Instructions and instruction systems are considered as important pillars in the productrealization process. However, often the activities to create, layout and use instructions arebased on tradition rather than a strategic thought in the industry today. In a model drivenengineering context there is a risk to focus on the information system at the sacrifice of theimportant operator interface. A three level instruction system development process isintroduced as a solution to establish a holistic instruction system: 1) Instruction systemdesign, 2) design framework for instructions, and 3) realize instruction. Studies indicatethat there is a great potential in how instruction systems are used due to both theeffectiveness in the creation of the instruction and the probability of non-conformities dueto the instruction formulation and layout.