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  • 101.
    Näsman, P
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Eneland, M
    Kommentarer till Ersättningsbeloppets fördelning i industribrand II 1950-19691976Rapport (Annet vitenskapelig)
  • 102.
    Näsman, P
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Mattsson, P
    40-talisternas stora svek: Kravmaskin för egna intressen1990Inngår i: Universitetsläraren, nr 2Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 103.
    Näsman, P
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Thedéen, T
    Valdeltagande, bebyggelsetyp och röstandelar i storstadsområdena Stockholm, Göteborg och Malmö vid riksdagsvalen 1982, 1985 och 19881990Rapport (Annet vitenskapelig)
  • 104.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    AID-analys1980Konferansepaper (Fagfellevurdert)
  • 105.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS.
    Appendix A: Some Basic Concepts of Statistics2010Inngår i: Risks in Technological Systems / [ed] Grimvall, G.; Holmgren, Å.; Jacobsson, P.; Thedéen, T., Springer-Verlag , 2010, s. 319-328Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 106.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Bicycle safety at Intersections: A before and after study1995Konferansepaper (Fagfellevurdert)
  • 107.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Cykelolyckor1994Konferansepaper (Annet vitenskapelig)
  • 108.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Det finns det statistik på. Högskoleutbildade - billiga och bra för näringslivet! Rekrytera!1987Inngår i: Resultat marketing, ISSN 0283-8710, nr 2Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 109.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Det svåra är att få alla att tala samma språk1986Inngår i: Fler högskoleutbildade till industrin, Centralorganisationen SACO/SR , 1986Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
  • 110.
    Näsman, Per
    KTH, Tidigare Institutioner                               , Infrastruktur.
    Empiriska demonstrationsexempel av data och datakällor för riskanalys/riskvärdering inom järnvägsområdet.1993Rapport (Annet vitenskapelig)
  • 111.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Gymnasiet är den bästa grunden för högskolestudier1984Inngår i: Arbetsterapeuten, ISSN 0345-0988, nr 4Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 112.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Industrins svårighet att rekrytera arbetskraft kommer att bestå framöver, ungdomskullarna minskar fram till år 20101988Inngår i: Resultat marketing, ISSN 0283-8710, nr 5Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 113.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Jan Gustavsson, mentor och vän: Festskrift med anledning av att Jan Gustavsson, Statistiska Institutionen, går i pension.1998Annet (Annet (populærvitenskap, debatt, mm))
  • 114.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Konsten att ljuga med statistik1987Inngår i: Resultat marketing, ISSN 0283-8710, nr 1Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 115.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Några statistiska grundbegrepp1998Inngår i: Risker i tekniska system / [ed] Grimvall G, Jacobsson P, Thedéen T, Stockholm: Utbildningsradion , 1998Kapittel i bok, del av antologi (Fagfellevurdert)
  • 116.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Några statistiska grundbegrepp2003Inngår i: Risker i tekniska system / [ed] Grimvall G, Jacobsson P, Thedéen T, Studentlitteratur, 2003Kapittel i bok, del av antologi (Fagfellevurdert)
  • 117.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transporter och samhällsekonomi (stängd 20110301), Säkerhetsforskning (stängd 20110301).
    Risk analysis: a tool in decision-making2005Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    In our daily life we are surrounded by different kind of risks and we constantly strive for better methods to quantify and in the prolongation manage these risks. Every activity involves some risks and there are some kinds of risks and some level of risks that we are unwilling to accept. We all like to live a life that is free from risks, but that is impossible.

    The word risk has a lot of different interpretations. In this thesis we shall let risk stand for the combination of random or uncertain events with negative consequences for human health, life and welfare and for the environment together with some measures of the likelihood of such events. We believe this is the prevailing concept or understanding of risk; as the probability of an event followed by some negative consequences or activities of that event.

    In risk analysis one tries to recognize the nature of various risks and to assess the magnitude of the risks. In the risk analysis it is very important to know what system to consider and this is not self evident in many cases. The situation is clearly different for planning and/or building a system compared with running the same system in a real time state. The system that is going to be the subject to the risk analysis must be clearly defined and the limitations and the boundaries of the system must be set. It is very important to ensure that all persons involved in a risk analysis have a common understanding of the system being considered, including relevant operations.

