This study analyzes the application domain of Digital Manufacturing while considering the new industrial paradigm. Based on content analysis, joint applications of digital manufacturing tools and advanced manufacturing technologies are framed and technological trends identified. The results reveal a new comprehensive framework that defines the application domain of digital manufacturing in Industry 4.0, as well as how digital manufacturing operates within Industry 4.0. The presented framework covers manufacturing life cycle phases, digital manufacturing tools used in each phase, and Industry 4.0 technologies used with the respective tools. The study contributes by positioning digital manufacturing conceptually and delimiting its application domain.