End-to-end learning for wireless communications has recently attracted much interest in the community, owing to the emergence of deep learning-based architectures for the physical layer. Neural network-based autoencoders have been proposed as potential replacements of traditional model-based transmitter and receiver structures. Such a replacement primarily provides an unprecedented level of flexibility, allowing to tune such emerging physical layer network stacks in many different directions. The semantic relevance of the transmitted messages is one of those directions. In this paper, we leverage a specific semantic relationship between the occurrence of a message (the source), and the channel statistics. Such a scenario could be illustrated for instance, in vehicular communications where the distance is to be conveyed between a leader and a follower. We study two autoencoder approaches where these special circumstances are exploited. We then evaluate our autoencoders, showing through the simulations that the semantic optimization can achieve significant improvements in the BLERs (up till 93.6%) and RMSEs (up till 87.3%) for vehicular communications leading to considerably reduced risks and needs for message retransmissions.