    During the past decades many studies have been carried out on risk related topics and the society has showed a significant interest in the field of risk analysis. Risk analysis is the interdisciplinary field of science that combines results and knowledge of probability theory, mathematical statistics, engineering, medicine, philosophy, psychology, economics and other applied disciplines.

    In this thesis we will give some examples of different risk analyses carried out basically within two areas. The first part of the thesis (paper 1- paper V) describes different risk analyses carried out in the area of transportation. This is an area with large differences between the different modes of transportation in respect to, for example number of users, number of accidents, magnitude of the accidents and accessible data. The latter part of the thesis (paper VI and paper VII) describes two risk analyses carried out in the field of medicine. Medicine is a science, which has used methods from the area of risk analysis for a long time. The different papers will be used to discuss risk analysis as a tool in decision-making.

    Fulltekst (pdf)
    FULLTEXT01
  • 118.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transporter och samhällsekonomi (stängd 20110301), Säkerhetsforskning (stängd 20110301).
    Risk, Risk Analysis and Decision-making with Reference to Biostatistics and the Field of Medicine2010Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Risk, risk analysis and decision-making are essential aspects of health care andmedicine, for patients as well as for physicians and for society as a whole, andthe concept of risk and risk analysis in decision-making has a long history. Theword risk has many different interpretations and has no commonly accepteddefinition. In this thesis, we shall let risk stand for the combination of randomor uncertain events with negative consequences for human health, life and/orwelfare and/or the environment together with some measures of the likelihoodof such events. We believe this is the dominant concept and understanding ofrisk, the risk being the likelihood or probability of an event followed by somenegative consequences or activities of that event.

    In this doctoral thesis, we focus on biostatistics, risks and risk analysis in thefield of medicine, a science which has been using methods from the area of riskanalysis for a long time. The seven papers (paper I - paper VII) presented inthis thesis, together with a general introduction to risk, risk analysis anddecision-making, will be used to illustrate and discuss risk analysis as a tool fordecision-making in the field of medicine. From my point a view, risk analysisin the field of medicine aims to reduce pain, raise the quality of life, reduce therisk of adverse events, compare cost efficiency between different treatmentregimes and prolong a healthy life. Based on results presented in the thesis, weconclude that biostatistics, risks and risk analysis used in the field of medicineare valuable methods for evaluation of hypotheses within the health care areaand a good basis for decision-making.

    Fulltekst (pdf)
    FULLTEXT01
  • 119.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Some Basic Concepts of Statistics2010Inngår i: Risks in Technological Systems / [ed] Grimvall, G.; Holmgren, Å.; Jacobsson, P.; Thedéen, T., Springer, 2010Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 120.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Stoppa undan revolvern Björn!1987Inngår i: Resultat marketing, ISSN 0283-8710, nr 3Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 121.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Valdistriktens storleksfördelning vid riksdagsvalet 19911994Rapport (Annet vitenskapelig)
  • 122.
    Näsman, Per
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS.
    Björklund, A
    Statistisk undersökning av matematikbakgrund, matematik D eller matematik E, från gymnasiet och studieresultat, avklarad poängsumma, vid KTH för studerande antagna till KTH höstterminerna 2001, 2002, 2003 respektive 20042007Rapport (Annet vitenskapelig)
  • 123.
    Näsman, Per
    et al.
    KTH, Tidigare Institutioner, Infrastruktur.
    Hernborn, H
    Holmberg, S
    Valu 2004. SVT:s vallokalsundersökning EU-parlamentsvalet 20042004Rapport (Annet vitenskapelig)
  • 124.
    Näsman, Per
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE).
    Holmberg, Sören
    Oscarsson, Henrik
    Gudmundson, Kajsa
    KTH Royal Institute of Technology.
    Lyssna på väljarna: Val 2018 EU Val 20192020Bok (Annet vitenskapelig)
  • 125.
    Näsman, Per
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transporter och samhällsekonomi (stängd 20110301), Transport och lokaliseringsanalys (stängd 20110301).
    Holmberg, Sören
    Wännström, Kent
    Valu 2009: SVT:s vallokalundersökning EU-parlamentsvalet 20092009Rapport (Annet vitenskapelig)
  • 126.
    Näsman, Per
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS.
    Thedéen, T.
    Hantering av miljörisker och människors oro2007Konferansepaper (Annet vitenskapelig)
  • 127.
    Näsman, Per
    et al.
    KTH, Tidigare Institutioner                               , Infrastruktur.
    Thedéen, Torbjörn
    En statistisk utvärdering av de mått SAS använder för att kontrollera uppfyllelsen av de flygsäkerhetsmål man satt upp1996Rapport (Annet vitenskapelig)
  • 128.
    Näsman, Per
    et al.
    KTH, Tidigare Institutioner                               , Infrastruktur.
    Thedéen, Torbjörn
    Säkerhetsanalys beträffande föreslagen ny vägsträckning jämfört med gammal vägsträckning av väg E 22, delen Söderåkra-Hossmo vid Vassmolösa1995Rapport (Annet vitenskapelig)
  • 129.
    Näsman, Per
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transporter och samhällsekonomi (stängd 20110301), Säkerhetsforskning (stängd 20110301).
    Westerman, Marie
    KTH.
    Doktorandrapport 2009: Karriären och studierna för forskarstudenter, antagna till studier vid KTH 2000-20012009Rapport (Annet vitenskapelig)
  • 130.
    Näsman, Per
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transporter och samhällsekonomi, Säkerhetsforskning.
    Örtendahl, Monica
    Perceived consequences among pregnant and non-pregnant women of continuing or ceasing to smoke.2007Inngår i: International Journal of Gynecology & Obstetrics, ISSN 0020-7292, Vol. 99, nr 2, s. 117-121Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective

