Due to a need of more compact bogies, the brake discs can be mounted on the railway wheels, bolted through the wheel web. Thus, the wheels are drilled and have multiple areas of contact with the brake discs. To establish maintenance procedures that will be applied to the  wheels,  SNCF  used  the  feedback  from  experience  (as  with  the  train  AGC)  which  gives  perfect  performance  in  terms  of  safety.  However,  to  optimize  the  maintenance  process, numerical  simulations  may  be  preferred  since  they  are  less  conservative.  This  report  describes  the  numerical  simulations,  based  on  the  finite  element  method,  that  were conducted to determine if the Régiolis wheel complies with the standard EN 13979-­‐1 from a mechanical  fatigue  point  of  view.  In  addition,  it  provides  additional  insights  regarding  the  loads and damage suffered by the wheel, which are not taken into account in the standard: the  damage  induced  by  disc  braking  and  the  fretting  that  may  occur  at  the  contact  interfaces. This study has been used as a decision support for the first inspection intervals of the Régiolis wheels.