatory responses through the vagus nerve and the α-7-nicotinic acetylcholine receptor (α7nAChR) on macrophages and immune cells. Sympathetic/parasympathetic imbalance and chronic inflammation are both linked to poor outcome in dialysis patients. The aim of this study was to investigate CAP activity in these patients.

    METHODS: Twenty dialysis patients, 12 hemodialysis (HD) and 8 peritoneal dialysis (PD) patients (12 male, 8 female; age range 47-83 years) and 8 controls (5 male, 3 female; age range 31-52 years) were analyzed for C-reactive protein (CRP), tumor necrosis factor (TNF), interleukin-1b (IL-1b), IL-6 and IL-10 at baseline. The cytokines were then assessed after whole blood stimulation ex vivo with lipopolysaccharide (LPS) (10 and 100 ng/mL) and again in the presence of 45 and 90 μmol/L GTS-21, a cholinergic α7nAChR agonist.

    RESULTS: CRP, TNF, IL-1 and IL-6 were significantly higher, whereas IL-10 was significantly lower at baseline in patients compared with controls. After LPS stimulation, TNF increased significantly more in patients than in controls but decreased to similar levels in both groups after addition of GTS-21. IL-6 attenuation was comparable with TNF and the IL-1b pattern was similar but remained significantly higher in patients. Interestingly, IL-10 increased after GTS-21 in a dose-dependent manner, but only in patients. Results in HD and PD patients did not differ.

    CONCLUSIONS: The response of immune cells after LPS exposure and cholinergic stimulation suggests a functional CAP in dialysis patients. It may thus be possible to target the α7nAChR control of cytokine release as an anti-inflammatory strategy and thereby improve outcome in these patients.

  • 27.
    Hjalmarsson, Håkan
    et al.
    KTH, Skolan för elektro- och systemteknik (EES), Reglerteknik.
    Lindqvist, Kristian
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Identification of performance limitations in control2001Ingår i: 2001 European Control Conference, ECC 2001, IEEE conference proceedings, 2001, s. 1446-1451Konferensbidrag (Refereegranskat)
    Abstract [en]

    Non-minimum phase zeros and poles of a process put upper and lower constraints on the bandwidth of a closed loop system. It is thus of great interest to be able to identify these quantities. In this contribution it is shown that non-minimum phase zeros and unstable poles can be identified using high order models without the standard o(n) (n is the model order) variance penalty for over modeling. An asymptotic, in the model order and the number of data, expression for the variance of non-minimum phase zeros is derived. This result shows that the problem of determining the performance limits of a system from experimental data is considerably easier than identifying the complete system. As a direct application of this an optimal experiment design problem for identification of performance limits is posed and solved.

  • 28. Li, Si
    et al.
    Zhuang, Cheng
    Hao, Manzhao
    He, Xin
    Marquez, Juan C.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Shanghai Jiao Tong University, China.
    Niu, Chuanxin M.
    Lan, Ning
    Coordinated alpha and gamma control of muscles and spindles in movement and posture2015Ingår i: Frontiers in Computational Neuroscience, ISSN 1662-5188, E-ISSN 1662-5188, Vol. 9, artikel-id 122Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Mounting evidence suggests that both a and gamma motoneurons are active during movement and posture, but how does the central motor system coordinate the alpha-gamma controls in these tasks remains sketchy due to lack of in vivo data. Here a computational model of alpha-gamma control of muscles and spindles was used to investigate a -gamma integration and coordination for movement and posture. The model comprised physiologically realistic spinal circuitry, muscles, proprioceptors, and skeletal biomechanics. In the model, we divided the cortical descending commands into static and dynamic sets, where static commands (alpha(s) and gamma(s)) were for posture maintenance and dynamic commands (alpha(d) and gamma(d)) were responsible for movement. We matched our model to human reaching movement data by straightforward adjustments of descending commands derived from either minimal-jerk trajectories or human EMGs. The matched movement showed smooth reach-to-hold trajectories qualitatively close to human behaviors, and the reproduced EMGs showed the classic tri-phasic patterns. In particular, the function of gamma(d) was to gate the alpha(d) command at the propriospinal neurons (PN) such that antagonistic muscles can accelerate or decelerate the limb with proper timing. Independent control of joint position and stiffness could be achieved by adjusting static commands. Deefferentation in the model indicated that accurate static commands of as and gamma(s) are essential to achieve stable terminal posture precisely, and that the gamma(d) command is as important as the alpha(d) command in controlling antagonistic muscles for desired movements. Deafferentation in the model showed that losing proprioceptive afferents mainly affected the terminal position of movement, similar to the abnormal behaviors observed in human and animals. Our results illustrated that tuning the simple forms of alpha-gamma commands can reproduce a range of human reach-to-hold movements, and it is necessary to coordinate the set of alpha-gamma descending commands for accurate and stable control of movement and posture.

  • 29. Mohino-Herranz, Inma
    et al.
    Gil-Pita, Roberto
    Ferreira, Javier
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Boras, Boras, Sweden.
    Rosa-Zurera, Manuel
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Boras, Boras, Sweden.
    Assessment of Mental, Emotional and Physical Stress through Analysis of Physiological Signals Using Smartphones2015Ingår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 15, nr 10, s. 25607-25627Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Determining the stress level of a subject in real time could be of special interest in certain professional activities to allow the monitoring of soldiers, pilots, emergency personnel and other professionals responsible for human lives. Assessment of current mental fitness for executing a task at hand might avoid unnecessary risks. To obtain this knowledge, two physiological measurements were recorded in this work using customized non-invasive wearable instrumentation that measures electrocardiogram (ECG) and thoracic electrical bioimpedance (TEB) signals. The relevant information from each measurement is extracted via evaluation of a reduced set of selected features. These features are primarily obtained from filtered and processed versions of the raw time measurements with calculations of certain statistical and descriptive parameters. Selection of the reduced set of features was performed using genetic algorithms, thus constraining the computational cost of the real-time implementation. Different classification approaches have been studied, but neural networks were chosen for this investigation because they represent a good tradeoff between the intelligence of the solution and computational complexity. Three different application scenarios were considered. In the first scenario, the proposed system is capable of distinguishing among different types of activity with a 21.2% probability error, for activities coded as neutral, emotional, mental and physical. In the second scenario, the proposed solution distinguishes among the three different emotional states of neutral, sadness and disgust, with a probability error of 4.8%. In the third scenario, the system is able to distinguish between low mental load and mental overload with a probability error of 32.3%. The computational cost was calculated, and the solution was implemented in commercially available Android-based smartphones. The results indicate that execution of such a monitoring solution is negligible compared to the nominal computational load of current smartphones.

  • 30.
    Raghavendra, Jammalamadaka
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Optomyography - Detection ofmuscle surface displacement using reflective photo resistor.2014Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    A human body can carry out many physiological complex processes which can be mechanical, electrical or bio-chemical. Each mechanical activity generates a signal that describes the characteristics of the particular action in the form of pressure or temperature. Any irregularity in the process changes the usual functioning thus affecting the performance of the system. Several techniques were introduced to evaluate these muscular signals in order to get a deeper understanding of the medical abnormalities. Displacement sensors, laser optics, electrodes, accelerometers and microphones are some of the widely used devices in measuring the electrical and mechanical activities produced in the muscles.

    The aim of this thesis project was to find and implement a simple non-contact optical method to measure and monitor the displacements caused on the surface of the skin due to muscular movements. In this study, a device was developed using photo electric sensors that can record surface changes caused on the skin due to the movements forearm muscles.

  • 31.
    Seoane, Fernando
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Boras, Sweden.
    Abtahi, Shirin
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Karolinska Institute, Sweden.
    Ellegard, L.
    Johannsson, G.
    Bosaeus, I.
    Ward, L C
    Slightly superior performance of bioimpedance spectroscopy over single frequency regression equations for assessment of total body water2015Ingår i: Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, IEEE conference proceedings, 2015, s. 3707-3710Konferensbidrag (Refereegranskat)
    Abstract [en]

    Electrical bioimpedance has been used for several decades to assess body fluid distribution and body composition by using single frequency and bioimpedance spectroscopic (BIS) techniques. It remains uncertain whether BIS methods have better performance compare to single frequency regression equations. In this work the performance of two BIS methods and four different 50 kHz single frequency prediction equations was studied in a data set of wrist-to-ankle tetrapolar BIS measurements (5-1000 kHz) together with reference values of total body water obtained by tritium dilution in 92 patients. Data were compared using regression techniques and BlandAltman plots. The results of this study showed that all methods produced similarly high correlation and concordance coefficients, indicating good accuracy as a method. Limits of agreement analysis indicated that the population level performance of Sun’s prediction equations was very similar to the performance of both BIS methods. However, BIS methods in practice have slightly better predictive performance than the single-frequency equations as judged by higher correlation and the limits of agreement from the Bland-Altman analysis. In any case, the authors believe that an accurate evaluation of performance of the methods cannot be done as long as the evaluation is done using Bland-Altman analysis, the commonly accepted technique for this kind of performance comparisons.

