Open this publication in new window or tab >>2020 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]
In the previous study [1], a novel contrast pulse sequence, CPS4, was introduced. The CPS4 combined sub-harmonic, ultra-harmonic and pulse inverse imaging to provide an improved contrast-to-tissue ratio (CTR). The CPS4 emits two pairs of transmitting waves at frequencies of f0/2 and 2*f0 with inversed phase within each pair and filters the received echoes at the frequency of f0. However, the performance of CPS4 was not optimized. Simulation study [2] shows that there is a pressure threshold for the sub-harmonic response generation of the ultrasound contrast agent (UCA). The threshold is expected to reach its local minima with the transmitting frequency around the resonance frequency. By lowering the threshold, more MBs could be excited to response sub-harmonic signal which could improve the CTR of CPS4.
The current study aims to investigate frequency-dependent performance of CPS4 with the polyvinyl alcohol microbubbles (PVA MBs). First a linear oscillator model adapted from Hoff and Church[3, 4] was built for single PVA MB. The attenuation and phase velocity of a PVA MB suspension were obtained to calibrate the linear oscillator. The model was used to estimate the resonance frequency of the MBs. The transmitting frequency of CPS4 for sub-harmonic was set at four frequency points around the local minima, i.e. resonance frequency. The performance of CPS4 at different frequencies were evaluated.
Keywords
microbubble model, ultrasound contrast agent
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-287170 (URN)
Conference
The 25th European symposium on Ultrasound Contrast Imaging
Note
No duplicate with DiVA 1264409
QC 20210803
2020-12-032020-12-032022-06-25Bibliographically approved