    To examine the perception of risk of smoking-related psychological and social outcomes, and the effect of pregnancy and intention to stop smoking on the perceived risk.

    Methods

    Eighty women were asked to make judgments about the probability of outcomes for smoking-related consequences. Four subgroups were created using the variables of pregnancy (pregnant versus not pregnant) and cessation of smoking (intention to stop versus no intention to stop). Judgments were based on the decision to stop and not stop smoking.

    Result

    Intention to stop smoking affected the estimated probabilities for the occurrence of consequences for both continuing and stopping smoking, whereas pregnancy did not affect the estimated probabilities. The estimated effect of stopping smoking was statistically significant.

    Conclusion

    Health messages about smoking for all population groups should consider both future risk of mortality and immediate quality-of-life effects of smoking.

  • 131.
    Näsman, Per
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transporter och samhällsekonomi (stängd 20110301), Säkerhetsforskning (stängd 20110301).
    Örtendahl, Monica
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transporter och samhällsekonomi (stängd 20110301), Säkerhetsforskning (stängd 20110301).
    Values and beliefs about consequences related to smoking among pregnant and non-pregnant women2007Inngår i: Journal of Obstetrics and Gynaecology, ISSN 0144-3615, E-ISSN 1364-6893, Vol. 27, nr 6, s. 558-563Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The purpose of the study was to test a model based on the product of value and belief, called expected utility (EU), on the addictive behaviour of smoking. A total of 40 pregnant and 40 non-pregnant women over a period of 2 weeks performed judgements on values and beliefs about consequences related to smoking for the conditions of continuing and stopping smoking. There were no differences between pregnant and non-pregnant women in the EU of smoking. Differences in expected utility between the conditions of continuing and stopping smoking were larger for health consequences compared with psychological and social consequences and consequences related to pregnancy. Expected utility gives a good description of judgements over time. Values as well as beliefs related to health consequences should be stressed in smoking cessation programmes, especially among pregnant women.