  • 32.
    Seoane, Fernando
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Univ Boras, Fac Care Sci Work Life & Social Welfare, Sweden.
    Abtahi, Shirin
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Karolinska Inst, Dept Clin Sci Intervent & Technol, Sweden.
    Ellegård, Lars
    Johannsson, Gudmundur
    Bosaeus, Ingvar
    Ward, Leigh C
    Mean Expected Error in Prediction of Total Body Water: A True Accuracy Comparison between Bioimpedance Spectroscopy and Single Frequency Regression Equations2015Ingår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, artikel-id 656323Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    For several decades electrical bioimpedance (EBI) has been used to assess body fluid distribution and body composition. Despite the development of several different approaches for assessing total body water (TBW), it remains uncertain whether bioimpedance spectroscopic (BIS) approaches are more accurate than single frequency regression equations. The main objective of this study was to answer this question by calculating the expected accuracy of a single measurement for different EBI methods. The results of this study showed that all methods produced similarly high correlation and concordance coefficients, indicating good accuracy as a method. Even the limits of agreement produced from the Bland-Altman analysis indicated that the performance of single frequency, Sun’s prediction equations, at population level was close to the performance of both BIS methods; however, when comparing the Mean Absolute Percentage Error value between the single frequency prediction equations and the BIS methods, a significant difference was obtained, indicating slightly better accuracy for the BIS methods. Despite the higher accuracy of BIS methods over 50 kHz prediction equations at both population and individual level, the magnitude of the improvement was small. Such slight improvement in accuracy of BIS methods is suggested insufficient to warrant their clinical use where the most accurate predictions of TBW are required, for example, when assessing over-fluidic status on dialysis. To reach expected errors below 4-5%, novel and individualized approaches must be developed to improve the accuracy of bioimpedance-based methods for the advent of innovative personalized health monitoring applications.

  • 33.
    Seoane, Fernando
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Borås, Sweden.
    Atefi, seyed Reza
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Jens, Tomner
    Karolinska Hospital.
    Kostulas, Konstantinos
    Karolinska Institute, Department of Neurology.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Electrical Bioimpedance Spectroscopy on Acute Unilateral Stroke Patients: Initial Observations regarding Differences between Sides2015Ingår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, artikel-id 613247Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose. Electrical Bioimpedance Cerebral Monitoring is assessment in real time of health of brain tissue through study of passive dielectric properties of brain. During the last two decades theory and technology have been developed in parallel with animal experiments aiming to confirm feasibility of using bioimpedance-based technology for prompt detection of brain damage. Here, for the first time, we show that electrical bioimpedance measurements for left and right hemispheres are significantly different in acute cases of unilateral stroke within 24 hours from onset. Methods. Electrical BIS measurements have been taken in healthy volunteers and patients suffering from acute stroke within 24 hours of onset. BIS measurements have been obtained using SFB7 bioimpedance spectrometer manufactured by Impedimed ltd. and 4-electrode method. Measurement electrodes, current, and voltage have been placed according to 10–20 EEG system obtaining mutual BIS measurements from 4 different channels situated in pairs symmetrically from the midsagittal line. Obtained BIS data has been analyzed, assessing for symmetries and differences regarding healthy control data.Results. 7 out of 10 patients for Side-2-Side comparisons and 8 out 10 for central/lateral comparison presented values outside the range defined by healthy control group. When combined only 1 of 10 patients exhibited values within the healthy range. Conclusions. If these initial observations are confirmed with more patients, we can foresee emerging of noninvasive monitoring technology for brain damage with the potential to lead to paradigm shift in treatment of brain stroke and traumatic brain damage.

