In concrete structures, material performance is typically determined at the level of the concrete mix (the microscale) and the overall shape and dimensions of a building element (the macroscale). However, recent developments in the field of 3D Concrete Printing (3DCP) are demonstrating that the design of concrete now also can take place at a previously impossible intermediate scale involving the shaping and placement of the material at the level of the printing nozzle (the mesoscale). By focusing directly on the design of print paths, advanced surface effects and internal porous material distributions can be achieved that significantly affect the aesthetic experience and structural performance of 3DCP structures. This ability to design the distribution of concrete according to local architectural, structural, and functional design criteria is an especially interesting application of 3DCP that could be exploited to customise material performance while at the same time optimising material use and reducing the self-weight of building elements. This paper specifically examines how four different three-dimensional print patterns produce distinct material structures at the mesoscale (mesostructures) and presents an experimental procedure for evaluating their load-bearing capacity.