The accretion-powered X-ray pulsar GX 301-2 was observed with the balloon-borne X-Calibur hard X-ray polarimeter during late 2018 December, with contiguous observations by the Neutron star Interior Composition Explorer Mission (NICER) X-ray telescope, the Swift X-ray Telescope and Burst Alert Telescope, and the Fermi Gamma-ray Burst Monitor spanning several months. The observations detected the pulsar in a rare apastron flaring state coinciding with a significant spin up of the pulsar discovered with the Fermi Gamma-ray Burst Monitor. The X-Calibur, NICER, and Swift observations reveal a pulse profile strongly dominated by one main peak, and the NICER and Swift data show strong variation of the profile from pulse to pulse. The X-Calibur observations constrain for the first time the linear polarization of the 15-35 keV emission from a highly magnetized accreting neutron star, indicating a polarization degree of % (90% confidence limit) averaged over all pulse phases. We discuss the spin up and the X-ray spectral and polarimetric results in the context of theoretical predictions. We conclude with a discussion of the scientific potential of future observations of highly magnetized neutron stars with the more sensitive follow-up mission XL-Calibur.