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2020 (engelsk)Inngår i: eLIFE, E-ISSN 2050-084X, Vol. 9, artikkel-id e55212Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
Growth plate and articular cartilage constitute a single anatomical entity early in development but later separate into two distinct structures by the secondary ossification center (SOC). The reason for such separation remains unknown. We found that evolutionarily SOC appears in animals conquering the land - amniotes. Analysis of the ossification pattern in mammals with specialized extremities (whales, bats, jerboa) revealed that SOC development correlates with the extent of mechanical loads. Mathematical modeling revealed that SOC reduces mechanical stress within the growth plate. Functional experiments revealed the high vulnerability of hypertrophic chondrocytes to mechanical stress and showed that SOC protects these cells from apoptosis caused by extensive loading. Atomic force microscopy showed that hypertrophic chondrocytes are the least mechanically stiff cells within the growth plate. Altogether, these findings suggest that SOC has evolved to protect the hypertrophic chondrocytes from the high mechanical stress encountered in the terrestrial environment.
sted, utgiver, år, opplag, sider
eLife Sciences Publications, Ltd, 2020
HSV kategori
Identifikatorer
urn:nbn:se:kth:diva-286228 (URN)10.7554/eLife.55212 (DOI)000584986800001 ()33063669 (PubMedID)2-s2.0-85094219487 (Scopus ID)
Merknad
QC 20201125
2020-11-252020-11-252026-09-25bibliografisk kontrollert