  • 34.
    Seoane, Fernando
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Ferreira, Javier
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Alvarez, Lorena
    Buendia, Ruben
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Ayllon, David
    Llerena, Cosme
    Gil-Pita, Roberto
    Sensorized Garments and Textrode-Enabled Measurement Instrumentation for Ambulatory Assessment of the Autonomic Nervous System Response in the ATREC Project2013Ingår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 13, nr 7, s. 8997-9015Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Advances in textile materials, technology and miniaturization of electronics for measurement instrumentation has boosted the development of wearable measurement systems. In several projects sensorized garments and non-invasive instrumentation have been integrated to assess on emotional, cognitive responses as well as physical arousal and status of mental stress through the study of the autonomous nervous system. Assessing the mental state of workers under stressful conditions is critical to identify which workers are in the proper state of mind and which are not ready to undertake a mission, which might consequently risk their own life and the lives of others. The project Assessment in Real Time of the Stress in Combatants (ATREC) aims to enable real time assessment of mental stress of the Spanish Armed Forces during military activities using a wearable measurement system containing sensorized garments and textile-enabled non-invasive instrumentation. This work describes the multiparametric sensorized garments and measurement instrumentation implemented in the first phase of the project required to evaluate physiological indicators and recording candidates that can be useful for detection of mental stress. For such purpose different sensorized garments have been constructed: a textrode chest-strap system with six repositionable textrodes, a sensorized glove and an upper-arm strap. The implemented textile-enabled instrumentation contains one skin galvanometer, two temperature sensors for skin and environmental temperature and an impedance pneumographer containing a 1-channel ECG amplifier to record cardiogenic biopotentials. With such combinations of garments and non-invasive measurement devices, a multiparametric wearable measurement system has been implemented able to record the following physiological parameters: heart and respiration rate, skin galvanic response, environmental and peripheral temperature. To ensure the proper functioning of the implemented garments and devices the full series of 12 sets have been functionally tested recording cardiogenic biopotential, thoracic impedance, galvanic skin response and temperature values. The experimental results indicate that the implemented wearable measurement systems operate according to the specifications and are ready to be used for mental stress experiments, which will be executed in the coming phases of the project with dozens of healthy volunteers.

  • 35.
    Seoane, Fernando
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Mohino-Herranz, Inmaculada
    Ferreira, Javier
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Alvarez, Lorena
    Buendia, Ruben
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Ayllon, David
    Llerena, Cosme
    Gil-Pita, Roberto
    Wearable Biomedical Measurement Systems for Assessment of Mental Stress of Combatants in Real Time2014Ingår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 14, nr 4, s. 7120-7141Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Spanish Ministry of Defense, through its Future Combatant program, has sought to develop technology aids with the aim of extending combatants' operational capabilities. Within this framework the ATREC project funded by the Coincidente program aims at analyzing diverse biometrics to assess by real time monitoring the stress levels of combatants. This project combines multidisciplinary disciplines and fields, including wearable instrumentation, textile technology, signal processing, pattern recognition and psychological analysis of the obtained information. In this work the ATREC project is described, including the different execution phases, the wearable biomedical measurement systems, the experimental setup, the biomedical signal analysis and speech processing performed. The preliminary results obtained from the data analysis collected during the first phase of the project are presented, indicating the good classification performance exhibited when using features obtained from electrocardiographic recordings and electrical bioimpedance measurements from the thorax. These results suggest that cardiac and respiration activity offer better biomarkers for assessment of stress than speech, galvanic skin response or skin temperature when recorded with wearable biomedical measurement systems.

  • 36.
    Seoane, Fernando
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Högskolan i Borås, Akademin för vård, arbetsliv och välfärd.
    Soroudi, Azadeh
    Högskolan i Borås, Sverige.
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik.
    Lu, Ke
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik.
    Skrifvars, Mikael
    Högskolan i Borås, Sverige.
    Printed Electronics Enabling a Textile-friendly Interconnection between Wearable Measurement Instrumentation & Sensorized Garments2016Konferensbidrag (Refereegranskat)
  • 37.
    Vega Barbas, Mario
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Universidad Politécnica de Madrid.
    Accessible interaction solution based on confidence for the deployment of pervasive sensitive services in intelligent environments2016Doktorsavhandling, monografi (Övrigt vetenskapligt)
    Abstract [sv]

    Tjänster baserade på informations- och kommunikationsteknik (IKT) blir allt mer vanligare i människors liv. För att främja acceptansen för IKT i både tekniska och sociala aspekter av människors liv har nya modeller för dessa tjänster skapats. Dessa modeller har en närmare knytning till människors verksamhet så att de inte bara förekommer i deras yrken eller fritid men också i mer intima områden som anknyter till individens egen identitet. Det är nu därför vanligt att hitta tjänster som tar hänsyn till användarens hälsa, vanor, ideologi, etc.  En analys av befintliga tjänster måste inkludera dessa aspekter men även användarnas känsla av identitet och medlemskap. På detta sätt är det möjligt att säkerställa den tekniska riktigheten hos dessa funktioner som i sin tur borgar för säkra och respektfulla lösningar som tar hänsyn till medlemmarnas medborgerliga rättigheter likväl som deras känsla av identitet och medlemskap.

