Since 2010, the Swedish e-Science Research Centre (SeRC) is funding and coordinating e-Science activities in a broad spectrum of scientific disciplines. After an initial 5-year phase that produced outstanding results, SeRC is increasingly focusing on fostering interactions between disciplines and has created so-called Multidisciplinary Collaborative Programs (MCPs). In these programs, domain researchers collaborate with e-Science methods and tool developers and e-Infrastructure providers. In this paper we give an overview of the initial phase of SeRC and present the new programs that started operating in 2019.