Dominant traditions in Western science have traditionally separated humans from nature, a division that is reproduced in the distinction between natural and social sciences. This rift has persistently hampered the ability of sustainability science to comprehensively understand and address the profound challenges of the Anthropocene. In this perspective, we aim to challenge entrenched separations between humans and nature by emphasizing the embeddedness of humans in the biosphere. We conceptualize embeddedness from a systems perspective and illustrate it using case studies on human microbiomes and freshwater availability. We discuss how a focus on embeddedness can increasingly be adopted in sustainability research through developments in sensing, modeling, and commoning practices. By highlighting these conceptual and practical opportunities for studying embeddedness in the biosphere, we seek to support transdisciplinary dialogues and practices toward sustainable futures.