  • 132.
    Oakes, Benjamin Donald
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Systemanalys och ekonomi.
    Mattsson, Lars-Göran
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Bäckström, Mats
    KTH, Skolan för elektro- och systemteknik (EES), Elektroteknisk teori och konstruktion. Saab Aeronautics, Sweden.
    A Dynamic Operational Model for Improving the Resilience of Wireless Networks Against JammingInngår i: Artikkel i tidsskrift (Fagfellevurdert)
  • 133.
    Oakes, Benjamin Donald
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS.
    Mattsson, Lars-Göran
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS.
    Glazunov, Andres Alayon
    CTH Chalmers Univ Technol, Commun & Antenna Syst Div, Dept Elect Engn, Gothenburg, Sweden..
    A Systems-Based Risk Assessment Framework for Intentional Electromagnetic Interference (IEMI) on Critical Infrastructures2018Inngår i: Risk Analysis, ISSN 0272-4332, E-ISSN 1539-6924, Vol. 38, nr 6, s. 1279-1305Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Modern infrastructures are becoming increasingly dependent on electronic systems, leaving them more vulnerable to electrical surges or electromagnetic interference. Electromagnetic disturbances appear in nature, e.g., lightning and solar wind; however, they may also be generated by man-made technology to maliciously damage or disturb electronic equipment. This article presents a systematic risk assessment framework for identifying possible, consequential, and plausible intentional electromagnetic interference (IEMI) attacks on an arbitrary distribution network infrastructure. In the absence of available data on IEMI occurrences, we find that a systems-based risk assessment is more useful than a probabilistic approach. We therefore modify the often applied definition of risk, i.e., a set of triplets containing scenario, probability, and consequence, to a set of quadruplets: scenario, resource requirements, plausibility, and consequence. Probability is replaced by resource requirements and plausibility, where the former is the minimum amount and type of equipment necessary to successfully carry out an attack scenario and the latter is a subjective assessment of the extent of the existence of attackers who possess the motivation, knowledge, and resources necessary to carry out the scenario. We apply the concept of intrusion areas and classify electromagnetic source technology according to key attributes. Worst-case scenarios are identified for different quantities of attacker resources. The most plausible and consequential of these are deemed the most important scenarios and should provide useful decision support in a countermeasures effort. Finally, an example of the proposed risk assessment framework, based on notional data, is provided on a hypothetical water distribution network.

  • 134.
    Oakes, Benjamin Donald
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Systemanalys och ekonomi.
    Mattsson, Lars-Göran
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Glazunov, Andrés Alayón
    A Systems-Based Risk Assessment Framework for Intentional Electromagnetic Interference (IEMI) on CriticalInfrastructuresArtikkel i tidsskrift (Fagfellevurdert)
  • 135. Pieper, R.
    et al.
    Kager, L.
    Näsman, Per
    KTH, Tidigare Institutioner                               , Infrastruktur.
    Acute Appendicitis: a Clinical Study of 1018 Cases of Emergency Appendectomy1982Inngår i: Acta chirurgica Scandinavica, ISSN 0001-5482, Vol. 148, nr 1, s. 51-62Artikkel i tidsskrift (Fagfellevurdert)
  • 136. Pieper, Rolf
    et al.
    Kager, L.
    Näsman, Per
    KTH, Tidigare Institutioner (före 2005), Infrastruktur.
    Clinical Significance of Mucosal Inflammation of the Vermiform Appendix1983Inngår i: Annals of Surgery, ISSN 0003-4932, E-ISSN 1528-1140, Vol. 197, nr 3, s. 368-374Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In 942 emergency appendectomies, the clinical data of 77 patients with inflammatory changes confined to the mucosa of the vermiform appendix were compared with data from 622 patients with diffuse acute appendicitis and 243 patients without evidence of inflammation in the appendix. In all cases, routine histologic sections of the specimens were reviewed. Of the 77 patients with mucosal appendiceal inflammation, 50 were female and 50% were under 17 years of age. In several clinical aspects, such as incidence of nausea, vomiting, migration of pain, and localized muscular rigidity, there existed significant differences between patients with mucosal inflammation and patients with diffuse appendicitis. Conversely, no statistically significant differences were found between patients with mucosal inflammation and patients without evident appendiceal inflammation. These results in addition to the frequent finding of histologically indistinguishable changes in appendices removed incidentally suggest that the condition is not responsible for the actual complaint.

