Change search
Refine search result
1234567 1 - 3 of 775
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Lauschke, Volker M.
    et al.
    Karolinska Inst, Sect Pharmacogenet, Dept Physiol & Pharmacol, Biomedicum 5B, SE-17177 Stockholm, Sweden..
    Shafagh, Reza Z.
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    Hendriks, Delilah F. G.
    Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, Stockholm, SE-171 77, Sweden; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, Utrecht, 3584 CT, Netherlands .
    Ingelman-Sundberg, Magnus
    Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
    3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications2019In: Biotechnology Journal, ISSN 1860-6768, E-ISSN 1860-7314, Vol. 14, no 7, article id 1800347Article, review/survey (Refereed)
    Abstract [en]

    Recent research has shown that the maintenance of relevant liver functions ex vivo requires models in which the cells exhibit an in vivo-like phenotype, often achieved by reconstitution of appropriate cellular interactions. Multiple different models have been presented that differ in the cells utilized, media, and culture conditions. Furthermore, several technologically different approaches have been presented including bioreactors, chips, and plate-based systems in fluidic or static media constituting of chemically diverse materials. Using such models, the ability to predict drug metabolism, drug toxicity, and liver functionality have increased tremendously as compared to conventional in vitro models in which cells are cultured as 2D monolayers. Here, the authors highlight important considerations for microphysiological systems for primary hepatocyte culture, review current culture paradigms, and discuss their opportunities for studies of drug metabolism, hepatotoxicity, liver biology, and disease.

  • 2.
    Hauser, Janosch
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    Stemme, Göran
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    Roxhed, Niclas
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    A BLOOD HEMATOCRIT TEST STRIP2019Conference paper (Other academic)
    Abstract [en]

    This paper reports a self-propelled microfluidichematocrit (HCT) test that uses the correlation betweenblood hematocrit and wicking distance of blood in a specialpaper matrix. The enabling feature is a novel blood volumemetering method that allows sampling from the fingertipand reliably generates a highly precise blood volume of47.7 ± 1.9 μl (CV 4%) that is transferred into a porouspaper matrix. A dissolvable valve ensures a relaxed timewindow for blood sampling, making it highly user-friendlyand resilient to overfilling. The presented hematocrit teststrip poses a simple, cheap, equipment-free solution forpatient-centric hematocrit measurements.

  • 3.
    Verma, Malvika
    et al.
    MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Vishwanath, Karan
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Eweje, Feyisope
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA..
    Roxhed, Niclas
    KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems.
    Grant, Tyler
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Castaneda, Macy
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Steiger, Christoph
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Mazdiyasni, Hormoz
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Bensel, Taylor
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Minahan, Daniel
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Soares, Vance
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Salama, John A. F.
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Lopes, Aaron
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Hess, Kaitlyn
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Cleveland, Cody
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Fulop, Daniel J.
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Univ Delaware, Biomed Engn Dept, 161 Colburn Lab, Newark, DE 19716 USA..
    Hayward, Alison
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Div Comparat Med, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Collins, Joy
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Tamang, Siddartha M.
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Hua, Tiffany
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Ikeanyi, Chinonyelum
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Zeidman, Gal
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Mule, Elizabeth
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Boominathan, Sooraj
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Popova, Ellena
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Miller, Jonathan B.
    MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Sloan Sch Management, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Bellinger, Andrew M.
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Dept Med, Cardiovasc Div, Boston, MA 02115 USA.;Lyndra Therapeut Inc, Watertown, MA 02472 USA..
    Collins, David
    Management Sci Hlth, Medford, MA 02155 USA.;Boston Univ, Sch Publ Hlth, Boston, MA 02118 USA..
    Leibowitz, Dalia
    MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Batra, Shelly
    Operat ASHA, New Delhi 110076, India..
    Ahuja, Sandeep
    Operat ASHA, New Delhi 110076, India..
    Bajiya, Manju
    Operat ASHA, New Delhi 110076, India..
    Batra, Sonali
    Operat ASHA, New Delhi 110076, India..
    Sarin, Rohit
    Natl Inst TB & Resp Dis, New Delhi 110030, India..
    Agarwal, Upasna
    Natl Inst TB & Resp Dis, New Delhi 110030, India..
    Khaparde, Sunil D.
    Former Deputy Director Gen & Head Cent TB Div, New Delhi 110011, India..
    Gupta, Neeraj K.
    Safdarjang Hosp, Dept Resp Med, New Delhi 110029, India..
    Gupta, Deepak
    All India Inst Med Sci, Div Pulm & Crit Care Med, New Delhi 110029, India..
    Bhatnagar, Anuj K.
    Rajan Babu Inst Pulm Med & TB, New Delhi 110009, India..
    Chopra, Kamal K.
    New Delhi TB Ctr, New Delhi 110002, India..
    Sharma, Nandini
    Maulana Azad Med Coll, Dept Community Med, New Delhi, India..
    Khanna, Ashwani
    Lok Nayak Hosp Chest Clin, New Delhi 110002, India..
    Chowdhury, Jayeeta
    Tata Trusts, Mumbai 400001, Maharashtra, India..
    Stoner, Robert
    MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Energy Initiat, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Slocum, Alexander H.
    MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Cima, Michael J.
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Furin, Jennifer
    Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA 02115 USA..
    Langer, Robert
    MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Media Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    Traverso, Giovanni
    MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
    A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment2019In: Science Translational Medicine, ISSN 1946-6234, E-ISSN 1946-6242, Vol. 11, no 483, article id eaau6267Article in journal (Refereed)
    Abstract [en]

    Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.

1234567 1 - 3 of 775
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf