Global pandemic of SARS-CoV-2 has infected more than 53 million people in more than 190 countries. The major transmission routes of most of the infectious viruses’ including SARS-CoV-2 remain aerosols and droplets. The source of which remains coughing, sneezing, urinary, and intestinal excretions. This book chapter focuses on the latter two sources of water and wastewater contamination with RNA of these contagious viruses. There has been studies regarding the presence of viral RNA of COVID-19 in wastewater in few of the countries like USA, Australia, Netherland, and India. This mainly happens due to the discharge of untreated wastewater from health care facilities and sewage treatment plants. Improper management of the waste has led to the contamination of surface water bodies. Fecal shedding of the virus is common in 50% of the infected individual, and urinal shedding in just around 5%. The former shedding is of the order of 103-105 copies/mL. The wastewater surveillance for SARS-CoV-2 RNA in wastewater gives the figure of 102-106 copies/L. The surveillance already known to track down many diseases, drugs in past has been a boon to the countries, where clinical testing is at a slow pace. Therefore, wastewater-based epidemiology is needed to have a better understanding of the water and wastewater surveillances, for prior detection of SARS-CoV-2 and other pathogens, sought to occur in future. The chapter deals with the occurrences, transport pathways, persistence, and removal of most of the reported infectious viruses in water and wastewater, with a special emphasize on SARS-CoV-2. Developing a proper framework and methodology containing environment and human health risk assessments will help the researchers and policyholders to look up for the alternative options. Even after a number of researches detecting the presence of SARS-CoV-2 in wastewater, there has been a limited knowledge in the potential role of water and wastewater in the transmission of these infectious viruses. A well summarized review would surely help in the assessment of the likely fate of most of these contagious human viruses.