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2025 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 15, no 1, article id 9694Article in journal (Refereed) Published
Abstract [en]
A lab-in-a-fiber component was fabricated using an optical fiber and a fiber capillary. It was used in a test suspension of fluorescently labeled and unlabeled cells and enabled detection of the labeled cells. Subsequently the labeled cells were selectively collected via suction into the capillary. A novel sampling technique reduced photobleaching of the labeled cells, extending the measurement time. The collected cells remained viable for downstream analysis. This platform’s low fabrication cost, simplicity, compatibility with standard laboratory equipment, and capacity for fully automated cell capture highlights its potential for future applications in minimally invasive sample collection and point-of-care diagnostics. We demonstrate this LiF device to showcase the capability of optical fiber technology in creating low-cost, low-complexity cancer diagnostic devices. Furthermore, the LiF device holds promise for in vivo diagnostics, facilitating cell isolation and analysis.
Place, publisher, year, edition, pages
Springer Nature, 2025
Keywords
Cancer diagnostics, Cell capture, Cell detection, Lab-in-a-Fiber
National Category
Molecular Biology
Identifiers
urn:nbn:se:kth:diva-362042 (URN)10.1038/s41598-025-92585-6 (DOI)001449593100013 ()40113943 (PubMedID)2-s2.0-105000517014 (Scopus ID)
Note
QC 20250428
2025-04-032025-04-032025-05-05Bibliographically approved