Electrochemical H2O2 production through the two-electron oxygen reduction reaction (2e− ORR) represents a transformative route for sustainable and decentralized chemical synthesis. Nevertheless, conventional catalysts struggle to achieve optimal intermediates adsorption and efficient proton-coupled electron transfer (PCET) under neutral conditions, as the sluggish dissociation of water imposes a severe kinetic bottleneck. Herein, we introduce a lattice hydrogen engineering strategy that confers unprecedented catalytic functionality to traditionally inert metal oxides. Through precise hydrogen implantation into the TiO2 lattice, we establish Ti-O2C-H active centers—a dual-function motif that simultaneously achieves near-ideal OOH* adsorption (positioned at the Sabatier volcano apex) and intrinsic proton reservoir capability. This atomically engineered H-TiO2 catalyst delivers > 95% H2O2 selectivity, operating stably for over 100 h at an industrial current density of 200 mA cm−2. This robust operation yields a high H2O2 production rate of 13,968 mmol g−1 h−1 with an energy efficiency of 41.3%. Crucially, the universality of lattice hydrogen engineering is demonstrated through the activation of WO3, MoO3, and Nb2O5, yielding comparable performance enhancements for neutral 2e− ORR. By unlocking metal oxides as a robust catalyst platform for H2O2 electrosynthesis, this work establishes a scalable pathway toward scalable, green and cost-effective peroxide production.