Multifocal contact lenses are increasingly popular interventions for controlling myopia. This study presents the short-termeffects of multifocal contact lenses on foveal and peripheral vision. TheMiSight contact lenses designed to inhibit myopia progression and the 1-Day Acuvue Moist contact lenses designed for presbyopia were investigated. The MiSight produced similar foveal results to spectacles despite the increased astigmatism and coma. The MiSight also reduced the low-contrast resolution acuity in the periphery, despite no clear change in relative peripheral refraction. When compared with spectacles, Acuvue Moist decreased accommodative response and reduced foveal high- and low-contrast resolution acuity, whereas peripheral thresholds were more similar to those of spectacles. The most likely treatment property for myopia control by theMiSight is the contrast reduction in the peripheral visual field and the changed accommodation.