    Historiskt sett, och ur ett tekniskt perspektiv, har användarperspektivet omfattats under begreppet teknisk acceptans. Inom detta område har användarvänliga lösningar anpassade till användarna själva uppmuntrat acceptans av dem. Acceptans av lösningar är önskvärt även om det är svårt att säkerställa. Denna svårighet beror på avsaknaden av antalet variabler som påverkar acceptansen av tekniska lösningar och svårigheten att optimera de kända variablerna.

    I denna avhandling studeras och karaktäriseras en av de variabler som påverkar acceptansen av befintliga tjänster: förtroende. Förtroendet definieras i psykologiska termer med syftet att kunna använda termen i typiska metoder för teknik. Det föreslås också olika verktyg för att underlätta optimering av detta förtroende inom tjänstesektorn.

    Hälso- och sjukvård i hemmet har valts som scenario för denna avhandling. Detta scenario presenterar ett antal restriktioner med avseende på acceptansen av den teknik som används för att skapa tjänster och hur dessa tjänster hanterar den förvärvade användarinformationen. För användaren är situationen mycket känslig och de erbjudna tjänsterna kan påverka användarens uppfattning av miljön och hemmet och/eller generera rädsla eller avsmak för att acceptera lösningen.

    När den generiska ramen är etablerad är det huvudsakliga syftet med denna avhandling att främja acceptans av nya tjänster för personlig hälsovård och deras användning i hemmet. Detta skall uppnås genom en layout som främjar ett psykologiskt förtroende hos användarna. För att uppnå detta mål har en uppsättning resultat, både begreppsmässiga, tekniska och experimentella, analyserats. Framför allt har en fullständig karaktärisering gjorts av känslan av förtroende från en teknologisk synvinkel och en definition av en känslig och allomfattande tjänst. Dessutom framläggs en metod för införandet av interaktionsdesign i de aktuella tjänsterna genom ett antal interaktionsmönster. Slutligen behandlar denna avhandling utvecklingen av en mjukvaruarkitektur för att säkerställa en korrekt användning av dessa känsliga tjänster.

    Resultaten pekar på att distributionsmodellen även kan användas för andra tjänster i informationssamhället där användaren utför vardagliga sysslor, såsom i det digitala hemmet eller andra miljöer (t.ex. skolor och arbetsplatser), där känsliga uppgifter hanteras. De framtida arbetsuppgifterna omfattar det överhängande behovet av att tillämpa resultaten på den pågående utvecklingen av forskningsprojekt som författaren är involverad i. Detta omfattar även utveckling av ny forskning som syftar till att skapa ny interaktionsteknik t.ex. avancerade gränssnitt, framtida leksaker, säkra visualiseringssystem eller säkerhetssystem baserat på användarens hälsa/tillstånd.

  • 38.
    Vega-Barbas, Mario
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Universidad Politécnica de Madrid, Spain.
    Pau, Ivan
    Universidad Politecnica de Madrid.
    Ferreira, Javier
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Universidad Politécnica de Madrid, Spain.
    Lebis, Evelyn
    CETEMMSA.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Borås, Sweden.
    Utilizing Smart Textiles-Enabled Sensorized Toy and Playful Interactions for Assessment of Psychomotor Development on Children2015Ingår i: Journal of Sensors, ISSN 1687-725X, E-ISSN 1687-7268, Vol. 2015, artikel-id 898047Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Emerging pervasive technologies like smart textiles make it possible to develop new and more accessible healthcare services for patients independently of their location or time. However, none of these new e-health solutions guarantee a complete user acceptance, especially in cases requiring extensive interaction between the user and the solution. So far, researchers have focused their efforts on new interactions techniques to improve the perception of privacy and confidence of the people using e-health services. In this way, the use of smart everyday objects arises as an interesting approach to facilitate the required interaction and increase user acceptance. Such Smart Daily Objects together with smart textiles provide researchers with a novel way to introduce sophisticated sensor technology in the daily life of people. This work presents a sensorized smart toy for assessment of psychomotor development in early childhood. The aim of this work is to design, develop, and evaluate the usability and playfulness of a smart textile-enabled sensorized toy that facilitates the user engagement in a personalized monitoring healthcare activity. To achieve this objective the monitoring is based on a smart textile sensorized toy as catalyzer of acceptance and multimodal sensing sources to monitor psychomotor development activities during playtime.

