In this paper I shall discuss the role of group cohomology in quantum mechanics and quantum field theory. First, I recall how cocycles of degree 1 and 2 appear naturally in the context of gauge anomalies. Then we investigate how group cohomology of degree 3 comes from a prolongation problem for group extensions and we discuss its role in quantum field theory. Finally, we discuss a generalization to representation theory where a representation is replaced by a 1-cocycle or its prolongation by a circle, and point out how this type of situations come up in the quantization of Yang-Mills theory. 

This talk is based on the paper [1], which contains references to the original literature. We study the quantization of chiral fermions coupled to generalized Dirac operators arising in NCG Yang-Mills theory. The cocycles describing chiral symmetry breaking are calculated. In particular, we introduce a generalized locality principle for the cocycles. Local cocycles are by definition expressions which can be written as generalized traces of operator commutators. In the case of pseudodifferential operators, these traces lead in fact to integrals of ordinary local de Rham forms. As an application of the general ideas we take the case of noncommutative tori.