Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolismVise andre og tillknytning
2025 (engelsk)Inngår i: Journal of Ethnopharmacology, ISSN 0378-8741, E-ISSN 1872-7573, Vol. 353, artikkel-id 120488Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
Ethnopharmacological relevance: Timely intervention in hepatic fibrosis (HF) is imperative to reduce mortality associated with cirrhosis and prevent progression to hepatocellular carcinoma. Bao Gan Ning Decoction (BGN), a Traditional Chinese Medicine formula, demonstrates therapeutic efficacy against HF. However, its mechanism of action remains incompletely defined. Aim of the study: To elucidate the mechanistic role of BGN in attenuating HF through modulation of specific gut microbiota taxa and bile acid (BA) metabolism. Materials and methods: HF was induced in mice using CCl<inf>4</inf>. Gut microbiota composition was analyzed using 16S rRNA gene sequencing. Hepatic BA profiles were quantified using LC-MS/MS, targeting 53 specific BA in negative ion mode through multiple reaction monitoring. Complementary histopathological, molecular, and functional analyses were performed. Results: The findings indicate that BGN mediates remodelling of the gut microbiota by enriching probiotic taxa (Lactobacillus, Bifidobacterium) and depleting pathobionts. Furthermore, BGN attenuates fibrosis by increasing anti-fibrotic BA levels (e.g., ursodeoxycholic acid) while reducing hepatotoxic BA; it activates the PPARα/CYP7A1 signalling axis to upregulate hepatointestinal BA transporters (Slc10a1/NTCP, ABCB11/BSEP, OSTα/β, Slc10a2/ASBT). Conclusions: BGN alleviates HF through gut microbiota-dependent restoration of BA homeostasis and activation of the PPARα/CYP7A1 pathway. This study provides novel mechanistic insights into BGN's anti-fibrotic activities, positioning it as a microbiota-modulating therapeutic candidate for HF management.
sted, utgiver, år, opplag, sider
Elsevier BV , 2025. Vol. 353, artikkel-id 120488
Emneord [en]
Bao Gan Ning decoction (BGN), Bile acid (BA), Gut microbiota, Hepatic fibrosis (HF), Traditional Chinese medicine (TCM)
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-369604DOI: 10.1016/j.jep.2025.120488ISI: 001566260300001PubMedID: 40865652Scopus ID: 2-s2.0-105014649720OAI: oai:DiVA.org:kth-369604DiVA, id: diva2:1997419
Merknad
QC 20250912
2025-09-122025-09-122025-12-08bibliografisk kontrollert