  • 39.
    Vega-Barbas, Mario
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Pau, Ivan
    Universidad Politecnica de Madrid.
    Martín-Ruiz, Maria Luisa
    Universidad Politecnica de Madrid.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Adaptive Software Architecture Based on Confident HCI for the Deployment of Sensitive Services in Smart Homes2015Ingår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 15, nr 4, s. 7294-7322Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Smart spaces foster the development of natural and appropriate forms of human-computer interaction by taking advantage of home customization. The interaction potential of the Smart Home, which is a special type of smart space, is of particular interest in fields in which the acceptance of new technologies is limited and restrictive. The integration of smart home design patterns with sensitive solutions can increase user acceptance. In this paper, we present the main challenges that have been identified in the literature for the successful deployment of sensitive services (e.g., telemedicine and assistive services) in smart spaces and a software architecture that models the functionalities of a Smart Home platform that are required to maintain and support such sensitive services. This architecture emphasizes user interaction as a key concept to facilitate the acceptance of sensitive services by end-users and utilizes activity theory to support its innovative design. The application of activity theory to the architecture eases the handling of novel concepts, such as understanding of the system by patients at home or the affordability of assistive services. Finally, we provide a proof-of-concept implementation of the architecture and compare the results with other architectures from the literature.

  • 40.
    Vega-Barbas, Mario
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Pau, Ivan
    Univerisdad Politecnica de Madrid.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Confidence: dependencies and their critical role in fostering user acceptance in pervasive applications2014Konferensbidrag (Refereegranskat)
    Abstract [en]

    Pervasive computing offers new scenarios where users are surrounded by invisible and proactive technology making smart spaces. Although the utility and power of solutions developed using this computer paradigm are proved, there are unresolved problems that hinder their acceptance and inclusion in our private life. Users have problems understanding the operations of a pervasive computing solution, and therefore they should trust that the solution works properly and according to their expectations. Nevertheless, the concept of trust is already framed in a specific use within the ecosystem of applications that can populate a smart space. To take this concept of trust to the whole space, we propose to study and define the concept of confidence. In contrast to the concept of trust, confidence has deeper psychological implications.

  • 41.
    Vega-Barbas, Mario
    et al.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Universidad Politécnica de Madrid, Spain.
    Pau, Ivan
    Universidad Politecnica de Madrid.
    Valero, Miguel Angel
    Universidad Politecnica de Madrid.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. University of Borås, Sweden.
    Adaptive Software Architecture for Confident Homecare in the Digital Home2014Konferensbidrag (Refereegranskat)
    Abstract [en]

    Smart spaces foster the development of more natural and suitable forms of human-computer interaction taking advantage of customization possibilities offered by the home. The interaction chances of the Digital Home, as a special type of smart space, have a special interest in fields where the acceptance of new technologies is low and restrictive. Homecare is a discipline where this acceptance is more problematic. The integration of digital home design patterns in homecare solutions should enhance the final acceptance of users. In this position paper, we present the main challenges identified from the literature for the successful implementation of homecare solutions in smart spaces and the design of a software architecture that models entities and functionalities involved in solving these challenges.

  • 42. Wollmann, Thomas
    et al.
    Abtahi, Farhad
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Eghdam, Abouzar
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik.
    Lindecrantz, Kaj
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik.
    Haag, Martin
    Koch, Sabine
    User-Centred Design and Usability Evaluation of a Heart Rate Variability Biofeedback Game2016Ingår i: IEEE Access, E-ISSN 2169-3536, Vol. 4, s. 5531-5539Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background and objective: Reduced heart rate variability (HRV) is an indicatorof a malfunctioning autonomic nervous system. Resonant frequencybreathing is a potential non-invasive means of intervention for improvingthe balance of the autonomic nervous system and increasing HRV. However,such breathing exercises are regarded as boring and monotonous tasks.The use of gaming elements (gamification) or a full gaming experience is awell-recognised method for achieving higher motivation and engagement invarious tasks. However, there is limited documented knowledge on how todesign a game for breathing exercises. In particular, the influence of additionalinteractive elements on the main course of training has not yet beenexplored. In this study, we evaluated the satisfaction levels achieved usingdifferent game elements and how disruptive they were to the main task, i.e.,paced breathing training.

