H2O2 produced from water radiolysis is expected to play a significant role in radiation induced oxidative dissolution of spent nuclear fuel under the anoxic conditions of a deep geological repository if the safety-barriers fail and ground water reaches the fuel. It was recently found that the coordination chemistry between U(vi), HCO32− and H2O2 can significantly suppress H2O2 induced dissolution of UO2 in 10 mM bicarbonate. This was attributed to the much lower reactivity of the U(vi)O22+-coordinated O22− as compared to free H2O2. We have extended the study to lower bicarbonate concentrations and explored the impact of ionic strength to elucidate the rationale for the low reactivity of complexed H2O2. The experimental results clearly show that dissolution of U(vi) becomes suppressed at [HCO3−] < 10 mM. Furthermore, we found that the reactivity of the peroxide in solutions containing U(vi) becomes increasingly more suppressed at lower carbonate concentration. The suppression is not influenced by the ionic strength, which implies that the low reactivity of O22− in ternary uranyl-peroxo-carbonato complexes is not caused by electrostatic repulsion between the negatively charged complex and the negatively charged UO2-surface as we previously hypothesized. Instead, the suppressed reactivity is suggested to be attributed to inherently higher stability of the peroxide functionality as a ligand to UO22+ compared to as free H2O2.