We introduce and study s-lecture hall P-partitions which is a generalization of s-lecture hall partitions to labeled (weighted) posets. We provide generating function identities for s-lecture hall P-partitions that generalize identities obtained by Savage and Schuster for s-lecture hall partitions, and by Stanley for P-partitions. We also prove that the corresponding (P, s)-Eulerian polynomials are real-rooted for certain pairs (P, s), and speculate on unimodality properties of these polynomials.