    Methods: An Android flight game was developed with three game modes thatdiffer in the degrees of multitasking they require. Design, development and evaluation were conducted using a user-centred approach, including contextanalysis, the design of game principle mock-ups, the selection of game principlesthrough a survey, the design of the game mechanics and GUI mock-up,icon testing and the performance of a summative study through user questionnairesand interviews. A summative evaluation of the developed gamewas performed with 11 healthy participants (ages 40-67) in a controlled setting.Results: The results confirm the potential of video games for motivatingplayers to engage in HRV biofeedback training. The highest training performanceon the first try was achieved through pure visualisation rather thanin a multitasking mode. Players had higher motivation to play the morechallenging game and were more interested in long-term engagement.Conclusion: A framework for gamified HRV biofeedback research is presented.It has been shown that multitasking has considerable influence onHRV biofeedback and should be used with an adaptive challenge level.

  • 43.
    Xie, Li
    et al.
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Elektroniksystem. KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, VinnExcellence Center for Intelligence in Paper and Packaging, iPACK.
    Yang, Geng
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Elektroniksystem. KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, VinnExcellence Center for Intelligence in Paper and Packaging, iPACK.
    Xu, Linlin
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, VinnExcellence Center for Intelligence in Paper and Packaging, iPACK.
    Seoane, Fernando
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system.
    Chen, Qiang
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Elektroniksystem. KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, VinnExcellence Center for Intelligence in Paper and Packaging, iPACK.
    Zheng, Lirong
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Elektroniksystem. KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, VinnExcellence Center for Intelligence in Paper and Packaging, iPACK. State Key Laboratory of ASICs and Systems, Fudan University, 200433, Shanghai, China .
    Characterization of dry biopotential electrodes2013Ingår i: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2013, s. 1478-1481Konferensbidrag (Refereegranskat)
    Abstract [en]

    Driven by the increased interest in wearable long-term healthcare monitoring systems, varieties of dry electrodes are proposed based on different materials with different patterns and structures. Most of the studies reported in the literature focus on proposing new electrodes and comparing its performance with commercial electrodes. Few papers are about detailed comparison among different dry electrodes. In this paper, printed metal-plate electrodes, textile based electrodes, and spiked electrodes are for the first time evaluated and compared under the same experimental setup. The contact impedance and noise characterization are measured. The in-vivo electrocardiogram (ECG) measurement is applied to evaluate the overall performance of different electrodes. Textile electrodes and printed electrodes gain comparable high-quality ECG signals. The ECG signal obtained by spiked electrodes is noisier. However, a clear ECG envelope can be observed and the signal quality can be easily improved by backend signal processing. The features of each type of electrodes are analyzed and the suitable application scenario is addressed.

  • 44. Zhuang, C.
    et al.
    Marquez, Juan C.
    KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinska sensorer, signaler och system. Shanghai Jiao Tong University, China.
    Qu, H. E.
    He, X.
    Lan, N.
    A neuromuscular electrical stimulation strategy based on muscle synergy for stroke rehabilitation2015Ingår i: International IEEE/EMBS Conference on Neural Engineering, NER, IEEE Computer Society, 2015, s. 816-819Konferensbidrag (Refereegranskat)
    Abstract [en]

    Recent experiments have suggested that the central nervous system (CNS) makes use of muscle synergies as a neural strategy to simplify the control of a variety of movements by using a single pattern of neural command signal. This nature of muscle coordination could have great significance in the treatment and rehabilitation of upper limb impairments for hemiparetic patients post stroke. The use of neuromuscular electrical stimulation (NMES) for neural prosthetics or therapeutic applications has been demonstrated as a promising clinical intervention for stroke patients to recover motor function of the upper extremity. However, the existing NMES systems do not provide control methods for the patient to achieve an individualized and functional rehabilitation training. In this research work, muscle synergies from the flexionextension elbow antagonistic muscles were studied. Using motion information and EMG signals, muscle synergies were extracted using non-negative matrix factorization (NMF) method. Reconstructed signals obtained from the muscle synergies were then applied to the virtual arm (VA) model to test a synergy based NMES strategy. Results show close resemblance to the original elbow trajectory of normal movements and thus the feasibility to control movements in stroke patients for rehabilitation.

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