  • 137. Quintana, M
    et al.
    Hjemdahl, P
    Sollevi, A
    Kahan, T
    Edner, M
    Rehnqvist, N
    Swahn, E
    Kjerr, A-C
    Näsman, P
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Attacc Investigators, -
    Left ventricular function and cardiovascular events following adjuvant therapy with adenosine in acute myocardial infarction treated with thrombolysis - Results of the ATTenuation by Adenosine of Cardiac Complications (ATTACC) study2003Inngår i: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 59, nr 1, s. 1-9Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Reperfusion therapy for acute myocardial infarction (AMI) reduces mortality but is also associated with reperfusion injury. The present study tested the hypothesis that adjuvant therapy with a low anti-inflammatory dose of adenosine might prevent reperfusion injury and preserve left ventricular function. Methods: Six hundred and eight patients with ST-elevation AMI were randomised to receive infusions of adenosine (10 mug.kg(-1)min(-1)) or placebo (saline) to be started with thrombolysis and maintained for 6 h. The primary endpoint was global and regional left ventricular systolic and diastolic function, as assessed by two-dimensional and Doppler echocardiography before hospital discharge. The secondary end-point was all cause and cardiovascular mortality, and non-fatal myocardial infarction during 12 months of follow-up. Results: No beneficial effect of adenosine was found regarding echocardiographic indices of left ventricular systolic or diastolic function. Recruitment was stopped due to this apparent lack of effect after an interim analysis. However, after 12 months of follow-up, cardiovascular mortality was 8.9% with adenosine and 12.1% with placebo treatment [odds ratio (OR) 0.71, 95% confidence interval (C.I.) 0.4-1.2, P=0.2] among all patients and 8.4% vs 14.6% (OR 0.53, 95% C.I. 0.23-1.24, P=0.09) among patients with anterior AMI. All cause mortality differed similarly. Non-fatal AMI was not reduced similarly by adenosine treatment. Survival curves indicate that possible survival benefits are maintained after the first year of follow-up. Conclusions: Adenosine, given as adjunctive treatment with thrombolysis, did not provide detectable improvement of echocardiographic indices of left ventricular function when assessed before hospital discharge. Cardiovascular and all cause mortality appear to have been reduced by low-dose adenosine treatment, and the size of the effect appears to be clinically relevant (absolute risk reductions of approximate to4%). The power of the study regarding morbidity and mortality was, however, limited. The results are compatible with a beneficial anti-inflammatory effect of adenosine treatment on reperfusion injury after thrombolysis, which may be mediated by inhibition of leukocytes in peripheral blood. A larger trial is warranted to possibly establish beneficial effects of low-dose adenosine on survival after thrombolysis.

  • 138. Quintana, M
    et al.
    Sollevi, A
    Rehnqvist, N
    Kahan, T
    Edner, M
    Swahn, E
    Näsman, P
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Kjerr, A-C
    Hjemdahl, P
    The effects of adenosine as adjuvant therapy in acute myocardial infarction on cardiovascular events: Results of the ATTenuation by Adenosine of Cardiac Complications (ATTAC) study2001Inngår i: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 22, nr Supplement S, s. 287-287Artikkel i tidsskrift (Fagfellevurdert)
  • 139. Rathnayake, N
    et al.
    Gustafsson, A
    Norhammar, A
    Kjellström, B
    Klinge, B
    Rydén, L
    Tervahartiala, T
    Sorsa, T
    PAROKRANK Steering Group; de Faire U.
    Lindahl, B
    Nygren, Å
    Näsman, Per
    PAROKRANK Steering Group; de Faire U.
    Svenungsson, E
    Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).2015Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, nr 7, artikkel-id e0126370Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background and Objective: Matrix metalloproteinase (MMP) -8, -9 and myeloperoxidase (MPO) are inflammatory mediators. The potential associations between MMP-8, -9, MPO and their abilities to reflect cardiovascular risk remains to be evaluated in saliva. The objective of this study was to investigate the levels and associations of salivary MMP-8, -9, MPO and tissue inhibitors of metalloproteinase (TIMP)-1 in myocardial infarction (MI) patients and controls with or without periodontitis. Materials and Methods: 200 patients with a first MI admitted to coronary care units in Sweden from May 2010 to December 2011 and 200 controls matched for age, gender, residential area and without previous MI were included. Dental examination and saliva sample collection was performed 6-10 weeks after the MI in patients and at baseline in controls. The biomarkers MMP -8, -9, MPO and TIMP-1 were analyzed by time-resolved immunofluorescence assay (IFMA), Western blot and Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: After compensation for gingivitis, gingival pockets and smoking, the mean salivary levels of MMP-8 (543 vs 440 ng/mL, p = 0.003) and MPO (1899 vs 1637 ng/mL, p = 0.02) were higher in non-MI subjects compared to MI patients. MMP-8, -9 and MPO correlated positively with clinical signs of gingival/periodontal inflammation while TIMP-1 correlated mainly negatively with these signs. The levels of latent and active forms of MMP-8 did not differ between the MI and non-MI groups. Additionally, MMP-8, MPO levels and MMP-8/TIMP-1 ratio were significantly higher in men compared to women with MI. Conclusions: This study shows that salivary levels of the analyzed biomarkers are associated with periodontal status. However, these biomarkers could not differentiate between patients with or without a MI. These findings illustrate the importance to consider the influence of oral conditions when analyzing levels of inflammatory salivary biomarkers.

