In this paper, we describe some of the methods used at KTH Mechanics in the field of turbulence simulations. High performance computing (HPC) resources, including the dedicated system "Ekman" with 10000 cores at KTH, are employed to perform some of the largest turbulence simulations with up to 10 billion grid points. The results are used to assess the fidelity of such types of simulations by comparing in detail to wind tunnel experiments, excellent agreement is obtained in general. Simulations can thus be considered numerical experiments, and are subject to the same scrutiny as "real" experimental data. Validated simulation data is extremely valuable as it may provide unprecedented insight into the turbulence dynamics. However, given the large size of the computations, the massively parallel simulation codes, post processing tools and storage solutions have to be specifically adapted, making turbulence simulations an interdisplinary area of e-Science.