Purpose: To examine the effects of prolonged intermittent exposures to moderately increased transmural pressure on finger vasoreactivity and thermoperception to localised cooling. Methods: Eleven men completed a 5-week regimen (3 sessions⋅week1; 55 min⋅session1), during which the vasculature in one arm (EXP) was exposed intermittently (10-min exposure: 5-min pause) to increased trans-mural pressure (from +65 mmHg week-1 to +105 mmHg week-5). Before and after the regimen, finger cuta-neous vascular conductance (CVC), temperature (Tavg), and thermoperception (thermal sensation, discomfort and pain) were monitored during a 30-min hand cold (8 ◦C water) provocation trial. The responses of the non-trained hand were examined during an additional cold trial. Results: After the regimen, baseline finger CVC and Tavg were higher in both hands (p ≤0.01). During cooling, neither finger CVC nor Tavg were modified (p >0.05). Yet the magnitude of the cold-induced drop of CVC was augmented in both hands, and to a similar extent (p ≤0.02). The regimen alleviated thermal pain in both hands (p ≤0.02); the sensation of coldness and thermal discomfort were attenuated mainly in the EXP hand (p =0.02). Conclusions: Present findings indicate that iterative local exposures to augmented intravascular pressure do not alter finger vasoreactivity to localised cooling. The pressure training, however, might impair finger basal vasomotor tone, and aggravate the magnitude of constrictor responsiveness to cooling. The pressure training also elicits thermoperceptual desensitisation to noxious thermal stimulus. To large extent, these vascular and perceptual adjustments seem to be transferred to the cutaneous vasculature of the non-trained limb.