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  • 1.
    Errando-Herranz, Carlos
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligenta system, Micro and Nanosystems.
    Takabayashi, A. Y.
    Edinger, Pierre
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligenta system, Micro and Nanosystems.
    Sattari, H.
    Gylfason, Kristinn B.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligenta system, Micro and Nanosystems.
    Quack, N.
    MEMS for Photonic Integrated Circuits2020In: IEEE Journal of Selected Topics in Quantum Electronics, ISSN 1077-260X, E-ISSN 1558-4542, Vol. 26, no 2, p. 1-16Article in journal (Refereed)
    Abstract [en]

    The field of microelectromechanical systems (MEMS) for photonic integrated circuits (PICs) is reviewed. This field leverages mechanics at the nanometer to micrometer scale to improve existing components and introduce novel functionalities in PICs. This review covers the MEMS actuation principles and the mechanical tuning mechanisms for integrated photonics. The state of the art of MEMS tunable components in PICs is quantitatively reviewed and critically assessed with respect to suitability for large-scale integration in existing PIC technology platforms. MEMS provide a powerful approach to overcome current limitations in PIC technologies and to enable a new design dimension with a wide range of applications.

  • 2.
    Lauschke, Volker M.
    et al.
    Karolinska Inst, Sect Pharmacogenet, Dept Physiol & Pharmacol, Biomedicum 5B, SE-17177 Stockholm, Sweden..
    Shafagh, Reza Z.
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    Hendriks, Delilah F. G.
    Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, Stockholm, SE-171 77, Sweden; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, Utrecht, 3584 CT, Netherlands .
    Ingelman-Sundberg, Magnus
    Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
    3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications2019In: Biotechnology Journal, ISSN 1860-6768, E-ISSN 1860-7314, Vol. 14, no 7, article id 1800347Article, review/survey (Refereed)
    Abstract [en]

    Recent research has shown that the maintenance of relevant liver functions ex vivo requires models in which the cells exhibit an in vivo-like phenotype, often achieved by reconstitution of appropriate cellular interactions. Multiple different models have been presented that differ in the cells utilized, media, and culture conditions. Furthermore, several technologically different approaches have been presented including bioreactors, chips, and plate-based systems in fluidic or static media constituting of chemically diverse materials. Using such models, the ability to predict drug metabolism, drug toxicity, and liver functionality have increased tremendously as compared to conventional in vitro models in which cells are cultured as 2D monolayers. Here, the authors highlight important considerations for microphysiological systems for primary hepatocyte culture, review current culture paradigms, and discuss their opportunities for studies of drug metabolism, hepatotoxicity, liver biology, and disease.

  • 3.
    Hauser, Janosch
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    Stemme, Göran
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    Roxhed, Niclas
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    A BLOOD HEMATOCRIT TEST STRIP2019Conference paper (Other academic)
    Abstract [en]

    This paper reports a self-propelled microfluidichematocrit (HCT) test that uses the correlation betweenblood hematocrit and wicking distance of blood in a specialpaper matrix. The enabling feature is a novel blood volumemetering method that allows sampling from the fingertipand reliably generates a highly precise blood volume of47.7 ± 1.9 μl (CV 4%) that is transferred into a porouspaper matrix. A dissolvable valve ensures a relaxed timewindow for blood sampling, making it highly user-friendlyand resilient to overfilling. The presented hematocrit teststrip poses a simple, cheap, equipment-free solution forpatient-centric hematocrit measurements.

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