Nuclear physical inputs are critical for predicting the abundance of r-process elements. Extensive sensitivity studies have recently been performed to gauge the impact of the individual properties of nuclei on the r-process. In this work, we investigate the impact of the large uncertainties in the theoretical predictions of the masses of neutron-rich Sn isotopes and the location of the neutron drip line on the abundance of r-process abundances. The uncertainties in the predicted r-process abundances are obtained through large-scale network calculations by simultaneously varying the masses and reaction rates of Sn within the predicted mass uncertainties. The calculations use a generally indicative astrophysical trajectory of neutron-star mergers and are based on three different mass models. The results indicate that the large uncertainty in the location of the neutron drip line for Sn can significantly and asymmetrically affect the predicted abundances of nuclei after the second peak, in particular around A=140−155, sometimes accompanied by a delayed freeze-out.