This study explores the application of resource orchestration (RO) theory to explain the management of production equipment design in large manufacturing firms. It sheds light on a customized application of dynamic RO in the context of production equipment design projects through an in-depth multiple case study. The findings suggest that effective RO across a portfolio of capital projects and leveraging equipment suppliers’ capabilities is essential for effective achievement of operational targets early on. The study showcases a broadening scope of RO beyond boundaries of an organization (unit) to a portfolio of projects spanning a network of manufacturers.