  • 140. Rehnqvist, N
    et al.
    Hjemdahl, P
    Billing, E
    Björkander, I
    Eriksson, SV
    Forslund, L
    Held, C
    Näsman, P
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Wallen, NH
    Effects of metoprolol vs verapamil in patients with stable angina pectoris: The Angina Prognosis Study in Stockholm (APSIS)1996Inngår i: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 17, nr 1, s. 76-81Artikkel i tidsskrift (Fagfellevurdert)
  • 141. Rehnqvist, N
    et al.
    Hjemdahl, P
    Billing, E
    Björkander, I
    Eriksson, SV
    Forslund, L
    Held, C
    Näsman, P
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Wallen, NH
    Effects on Cardiovascular End Points and Psychological Variables of Metoprolol and Verapamil in Patients with Stable Angina Pectoris: The Angina Prognosis Study in Stockholm (APSIS)1995Inngår i: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 25, nr 2 (Supplement 1), s. 313A-314AArtikkel i tidsskrift (Fagfellevurdert)
  • 142. Rehnqvist, N
    et al.
    Hjemdahl, P
    Billing, E
    Björkander, I
    Eriksson, SV
    Forslund, L
    Held, C
    Näsman, P
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Wallen, NH
    Prevention of cardiac events in patients with angina pectoris: Results of the APSIS study1995Inngår i: European Heart Journal, Supplement, ISSN 1520-765X, E-ISSN 1554-2815, Vol. 16, nr Suppl. H, s. 18-18Artikkel i tidsskrift (Fagfellevurdert)
  • 143. Rehnqvist, N
    et al.
    Hjemdahl, P
    Billing, E
    Björkander, I
    Eriksson, SV
    Forslund, L
    Held, C
    Näsman, P
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för transportstudier, CTS. KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Wallen, NH
    Treatment of stable angina pectoris with calcium antagonists and beta-blockers: The APSIS study1995Inngår i: Cardiologia, ISSN 0393-1978, Vol. 40, nr Suppl 1 al n 12, s. 301-301Artikkel i tidsskrift (Fagfellevurdert)
  • 144. Ritsinger, V.
    et al.
    Brismar, K.
    Malmberg, K.
    Mellbin, L.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Rydén, L.
    Söderberg, S.
    Tenerz, Å.
    Norhammar, A.
    Elevated levels of adipokines predict outcome after acute myocardial infarction: A long-term follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort2017Inngår i: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 14, nr 2, s. 77-87Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Adiponectin and leptin are associated with insulin resistance and cardiovascular disease. Information on the prognostic value after an acute myocardial infarction is still conflicting. Methods: Patients (n = 180) without known diabetes and with admission glucose of <11 mmol/L admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/heart failure) until the end of 2011 (median: 11.6 years). Plasma adiponectin and leptin were related to outcome in Cox proportional-hazard regression analyses. Results: Median age was 64 years and 69% were male. Total mortality was 34% (n = 61) and 44% (n = 80) experienced a cardiovascular event. Adiponectin at discharge predicted cardiovascular events (hazard ratio; 95% confidence interval; 1.45; 1.02-2.07, p = 0.038), total mortality (2.53; 1.64-3.91, p < 0.001) and cancer mortality (3.64; 1.51-8.74, p = 0.004). After adjustment for age, sex, body mass index, previous myocardial infarction and heart failure, adiponectin predicted total mortality (1.79; 1.07-3.00, p = 0.027) but not cardiovascular events. High levels of leptin were associated with cardiovascular events during the first 7 years, after which the association was attenuated. Leptin did not predict total mortality. Conclusion: In patients with acute myocardial infarction but without previously known diabetes, high levels of adiponectin at discharge predicted total mortality. The present results support the hypothesis that high rather than low levels of adiponectin predict mortality after acute myocardial infarction.

