In this chapter, we argue in favor of a place-oriented public health perspective on safety in public spaces. We start by illustrating how public spaces can affect individuals’ health via their impact on individuals’ behavior, patterns of crime victimization, and fall injuries. Using a bibliometric visualization tool, we identify clusters of research in this area published from 1968 to 2018. Then, we illustrate this body of literature by introducing three of the most recent research strands. The chapter closes with a discussion of theoretical and practical potentialities as well as future challenges when adopting a place-oriented public health perspective to safety in public spaces.