  • 145. Ritsinger, V.
    et al.
    Brismar, Kerstin
    Malmberg, K.
    Mellbin, L.
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Ryden, L.
    Soderberg, S.
    Tenerz, A.
    Norhammar, A.
    Elevated levels of adipokines predict outcome after acute myocardial infarction. Long-term follow-up of the GAMI cohort2016Inngår i: EUROPEAN HEART JOURNAL, ISSN 0195-668X, Vol. 37, s. 459-459Artikkel i tidsskrift (Fagfellevurdert)
  • 146. Ritsinger, Viveca
    et al.
    Tanoglidi, Eleni
    Malmberg, Klas
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Ryden, Lars
    Tenerz, Ake
    Norhammar, Anna
    Sustained prognostic implications of newly detected glucose abnormalities in patients with acute myocardial infarction: Longterm follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort2015Inngår i: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 12, nr 1, s. 23-32Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To investigate long-term prognostic importance of newly discovered glucose disturbances in patients with acute myocardial infarction (AMI). Methods: During 1998-2001, consecutive patients with AMI (n=167) and healthy controls (n=184) with no previously known diabetes were investigated with an oral glucose tolerance test (OGTT). Patients and controls were separately followed up for cardiovascular events (first of cardiovascular mortality/AMI/stroke/heart failure) during a decade. Results: In all, 68% of the patients and 35% of the controls had newly detected abnormal glucose tolerance (AGT). Cardiovascular event (n=72, p=0.0019) and cardiovascular mortality (n=31, p=0.031) were more frequent in patients with newly detected AGT. Regarding patients, a Cox proportional-hazard regression analysis identified AGT (hazard ratio (HR): 2.30; 95% confidence interval (CI): 1.24-4.25; p=0.008) and previous AMI (HR: 2.39; CI: 1.31-4.35; p=0.004) as prognostically important. Conclusion: An OGTT at discharge after AMI disclosed a high proportion of patients with previously unknown AGT which had a significant and independent association with long-term prognosis.

  • 147. Ritsinger, Viveca
    et al.
    Tanoglidi, Eleni
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transport- och lokaliseringsanalys.
    Malmberg, Klas
    Rydén, Lars
    Tenerz, Åke
    Norhammar, Anna
    The Long-term Impact of Newly Discovered Glucose Abnormalities in Patients With Acute Myocardial Infarction2013Inngår i: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 128, nr 22, s. 10261-Artikkel i tidsskrift (Annet vitenskapelig)
  • 148.
    Rudberg, Ann-Sofie
    et al.
    Karolinska Inst, Dept Clin Neurosci, Div Neurol, Tomtebodavagen 18A,Floor 5, S-17177 Stockholm, Sweden..
    Berge, Eivind
    Oslo Univ Hosp, Dept Internal Med & Cardiol, Oslo, Norway.;Univ Tromso, Inst Clin Med, Tromso, Norway..
    Gustavsson, Anders
    Quantify Res, Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden..
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Centra, Centrum för trafikforskning, CTR.
    Lundström, Erik
    Karolinska Inst, Dept Clin Neurosci, Div Neurol, Tomtebodavagen 18A,Floor 5, S-17177 Stockholm, Sweden..
    Long-term health-related quality of life, survival and costs by different levels of functional outcome six months after stroke2018Inngår i: European Stroke Journal, ISSN 2396-9873, E-ISSN 2396-9881, Vol. 3, nr 2, s. 157-164Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: Information about the impact of functional outcome after stroke is currently missing on health-related quality of life, survival and costs. This information would be valuable for health economic evaluations and for allocation of resources in stroke health care. Patients and methods: Data on 297 Swedish patients included in the Third International Stroke Trial were analysed including functional outcome at six months (measured by Oxford Handicap Scale), health-related quality of life up to 18 months (EQ-5D-3L) and survival up to 36 months. We used record linkage to collect data on costs up to 36 months, using national patient registers. Results: Patients with a better functional outcome level at six months had a significantly better health-related quality of life at 18 months (p<0.05), better long-term survival (p<0.05) and lower costs (p<0.001), for all time points up to 36 months. The difference in costs was mainly due to differences in days spent in hospital (p<0.005). Discussion: This study showed an association between functional outcome at six months and health-related quality of life up to 18 months, and costs up to 36 months. Conclusion: Functional outcome six months after stroke is an important determinant of health-related quality of life, survival and costs over 36 months. Effective interventions aimed at reducing short-term disability levels are therefore also expected to reduce the overall burden of stroke.

  • 149. Ryden, Lars
    et al.
    Buhlin, Kare
    Ekstrand, Eva
    de Faire, Ulf
    Gustafsson, Anders
    Holmer, Jacob
    Kjellstrom, Barbro
    Lindahl, Bertil
    Norhammar, Anna
    Nygren, Ake
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Transportvetenskap, Transportplanering, ekonomi och teknik.
    Rathnayake, Nilminie
    Svenungsson, Elisabet
    Klinge, Bjoern
    Periodontitis Increases the Risk of a First Myocardial Infarction A Report From the PAROKRANK Study2016Inngår i: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 133, nr 6, s. 576-583Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background The relationship between periodontitis (PD) and cardiovascular disease is debated. PD is common in patients with cardiovascular disease. It has been postulated that PD could be causally related to the risk for cardiovascular disease, a hypothesis tested in the Periodontitis and Its Relation to Coronary Artery Disease (PAROKRANK) study. Methods and Results Eight hundred five patients (<75 years of age) with a first myocardial infarction (MI) and 805 age- (mean 628), sex- (male 81%), and area-matched controls without MI underwent standardized dental examination including panoramic x-ray. The periodontal status was defined as healthy (80% remaining bone) or as mild-moderate (from 79% to 66%) or severe PD (<66%). Great efforts were made to collect information on possibly related confounders (approximate to 100 variables). Statistical comparisons included the Student pairwise t test and the McNemar test in 2x2 contingency tables. Contingency tables exceeding 2x2 with ranked alternatives were tested by Wilcoxon signed rank test. Odds ratios (95% confidence intervals) were calculated by conditional logistic regression. PD was more common (43%) in patients than in controls (33%; P<0.001). There was an increased risk for MI among those with PD (odds ratio, 1.49; 95% confidence interval, 1.21-1.83), which remained significant (odds ratio, 1.28; 95% confidence interval, 1.03-1.60) after adjusting for variables that differed between patients and controls (smoking habits, diabetes mellitus, years of education, and marital status). Conclusions In this large case-control study of PD, verified by radiographic bone loss and with a careful consideration of potential confounders, the risk of a first MI was significantly increased in patients with PD even after adjustment for confounding factors. These findings strengthen the possibility of an independent relationship between PD and MI.

  • 150.
    Sippl, Natalie
    et al.
    Karolinska Inst, Rheumatol Unit, Dept Med Solna, Karolinska Univ Hosp, Stockholm, Sweden..
    Grosso, Giorgia
    Karolinska Inst, Rheumatol Unit, Dept Med Solna, Karolinska Univ Hosp, Stockholm, Sweden..
    Ferrannini, Giulia
    Karolinska Inst, Dept Med Heart & Vasc Theme, Karolinska Univ Hosp, Stockholm, Sweden..
    de Faire, Ulf
    Karolinska Inst, Div Cardiovasc Epidemiol, IMM, Stockholm, Sweden..
    Lindahl, Bertil
    Karolinska Inst, Dept Clin Immunol & Transfus Med, Unit Clin Immunol, Karolinska Univ Hosp, Stockholm, Sweden..
    Näsman, Per
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Fastigheter och byggande, Bygg- och fastighetsekonomi.
    Norhammar, Anna
    Karolinska Inst, Dept Med Heart & Vasc Theme, Karolinska Univ Hosp, Stockholm, Sweden.;Capio St Gorans Hosp, Stockholm, Sweden..
    Ryden, Lars
    Karolinska Inst, Dept Med Heart & Vasc Theme, Karolinska Univ Hosp, Stockholm, Sweden..
    Svenungsson, Elisabet
    Karolinska Inst, Rheumatol Unit, Dept Med Solna, Karolinska Univ Hosp, Stockholm, Sweden..
    Amara, Khaled
    Karolinska Inst, Rheumatol Unit, Dept Med Solna, Karolinska Univ Hosp, Stockholm, Sweden..
    Domain specific anti-beta 2GPI antibodies in patients with First Myocardial Infarction2019Inngår i: Lupus, ISSN 0961-2033, E-ISSN 1477-0962, Vol. 28, s. 39-40Artikkel i tidsskrift (Annet vitenskapelig)
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